Table II.
Transgenic mice that express the truncated apoL-I devoid of the SRA-interacting domain do not protect from infection with T. b. brucei or T. b. brucei-SRA
| Transgenic DNA |
Trypanosome species (1.78 × 106 injected i.p.) |
Number mice alive/ number mice infected |
|
|---|---|---|---|
| Day 3 | Day 50 | ||
| ApoL-I | T. b. brucei | 5/5 | 3/5a |
| Tr-apoL-I | 0/5b | ||
| Vector | 0/5b | ||
| ApoL-I | T. b. brucei SRA | 0/5b | |
| Tr-ApoL-I | 0/5b | ||
| Vector | 0/5b | ||
Tg mice expressing full-length apoL-I or truncated apoL-I infected with 1.78 x106T. b. brucei (Lister 427-derived line) or T. b. brucei-SRA (Lister 427-derived line expressing the SRA gene). n = 5 per group.
a
No parasites detectable.
b
Parasitemia ≥ 1 × 109/ml before mice were killed.