Figure 2.
A distinct metabolite profile is associated with symptomatic and vulnerable plaques. (A) Principal component analysis score plot of the first and second principal components with cluster 1 (blue), cluster 2 (red), and cluster 3 (yellow) plaques. (B) Number of asymptomatic and symptomatic (i.e. patients had a preceding stroke, transient ischaemic attack, or amaurosis fugax within the month prior to surgery) plaques assigned to cluster 1 (n = 51) and 2 (n = 78). (C) Principal component analysis score plot with symptomatic (brown) and asymptomatic (teal) plaques. (D) Number of plaques with a high (above median) and low (below median) vulnerability index assigned to cluster 1 (n = 50) and cluster 2 (n = 77). (E) Principal component analysis score plot showing plaques with a high or low vulnerability index in magenta or lime green, respectively. (F) Kaplan–Meier curves of cardiovascular event-free survival for cluster 1 (n = 51) and 2 (n = 78) and number of subjects at risk. Cardiovascular events were defined as incident myocardial infarction, stroke, transient ischaemic attack, amaurosis fugax, and cardiovascular death. Percentages in bar graphs show the proportion within each cluster. Data for cluster 3 can be found in Supplementary material online, Figure S2.