(Q38128383)

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Oxygen sensing, hypoxia-inducible factors, and disease pathophysiology

scientific article published on 07 August 2013

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Europe PubMed Central

PubMed publication ID

29 August 2017

Oxygen sensing, hypoxia-inducible factors, and disease pathophysiology (English)

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Europe PubMed Central

PubMed publication ID

29 August 2017

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pathophysiology

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based on heuristic

inferred from title

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based on heuristic

inferred from title

Gregg L. Semenza

1

object named as

Gregg L Semenza

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Europe PubMed Central

PubMed publication ID

29 August 2017

publication date

7 August 2013

1 reference

Europe PubMed Central

PubMed publication ID

29 August 2017

Annual Review of Pathology: Mechanisms of Disease

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Europe PubMed Central

PubMed publication ID

29 August 2017

9

1 reference

Europe PubMed Central

PubMed publication ID

29 August 2017

47-71

1 reference

Europe PubMed Central

PubMed publication ID

29 August 2017

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12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV-PATHOL-012513-104720

Hypoxia promotes isocitrate dehydrogenase-dependent carboxylation of α-ketoglutarate to citrate to support cell growth and viability

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV-PATHOL-012513-104720

Hypoxia-inducible factors regulate tumorigenic capacity of glioma stem cells

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV-PATHOL-012513-104720

Ranibizumab for neovascular age-related macular degeneration

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV-PATHOL-012513-104720

Significant correlation of hypoxia-inducible factor-1alpha with treatment outcome in cervical cancer treated with radical radiotherapy

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV-PATHOL-012513-104720

Acriflavine inhibits HIF-1 dimerization, tumor growth, and vascularization

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV-PATHOL-012513-104720

Chronic intermittent hypoxia induces atherosclerosis via activation of adipose angiopoietin-like 4.

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV-PATHOL-012513-104720

Disruption of oxygen homeostasis underlies congenital Chuvash polycythemia

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV-PATHOL-012513-104720

Hypoxia-inducible factor 1alpha polymorphism and coronary collaterals in patients with ischemic heart disease

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV-PATHOL-012513-104720

Inter-Society Consensus for the Management of Peripheral Arterial Disease (TASC II)

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV-PATHOL-012513-104720

Cardia bifida, defective heart development and abnormal neural crest migration in embryos lacking hypoxia-inducible factor-1alpha

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV-PATHOL-012513-104720

Age-dependent impairment of HIF-1alpha expression in diabetic mice: Correction with electroporation-facilitated gene therapy increases wound healing, angiogenesis, and circulating angiogenic cells

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV-PATHOL-012513-104720

Lower mortality from coronary heart disease and stroke at higher altitudes in Switzerland.

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV-PATHOL-012513-104720

Hypoxia-inducible factor-1 deficiency results in dysregulated erythropoiesis signaling and iron homeostasis in mouse development

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV-PATHOL-012513-104720

Hypoxia promotes glycogen accumulation through hypoxia inducible factor (HIF)-mediated induction of glycogen synthase 1

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV-PATHOL-012513-104720

Intermittent hypoxia degrades HIF-2alpha via calpains resulting in oxidative stress: implications for recurrent apnea-induced morbidities.

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV-PATHOL-012513-104720

Macrophage Expression of Hypoxia-Inducible Factor-1α Suppresses T-Cell Function and Promotes Tumor Progression

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV-PATHOL-012513-104720

Impaired angiogenesis and mobilization of circulating angiogenic cells in HIF-1alpha heterozygous-null mice after burn wounding

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV-PATHOL-012513-104720

HIF-1 mediates adaptation to hypoxia by actively downregulating mitochondrial oxygen consumption

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV-PATHOL-012513-104720

Metabolic reprogramming by HIF-1 promotes the survival of bone marrow–derived angiogenic cells in ischemic tissue

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV-PATHOL-012513-104720

Characterization of a subset of the basic-helix-loop-helix-PAS superfamily that interacts with components of the dioxin signaling pathway

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV-PATHOL-012513-104720

Involvement of oxygen-sensing pathways in physiologic and pathologic erythropoiesis

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV-PATHOL-012513-104720

Hypoxia inducible factor 1 mediates hypoxia-induced TRPC expression and elevated intracellular Ca2+ in pulmonary arterial smooth muscle cells

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV-PATHOL-012513-104720

Expression of hypoxia-inducible factor-1 alpha in oligodendrogliomas: its impact on prognosis and on neoangiogenesis

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV-PATHOL-012513-104720

Hypoxia-inducible factor 1 transcriptional activity in endothelial cells is required for acute phase cardioprotection induced by ischemic preconditioning

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV-PATHOL-012513-104720

p53-induced inhibition of Hif-1 causes cardiac dysfunction during pressure overload

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV-PATHOL-012513-104720

Prognostic significance of Hypoxia-Inducible Factor 1 alpha(HIF-1 alpha) expression in serous ovarian cancer: an immunohistochemical study

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV-PATHOL-012513-104720

HIF-1α regulates function and differentiation of myeloid-derived suppressor cells in the tumor microenvironment

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV-PATHOL-012513-104720

Lymphangiogenesis and lymphatic metastasis in breast cancer

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV-PATHOL-012513-104720

Blockade of B7-H1 improves myeloid dendritic cell–mediated antitumor immunity

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV-PATHOL-012513-104720

Evaluation of hypoxia-inducible factor 1alpha overexpression as a predictor of tumour recurrence and progression in superficial urothelial bladder carcinoma.

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV-PATHOL-012513-104720

Reductive glutamine metabolism by IDH1 mediates lipogenesis under hypoxia

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV-PATHOL-012513-104720

Effect of episodic hypoxia on sympathetic activity and blood pressure

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV-PATHOL-012513-104720

Systemic, cellular and molecular analysis of chemoreflex-mediated sympathoexcitation by chronic intermittent hypoxia

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV-PATHOL-012513-104720

Donor treatment with a PHD-inhibitor activating HIFs prevents graft injury and prolongs survival in an allogenic kidney transplant model

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV-PATHOL-012513-104720

Effects of aging and hypoxia-inducible factor-1 activity on angiogenic cell mobilization and recovery of perfusion after limb ischemia

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV-PATHOL-012513-104720

The angiopoietin-2 gene of endothelial cells is up-regulated in hypoxia by a HIF binding site located in its first intron and by the central factors GATA-2 and Ets-1.

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV-PATHOL-012513-104720

Tumour hypoxia promotes tolerance and angiogenesis via CCL28 and T(reg) cells.

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV-PATHOL-012513-104720

Cell type-specific regulation of angiogenic growth factor gene expression and induction of angiogenesis in nonischemic tissue by a constitutively active form of hypoxia-inducible factor 1.

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV-PATHOL-012513-104720

The cooperative induction of hypoxia-inducible factor-1 alpha and STAT3 during hypoxia induced an impairment of tumor susceptibility to CTL-mediated cell lysis.

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV-PATHOL-012513-104720

Progenitor cell trafficking is regulated by hypoxic gradients through HIF-1 induction of SDF-1

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV-PATHOL-012513-104720

Myocardial reperfusion: a double-edged sword?

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV-PATHOL-012513-104720

Polymorphisms in hypoxia inducible factor 1 and the initial clinical presentation of coronary disease

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV-PATHOL-012513-104720

Activation of a HIF1alpha-PPARgamma axis underlies the integration of glycolytic and lipid anabolic pathways in pathologic cardiac hypertrophy.

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV-PATHOL-012513-104720

Synergistic effect of HIF-1alpha gene therapy and HIF-1-activated bone marrow-derived angiogenic cells in a mouse model of limb ischemia

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV-PATHOL-012513-104720

Stromal cell-derived factor-1alpha and CXCR4 expression in hemangioblastoma and clear cell-renal cell carcinoma: von Hippel-Lindau loss-of-function induces expression of a ligand and its receptor

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV-PATHOL-012513-104720

Endothelial expression of hypoxia-inducible factor 1 protects the murine heart and aorta from pressure overload by suppression of TGF-β signaling

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV-PATHOL-012513-104720

Hypoxia-inducible factor 1 is a master regulator of breast cancer metastatic niche formation

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV-PATHOL-012513-104720

Human cancers converge at the HIF-2alpha oncogenic axis.

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV-PATHOL-012513-104720

Hypoxia-inducible factor 1 alpha expression correlates with angiogenesis and unfavorable prognosis in bladder cancer

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV-PATHOL-012513-104720

HIF-1alpha and CA IX staining in invasive breast carcinomas: prognosis and treatment outcome.

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV-PATHOL-012513-104720

Expression of hypoxia-inducible factor 1alpha, hypoxia-inducible factor 2alpha, and von Hippel-Lindau protein in epithelial ovarian neoplasms and allelic loss of von Hippel-Lindau gene: nuclear expression of hypoxia-inducible factor 1alpha is an ind

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV-PATHOL-012513-104720

Ecto-5'-nucleotidase (CD73) regulation by hypoxia-inducible factor-1 mediates permeability changes in intestinal epithelia

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV-PATHOL-012513-104720

Tumor hypoxia and malignant progression.

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV-PATHOL-012513-104720

Integrative analysis of HIF binding and transactivation reveals its role in maintaining histone methylation homeostasis

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV-PATHOL-012513-104720

RETRACTED: Lysyl oxidase is essential for hypoxia-induced metastasis

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV-PATHOL-012513-104720

Hypoxia, hypoxia-inducible transcription factor, and macrophages in human atherosclerotic plaques are correlated with intraplaque angiogenesis

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV-PATHOL-012513-104720

PML inhibits HIF-1alpha translation and neoangiogenesis through repression of mTOR

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV-PATHOL-012513-104720

Procollagen lysyl hydroxylase 2 is essential for hypoxia-induced breast cancer metastasis

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV-PATHOL-012513-104720

The synergism of age and db/db genotype impairs wound healing

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV-PATHOL-012513-104720

HIF-dependent antitumorigenic effect of antioxidants in vivo

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV-PATHOL-012513-104720

Heterozygous HIF-1alpha deficiency impairs carotid body-mediated systemic responses and reactive oxygen species generation in mice exposed to intermittent hypoxia

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV-PATHOL-012513-104720

Hypoxia-inducible factor-1 is central to cardioprotection: a new paradigm for ischemic preconditioning

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV-PATHOL-012513-104720

NADPH oxidase is required for the sensory plasticity of the carotid body by chronic intermittent hypoxia.

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV-PATHOL-012513-104720

Hypoxia-inducible factor-1alpha and -2alpha are expressed in most rectal cancers but only hypoxia-inducible factor-1alpha is associated with prognosis

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV-PATHOL-012513-104720

Hypoxia-Inducible Factor-1 Expression Predicts a Poor Response to Primary Chemoendocrine Therapy and Disease-Free Survival in Primary Human Breast Cancer

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV-PATHOL-012513-104720

TSC2 regulates VEGF through mTOR-dependent and -independent pathways

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV-PATHOL-012513-104720

Chronic lung allograft rejection and airway microvasculature: Is HIF-1 the missing link?

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV-PATHOL-012513-104720

Adenovirus-mediated HIF-1α gene transfer promotes repair of mouse airway allograft microvasculature and attenuates chronic rejection

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV-PATHOL-012513-104720

Detection and characterization of tumor hypoxia using pO2 histography

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV-PATHOL-012513-104720

Sustained expression of Hif-1alpha in the diabetic environment promotes angiogenesis and cutaneous wound repair

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV-PATHOL-012513-104720

Hypoxia Response Elements in the Aldolase A, Enolase 1, and Lactate Dehydrogenase A Gene Promoters Contain Essential Binding Sites for Hypoxia-inducible Factor 1

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV-PATHOL-012513-104720

Hypoxia-inducible factor-1alpha expression in the gastric carcinogenesis sequence and its prognostic role in gastric and gastro-oesophageal adenocarcinomas

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV-PATHOL-012513-104720

mTOR and HIF-1alpha-mediated tumor metabolism in an LKB1 mouse model of Peutz-Jeghers syndrome

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV-PATHOL-012513-104720

A novel bHLH-PAS factor with close sequence similarity to hypoxia-inducible factor 1alpha regulates the VEGF expression and is potentially involved in lung and vascular development

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV-PATHOL-012513-104720

Purification and characterization of hypoxia-inducible factor 1

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV-PATHOL-012513-104720

Transcriptional regulation of vascular endothelial cell responses to hypoxia by HIF-1.

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV-PATHOL-012513-104720

Identifiers

10.1146/ANNUREV-PATHOL-012513-104720

1 reference

Europe PubMed Central

PubMed publication ID

29 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

29 August 2017

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