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. 1989 Sep;9(9):4109–4112. doi: 10.1128/mcb.9.9.4109

Autoregulation of interleukin 6 and granulocyte-macrophage colony-stimulating factor in the differentiation of myeloid leukemic cells.

Y Shabo 1, J Lotem 1, L Sachs 1
PMCID: PMC362483  PMID: 2674690

Abstract

Induction of differentiation in one type of clone of mouse myeloid leukemic cells by mouse or human interleukin 6 (IL-6) and in another type of clone by mouse granulocyte-macrophage colony-stimulating factor (GM-CSF) was found to be associated with induction of IL-6 and GM-CSF mRNA and protein. The results indicated that IL-6 and GM-CSF could positively autoregulate their own gene expression during myeloid cell differentiation. It is suggested that this autoregulation may serve to enhance and prolong the signal induced by these proteins in cells transiently exposed to IL-6 or GM-CSF.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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