(Q38348243)

2 September 2017

title

B cell-specific and stimulation-responsive enhancers derepress Aicda by overcoming the effects of silencers (English)

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2 September 2017

Tasuku Honjo

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2 September 2017

Sidonia Fagarasan

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2 September 2017

Thinh Huy Tran

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2 September 2017

Mikiyo Nakata

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2 September 2017

Keiichiro Suzuki

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2 September 2017

Nasim A Begum

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2 September 2017

Reiko Shinkura

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2 September 2017

Hitoshi Nagaoka

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2 September 2017

language of work or name

English

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publication date

6 December 2009

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2 September 2017

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2 September 2017

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2 September 2017

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2 September 2017

page(s)

148-154

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Class switch recombination and hypermutation require activation-induced cytidine deaminase (AID), a potential RNA editing enzyme

2 September 2017

cites work

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Activation-induced cytidine deaminase (AID) deficiency causes the autosomal recessive form of the Hyper-IgM syndrome (HIGM2)

21 January 2018

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Molecular mechanism of class switch recombination: linkage with somatic hypermutation

21 January 2018

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Mechanism and regulation of class switch recombination

21 January 2018

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AID is required to initiate Nbs1/gamma-H2AX focus formation and mutations at sites of class switching

21 January 2018

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The C-terminal region of activation-induced cytidine deaminase is responsible for a recombination function other than DNA cleavage in class switch recombination

21 January 2018

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Activation-induced deaminase (AID)-directed hypermutation in the immunoglobulin Smu region: implication of AID involvement in a common step of class switch recombination and somatic hypermutation

21 January 2018

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De novo protein synthesis is required for activation-induced cytidine deaminase-dependent DNA cleavage in immunoglobulin class switch recombination

21 January 2018

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Specific expression of activation-induced cytidine deaminase (AID), a novel member of the RNA-editing deaminase family in germinal center B cells

21 January 2018

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AID is required for c-myc/IgH chromosome translocations in vivo

21 January 2018

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Activation-induced cytidine deaminase (AID) promotes B cell lymphomagenesis in Emu-cmyc transgenic mice

21 January 2018

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AID-deficient Bcl-xL transgenic mice develop delayed atypical plasma cell tumors with unusual Ig/Myc chromosomal rearrangements

21 January 2018

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AID is required for germinal center-derived lymphomagenesis

21 January 2018

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AID expression levels determine the extent of cMyc oncogenic translocations and the incidence of B cell tumor development

21 January 2018

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Activation-induced cytidine deaminase acts as a mutator in BCR-ABL1-transformed acute lymphoblastic leukemia cells

21 January 2018

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EBV-Encoded Latent Membrane Protein 1 Cooperates with BAFF/BLyS and APRIL to Induce T Cell-Independent Ig Heavy Chain Class Switching

21 January 2018

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Hepatitis C virus induces a mutator phenotype: enhanced mutations of immunoglobulin and protooncogenes

21 January 2018

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Expression of activation-induced cytidine deaminase in human hepatocytes via NF-kappaB signaling

21 January 2018

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Organ-specific profiles of genetic changes in cancers caused by activation-induced cytidine deaminase expression

21 January 2018

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Constitutive expression of AID leads to tumorigenesis

21 January 2018

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Tissue-specific sensitivity to AID expression in transgenic mouse models.

21 January 2018

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Identification of a ubiquitously active promoter of the murine activation-induced cytidine deaminase (AICDA) gene

21 January 2018

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E-proteins directly regulate expression of activation-induced deaminase in mature B cells

21 January 2018

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The balance between Pax5 and Id2 activities is the key to AID gene expression

21 January 2018

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Induction of activation-induced cytidine deaminase gene expression by IL-4 and CD40 ligation is dependent on STAT6 and NFkappaB.

21 January 2018

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High frequency class switching of an IgM+ B lymphoma clone CH12F3 to IgA+ cells.

21 January 2018

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Regulation of AID expression in the immune response

21 January 2018

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HoxC4 binds to the promoter of the cytidine deaminase AID gene to induce AID expression, class-switch DNA recombination and somatic hypermutation

21 January 2018

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The Sp-family of transcription factors

21 January 2018

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Specificity of nuclear protein binding to a CYP1A1 negative regulatory element

21 January 2018

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Myb binding sites within the N-ras promoter repress transcription

21 January 2018

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Negative regulation of CD4 gene expression by a HES-1-c-Myb complex

21 January 2018

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Molecular mechanisms of E2F-dependent activation and pRB-mediated repression

21 January 2018

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Sibling rivalry in the E2F family

21 January 2018

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Class switch recombination and somatic hypermutation in early mouse B cells are mediated by B cell and Toll-like receptors

21 January 2018

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T-independent activation-induced cytidine deaminase expression, class-switch recombination, and antibody production by immature/transitional 1 B cells

21 January 2018

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Viral induction of AID is independent of the interferon and the Toll-like receptor signaling pathways but requires NF-kappaB.

21 January 2018

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RNA-dependent protein kinase PKR is required for activation of NF-kappa B by IFN-gamma in a STAT1-independent pathway.

21 January 2018

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Interferon-gamma-induced factor binding to the interleukin-4-responsive element of CD23b promoter in human tonsillar mononuclear cells: role in transient up-regulation of the interleukin-4-induced CD23b mRNA.

21 January 2018

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PipMaker--a web server for aligning two genomic DNA sequences

21 January 2018

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rVista for comparative sequence-based discovery of functional transcription factor binding sites

21 January 2018

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A composite C/EBP binding site is essential for the activity of the promoter of the IL-3/IL-5/granulocyte-macrophage colony-stimulating factor receptor beta c gene

21 January 2018

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12 December 2020

IFN-gamma-dependent and -independent initiation of switch recombination by NK cells

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12 December 2020

Distinct and Overlapping Roles for E2F Family Members in Transcription, Proliferation and Apoptosis

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12 December 2020

c-Myb repression of c-erbB-2 transcription by direct binding to the c-erbB-2 promoter

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12 December 2020

BLAST 2 Sequences, a new tool for comparing protein and nucleotide sequences

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12 December 2020

Role of AID in tumorigenesis

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12 December 2020

Helicobacter pylori infection triggers aberrant expression of activation-induced cytidine deaminase in gastric epithelium

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12 December 2020

Identifiers

DOI

10.1038/NI.1829

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2 September 2017

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