Abstract
HDL metabolism represents a major target for the development of therapies intended to reduce the risk of atherosclerotic cardiovascular disease. HDL metabolism is complex and involves dissociation of HDL apolipoprotein and HDL cholesterol metabolism. Advances in our understanding of the molecular regulation of HDL metabolism, macrophage cholesterol efflux, and HDL function will lead to a variety of novel therapeutics.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Animals
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Apolipoprotein A-I / metabolism
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Arteriosclerosis / drug therapy*
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Arteriosclerosis / metabolism
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Arteriosclerosis / physiopathology
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Cholesterol / metabolism
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Cholesterol, HDL / metabolism
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Humans
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Lipoproteins, HDL / metabolism*
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Lipoproteins, HDL / physiology
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Models, Biological
Substances
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Apolipoprotein A-I
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Cholesterol, HDL
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Lipoproteins, HDL
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Cholesterol