(Q38151562)

29 August 2017

title

The genetic complexity of common cancers and the promise of personalized medicine: is there any hope? (English)

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29 August 2017

main subject

personalized medicine

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Jean-Charles Soria

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author name string

Monica Arnedos

series ordinal

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29 August 2017

Philippe Vielh

series ordinal

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29 August 2017

Fabrice Andre

series ordinal

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29 August 2017

publication date

1 January 2014

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29 August 2017

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29 August 2017

volume

232

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29 August 2017

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29 August 2017

page(s)

274-282

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Initial sequencing and analysis of the human genome

29 August 2017

cites work

1 reference

The genetic basis for cancer treatment decisions

21 January 2018

1 reference

Advances in understanding cancer genomes through second-generation sequencing

21 January 2018

1 reference

Clonal evolution in relapsed acute myeloid leukaemia revealed by whole-genome sequencing

21 January 2018

1 reference

Personalized oncology through integrative high-throughput sequencing: a pilot study

21 January 2018

1 reference

Efficacy and safety of trastuzumab as a single agent in first-line treatment of HER2-overexpressing metastatic breast cancer

21 January 2018

1 reference

Trastuzumab plus adjuvant chemotherapy for operable HER2-positive breast cancer

21 January 2018

1 reference

EGFR mutations in non-small-cell lung cancer: analysis of a large series of cases and development of a rapid and sensitive method for diagnostic screening with potential implications on pharmacologic treatment

21 January 2018

1 reference

Inhibition of Mutated, Activated BRAF in Metastatic Melanoma

21 January 2018

1 reference

Cancer immunoediting: antigens, mechanisms, and implications to cancer immunotherapy

21 January 2018

1 reference

21 January 2018

1 reference

21 January 2018

The Hallmarks of Cancer

1 reference

Patterns of somatic mutation in human cancer genomes

21 January 2018

1 reference

The consensus coding sequences of human breast and colorectal cancers

21 January 2018

1 reference

The genomic landscapes of human breast and colorectal cancers

21 January 2018

1 reference

The genetic landscape of the childhood cancer medulloblastoma

21 January 2018

1 reference

Somatic mutations affect key pathways in lung adenocarcinoma

21 January 2018

1 reference

Diverse somatic mutation patterns and pathway alterations in human cancers

21 January 2018

1 reference

A small-cell lung cancer genome with complex signatures of tobacco exposure

21 January 2018

1 reference

A comprehensive catalogue of somatic mutations from a human cancer genome

21 January 2018

1 reference

Profiling critical cancer gene mutations in clinical tumor samples

21 January 2018

1 reference

Initial genome sequencing and analysis of multiple myeloma

21 January 2018

1 reference

COSMIC: mining complete cancer genomes in the Catalogue of Somatic Mutations in Cancer

21 January 2018

1 reference

The patterns and dynamics of genomic instability in metastatic pancreatic cancer

21 January 2018

1 reference

Distant metastasis occurs late during the genetic evolution of pancreatic cancer

21 January 2018

1 reference

Intratumor Heterogeneity and Branched Evolution Revealed by Multiregion Sequencing

21 January 2018

1 reference

Intratumor heterogeneity and chemotherapy-induced changes in EGFR status in non-small cell lung cancer

21 January 2018

1 reference

Next-generation sequencing reveals high concordance of recurrent somatic alterations between primary tumor and metastases from patients with non-small-cell lung cancer

21 January 2018

1 reference

Patient-oriented gene set analysis for cancer mutation data

21 January 2018

1 reference

Comparison of four chemotherapy regimens for advanced non-small-cell lung cancer

21 January 2018

1 reference

Identification of the transforming EML4-ALK fusion gene in non-small-cell lung cancer

21 January 2018

1 reference

Anaplastic lymphoma kinase inhibition in non-small-cell lung cancer

21 January 2018

1 reference

Multi-institutional randomized phase II trial of gefitinib for previously treated patients with advanced non-small-cell lung cancer (The IDEAL 1 Trial) [corrected].

21 January 2018

1 reference

Gefitinib in combination with paclitaxel and carboplatin in advanced non-small-cell lung cancer: a phase III trial--INTACT 2.

21 January 2018

1 reference

Gefitinib in combination with gemcitabine and cisplatin in advanced non-small-cell lung cancer: a phase III trial--INTACT 1.

21 January 2018

1 reference

EGFR mutations in lung cancer: correlation with clinical response to gefitinib therapy

21 January 2018

1 reference

Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib

21 January 2018

1 reference

New pathologic classification of lung cancer: relevance for clinical practice and clinical trials

21 January 2018

1 reference

Comprehensive genomic characterization of squamous cell lung cancers

21 January 2018

1 reference

Randomized phase III study of temozolomide versus dacarbazine in the treatment of patients with advanced metastatic malignant melanoma

21 January 2018

1 reference

Mutations of the BRAF gene in human cancer

21 January 2018

1 reference

Survival in BRAF V600-mutant advanced melanoma treated with vemurafenib

21 January 2018

1 reference

Improved survival with vemurafenib in melanoma with BRAF V600E mutation

21 January 2018

1 reference

Inhibition of PI3K/mTOR leads to adaptive resistance in matrix-attached cancer cells

21 January 2018

1 reference

AKT inhibition relieves feedback suppression of receptor tyrosine kinase expression and activity

21 January 2018

1 reference

Loss of HER2 amplification following trastuzumab-based neoadjuvant systemic therapy and survival outcomes

21 January 2018

1 reference

Acquired resistance of lung adenocarcinomas to gefitinib or erlotinib is associated with a second mutation in the EGFR kinase domain

21 January 2018

1 reference

MET amplification leads to gefitinib resistance in lung cancer by activating ERBB3 signaling

21 January 2018

1 reference

Genotypic and histological evolution of lung cancers acquiring resistance to EGFR inhibitors

21 January 2018

1 reference

COT drives resistance to RAF inhibition through MAP kinase pathway reactivation

21 January 2018

1 reference

EML4-ALK mutations in lung cancer that confer resistance to ALK inhibitors.

21 January 2018

1 reference

Detection of mutations in EGFR in circulating lung-cancer cells

21 January 2018

1 reference

Detection and quantification of mutations in the plasma of patients with colorectal tumors

21 January 2018

1 reference

Detection of tumor PIK3CA status in metastatic breast cancer using peripheral blood

21 January 2018

1 reference

Detection of BRAF mutations in the tumour and serum of patients enrolled in the AZD6244 (ARRY-142886) advanced melanoma phase II study.

21 January 2018

1 reference

Envisioning the future of early anticancer drug development

21 January 2018

1 reference

Pilot Study Using Molecular Profiling of Patients' Tumors to Find Potential Targets and Select Treatments for Their Refractory Cancers

21 January 2018

1 reference

High-throughput detection of actionable genomic alterations in clinical tumor samples by targeted, massively parallel sequencing

21 January 2018

1 reference

A cellular oncogene is translocated to the Philadelphia chromosome in chronic myelocytic leukaemia

21 January 2018

1 reference

21 January 2018

Identifiers

DOI

10.1002/PATH.4276

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29 August 2017

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