NK cell cytotoxicity is controlled by numerous NK inhibitory and activating receptors. Most of
the inhibitory receptors bind MHC class I proteins and are expressed in a variegated fashion…

Transcription of a gene usually ends at a regulated termination point, preventing the RNA-polymerase
from reading through the next gene. However, sporadic reports suggest that …

G-protein-coupled receptors (GPCRs) represent an important group of targets for
pharmaceutical therapeutics. The completion of the human genome revealed a large number of …

The B7-like protein family members play critical immunomodulatory roles and constitute
attractive targets for the development of novel therapies for human diseases. We identified Ig-…

Prostate-specific antigen (PSA) and human kallikrein 2 are closely related products of the
human kallikrein genes KLK3 and KLK2, respectively. Both PSA and human kallikrein 2 are …

Blocking conformational changes in biologically active proteins holds therapeutic promise.
Inspired by the susceptibility of viral entry to inhibition by synthetic peptides that block the …

The small molecular weight GTP-binding protein Rac (1 or 2) is an obligatory participant in
the activation of the superoxide-generating NADPH oxidase. Active NADPH oxidase can be …

CD40, a TNF receptor (TNFR) family member, is composed of four cysteine rich domains (CRDs)
followed by a transmembrane domain and a signaling intracellular C-terminus. CD154 …

Recombinant cytokines have limited anticancer efficacy mostly due to a narrow therapeutic
window and systemic adverse effects. IL18 is an inflammasome-induced proinflammatory …

Chordin-like cysteine-rich repeats (CRs) are conserved domains present in an expanding
family of secreted proteins that associate with members of the TGFβ superfamily. In this study, …