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. Author manuscript; available in PMC: 2017 Apr 19.
Published in final edited form as: Immunity. 2016 Mar 29;44(4):807–820. doi: 10.1016/j.immuni.2016.02.005

Figure 4. BAI1-ELMO dependent signaling is required for lowering colonic inflammation.

Figure 4

(A) Schematic of wild type BAI1 with the AAA mutation indicated.

(B) Colons from control and E2A-cre, BAI1-AAATg mice were stained for HA-BAI1 (green), EpCAM (red) and Hoechst 33342 (blue). Scale bars=100 µm.

(C and D) Changes in body weight and disease severity index after DSS (3%) treatment in control (n=5; 5M) and E2A-cre, BAI1-AAATg (n=6; 6M) mice.

(E) Colon length in control (n=7; 7M) and E2A-cre, BAI1-AAATg mice (n=11; 11M).

(F, G) H&E staining and apoptotic cell numbers within colons of control (n=3; 3M) and E2A-cre, BAI1-AAATg (n=4; 4M) mice after DSS (3%) treatment. Scale bars=100µm.

Data are representative of at least two or three independent experiments. Error bars indicate s.e.m. N.S, not significant. M, male. See also Figure S4.