(Q38137348)

29 August 2017

title

Engineering stereoselectivity of ThDP-dependent enzymes (English)

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29 August 2017

1 reference

Helen C Hailes

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Dörte Rother

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Martina Pohl

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Jürgen Pleiss

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29 August 2017

Michael Müller

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29 August 2017

Robert Westphal

series ordinal

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29 August 2017

John M Ward

series ordinal

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29 August 2017

Constantin Vogel

series ordinal

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29 August 2017

language of work or name

English

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publication date

13 September 2013

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29 August 2017

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29 August 2017

volume

280

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29 August 2017

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29 August 2017

page(s)

6374-6394

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Current mechanistic understanding of thiamin diphosphate-dependent enzymatic reactions

29 August 2017

cites work

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12496

Structure, mechanism and catalytic duality of thiamine-dependent enzymes

21 January 2018

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CC bond formation using ThDP-dependent lyases

21 January 2018

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21 January 2018

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The Thiamine diphosphate dependent Enzyme Engineering Database: a tool for the systematic analysis of sequence and structure relations

21 January 2018

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Thiamin diphosphate in biological chemistry: exploitation of diverse thiamin diphosphate-dependent enzymes for asymmetric chemoenzymatic synthesis.

21 January 2018

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Examination of substrate binding in thiamin diphosphate-dependent transketolase by protein crystallography and site-directed mutagenesis

21 January 2018

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https://api.crossref.org/works/10.1111%2FFEBS.12496

Directed evolution of transketolase activity on non-phosphorylated substrates.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12496

Rational substrate and enzyme engineering of transketolase for aromatics.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12496

Enhancement of the substrate scope of transketolase.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12496

Acetohydroxyacid synthase: a new enzyme for chiral synthesis of R-phenylacetylcarbinol

21 January 2018

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Mechanisms of acetohydroxyacid synthases

21 January 2018

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Monitoring the acetohydroxy acid synthase reaction and related carboligations by circular dichroism spectroscopy

21 January 2018

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Significant Catalytic Roles for Glu47 and Gln 110 in All Four of the C−C Bond-Making and -Breaking Steps of the Reactions of Acetohydroxyacid Synthase II

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12496

Many of the functional differences between acetohydroxyacid synthase (AHAS) isozyme I and other AHASs are a result of the rapid formation and breakdown of the covalent acetolactate-thiamin diphosphate adduct in AHAS I.

21 January 2018

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Development of a donor-acceptor concept for enzymatic cross-coupling reactions of aldehydes: the first asymmetric cross-benzoin condensation

21 January 2018

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https://api.crossref.org/works/10.1111%2FFEBS.12496

Alteration of the substrate specificity of benzoylformate decarboxylase from Pseudomonas putida by directed evolution

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12496

Exchanging the substrate specificities of pyruvate decarboxylase from Zymomonas mobilis and benzoylformate decarboxylase from Pseudomonas putida.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12496

An activity, stability and selectivity comparison of propioin synthesis by thiamine diphosphate-dependent enzymes in a solid/gas bioreactor

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12496

Rational protein design of ThDP-dependent enzymes-engineering stereoselectivity

21 January 2018

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Factors mediating activity, selectivity, and substrate specificity for the thiamin diphosphate-dependent enzymes benzaldehyde lyase and benzoylformate decarboxylase.

21 January 2018

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The production of (R)-2-hydroxy-1-phenyl-propan-1-one derivatives by benzaldehyde lyase from Pseudomonas fluorescens in a continuously operated membrane reactor

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12496

Benzaldehyde lyase-catalyzed diastereoselective C-C bond formation by simultaneous carboligation and kinetic resolution

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12496

Identification, cloning, and characterization of a Lactococcus lactis branched-chain alpha-keto acid decarboxylase involved in flavor formation

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12496

Cyclohexane-1,2-dione hydrolase from denitrifying Azoarcus sp. strain 22Lin, a novel member of the thiamine diphosphate enzyme family

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12496

Crystal structure of a ring-cleaving cyclohexane-1,2-dione hydrolase, a novel member of the thiamine diphosphate enzyme family

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12496

α-Hydroxy-β-keto acid rearrangement-decarboxylation: impact on thiamine diphosphate-dependent enzymatic transformations.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12496

TCA cycle involved enzymes SucA and Kgd, as well as MenD: efficient biocatalysts for asymmetric C-C bond formation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12496

Functional plasticity and allosteric regulation of α-ketoglutarate decarboxylase in central mycobacterial metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12496

Enantioselective intermolecular aldehyde-ketone cross-coupling through an enzymatic carboligation reaction.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12496

Thiamin diphosphate catalysis: enzymic and nonenzymic covalent intermediates

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12496

Evolutionary analysis of the TPP-dependent enzyme family.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12496

Biosynthesis of 2-aceto-2-hydroxy acids: acetolactate synthases and acetohydroxyacid synthases

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12496

Binding and activation of thiamin diphosphate in acetohydroxyacid synthase

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12496

Structure and mechanism of the ThDP-dependent benzaldehyde lyase from Pseudomonas fluorescens

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12496

The crystal structure of benzoylformate decarboxylase at 1.6 A resolution: diversity of catalytic residues in thiamin diphosphate-dependent enzymes

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12496

Structural and kinetic analysis of catalysis by a thiamin diphosphate-dependent enzyme, benzoylformate decarboxylase

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12496

The route of ethanol formation in Zymomonas mobilis

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12496

High resolution crystal structure of pyruvate decarboxylase from Zymomonas mobilis. Implications for substrate activation in pyruvate decarboxylases

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12496

Pyruvate decarboxylase: a key enzyme for the oxidative metabolism of lactic acid by Acetobacter pasteurianus

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12496

Menaquinone biosynthesis in Escherichia coli: identification of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate as a novel intermediate and re-evaluation of MenD activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12496

Specificity and Reactivity in Menaquinone Biosynthesis: The Structure of Escherichia coli MenD (2-Succinyl-5-Enolpyruvyl-6-Hydroxy-3-Cyclohexadiene-1-Carboxylate Synthase)

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12496

Structure and Reactivity of Bacillus subtilis MenD Catalyzing the First Committed Step in Menaquinone Biosynthesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12496

Structural and functional analysis of Vitamin K2 synthesis protein MenD

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12496

Crystallization and preliminary X-ray crystallographic data with Escherichia coli transketolase.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12496

Strain and near attack conformers in enzymic thiamin catalysis: X-ray crystallographic snapshots of bacterial transketolase in covalent complex with donor ketoses xylulose 5-phosphate and fructose 6-phosphate, and in noncovalent complex with [...]

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12496

Using substrate analogues to probe the kinetic mechanism and active site of Escherichia coli MenD.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12496

Exploring the active site of benzaldehyde lyase by modeling and mutagenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12496

Active-site engineering of benzaldehyde lyase shows that a point mutation can confer both new reactivity and susceptibility to mechanism-based inhibition

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12496

Double Duty for a Conserved Glutamate in Pyruvate Decarboxylase: Evidence of the Participation in Stereoelectronically Controlled Decarboxylation and in Protonation of the Nascent Carbanion/Enamine Intermediate,

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12496

Synthesis with good enantiomeric excess of both enantiomers of alpha-ketols and acetolactates by two thiamin diphosphate-dependent decarboxylases.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12496

Benzoylformate decarboxylase from Pseudomonas putida as stable catalyst for the synthesis of chiral 2-hydroxy ketones

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12496

Influence of Organic Solvents on Enzymatic Asymmetric Carboligations

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12496

Substrate range of acetohydroxy acid synthase I from Escherichia coli in the stereoselective synthesis of alpha-hydroxy ketones

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12496

(S)-Selective MenD variants from Escherichia coli provide access to new functionalized chiral α-hydroxy ketones

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12496

Crystal structure of yeast acetohydroxyacid synthase: a target for herbicidal inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12496

A standard numbering scheme for thiamine diphosphate-dependent decarboxylases

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12496

Refined structure of transketolase from Saccharomyces cerevisiae at 2.0 A resolution

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12496

The Crystal Structure of Human Transketolase and New Insights into Its Mode of Action

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12496

A microplate-based evaluation of complex denaturation pathways: structural stability of Escherichia coli transketolase.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12496

A colorimetric assay for screening transketolase activity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12496

Directed evolution of transketolase substrate specificity towards an aliphatic aldehyde

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12496

Directed evolution to re-adapt a co-evolved network within an enzyme.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12496

A pH-based high-throughput assay for transketolase: fingerprinting of substrate tolerance and quantitative kinetics.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12496

α,α′-Dihydroxyketone formation using aromatic and heteroaromatic aldehydes with evolved transketolase enzymes

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12496

Cyclohexane-1,2-dione hydrolase: A new tool to degrade alicyclic compounds

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12496

Asp477 is a determinant of the enantioselectivity in yeast transketolase

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12496

Transketolase from Escherichia coli: A practical procedure for using the biocatalyst for asymmetric carbon-carbon bond synthesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12496

Preparative enantioselective synthesis of benzoins and (R)-2-hydroxy-1-phenylpropanone using benzaldehyde lyase

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12496

Conversion of Pyruvate Decarboxylase into an Enantioselective Carboligase with Biosynthetic Potential

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12496

S-Selective Mixed Carboligation by Structure-Based Design of the Pyruvate Decarboxylase from Acetobacter pasteurianus

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12496

21 January 2018

Identifiers

DOI

10.1111/FEBS.12496

1 reference

29 August 2017

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