(Q39474871)

12 September 2017

title

Therapeutic reactivation of mutant p53 protein by quinazoline derivatives (English)

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12 September 2017

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William A Denny

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12 September 2017

Hamish S Sutherland

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12 September 2017

In Young Hwang

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12 September 2017

Elaine S Marshall

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12 September 2017

Brent S Lindsay

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12 September 2017

Catherine Gilchrist

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12 September 2017

Wayne R Joseph

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12 September 2017

Debra Greenhalgh

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12 September 2017

Emma Richardson

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12 September 2017

Philip Kestell

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12 September 2017

Angela Ding

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12 September 2017

Bruce C Baguley

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12 September 2017

publication date

13 September 2011

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Investigational New Drugs

12 September 2017

published in

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12 September 2017

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12 September 2017

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12 September 2017

page(s)

2035-2045

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describes a project that uses

12 September 2017

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Cancer. p53, guardian of the genome

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https://api.crossref.org/works/10.1007%2FS10637-011-9744-Z

p53, the cellular gatekeeper for growth and division

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10637-011-9744-Z

p53: traffic cop at the crossroads of DNA repair and recombination

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10637-011-9744-Z

Regulation of mitochondrial apoptotic events by p53-mediated disruption of complexes between antiapoptotic Bcl-2 members and Bim.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10637-011-9744-Z

Senescence and tumour clearance is triggered by p53 restoration in murine liver carcinomas

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10637-011-9744-Z

The effects of wild-type p53 tumor suppressor activity and mutant p53 gain-of-function on cell growth

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10637-011-9744-Z

Translating p53 into the clinic.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10637-011-9744-Z

Awakening guardian angels: drugging the p53 pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10637-011-9744-Z

CP-31398 restores mutant p53 tumor suppressor function and inhibits UVB-induced skin carcinogenesis in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10637-011-9744-Z

Targeting mutant p53 shows promise for sunscreens and skin cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10637-011-9744-Z

Characterization of the p53-rescue drug CP-31398 in vitro and in living cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10637-011-9744-Z

CP-31398, a novel p53-stabilizing agent, induces p53-dependent and p53-independent glioma cell death

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10637-011-9744-Z

Synthesis and antihyperglycemic activity of suitably functionalized 3H-quinazolin-4-ones☆

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10637-011-9744-Z

Resistance mechanisms determining the in vitro sensitivity to paclitaxel of tumour cells cultured from patients with ovarian cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10637-011-9744-Z

Guidelines for the welfare and use of animals in cancer research

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10637-011-9744-Z

Modelling cell death in human tumour cell lines exposed to the anticancer drug paclitaxel

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10637-011-9744-Z

In vivo activation of the p53 pathway by small-molecule antagonists of MDM2

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10637-011-9744-Z

Potential antitumor agents. 34. Quantitative relationships between DNA binding and molecular structure for 9-anilinoacridines substituted in the anilino ring.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10637-011-9744-Z

Mechanism of antitumor drug action: poisoning of mammalian DNA topoisomerase II on DNA by 4'-(9-acridinylamino)-methanesulfon-m-anisidide

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10637-011-9744-Z

Multiple patterns of resistance of human leukemia cell sublines to amsacrine analogues

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10637-011-9744-Z

DNA damage response as a candidate anti-cancer barrier in early human tumorigenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10637-011-9744-Z

Targeting wild-type and mutant p53 with small molecule CP-31398 blocks the growth of rhabdomyosarcoma by inducing reactive oxygen species-dependent apoptosis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10637-011-9744-Z

How p53 binds DNA as a tetramer

21 January 2018

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https://api.crossref.org/works/10.1007%2FS10637-011-9744-Z

Structural basis of DNA recognition by p53 tetramers.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10637-011-9744-Z

DNA intercalating anti-tumour agents

21 January 2018

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12 December 2020

Radiation-induced cell cycle delays and p53 status of early passage melanoma cell lines

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12 December 2020

Action of SN 28049, a new DNA binding topoisomerase II-directed antitumour drug: comparison with doxorubicin and etoposide

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12 December 2020

Pharmacological rescue of mutant p53 conformation and function

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12 December 2020

MDM2 binding induces a conformational change in p53 that is opposed by heat-shock protein 90 and precedes p53 proteasomal degradation

1 reference

12 December 2020

10.1007/S10637-011-9744-Z

Identifiers

DOI

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12 September 2017

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