(Q38089805)

28 August 2017

title

Expression of biosynthetic gene clusters in heterologous hosts for natural product production and combinatorial biosynthesis (English)

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28 August 2017

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Ute Galm

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28 August 2017

Ben Shen

series ordinal

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28 August 2017

language of work or name

English

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publication date

1 October 2006

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Expert Opinion on Drug Discovery

28 August 2017

published in

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28 August 2017

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28 August 2017

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28 August 2017

page(s)

409-437

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Natural products as sources of new drugs over the period 1981-2002.

28 August 2017

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Recent developments towards the heterologous expression of complex bacterial natural product biosynthetic pathways.

21 January 2018

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Genetic approaches to harvesting lichen products

21 January 2018

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Cloning, sequencing, analysis, and heterologous expression of the fredericamycin biosynthetic gene cluster from Streptomyces griseus

21 January 2018

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Cloning and heterologous expression of the macrotetrolide biosynthetic gene cluster revealed a novel polyketide synthase that lacks an acyl carrier protein

21 January 2018

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Iteration as programmed event during polyketide assembly; molecular analysis of the aureothin biosynthesis gene cluster

21 January 2018

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Insights about the biosynthesis of the avermectin deoxysugar L-oleandrose through heterologous expression of Streptomyces avermitilis deoxysugar genes in Streptomyces lividans

21 January 2018

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Heterologous expression of novobiocin and clorobiocin biosynthetic gene clusters

21 January 2018

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Production of 8'-halogenated and 8'-unsubstituted novobiocin derivatives in genetically engineered streptomyces coelicolor strains.

21 January 2018

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Biosynthesis of the antitumor agent chartreusin involves the oxidative rearrangement of an anthracyclic polyketide

21 January 2018

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Molecular cloning, sequence analysis, and heterologous expression of the phosphinothricin tripeptide biosynthetic gene cluster from Streptomyces viridochromogenes DSM 40736.

21 January 2018

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Cloning, sequencing and analysis of the enterocin biosynthesis gene cluster from the marine isolate 'Streptomyces maritimus': evidence for the derailment of an aromatic polyketide synthase.

21 January 2018

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The biosynthetic gene cluster for the antitumor rebeccamycin: characterization and generation of indolocarbazole derivatives

21 January 2018

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Molecular characterization of the safracin biosynthetic pathway from Pseudomonas fluorescens A2-2: designing new cytotoxic compounds

21 January 2018

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Cloning and heterologous expression of the epothilone gene cluster.

21 January 2018

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A multiplasmid approach to preparing large libraries of polyketides

21 January 2018

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Engineered biosynthesis of a complete macrolactone in a heterologous host

21 January 2018

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Cloning and heterologous expression of the entire set of structural genes for nikkomycin synthesis from Streptomyces tendae Tü901 in Streptomyces lividans

21 January 2018

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Biosynthesis of Yersiniabactin, a complex polyketide-nonribosomal peptide, using Escherichia coli as a heterologous host

21 January 2018

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Heterologous production of epothilone C and D in Escherichia coli.

21 January 2018

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Heterologous production of the antifungal polyketide antibiotic soraphen A of Sorangium cellulosum So ce26 in Streptomyces lividans

21 January 2018

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https://api.crossref.org/works/10.1517%2F17460441.1.5.409

Reduction of liver Fas expression by an antisense oligonucleotide protects mice from fulminant hepatitis

21 January 2018

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https://api.crossref.org/works/10.1517%2F17460441.1.5.409

Heterologous expression of a myxobacterial natural products assembly line in pseudomonads via red/ET recombineering

21 January 2018

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https://api.crossref.org/works/10.1517%2F17460441.1.5.409

Total synthesis of long DNA sequences: synthesis of a contiguous 32-kb polyketide synthase gene cluster.

21 January 2018

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https://api.crossref.org/works/10.1517%2F17460441.1.5.409

Combinatorial polyketide biosynthesis by de novo design and rearrangement of modular polyketide synthase genes.

21 January 2018

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https://api.crossref.org/works/10.1517%2F17460441.1.5.409

Cloning, sequencing, and functional analysis of an iterative type I polyketide synthase gene cluster for biosynthesis of the antitumor chlorinated polyenone neocarzilin in "Streptomyces carzinostaticus"

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.1.5.409

Susceptibility of methicillin-resistant staphylococci to oregano essential oil, carvacrol and thymol

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.1.5.409

Heterologous expression of epothilone biosynthetic genes in Myxococcus xanthus

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.1.5.409

Optimizing the heterologous production of epothilone D in Myxococcus xanthus

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.1.5.409

Characterization of a new type of phosphopantetheinyl transferase for fatty acid and siderophore synthesis in Pseudomonas aeruginosa

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.1.5.409

Posttranslational modification of myxobacterial carrier protein domains in Pseudomonas sp. by an intrinsic phosphopantetheinyl transferase.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.1.5.409

Bacterial type III polyketide synthases: phylogenetic analysis and potential for the production of novel secondary metabolites by heterologous expression in pseudomonads

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.1.5.409

Shotgun cloning and heterologous expression of the patellamide gene cluster as a strategy to achieving sustained metabolite production

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.1.5.409

The biosynthesis of indolocarbazoles in a heterologous E. coli host.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.1.5.409

The biosynthetic gene cluster for the antitumor drug bleomycin from Streptomyces verticillus ATCC15003 supporting functional interactions between nonribosomal peptide synthetases and a polyketide synthase

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.1.5.409

Compilation and analysis of DNA sequences associated with apparent streptomycete promoters

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.1.5.409

A two-plasmid system for the glycosylation of polyketide antibiotics: bioconversion of epsilon-rhodomycinone to rhodomycin D

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.1.5.409

Combinatorial biosynthesis of antibiotics: challenges and opportunities

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.1.5.409

Combinatorial biosynthesis of antitumor indolocarbazole compounds

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.1.5.409

StreptomycesGenetics: A Genomic Perspective

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.1.5.409

Molecular mechanisms underlying nonribosomal peptide synthesis: approaches to new antibiotics

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.1.5.409

Substrate recognition by nonribosomal peptide synthetase multi-enzymes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.1.5.409

Polyketide biosynthesis beyond the type I, II and III polyketide synthase paradigms

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.1.5.409

Polyketide and nonribosomal peptide antibiotics: modularity and versatility

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.1.5.409

NRPS-PKS: a knowledge-based resource for analysis of NRPS/PKS megasynthases

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.1.5.409

Specificity prediction of adenylation domains in nonribosomal peptide synthetases (NRPS) using transductive support vector machines (TSVMs)

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.1.5.409

Discovery of a new peptide natural product by Streptomyces coelicolor genome mining

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.1.5.409

Engineered biosynthesis of the peptide antibiotic bacitracin in the surrogate host Bacillus subtilis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.1.5.409

Cloning the soil metagenome: a strategy for accessing the genetic and functional diversity of uncultured microorganisms

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.1.5.409

Isolation of antibiotics turbomycin a and B from a metagenomic library of soil microbial DNA

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.1.5.409

Biotechnological prospects from metagenomics

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.1.5.409

Characterization of uncultivated prokaryotes: isolation and analysis of a 40-kilobase-pair genome fragment from a planktonic marine archaeon

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.1.5.409

Construction and analysis of bacterial artificial chromosome libraries from a marine microbial assemblage

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.1.5.409

Cloning and stable maintenance of 300-kilobase-pair fragments of human DNA in Escherichia coli using an F-factor-based vector

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.1.5.409

Artificial chromosomes for antibiotic-producing actinomycetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.1.5.409

Assembly of large genomic segments in artificial chromosomes by homologous recombination in Escherichia coli

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.1.5.409

Artificial chromosome libraries of Streptomyces coelicolor A3(2) and Planobispora rosea

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.1.5.409

The commercial production of chemicals using pathway engineering

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.1.5.409

Heterologous biosynthesis of truncated hexaketides derived from the actinorhodin polyketide synthase.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.1.5.409

Biosynthesis of ansatrienin (mycotrienin) and naphthomycin. Identification and analysis of two separate biosynthetic gene clusters in Streptomyces collinus Tü 1892.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.1.5.409

Organization of the biosynthetic gene cluster for the polyketide anthelmintic macrolide avermectin in Streptomyces avermitilis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.1.5.409

Biosynthesis of the orthosomycin antibiotic avilamycin A: deductions from the molecular analysis of the avi biosynthetic gene cluster of Streptomyces viridochromogenes Tü57 and production of new antibiotics

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.1.5.409

Cloning of an avilamycin biosynthetic gene cluster from Streptomyces viridochromogenes Tü57

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.1.5.409

The blasticidin S biosynthesis gene cluster from Streptomyces griseochromogenes: sequence analysis, organization, and initial characterization

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.1.5.409

Chalcomycin biosynthesis gene cluster from Streptomyces bikiniensis: novel features of an unusual ketolide produced through expression of the chm polyketide synthase in Streptomyces fradiae

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.1.5.409

Cloning and engineering of the cinnamycin biosynthetic gene cluster from Streptomyces cinnamoneus cinnamoneus DSM 40005

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.1.5.409

Molecular cloning and sequence analysis of the clorobiocin biosynthetic gene cluster: new insights into the biosynthesis of aminocoumarin antibiotics

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.1.5.409

Biosynthetic Studies of Daunorubicin and Tetracenomycin C

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.1.5.409

Characterization of the Streptomyces peucetius ATCC 29050 genes encoding doxorubicin polyketide synthase

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.1.5.409

Minimal Streptomyces sp. strain C5 daunorubicin polyketide biosynthesis genes required for aklanonic acid biosynthesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.1.5.409

Sequencing and mutagenesis of genes from the erythromycin biosynthetic gene cluster of Saccharopolyspora erythraea that are involved in L-mycarose and D-desosamine production

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.1.5.409

Biosynthesis of a natural polyketide-isoprenoid hybrid compound, furaquinocin A: identification and heterologous expression of the gene cluster

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.1.5.409

The granaticin biosynthetic gene cluster of Streptomyces violaceoruber Tü22: sequence analysis and expression in a heterologous host

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.1.5.409

Characterization of a vanillic acid non-oxidative decarboxylation gene cluster from Streptomyces sp. D7.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.1.5.409

Cloning and characterization of a gene cluster from Streptomyces cyanogenus S136 probably involved in landomycin biosynthesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.1.5.409

Cloning, sequencing and heterologous expression of the medermycin biosynthetic gene cluster of Streptomyces sp. AM-7161: towards comparative analysis of the benzoisochromanequinone gene clusters

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.1.5.409

The multifunctional 6-methylsalicylic acid synthase gene of Penicillium patulum. Its gene structure relative to that of other polyketide synthases

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.1.5.409

Structure and biosynthesis of myxochromides S1-3 in Stigmatella aurantiaca: evidence for an iterative bacterial type I polyketide synthase and for module skipping in nonribosomal peptide biosynthesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.1.5.409

Isolation and characterization of the naphthocyclinone gene cluster from Streptomyces arenae DSM 40737 and heterologous expression of the polyketide synthase genes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.1.5.409

Neocarzinostatin naphthoate synthase: an unique iterative type I PKS from neocarzinostatin producer Streptomyces carzinostaticus.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.1.5.409

Molecular characterization of co-transcribed genes from Streptomyces tendae Tü901 involved in the biosynthesis of the peptidyl moiety and assembly of the peptidyl nucleoside antibiotic nikkomycin

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.1.5.409

The entire nogalamycin biosynthetic gene cluster of Streptomyces nogalater: characterization of a 20-kb DNA region and generation of hybrid structures

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.1.5.409

Identification of the novobiocin biosynthetic gene cluster of Streptomyces spheroides NCIB 11891

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.1.5.409

The biosynthetic pathway of the aminonucleoside antibiotic puromycin, as deduced from the molecular analysis of the pur cluster of Streptomyces alboniger

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.1.5.409

Cloning, nucleotide sequence, and heterologous expression of the biosynthetic gene cluster for R1128, a non-steroidal estrogen receptor antagonist. Insights into an unusual priming mechanism

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.1.5.409

Biosynthesis of the ansamycin antibiotic rifamycin: deductions from the molecular analysis of the rif biosynthetic gene cluster of Amycolatopsis mediterranei S699.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.1.5.409

Characterization of the biosynthetic gene cluster for the antifungal polyketide soraphen A from Sorangium cellulosum So ce26.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.1.5.409

Isolation, characterization, and heterologous expression of the biosynthesis gene cluster for the antitumor anthracycline steffimycin

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.1.5.409

Cloning and heterologous expression of a gene cluster for the biosynthesis of tetracenomycin C, the anthracycline antitumor antibiotic of Streptomyces glaucescens

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.1.5.409

Cloning and heterologous expression of the entire gene clusters for PD 116740 from Streptomyces strain WP 4669 and tetrangulol and tetrangomycin from Streptomyces rimosus NRRL 3016

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.1.5.409

Deciphering the biosynthesis pathway of the antitumor thiocoraline from a marine actinomycete and its expression in two streptomyces species

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.1.5.409

The tylosin biosynthetic cluster from Streptomyces fradiae: genetic organization of the left region

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.1.5.409

Genetic localization and heterologous expression of validamycin biosynthetic gene cluster isolated from Streptomyces hygroscopicus var. limoneus KCCM 11405 (IFO 12704).

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.1.5.409

Iron acquisition in plague: modular logic in enzymatic biogenesis of yersiniabactin by Yersinia pestis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.1.5.409

Molecular cloning of the whole biosynthetic pathway of a Streptomyces antibiotic and its expression in a heterologous host

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.1.5.409

Cloning of the staurosporine biosynthetic gene cluster from Streptomyces sp. TP-A0274 and its heterologous expression in Streptomyces lividans.

21 January 2018

1 reference

12 April 2024

https://opencitations.net/index/api/v1/citations/10.7164/ANTIBIOTICS.55.1063

Cloning and Heterologous Expression of Blasticidin S Biosynthetic Genes from Streptomyces griseochromogenes.

1 reference

12 April 2024

https://opencitations.net/index/api/v1/citations/10.7164/ANTIBIOTICS.51.570

Cloning and heterologous expression in Streptomyces lividans of Streptomyces rimosus genes involved in oxytetracycline biosynthesis

1 reference

12 April 2024

https://opencitations.net/index/api/v1/citations/10.1128/JB.171.2.887-895.1989

Identifiers

DOI

10.1517/17460441.1.5.409

1 reference

28 August 2017

1 reference