Positive allosteric modulation of the M 1 muscarinic receptor represents an approach to treat
the cognitive decline in patients with Alzheimer’s disease. Replacement of a quinolone ring …

… Chang a , Jenny M.-C. Wai a , Christina N. Di Marco a , Victoria Cofre a , Robert M.
DiPardo a , Sean P. Cook b , Matthew J. … SD Kuduk, CN Di Marco, RK Chang, RM …

One approach to ameliorate the cognitive decline in Alzheimer’s disease (AD) has been to
restore neuronal signaling from the basal forebrain cholinergic system via the activation of the …

A series of carbo- and heterocyclic α-hydroxy amide-derived bradykinin B 1 antagonists was
prepared and evaluated. A 4,4-difluorocyclohexyl α-hydroxy amide was incorporated along …

Antagonism of the bradykinin B 1 receptor represents a potential treatment for chronic pain
and inflammation. Novel antagonists incorporating α-hydroxy amides were designed that …

A series of benzothiophene methyl amines were examined in an effort to identify non-amidine
chemotypes with reduced polypharmacology from existing leads with the goal of finding …

The thesis investigates the interrogative constructions in Isbukun Bunun spoken in Taitung
Prefecture. Specifically, we focus on the construction of wh-questions and the syntactic …

The design and synthesis of a novel class of human bradykinin B 1 antagonists featuring
difluoroethyl ether and isoxazole carboxamide moieties are disclosed. Compound 7g displayed …