(Q38285750)

1 September 2017

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title

Pulmonary toxicity of nanomaterials: a critical comparison of published in vitro assays and in vivo inhalation or instillation studies (English)

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1 September 2017

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Jürgen Schnekenburger

object named as

Jürgen Schnekenburger

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Lan Ma-Hock

object named as

Lan Ma-Hock

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1 September 2017

Robert Landsiedel

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1 September 2017

Ursula G Sauer

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1 September 2017

Jürgen Schnekenburger

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1 September 2017

Martin Wiemann

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1 September 2017

publication date

1 November 2014

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1 September 2017

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1 September 2017

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1 September 2017

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1 September 2017

page(s)

2557-2585

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Development of in vitro systems for nanotoxicology: methodological considerations

1 September 2017

cites work

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Correlation between particle size, in vivo particle persistence, and lung injury

21 January 2018

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A multi-stakeholder perspective on the use of alternative test strategies for nanomaterial safety assessment

21 January 2018

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Predictive value of in vitro assays depends on the mechanism of toxicity of metal oxide nanoparticles

21 January 2018

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Nanomaterial cell interactions: are current in vitro tests reliable?

21 January 2018

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Interlaboratory evaluation of in vitro cytotoxicity and inflammatory responses to engineered nanomaterials: the NIEHS Nano GO Consortium

21 January 2018

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Assessing the relevance of in vitro studies in nanotoxicology by examining correlations between in vitro and in vivo data

21 January 2018

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https://api.crossref.org/works/10.2217%2FNNM.14.149

Applicability of rat precision-cut lung slices in evaluating nanomaterial cytotoxicity, apoptosis, oxidative stress, and inflammation.

21 January 2018

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Concept of assessing nanoparticle hazards considering nanoparticle dosemetric and chemical/biological response metrics

21 January 2018

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Genotoxicity investigations on nanomaterials

21 January 2018

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Toxico-/biokinetics of nanomaterials

21 January 2018

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Nanostructured calcium silicate hydrate seeds accelerate concrete hardening: a combined assessment of benefits and risks

21 January 2018

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Possible mechanisms to explain dust overloading of the lungs

21 January 2018

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Inflammation caused by particles and fibers

21 January 2018

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https://api.crossref.org/works/10.2217%2FNNM.14.149

The pro-inflammatory effects of low-toxicity low-solubility particles, nanoparticles and fine particles, on epithelial cells in vitro: the role of surface area

21 January 2018

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https://api.crossref.org/works/10.2217%2FNNM.14.149

Concern-driven integrated approaches to nanomaterial testing and assessment--report of the NanoSafety Cluster Working Group 10

21 January 2018

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https://api.crossref.org/works/10.2217%2FNNM.14.149

Progressive severe lung injury by zinc oxide nanoparticles; the role of Zn2+ dissolution inside lysosomes.

21 January 2018

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https://api.crossref.org/works/10.2217%2FNNM.14.149

Differential pro-inflammatory effects of metal oxide nanoparticles and their soluble ions in vitro and in vivo; zinc and copper nanoparticles, but not their ions, recruit eosinophils to the lungs

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FNNM.14.149

Understanding biophysicochemical interactions at the nano-bio interface

21 January 2018

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https://api.crossref.org/works/10.2217%2FNNM.14.149

Testing metal-oxide nanomaterials for human safety

21 January 2018

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https://api.crossref.org/works/10.2217%2FNNM.14.149

Oxidative stress, inflammatory biomarkers, and toxicity in mouse lung and liver after inhalation exposure to 100% biodiesel or petroleum diesel emissions

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FNNM.14.149

Mechanisms of carbon nanotube-induced toxicity: focus on oxidative stress

21 January 2018

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https://api.crossref.org/works/10.2217%2FNNM.14.149

Molecular modeling in structural nano-toxicology: interactions of nano-particles with nano-machinery of cells

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FNNM.14.149

Translocation of ultrafine insoluble iridium particles from lung epithelium to extrapulmonary organs is size dependent but very low

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FNNM.14.149

Size dependence of the translocation of inhaled iridium and carbon nanoparticle aggregates from the lung of rats to the blood and secondary target organs

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FNNM.14.149

An in vivo and in vitro toxicological characterisation of realistic nanoscale CeO2 inhalation exposures

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FNNM.14.149

An integrated approach for the in vitro dosimetry of engineered nanomaterials

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FNNM.14.149

The Evolution of the Protein Corona around Nanoparticles: A Test Study

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FNNM.14.149

Physical-chemical aspects of protein corona: relevance to in vitro and in vivo biological impacts of nanoparticles

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FNNM.14.149

Biomolecular coronas provide the biological identity of nanosized materials

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FNNM.14.149

Optimized dispersion of nanoparticles for biological in vitro and in vivo studies

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FNNM.14.149

Physicochemical properties of nanoparticles regulate translocation across pulmonary surfactant monolayer and formation of lipoprotein corona

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FNNM.14.149

Rapid translocation of nanoparticles from the lung airspaces to the body

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FNNM.14.149

Inhalation studies for the safety assessment of nanomaterials: status quo and the way forward

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FNNM.14.149

Safety assessment for nanotechnology and nanomedicine: concepts of nanotoxicology

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FNNM.14.149

Cytotoxicity of zinc oxide (ZnO) nanoparticles is influenced by cell density and culture format.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FNNM.14.149

Physicochemical characteristics of nanomaterials that affect pulmonary inflammation

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FNNM.14.149

Proinflammogenic effects of low-toxicity and metal nanoparticles in vivo and in vitro: highlighting the role of particle surface area and surface reactivity

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FNNM.14.149

Development of risk-based nanomaterial groups for occupational exposure control

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FNNM.14.149

Subchronic 13-week inhalation exposure of rats to multiwalled carbon nanotubes: toxic effects are determined by density of agglomerate structures, not fibrillar structures

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FNNM.14.149

Impact of agglomeration state of nano- and submicron sized gold particles on pulmonary inflammation

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FNNM.14.149

Differential lung inflammation and injury with tobacco smoke exposure in Wistar Kyoto and spontaneously hypertensive rats

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FNNM.14.149

Particokinetics in vitro: dosimetry considerations for in vitro nanoparticle toxicity assessments

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FNNM.14.149

ISDD: A computational model of particle sedimentation, diffusion and target cell dosimetry for in vitro toxicity studies

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FNNM.14.149

A multiple-path model of particle deposition in the rat lung.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FNNM.14.149

Metrics, dose, and dose concept: the need for a proper dose concept in the risk assessment of nanoparticles.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FNNM.14.149

A predictive toxicological paradigm for the safety assessment of nanomaterials.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FNNM.14.149

No time to lose--high throughput screening to assess nanomaterial safety

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FNNM.14.149

Zinc oxide nanoparticle induced autophagic cell death and mitochondrial damage via reactive oxygen species generation.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FNNM.14.149

A review of the in vivo and in vitro toxicity of silver and gold particulates: particle attributes and biological mechanisms responsible for the observed toxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FNNM.14.149

In vitro assessment of engineered nanomaterials using a hepatocyte cell line: cytotoxicity, pro-inflammatory cytokines and functional markers

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FNNM.14.149

Induction of inflammation in vascular endothelial cells by metal oxide nanoparticles: effect of particle composition

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FNNM.14.149

Cytotoxic, genotoxic and pro-inflammatory effects of zinc oxide nanoparticles in human nasal mucosa cells in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FNNM.14.149

Effects of various physicochemical characteristics on the toxicities of ZnO and TiO nanoparticles toward human lung epithelial cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FNNM.14.149

Engineered nanomaterials cause cytotoxicity and activation on mouse antigen presenting cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FNNM.14.149

Oxidative stress and apoptosis induced by titanium dioxide nanoparticles in cultured BEAS-2B cells

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FNNM.14.149

Independent cytotoxic and inflammatory responses to zinc oxide nanoparticles in human monocytes and macrophages.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FNNM.14.149

Cytotoxicity and genotoxicity of silver nanoparticles in the human lung cancer cell line, A549.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FNNM.14.149

Evaluation of the cytotoxic and inflammatory potential of differentially shaped zinc oxide nanoparticles

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FNNM.14.149

Exposure of silver-nanoparticles and silver-ions to lung cells in vitro at the air-liquid interface

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FNNM.14.149

Genotoxic effects of silver nanoparticles stimulated by oxidative stress in human normal bronchial epithelial (BEAS-2B) cells

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FNNM.14.149

Mechanism of uptake of ZnO nanoparticles and inflammatory responses in macrophages require PI3K mediated MAPKs signaling.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FNNM.14.149

Assessing toxicity of fine and nanoparticles: comparing in vitro measurements to in vivo pulmonary toxicity profiles

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FNNM.14.149

Application of short-term inhalation studies to assess the inhalation toxicity of nanomaterials

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FNNM.14.149

Subchronic inhalation toxicity of silver nanoparticles.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FNNM.14.149

Recovery from silver-nanoparticle-exposure-induced lung inflammation and lung function changes in Sprague Dawley rats

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FNNM.14.149

Silver and nanoparticles of silver in wound dressings: a review of efficacy and safety

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FNNM.14.149

Zinc oxide nanoparticles interfere with zinc ion homeostasis to cause cytotoxicity.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FNNM.14.149

Hazard identification of inhaled nanomaterials: making use of short-term inhalation studies

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FNNM.14.149

Long-term pulmonary responses of three laboratory rodent species to subchronic inhalation of pigmentary titanium dioxide particles

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FNNM.14.149

Pulmonary responses of mice, rats, and hamsters to subchronic inhalation of ultrafine titanium dioxide particles

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FNNM.14.149

Pulmonary response of rats exposed to titanium dioxide (TiO2) by inhalation for two years.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FNNM.14.149

Correlating nanoscale titania structure with toxicity: a cytotoxicity and inflammatory response study with human dermal fibroblasts and human lung epithelial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FNNM.14.149

Identification of the mechanisms that drive the toxicity of TiO(2 )particulates: the contribution of physicochemical characteristics

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FNNM.14.149

Pulmonary retention of ultrafine and fine particles in rats

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FNNM.14.149

Oxidative stress induced by cerium oxide nanoparticles in cultured BEAS-2B cells

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FNNM.14.149

Oxidative stress of CeO2 nanoparticles via p38-Nrf-2 signaling pathway in human bronchial epithelial cell, Beas-2B.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FNNM.14.149

Microsomal glutathione transferase 1 protects against toxicity induced by silica nanoparticles but not by zinc oxide nanoparticles

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FNNM.14.149

Cytotoxicity and genotoxicity of ceria nanoparticles on different cell lines in vitro.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FNNM.14.149

Cerium and yttrium oxide nanoparticles are neuroprotective

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FNNM.14.149

Comparison of the mechanism of toxicity of zinc oxide and cerium oxide nanoparticles based on dissolution and oxidative stress properties

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FNNM.14.149

Metal oxide nanoparticles induce unique inflammatory footprints in the lung: important implications for nanoparticle testing

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FNNM.14.149

Acute inhalation toxicity of cerium oxide nanoparticles in rats.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FNNM.14.149

The nanosilica hazard: another variable entity

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FNNM.14.149

The dissolution rates of SiO2 nanoparticles as a function of particle size

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FNNM.14.149

Evaluation of cellular effects of silicon dioxide nanoparticles.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FNNM.14.149

Bio-active engineered 50 nm silica nanoparticles with bone anabolic activity: therapeutic index, effective concentration, and cytotoxicity profile in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FNNM.14.149

Amorphous silica nanoparticles do not induce cytotoxicity, cell transformation or genotoxicity in Balb/3T3 mouse fibroblasts

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FNNM.14.149

Interactions of silica nanoparticles with lung epithelial cells and the association to flotillins

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FNNM.14.149

Size-dependent cytotoxicity of monodisperse silica nanoparticles in human endothelial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FNNM.14.149

Safety evaluation of engineered nanomaterials for health risk assessment: an experimental tiered testing approach using pristine and functionalized carbon nanotubes

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FNNM.14.149

Screening of different metal oxide nanoparticles reveals selective toxicity and inflammatory potential of silica nanoparticles in lung epithelial cells and macrophages

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FNNM.14.149

Evaluation of apoptosis induced by nanoparticles and fine particles in RAW 264.7 macrophages: facts and artefacts

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FNNM.14.149

Physicochemical properties determine nanomaterial cellular uptake, transport, and fate

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FNNM.14.149

Subchronic inhalation toxicity of amorphous silicas and quartz dust in rats

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FNNM.14.149

Cytotoxicity in the age of nano: the role of fourth period transition metal oxide nanoparticle physicochemical properties

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FNNM.14.149

A critical review of the biological mechanisms underlying the in vivo and in vitro toxicity of carbon nanotubes: The contribution of physico-chemical characteristics

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FNNM.14.149

Use of back-scatter electron signals to visualise cell/nanowires interactions in vitro and in vivo; frustrated phagocytosis of long fibres in macrophages and compartmentalisation in mesothelial cells in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FNNM.14.149

Mechanisms of toxicity by carbon nanotubes

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FNNM.14.149

Asbestos, carbon nanotubes and the pleural mesothelium: a review of the hypothesis regarding the role of long fibre retention in the parietal pleura, inflammation and mesothelioma

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FNNM.14.149

The threshold length for fiber-induced acute pleural inflammation: shedding light on the early events in asbestos-induced mesothelioma

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FNNM.14.149

Use of silver nanowires to determine thresholds for fibre length-dependent pulmonary inflammation and inhibition of macrophage migration in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FNNM.14.149

The mechanism of pleural inflammation by long carbon nanotubes: interaction of long fibres with macrophages stimulates them to amplify pro-inflammatory responses in mesothelial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FNNM.14.149

Multi-walled carbon nanotubes induce cytotoxicity and genotoxicity in human lung epithelial cells.

21 January 2018

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https://api.crossref.org/works/10.2217%2FNNM.14.149

Effect of dispersants of multi-walled carbon nanotubes on cellular uptake and biological responses

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FNNM.14.149

The role of iron impurities in the toxic effects exerted by short multiwalled carbon nanotubes (MWCNT) in murine alveolar macrophages.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FNNM.14.149

Comparative cyto-genotoxicity assessment of functionalized and pristine multiwalled carbon nanotubes on human lung epithelial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FNNM.14.149

Comparative inhalation toxicity of multi-wall carbon nanotubes, graphene, graphite nanoplatelets and low surface carbon black

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FNNM.14.149

Inhalation toxicity of multiwall carbon nanotubes in rats exposed for 3 months

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FNNM.14.149

Promotion of lung adenocarcinoma following inhalation exposure to multi-walled carbon nanotubes

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FNNM.14.149

Carbon nanotubes enhance metastatic growth of lung carcinoma via up-regulation of myeloid-derived suppressor cells

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FNNM.14.149

Absence of Carcinogenic Response to Multiwall Carbon Nanotubes in a 2-Year Bioassay in the Peritoneal Cavity of the Rat

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FNNM.14.149

Assessing nanoparticle toxicity in cell-based assays: influence of cell culture parameters and optimized models for bridging the in vitro-in vivo gap.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FNNM.14.149

Relating Nanoparticle Properties to Biological Outcomes in Exposure Escalation Experiments

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FNNM.14.149

Toward toxicity testing of nanomaterials in the 21st century: a paradigm for moving forward

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FNNM.14.149

The contributions of metal impurities and tube structure to the toxicity of carbon nanotube materials

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FNNM.14.149

Not ready to use – overcoming pitfalls when dispersing nanoparticles in physiological media

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FNNM.14.149

21 January 2018

Identifiers

DOI

10.2217/NNM.14.149

1 reference

1 September 2017

1 reference