Figure 1. Clearing of lung tissue allows visualization of tumour burden and other biologically relevant features.
(a) CT scan of KP-tumour-bearing mouse and identification of large lung tumour (big arrow). (b–d) Process of clearing and imaging lungs and identification of small tumours (small arrows). (e) Wide-field image of whole lung from KP tumour-bearing animal. (f) × 4 slice of a tumour from box in e. (g) × 20-magnification imaging slice of a single tumour from box in f. (h) Computational 3D-rendering of a whole-lung tumour nodule. Scale bars, 5 mm (b); 1,000 μm (e,f); 100 μm (g,h).