FIGURE 4.
Oxygen consumption and RER in Slc25a25 wild-type (WT) and KO mice. A, VO2 consumption and RER in 9-week-old WT (n = 5), heterozygous (n = 6), and KO (n = 5) mice fed a high fat diet for 8 days and exposed to 4 °C for 56 h. Bar graphs represent VO2 and RER for 24 h at 28 °C and 48 h at 4 °C. Data are mean ± S.E. a-c, means are statistically significant at p < 0.05. B, VO2 consumption in WT (n = 8) and KO (n = 8) mice fed high fat diet at 20 and 28 °C ambient temperature. Bar graph represents VO2 during light and dark hours for 3 days on week 10 at 20 °C and for 3 days on week 20 at 28 °C. Data are mean ± S.E.