Figure 4.
mRNA levels of genes involved in glycolysis and the pentose-phosphate pathway are elevated in high-risk plaques. (A) Hierarchical clustering of the mRNA levels of glucose catabolism genes, as well as two transcription factors (TF) regulating glycolysis. Plaques [n = 10 (cluster 1), n = 13 (cluster 2)] branched into two prominent groups are marked to the right with cyan and magenta coloured bars. Each row represents one plaque and numbers to the right indicate the metabolite cluster which the respective plaque belongs to. (B, C) Plaque levels of vascular endothelial growth factor-A and sirtuin 2 [n = 45 (cluster 1), n = 77 (cluster 2)]. Vertical lines show the median, dots depict single plaques. Data for cluster 3 can be found in Supplementary material online, Figure S9.