(Q38559208)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26234644%20AND%20SRC:MED&resulttype=core&format=json

20 February 2020

review article

1 reference

title

Medically important fungi respond to azole drugs: an update (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26234644%20AND%20SRC:MED&resulttype=core&format=json

20 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26234644%20AND%20SRC:MED&resulttype=core&format=json

20 February 2020

Martin Zavrel

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26234644%20AND%20SRC:MED&resulttype=core&format=json

20 February 2020

publication date

3 August 2015

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26234644%20AND%20SRC:MED&resulttype=core&format=json

20 February 2020

number of pages

1 reference

based on heuristic

inferred from page(s)

published in

Future Microbiology

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26234644%20AND%20SRC:MED&resulttype=core&format=json

20 February 2020

volume

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26234644%20AND%20SRC:MED&resulttype=core&format=json

20 February 2020

issue

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26234644%20AND%20SRC:MED&resulttype=core&format=json

20 February 2020

page(s)

1355-1373

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26234644%20AND%20SRC:MED&resulttype=core&format=json

Candidaemia in Europe: epidemiology and resistance

20 February 2020

cites work

1 reference

Nosocomial bloodstream infections in US hospitals: analysis of 24,179 cases from a prospective nationwide surveillance study

21 January 2018

1 reference

Recent trends in the epidemiology of invasive mycoses

21 January 2018

1 reference

Changes in incidence and antifungal drug resistance in candidemia: results from population-based laboratory surveillance in Atlanta and Baltimore, 2008-2011.

21 January 2018

1 reference

Species identification and antifungal susceptibility testing of Candida bloodstream isolates from population-based surveillance studies in two U.S. cities from 2008 to 2011.

21 January 2018

1 reference

The epidemiology of candidemia in two United States cities: results of a population-based active surveillance

21 January 2018

1 reference

Incidence of bloodstream infections due to Candida species and in vitro susceptibilities of isolates collected from 1998 to 2000 in a population-based active surveillance program

21 January 2018

1 reference

Hidden killers: human fungal infections

21 January 2018

1 reference

Epidemiology and risk factors for invasive candidiasis

21 January 2018

1 reference

Rare and emerging opportunistic fungal pathogens: concern for resistance beyond Candida albicans and Aspergillus fumigatus.

21 January 2018

1 reference

Multilaboratory study of epidemiological cutoff values for detection of resistance in eight Candida species to fluconazole, posaconazole, and voriconazole

21 January 2018

1 reference

Has antifungal susceptibility testing come of age?

21 January 2018

1 reference

Antifungal agents: mechanisms of action

21 January 2018

1 reference

Azole drugs are imported by facilitated diffusion in Candida albicans and other pathogenic fungi

21 January 2018

1 reference

Architecture of a single membrane spanning cytochrome P450 suggests constraints that orient the catalytic domain relative to a bilayer

21 January 2018

1 reference

Candida glabrata erg1 mutant with increased sensitivity to azoles and to low oxygen tension

21 January 2018

1 reference

Cytochrome P-450-dependent 14 alpha-sterol demethylase of Candida albicans and its interaction with azole antifungals

21 January 2018

1 reference

Prevalence of molecular mechanisms of resistance to azole antifungal agents in Candida albicans strains displaying high-level fluconazole resistance isolated from human immunodeficiency virus-infected patients

21 January 2018

1 reference

Amino acid substitutions in the cytochrome P-450 lanosterol 14alpha-demethylase (CYP51A1) from azole-resistant Candida albicans clinical isolates contribute to resistance to azole antifungal agents

21 January 2018

1 reference

Contribution of mutations in the cytochrome P450 14alpha-demethylase (Erg11p, Cyp51p) to azole resistance in Candida albicans

21 January 2018

1 reference

Inhibition and interaction of cytochrome P450 ofCandida kruseiwith azole antifungal drugs

21 January 2018

1 reference

Three-dimensional models of wild-type and mutated forms of cytochrome P450 14alpha-sterol demethylases from Aspergillus fumigatus and Candida albicans provide insights into posaconazole binding.

21 January 2018

1 reference

Expression, purification, and characterization of Aspergillus fumigatus sterol 14-alpha demethylase (CYP51) isoenzymes A and B.

21 January 2018

1 reference

Azole affinity of sterol 14α-demethylase (CYP51) enzymes from Candida albicans and Homo sapiens

21 January 2018

1 reference

A three-dimensional model of lanosterol 14alpha-demethylase of Candida albicans and its interaction with azole antifungals

21 January 2018

1 reference

Upregulation of ERG genes in Candida species by azoles and other sterol biosynthesis inhibitors

21 January 2018

1 reference

Candida albicans UPC2 is transcriptionally induced in response to antifungal drugs and anaerobicity through Upc2p-dependent and -independent mechanisms.

21 January 2018

1 reference

Candida albicans zinc cluster protein Upc2p confers resistance to antifungal drugs and is an activator of ergosterol biosynthetic genes

21 January 2018

1 reference

Role of Candida albicans transcription factor Upc2p in drug resistance and sterol metabolism

21 January 2018

1 reference

A gain-of-function mutation in the transcription factor Upc2p causes upregulation of ergosterol biosynthesis genes and increased fluconazole resistance in a clinical Candida albicans isolate.

21 January 2018

1 reference

Gain-of-function mutations in UPC2 are a frequent cause of ERG11 upregulation in azole-resistant clinical isolates of Candida albicans

21 January 2018

1 reference

An A643T mutation in the transcription factor Upc2p causes constitutive ERG11 upregulation and increased fluconazole resistance in Candida albicans

21 January 2018

1 reference

An A643V amino acid substitution in Upc2p contributes to azole resistance in well-characterized clinical isolates of Candida albicans.

21 January 2018

1 reference

Genotypic evolution of azole resistance mechanisms in sequential Candida albicans isolates

21 January 2018

1 reference

TAC1, transcriptional activator of CDR genes, is a new transcription factor involved in the regulation of Candida albicans ABC transporters CDR1 and CDR2.

21 January 2018

1 reference

Regulation of efflux pump expression and drug resistance by the transcription factors Mrr1, Upc2, and Cap1 in Candida albicans

21 January 2018

1 reference

Distinct roles of Candida albicans drug resistance transcription factors TAC1, MRR1, and UPC2 in virulence

21 January 2018

1 reference

The transcription factor Ndt80 does not contribute to Mrr1-, Tac1-, and Upc2-mediated fluconazole resistance in Candida albicans

21 January 2018

1 reference

Defective sterol C5-6 desaturation and azole resistance: a new hypothesis for the mode of action of azole antifungals

21 January 2018

1 reference

Fluconazole treatment is effective against a Candida albicans erg3/erg3 mutant in vivo despite in vitro resistance

21 January 2018

1 reference

Inactivation of sterol Delta5,6-desaturase attenuates virulence in Candida albicans

21 January 2018

1 reference

Deletion of the Candida glabrata ERG3 and ERG11 genes: effect on cell viability, cell growth, sterol composition, and antifungal susceptibility

21 January 2018

1 reference

Candida albicans mutations in the ergosterol biosynthetic pathway and resistance to several antifungal agents

21 January 2018

1 reference

Aspergillus fumigatus C-5 sterol desaturases Erg3A and Erg3B: role in sterol biosynthesis and antifungal drug susceptibility.

21 January 2018

1 reference

Characterization of three classes of membrane proteins involved in fungal azole resistance by functional hyperexpression in Saccharomyces cerevisiae

21 January 2018

1 reference

A common drug-responsive element mediates the upregulation of the Candida albicans ABC transporters CDR1 and CDR2, two genes involved in antifungal drug resistance

21 January 2018

1 reference

A mutation in Tac1p, a transcription factor regulating CDR1 and CDR2, is coupled with loss of heterozygosity at chromosome 5 to mediate antifungal resistance in Candida albicans

21 January 2018

1 reference

Functional analysis of cis- and trans-acting elements of the Candida albicans CDR2 promoter with a novel promoter reporter system.

21 January 2018

1 reference

The zinc cluster transcription factor Tac1p regulates PDR16 expression in Candida albicans

21 January 2018

1 reference

Genomewide location analysis of Candida albicans Upc2p, a regulator of sterol metabolism and azole drug resistance

21 January 2018

1 reference

Transcriptional activation and increased mRNA stability contribute to overexpression of CDR1 in azole-resistant Candida albicans

21 January 2018

1 reference

A novel multidrug efflux transporter gene of the major facilitator superfamily from Candida albicans (FLU1) conferring resistance to fluconazole.

21 January 2018

1 reference

Mechanisms of resistance to azole antifungal agents in Candida albicans isolates from AIDS patients involve specific multidrug transporters

21 January 2018

1 reference

Mutations in the multi-drug resistance regulator MRR1, followed by loss of heterozygosity, are the main cause of MDR1 overexpression in fluconazole-resistant Candida albicans strains

21 January 2018

1 reference

The transcription factor Mrr1p controls expression of the MDR1 efflux pump and mediates multidrug resistance in Candida albicans

21 January 2018

1 reference

Aneuploidy and isochromosome formation in drug-resistant Candida albicans

21 January 2018

1 reference

Homozygosity at the Candida albicans MTL locus associated with azole resistance

21 January 2018

1 reference

Candida albicans pathogenicity mechanisms.

21 January 2018

1 reference

Hsp90 potentiates the rapid evolution of new traits: drug resistance in diverse fungi

21 January 2018

1 reference

The calcineurin target, Crz1, functions in azole tolerance but is not required for virulence of Candida albicans

21 January 2018

1 reference

Calcineurin signaling and membrane lipid homeostasis regulates iron mediated multidrug resistance mechanisms in Candida albicans

21 January 2018

1 reference

Antifungal activity of amphotericin B, fluconazole, and voriconazole in an in vitro model of Candida catheter-related bloodstream infection

21 January 2018

1 reference

Resistance of Candida albicans biofilms to antifungal agents in vitro

21 January 2018

1 reference

Candida albicans biofilms: more than filamentation

21 January 2018

1 reference

Genetics and genomics of Candida albicans biofilm formation

21 January 2018

1 reference

Investigation of multidrug efflux pumps in relation to fluconazole resistance in Candida albicans biofilms

21 January 2018

1 reference

Putative role of beta-1,3 glucans in Candida albicans biofilm resistance.

21 January 2018

1 reference

Genetic basis of Candida biofilm resistance due to drug-sequestering matrix glucan.

21 January 2018

1 reference

Role of ATP-binding-cassette transporter genes in high-frequency acquisition of resistance to azole antifungals in Candida glabrata.

21 January 2018

1 reference

The ATP-binding cassette transporter-encoding gene CgSNQ2 is contributing to the CgPDR1-dependent azole resistance of Candida glabrata

21 January 2018

1 reference

Candida glabrata PDR1, a transcriptional regulator of a pleiotropic drug resistance network, mediates azole resistance in clinical isolates and petite mutants

21 January 2018

1 reference

Candida glabrata drug:H+ antiporter CgQdr2 confers imidazole drug resistance, being activated by transcription factor CgPdr1.

21 January 2018

1 reference

Effect of pH on in vitro susceptibility of Candida glabrata and Candida albicans to 11 antifungal agents and implications for clinical use.

21 January 2018

1 reference

Gain of function mutations in CgPDR1 of Candida glabrata not only mediate antifungal resistance but also enhance virulence

21 January 2018

1 reference

Formation of new chromosomes as a virulence mechanism in yeast Candida glabrata

21 January 2018

1 reference

Proteomics of drug resistance in Candida glabrata biofilms.

21 January 2018

1 reference

Biological consequences of petite mutations in Candida glabrata

21 January 2018

1 reference

Sterol uptake in Candida glabrata: rescue of sterol auxotrophic strains

21 January 2018

1 reference

The Candida glabrata sterol scavenging mechanism, mediated by the ATP-binding cassette transporter Aus1p, is regulated by iron limitation.

21 January 2018

1 reference

The Candida glabrata putative sterol transporter gene CgAUS1 protects cells against azoles in the presence of serum

21 January 2018

1 reference

Comparison of sterol import under aerobic and anaerobic conditions in three fungal species, Candida albicans, Candida glabrata, and Saccharomyces cerevisiae.

21 January 2018

1 reference

Transcriptional profiling identifies two members of the ATP-binding cassette transporter superfamily required for sterol uptake in yeast

21 January 2018

1 reference

Triazole fungicides can induce cross-resistance to medical triazoles in Aspergillus fumigatus

21 January 2018

1 reference

Azole Resistance In Aspergillus Fumigatus : A New Challenge In The Management Of Invasive Aspergillosis?

21 January 2018

1 reference

A point mutation in the 14alpha-sterol demethylase gene cyp51A contributes to itraconazole resistance in Aspergillus fumigatus

21 January 2018

1 reference

Multi-azole resistance in Aspergillus fumigatus

21 January 2018

1 reference

Substitutions at methionine 220 in the 14alpha-sterol demethylase (Cyp51A) of Aspergillus fumigatus are responsible for resistance in vitro to azole antifungal drugs

21 January 2018

1 reference

Acquired antifungal drug resistance in Aspergillus fumigatus: epidemiology and detection.

21 January 2018

1 reference

Molecular epidemiology of Aspergillus fumigatus isolates harboring the TR34/L98H azole resistance mechanism.

21 January 2018

1 reference

Emergence of azole resistance in Aspergillus fumigatus and spread of a single resistance mechanism

21 January 2018

1 reference

Rapid detection of triazole antifungal resistance in Aspergillus fumigatus

21 January 2018

1 reference

Discovery of a HapE mutation that causes azole resistance in Aspergillus fumigatus through whole genome sequencing and sexual crossing

21 January 2018

1 reference

Genomic sequence of the pathogenic and allergenic filamentous fungus Aspergillus fumigatus

21 January 2018

1 reference

Increased expression of a novel Aspergillus fumigatus ABC transporter gene, atrF, in the presence of itraconazole in an itraconazole resistant clinical isolate

21 January 2018

1 reference

The cdr1B efflux transporter is associated with non-cyp51a-mediated itraconazole resistance in Aspergillus fumigatus

21 January 2018

1 reference

Azole resistance of Aspergillus fumigatus biofilms is partly associated with efflux pump activity

21 January 2018

1 reference

Cholesterol import by Aspergillus fumigatus and its influence on antifungal potency of sterol biosynthesis inhibitors

21 January 2018

1 reference

Resistant P45051A1 activity in azole antifungal tolerant Cryptococcus neoformans from AIDS patients.

21 January 2018

1 reference

G484S amino acid substitution in lanosterol 14-alpha demethylase (ERG11) is related to fluconazole resistance in a recurrent Cryptococcus neoformans clinical isolate

21 January 2018

1 reference

Cross-resistance to polyene and azole drugs in Cryptococcus neoformans

21 January 2018

1 reference

Identification and characterization of a Cryptococcus neoformans ATP binding cassette (ABC) transporter-encoding gene, CnAFR1, involved in the resistance to fluconazole

21 January 2018

1 reference

Cryptococcus neoformans overcomes stress of azole drugs by formation of disomy in specific multiple chromosomes

21 January 2018

1 reference

Incidence of polyene-resistant yeasts recovered from clinical specimens

21 January 2018

1 reference

Elevated cell wall chitin in Candida albicans confers echinocandin resistance in vivo

21 January 2018

1 reference

Functional analysis of Candida albicans GPI-anchored proteins: roles in cell wall integrity and caspofungin sensitivity

21 January 2018

1 reference

Paradoxical effect of caspofungin: reduced activity against Candida albicans at high drug concentrations

21 January 2018

1 reference

Escape of Candida from caspofungin inhibition at concentrations above the MIC (paradoxical effect) accomplished by increased cell wall chitin; evidence for beta-1,6-glucan synthesis inhibition by caspofungin

21 January 2018

1 reference

Resistance to echinocandin-class antifungal drugs

21 January 2018

1 reference

Effect of Candida glabrata FKS1 and FKS2 mutations on echinocandin sensitivity and kinetics of 1,3-beta-D-glucan synthase: implication for the existing susceptibility breakpoint

21 January 2018

1 reference

Breakthrough Aspergillus fumigatus and Candida albicans double infection during caspofungin treatment: laboratory characteristics and implication for susceptibility testing.

21 January 2018

1 reference

Establishing in vitro-in vivo correlations for Aspergillus fumigatus: the challenge of azoles versus echinocandins.

21 January 2018

1 reference

Molecular mechanisms of primary resistance to flucytosine in Candida albicans

21 January 2018

1 reference

Clade-specific flucytosine resistance is due to a single nucleotide change in the FUR1 gene of Candida albicans

21 January 2018

1 reference

Inactivation of the FCY2 gene encoding purine-cytosine permease promotes cross-resistance to flucytosine and fluconazole in Candida lusitaniae.

21 January 2018

1 reference

Calcineurin is essential for survival during membrane stress in Candida albicans

21 January 2018

1 reference

In vitro activity of calcineurin and heat shock protein 90 Inhibitors against Aspergillus fumigatus azole- and echinocandin-resistant strains.

21 January 2018

1 reference

Ergosterol biosynthesis inhibitors become fungicidal when combined with calcineurin inhibitors against Candida albicans, Candida glabrata, and Candida krusei

21 January 2018

1 reference

The monoamine oxidase A inhibitor clorgyline is a broad-spectrum inhibitor of fungal ABC and MFS transporter efflux pump activities which reverses the azole resistance of Candida albicans and Candida glabrata clinical isolates

21 January 2018

1 reference

Inhibition of fungal ABC transporters by unnarmicin A and unnarmicin C, novel cyclic peptides from marine bacterium

21 January 2018

1 reference

Ibuprofen reverts antifungal resistance on Candida albicans showing overexpression of CDR genes.

21 January 2018

1 reference

Synergistic activity of azoles with amiodarone against clinically resistant Candida albicans tested by chequerboard and time-kill methods

21 January 2018

1 reference

Sensitization of Candida albicans biofilms to various antifungal drugs by cyclosporine A.

21 January 2018

1 reference

Calcineurin regulates innate antifungal immunity in neutrophils

21 January 2018

1 reference

Pharmacology of Systemic Antifungal Agents

21 January 2018

1 reference

21 January 2018

Identifiers

DOI

10.2217/FMB.15.47

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26234644%20AND%20SRC:MED&resulttype=core&format=json

20 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26234644%20AND%20SRC:MED&resulttype=core&format=json