Abstract
Recent studies indicate that cellular metabolism plays a key role in supporting immune cell maintenance and development. Here, we review how metabolism guides immune cell activation and differentiation to distinct cellular states, and how differential regulation of metabolism allows for context-dependent support during activation and lineage commitment. We discuss emerging principles of metabolic support of immune cell function in physiology and disease, as well as their general relevance to the field of cell biology.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Animals
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Cell Differentiation / immunology
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Cell Differentiation / physiology*
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Cell Lineage / immunology
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Cell Lineage / physiology
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Energy Metabolism / immunology
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Energy Metabolism / physiology*
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Humans
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Immune System / cytology
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Immune System / metabolism
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Immune System / physiology*
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Immunity / immunology
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Immunity / physiology*
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Macrophages / immunology
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Macrophages / metabolism
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Macrophages / physiology
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Models, Biological
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T-Lymphocytes / immunology
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T-Lymphocytes / metabolism
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T-Lymphocytes / physiology