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Expression of rib-1, a Caenorhabditis elegans homolog of the human tumor suppressor EXT genes, is indispensable for heparan sulfate synthesis and embryonic morphogenesis.
Kitagawa H, Izumikawa T, Mizuguchi S, Dejima K, Nomura KH, Egusa N, Taniguchi F, Tamura J, Gengyo-Ando K, Mitani S, Nomura K, Sugahara K. Kitagawa H, et al. Among authors: egusa n. J Biol Chem. 2007 Mar 16;282(11):8533-44. doi: 10.1074/jbc.M611107200. Epub 2007 Jan 19. J Biol Chem. 2007. PMID: 17237233 Free article.
Heparan sulfate polymerization in Drosophila.
Izumikawa T, Egusa N, Taniguchi F, Sugahara K, Kitagawa H. Izumikawa T, et al. Among authors: egusa n. J Biol Chem. 2006 Jan 27;281(4):1929-34. doi: 10.1074/jbc.M509138200. Epub 2005 Nov 21. J Biol Chem. 2006. PMID: 16303756 Free article.
rib-2, a Caenorhabditis elegans homolog of the human tumor suppressor EXT genes encodes a novel alpha1,4-N-acetylglucosaminyltransferase involved in the biosynthetic initiation and elongation of heparan sulfate.
Kitagawa H, Egusa N, Tamura JI, Kusche-Gullberg M, Lindahl U, Sugahara K. Kitagawa H, et al. Among authors: egusa n. J Biol Chem. 2001 Feb 16;276(7):4834-8. doi: 10.1074/jbc.C000835200. Epub 2000 Dec 19. J Biol Chem. 2001. PMID: 11121397 Free article.