(Q38689010)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26740081%20AND%20SRC:MED&resulttype=core&format=json

4 March 2020

title

LRRK2 at the Crossroad Between Autophagy and Microtubule Trafficking: Insights into Parkinson's Disease (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26740081%20AND%20SRC:MED&resulttype=core&format=json

4 March 2020

0 references

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26740081%20AND%20SRC:MED&resulttype=core&format=json

4 March 2020

A Raquel Esteves

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26740081%20AND%20SRC:MED&resulttype=core&format=json

4 March 2020

publication date

8 July 2016

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4 March 2020

1 reference

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4 March 2020

volume

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4 March 2020

issue

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26740081%20AND%20SRC:MED&resulttype=core&format=json

4 March 2020

page(s)

16-26

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26740081%20AND%20SRC:MED&resulttype=core&format=json

LRRK2 regulates autophagic activity and localizes to specific membrane microdomains in a novel human genomic reporter cellular model

4 March 2020

cites work

1 reference

https://api.crossref.org/works/10.1177%2F1073858415616558

Mutations in LRRK2 increase phosphorylation of peroxiredoxin 3 exacerbating oxidative stress-induced neuronal death

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1073858415616558

Mitochondrial metabolism in Parkinson's disease impairs quality control autophagy by hampering microtubule-dependent traffic

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1073858415616558

LRRK2 phosphorylates novel tau epitopes and promotes tauopathy

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1073858415616558

Localization of LRRK2 to membranous and vesicular structures in mammalian brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1073858415616558

Dynamic and redundant regulation of LRRK2 and LRRK1 expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1073858415616558

The LRRK2 G2019S mutant exacerbates basal autophagy through activation of the MEK/ERK pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1073858415616558

Leucine-rich repeat kinase 2 functionally interacts with microtubules and kinase-dependently modulates cell migration

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1073858415616558

The mitochondrial cascade hypothesis for Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1073858415616558

Corticobasal syndrome and primary progressive aphasia as manifestations of LRRK2 gene mutations

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1073858415616558

Mutant LRRK2 elicits calcium imbalance and depletion of dendritic mitochondria in neurons

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1073858415616558

Pharmacological rescue of mitochondrial deficits in iPSC-derived neural cells from patients with familial Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1073858415616558

Roles of the Drosophila LRRK2 homolog in Rab7-dependent lysosomal positioning

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1073858415616558

The Upshot of LRRK2 Inhibition to Parkinson's Disease Paradigm

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1073858415616558

The rescue of microtubule-dependent traffic recovers mitochondrial function in Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1073858415616558

LRRK2, a puzzling protein: insights into Parkinson's disease pathogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1073858415616558

Regulation of physiologic actions of LRRK2: focus on autophagy

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1073858415616558

Leucine-rich repeat kinase 2 phosphorylates brain tubulin-beta isoforms and modulates microtubule stability--a point of convergence in parkinsonian neurodegeneration?

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1073858415616558

Increasing microtubule acetylation rescues axonal transport and locomotor deficits caused by LRRK2 Roc-COR domain mutations

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1073858415616558

Leucine-rich repeat kinase 2 regulates autophagy through a calcium-dependent pathway involving NAADP

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1073858415616558

LRRK2 delays degradative receptor trafficking by impeding late endosomal budding through decreasing Rab7 activity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1073858415616558

Leucine-rich repeat kinase 2 mutations and Parkinson's disease: three questions

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1073858415616558

The Parkinson's disease kinase LRRK2 autophosphorylates its GTPase domain at multiple sites

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1073858415616558

LRRK2 Promotes Tau Accumulation, Aggregation and Release.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1073858415616558

Leucine-rich repeat kinase 2 associates with lipid rafts

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1073858415616558

Coordinate Regulation of Neurite Outgrowth by LRRK2 and Its Interactor, Rab5.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1073858415616558

The dardarin G 2019 S mutation is a common cause of Parkinson's disease but not other neurodegenerative diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1073858415616558

Localization of Parkinson's disease-associated LRRK2 in normal and pathological human brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1073858415616558

Abnormal localization of leucine-rich repeat kinase 2 to the endosomal-lysosomal compartment in lewy body disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1073858415616558

Maturation of autophagosomes and endosomes: a key role for Rab7.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1073858415616558

Leucine-rich repeat kinase 2 regulates tau phosphorylation through direct activation of glycogen synthase kinase-3β

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1073858415616558

LRRK2 phosphorylates tubulin-associated tau but not the free molecule: LRRK2-mediated regulation of the tau-tubulin association and neurite outgrowth

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1073858415616558

LRRK2 Parkinson disease mutations enhance its microtubule association.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1073858415616558

A direct interaction between leucine-rich repeat kinase 2 and specific β-tubulin isoforms regulates tubulin acetylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1073858415616558

The familial Parkinsonism gene LRRK2 regulates neurite process morphology

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1073858415616558

RAB7L1 interacts with LRRK2 to modify intraneuronal protein sorting and Parkinson's disease risk

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1073858415616558

Inhibition of LRRK2 kinase activity stimulates macroautophagy

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1073858415616558

Pathogenic Parkinson's disease mutations across the functional domains of LRRK2 alter the autophagic/lysosomal response to starvation

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1073858415616558

Impaired dopaminergic neurotransmission and microtubule-associated protein tau alterations in human LRRK2 transgenic mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1073858415616558

Mitochondrial impairment in patients with Parkinson disease with the G2019S mutation in LRRK2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1073858415616558

Leucine-rich repeat kinase 2 disturbs mitochondrial dynamics via Dynamin-like protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1073858415616558

Interplay of LRRK2 with chaperone-mediated autophagy

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1073858415616558

G2019S leucine-rich repeat kinase 2 causes uncoupling protein-mediated mitochondrial depolarization

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1073858415616558

Phosphorylation of ezrin/radixin/moesin proteins by LRRK2 promotes the rearrangement of actin cytoskeleton in neuronal morphogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1073858415616558

Dopaminergic neuronal loss, reduced neurite complexity and autophagic abnormalities in transgenic mice expressing G2019S mutant LRRK2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1073858415616558

Is inhibition of kinase activity the only therapeutic strategy for LRRK2-associated Parkinson's disease?

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1073858415616558

The LRRK2 inhibitor GSK2578215A induces protective autophagy in SH-SY5Y cells: involvement of Drp-1-mediated mitochondrial fission and mitochondrial-derived ROS signaling.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1073858415616558

Mutations in LRRK2 potentiate age-related impairment of autophagic flux

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1073858415616558

LRRK2 modulates vulnerability to mitochondrial dysfunction in Caenorhabditis elegans

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1073858415616558

Disease-specific phenotypes in dopamine neurons from human iPS-based models of genetic and sporadic Parkinson's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1073858415616558

LRRK2 mutations cause mitochondrial DNA damage in iPSC-derived neural cells from Parkinson's disease patients: reversal by gene correction

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1073858415616558

LRRK2 p.G2019S mutation is not common among Alzheimer's disease patients in Brazil

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1073858415616558

Membrane recruitment of endogenous LRRK2 precedes its potent regulation of autophagy

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1073858415616558

Functional interaction of Parkinson's disease-associated LRRK2 with members of the dynamin GTPase superfamily

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1073858415616558

Inhibition of excessive mitochondrial fission reduced aberrant autophagy and neuronal damage caused by LRRK2 G2019S mutation

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1073858415616558

Loss of leucine-rich repeat kinase 2 causes age-dependent bi-phasic alterations of the autophagy pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1073858415616558

Loss of leucine-rich repeat kinase 2 causes impairment of protein degradation pathways, accumulation of alpha-synuclein, and apoptotic cell death in aged mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1073858415616558

LRRK2 regulates mitochondrial dynamics and function through direct interaction with DLP1

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1073858415616558

LRRK2 transport is regulated by its novel interacting partner Rab32

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1073858415616558

Autophagy gone awry in neurodegenerative diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1073858415616558

GTPase activity plays a key role in the pathobiology of LRRK2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1073858415616558

G2019S LRRK2 mutant fibroblasts from Parkinson's disease patients show increased sensitivity to neurotoxin 1-methyl-4-phenylpyridinium dependent of autophagy.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1073858415616558

Mitochondrial dysfunction driven by the LRRK2-mediated pathway is associated with loss of Purkinje cells and motor coordination deficits in diabetic rat model

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1073858415616558

Analysis of the LRRK2 G2019S mutation in Alzheimer Disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1073858415616558

Mutations in LRRK2 cause autosomal-dominant parkinsonism with pleomorphic pathology

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1073858415616558

21 January 2018

Identifiers

DOI

10.1177/1073858415616558

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26740081%20AND%20SRC:MED&resulttype=core&format=json

4 March 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26740081%20AND%20SRC:MED&resulttype=core&format=json