(Q39154682)

9 September 2017

title

Opposing effects of podocin on the gating of podocyte TRPC6 channels evoked by membrane stretch or diacylglycerol (English)

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9 September 2017

Thomas Benzing

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9 September 2017

Marc Anderson

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9 September 2017

Eun Young Kim

series ordinal

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9 September 2017

Henning Hagmann

series ordinal

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9 September 2017

Stuart E Dryer

series ordinal

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9 September 2017

publication date

8 May 2013

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American Journal of Physiology - Cell Physiology

9 September 2017

published in

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9 September 2017

volume

305

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9 September 2017

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9 September 2017

page(s)

C276-89

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Xerocytosis is caused by mutations that alter the kinetics of the mechanosensitive channel PIEZO1

9 September 2017

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TRPC6 channels and their binding partners in podocytes: role in glomerular filtration and pathophysiology

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Mechanical deformation of ventricular myocytes modulates both TRPC6 and Kir2.3 channels

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Stretch, tension and adhesion - adaptive mechanisms of the actin cytoskeleton in podocytes

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Human TRPC6 expressed in HEK 293 cells forms non-selective cation channels with limited Ca2+ permeability

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Flufenamic acid is a tool for investigating TRPC6-mediated calcium signalling in human conditionally immortalised podocytes and HEK293 cells

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MEC-2 regulates C. elegans DEG/ENaC channels needed for mechanosensation

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A novel TRPC6 mutation that causes childhood FSGS.

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Specific podocin mutations determine age of onset of nephrotic syndrome all the way into adult life

21 January 2018

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Light microscopic visualization of podocyte ultrastructure demonstrates oscillating glomerular contractions.

21 January 2018

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Renal blood flow regulation and arterial pressure fluctuations: a case study in nonlinear dynamics

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Molecular basis of the functional podocin-nephrin complex: mutations in the NPHS2 gene disrupt nephrin targeting to lipid raft microdomains

21 January 2018

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Podocin and MEC-2 bind cholesterol to regulate the activity of associated ion channels

21 January 2018

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Synergistic activation of vascular TRPC6 channel by receptor and mechanical stimulation via phospholipase C/diacylglycerol and phospholipase A2/omega-hydroxylase/20-HETE pathways

21 January 2018

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Lanthanides potentiate TRPC5 currents by an action at extracellular sites close to the pore mouth

21 January 2018

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Cloning of rat homologue of podocin: expression in proteinuric states and in developing glomeruli

21 January 2018

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Nephrin promotes cell-cell adhesion through homophilic interactions

21 January 2018

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Nephrin binds to the COOH terminus of a large-conductance Ca2+-activated K+ channel isoform and regulates its expression on the cell surface

21 January 2018

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Canonical transient receptor potential channel (TRPC)3 and TRPC6 associate with large-conductance Ca2+-activated K+ (BKCa) channels: role in BKCa trafficking to the surface of cultured podocytes

21 January 2018

1 reference

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Neph1 regulates steady-state surface expression of Slo1 Ca(2+)-activated K(+) channels: different effects in embryonic neurons and podocytes

21 January 2018

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Regulation of podocyte BK(Ca) channels by synaptopodin, Rho, and actin microfilaments

21 January 2018

1 reference

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Insulin increases surface expression of TRPC6 channels in podocytes: role of NADPH oxidases and reactive oxygen species

21 January 2018

1 reference

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Sustained activation of N-methyl-D-aspartate receptors in podoctyes leads to oxidative stress, mobilization of transient receptor potential canonical 6 channels, nuclear factor of activated T cells activation, and apoptotic cell death

21 January 2018

1 reference

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Expression of podocyte-associated molecules in acquired human kidney diseases

21 January 2018

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Inhibition of TRPM2 cation channels by N-(p-amylcinnamoyl)anthranilic acid.

21 January 2018

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Podocyte-specific overexpression of wild type or mutant trpc6 in mice is sufficient to cause glomerular disease

21 January 2018

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Podocyte-associated molecules in puromycin aminonucleoside nephrosis of the rat.

21 January 2018

1 reference

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Podocin inactivation in mature kidneys causes focal segmental glomerulosclerosis and nephrotic syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00095.2013

Glomerular filtration into the subpodocyte space is highly restricted under physiological perfusion conditions

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00095.2013

Disease-causing missense mutations in NPHS2 gene alter normal nephrin trafficking to the plasma membrane

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00095.2013

Canonical TRP channels and mechanotransduction: from physiology to disease states.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00095.2013

Nephrin--a unique structural and signaling protein of the kidney filter

21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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https://api.crossref.org/works/10.1152%2FAJPCELL.00095.2013

Stomatin modulates gating of acid-sensing ion channels

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00095.2013

Glomerular podocytes possess the synaptic vesicle molecule Rab3A and its specific effector rabphilin-3a

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00095.2013

TRPC6 is a glomerular slit diaphragm-associated channel required for normal renal function

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00095.2013

Podocin localizes in the kidney to the slit diaphragm area

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00095.2013

The molecular and functional phenotype of glomerular podocytes reveals key features of contractile smooth muscle cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00095.2013

Evidence for restriction of fluid and solute movement across the glomerular capillary wall by the subpodocyte space

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00095.2013

Lipid-protein interactions along the slit diaphragm of podocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00095.2013

The von Hippel-Lindau tumor suppressor protein controls ciliogenesis by orienting microtubule growth

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00095.2013

TRPC6 mutations associated with focal segmental glomerulosclerosis cause constitutive activation of NFAT-dependent transcription.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00095.2013

Podocin, a raft-associated component of the glomerular slit diaphragm, interacts with CD2AP and nephrin

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00095.2013

A common mechanism underlies stretch activation and receptor activation of TRPC6 channels

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00095.2013

G protein-mediated stretch reception

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00095.2013

Bilayer-dependent inhibition of mechanosensitive channels by neuroactive peptide enantiomers.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00095.2013

Antagonistic Regulation of Actin Dynamics and Cell Motility by TRPC5 and TRPC6 Channels

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00095.2013

Nephrin strands contribute to a porous slit diaphragm scaffold as revealed by electron tomography

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00095.2013

NPHS2 mutation analysis shows genetic heterogeneity of steroid-resistant nephrotic syndrome and low post-transplant recurrence.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00095.2013

A stomatin-domain protein essential for touch sensation in the mouse

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00095.2013

A mutation in the TRPC6 cation channel causes familial focal segmental glomerulosclerosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00095.2013

Biophysical properties of normal and diseased renal glomeruli

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00095.2013

10.1152/AJPCELL.00095.2013

21 January 2018

Identifiers

DOI

1 reference

9 September 2017

1 reference