(Q38077051)

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The eIF2α kinases: their structures and functions

scientific article published on 26 January 2013

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scholarly article

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Europe PubMed Central

PubMed publication ID

28 August 2017

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Europe PubMed Central

The eIF2α kinases: their structures and functions (English)

1 reference

Europe PubMed Central

PubMed publication ID

28 August 2017

Adrienne M Gorman

object named as

Adrienne M Gorman

2

0 references

object named as

Afshin Samali

4

0 references

author name string

Neysan Donnelly

1

1 reference

Europe PubMed Central

PubMed publication ID

28 August 2017

Sanjeev Gupta

3

1 reference

Europe PubMed Central

PubMed publication ID

28 August 2017

publication date

26 January 2013

1 reference

Europe PubMed Central

PubMed publication ID

28 August 2017

Cellular and Molecular Life Sciences

1 reference

Europe PubMed Central

PubMed publication ID

28 August 2017

70

1 reference

Europe PubMed Central

PubMed publication ID

28 August 2017

19

1 reference

Europe PubMed Central

PubMed publication ID

28 August 2017

3493-3511

1 reference

Europe PubMed Central

PubMed publication ID

28 August 2017

Essential role for the dsRNA-dependent protein kinase PKR in innate immunity to viral infection

1 reference

https://pubmed.ncbi.nlm.nih.gov/23354059

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

IRE1 signaling affects cell fate during the unfolded protein response

1 reference

https://pubmed.ncbi.nlm.nih.gov/23354059

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inactivation of the PKR protein kinase and stimulation of mRNA translation by the cellular co-chaperone P58(IPK) does not require J domain function

1 reference

https://pubmed.ncbi.nlm.nih.gov/23354059

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Phosphorylation of the alpha subunit of eukaryotic initiation factor 2 is required for activation of NF-kappaB in response to diverse cellular stresses

1 reference

https://pubmed.ncbi.nlm.nih.gov/23354059

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

ER stress, hypoxia tolerance and tumor progression.

1 reference

https://pubmed.ncbi.nlm.nih.gov/23354059

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Stress-induced gene expression requires programmed recovery from translational repression

1 reference

https://pubmed.ncbi.nlm.nih.gov/23354059

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

PTEN Tumor Suppressor Network in PI3K-Akt Pathway Control

1 reference

https://pubmed.ncbi.nlm.nih.gov/23354059

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mechanistic Link between PKR Dimerization, Autophosphorylation, and eIF2α Substrate Recognition

1 reference

https://pubmed.ncbi.nlm.nih.gov/23354059

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Oxidative folding: cellular strategies for dealing with the resultant equimolar production of reactive oxygen species

1 reference

https://pubmed.ncbi.nlm.nih.gov/23354059

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Haem-regulated eIF2alpha kinase is necessary for adaptive gene expression in erythroid precursors under the stress of iron deficiency.

1 reference

https://pubmed.ncbi.nlm.nih.gov/23354059

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Ceramide regulates protein synthesis by a novel mechanism involving the cellular PKR activator RAX.

1 reference

https://pubmed.ncbi.nlm.nih.gov/23354059

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Dual function of pancreatic endoplasmic reticulum kinase in tumor cell growth arrest and survival.

1 reference

https://pubmed.ncbi.nlm.nih.gov/23354059

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Tumor suppression by PTEN requires the activation of the PKR-eIF2alpha phosphorylation pathway

1 reference

https://pubmed.ncbi.nlm.nih.gov/23354059

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

PKR and GCN2 kinases and guanine nucleotide exchange factor eukaryotic translation initiation factor 2B (eIF2B) recognize overlapping surfaces on eIF2alpha

1 reference

https://pubmed.ncbi.nlm.nih.gov/23354059

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

PKR-dependent CHOP induction limits hyperoxia-induced lung injury.

1 reference

https://pubmed.ncbi.nlm.nih.gov/23354059

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Functional expression and characterization of the interferon-induced double-stranded RNA activated P68 protein kinase from Escherichia coli

1 reference

https://pubmed.ncbi.nlm.nih.gov/23354059

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

C/EBP homology protein (CHOP) interacts with activating transcription factor 4 (ATF4) and negatively regulates the stress-dependent induction of the asparagine synthetase gene

1 reference

https://pubmed.ncbi.nlm.nih.gov/23354059

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Deficient signaling in mice devoid of double-stranded RNA-dependent protein kinase

1 reference

https://pubmed.ncbi.nlm.nih.gov/23354059

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Snf1 promotes phosphorylation of the alpha subunit of eukaryotic translation initiation factor 2 by activating Gcn2 and inhibiting phosphatases Glc7 and Sit4.

1 reference

https://pubmed.ncbi.nlm.nih.gov/23354059

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

PKR, a p53 target gene, plays a crucial role in the tumor-suppressor function of p53

1 reference

https://pubmed.ncbi.nlm.nih.gov/23354059

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Melanoma differentiation-associated gene-7 protein physically associates with the double-stranded RNA-activated protein kinase PKR.

1 reference

https://pubmed.ncbi.nlm.nih.gov/23354059

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Modular structure of PACT: distinct domains for binding and activating PKR

1 reference

https://pubmed.ncbi.nlm.nih.gov/23354059

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

RNA-binding proteins TIA-1 and TIAR link the phosphorylation of eIF-2 alpha to the assembly of mammalian stress granules

1 reference

https://pubmed.ncbi.nlm.nih.gov/23354059

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Coordination of ER and oxidative stress signaling: the PERK/Nrf2 signaling pathway

1 reference

https://pubmed.ncbi.nlm.nih.gov/23354059

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mediators of endoplasmic reticulum stress-induced apoptosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/23354059

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Structure of the Keap1:Nrf2 interface provides mechanistic insight into Nrf2 signaling

1 reference

https://pubmed.ncbi.nlm.nih.gov/23354059

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Dynamic interaction of BiP and ER stress transducers in the unfolded-protein response

1 reference

https://pubmed.ncbi.nlm.nih.gov/23354059

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Ero1 and redox homeostasis in the endoplasmic reticulum.

1 reference

https://pubmed.ncbi.nlm.nih.gov/23354059

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The structure of the PERK kinase domain suggests the mechanism for its activation

1 reference

https://pubmed.ncbi.nlm.nih.gov/23354059

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Heterologous dimerization domains functionally substitute for the double-stranded RNA binding domains of the kinase PKR.

1 reference

https://pubmed.ncbi.nlm.nih.gov/23354059

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Characterization of transgenic mice with targeted disruption of the catalytic domain of the double-stranded RNA-dependent protein kinase, PKR.

1 reference

https://pubmed.ncbi.nlm.nih.gov/23354059

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Targeting the endoplasmic reticulum-stress response as an anticancer strategy

1 reference

https://pubmed.ncbi.nlm.nih.gov/23354059

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A model for the double-stranded RNA (dsRNA)-dependent dimerization and activation of the dsRNA-activated protein kinase PKR.

1 reference

https://pubmed.ncbi.nlm.nih.gov/23354059

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Translational control in stress and apoptosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/23354059

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

An integrated stress response regulates amino acid metabolism and resistance to oxidative stress

1 reference

https://pubmed.ncbi.nlm.nih.gov/23354059

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Abrogation of translation initiation factor eIF-2 phosphorylation causes malignant transformation of NIH 3T3 cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/23354059

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Multiple autophosphorylation is essential for the formation of the active and stable homodimer of heme-regulated eIF2alpha kinase

1 reference

https://pubmed.ncbi.nlm.nih.gov/23354059

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The Hsp90 chaperone complex is both a facilitator and a repressor of the dsRNA-dependent kinase PKR

1 reference

https://pubmed.ncbi.nlm.nih.gov/23354059

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

NF-kappaB and cancer-identifying targets and mechanisms

1 reference

https://pubmed.ncbi.nlm.nih.gov/23354059

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Stress-Induced Phosphorylation of PACT Reduces Its Interaction with TRBP and Leads to PKR Activation

1 reference

https://pubmed.ncbi.nlm.nih.gov/23354059

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inhibition of PKR by RNA and DNA viruses

1 reference

https://pubmed.ncbi.nlm.nih.gov/23354059

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Autophosphorylation sites participate in the activation of the double-stranded-RNA-activated protein kinase PKR

1 reference

https://pubmed.ncbi.nlm.nih.gov/23354059

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Differential regulation of CHOP translation by phosphorylated eIF4E under stress conditions

1 reference

https://pubmed.ncbi.nlm.nih.gov/23354059

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Essential role of PACT-mediated PKR activation in tunicamycin-induced apoptosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/23354059

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Uncharged tRNA activates GCN2 by displacing the protein kinase moiety from a bipartite tRNA-binding domain

1 reference

https://pubmed.ncbi.nlm.nih.gov/23354059

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Preservation of liver protein synthesis during dietary leucine deprivation occurs at the expense of skeletal muscle mass in mice deleted for eIF2 kinase GCN2.

1 reference

https://pubmed.ncbi.nlm.nih.gov/23354059

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Autophosphorylation in the activation loop is required for full kinase activity in vivo of human and yeast eukaryotic initiation factor 2alpha kinases PKR and GCN2

1 reference

https://pubmed.ncbi.nlm.nih.gov/23354059

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Stress hypERactivation in the β-cell

1 reference

https://pubmed.ncbi.nlm.nih.gov/23354059

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

PKR-like endoplasmic reticulum kinase (PERK) activation following brain ischemia is independent of unfolded nascent proteins

1 reference

https://pubmed.ncbi.nlm.nih.gov/23354059

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The Gcn2 kinase as a cell cycle regulator

1 reference

https://pubmed.ncbi.nlm.nih.gov/23354059

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Amino Acid Limitation Induces Expression ofCHOP, a CCAAT/Enhancer Binding Protein-related Gene, at Both Transcriptional and Post-transcriptional Levels

1 reference

https://pubmed.ncbi.nlm.nih.gov/23354059

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Activation of PKR: an open and shut case?

1 reference

https://pubmed.ncbi.nlm.nih.gov/23354059

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The double-strand RNA-dependent protein kinase PKR plays a significant role in a sustained ER stress-induced apoptosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/23354059

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

TRB3, a novel ER stress-inducible gene, is induced via ATF4-CHOP pathway and is involved in cell death

1 reference

https://pubmed.ncbi.nlm.nih.gov/23354059

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The GCN2 kinase biases feeding behavior to maintain amino acid homeostasis in omnivores

1 reference

https://pubmed.ncbi.nlm.nih.gov/23354059

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Hepatic heme-regulated inhibitor (HRI) eukaryotic initiation factor 2alpha kinase: a protagonist of heme-mediated translational control of CYP2B enzymes and a modulator of basal endoplasmic reticulum stress tone

1 reference

https://pubmed.ncbi.nlm.nih.gov/23354059

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Double-stranded RNA-dependent protein kinase phosphorylation of the alpha-subunit of eukaryotic translation initiation factor 2 mediates apoptosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/23354059

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Protein translation and folding are coupled by an endoplasmic-reticulum-resident kinase

1 reference

https://pubmed.ncbi.nlm.nih.gov/23354059

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The GCN2 eIF2alpha kinase regulates fatty-acid homeostasis in the liver during deprivation of an essential amino acid.

1 reference

https://pubmed.ncbi.nlm.nih.gov/23354059

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The eIF2alpha kinases inhibit vesicular stomatitis virus replication independently of eIF2alpha phosphorylation

1 reference

https://pubmed.ncbi.nlm.nih.gov/23354059

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Double-stranded RNA-dependent protein kinase links pathogen sensing with stress and metabolic homeostasis

1 reference

https://pubmed.ncbi.nlm.nih.gov/23354059

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Roles of CHOP/GADD153 in endoplasmic reticulum stress

1 reference

https://pubmed.ncbi.nlm.nih.gov/23354059

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inhibition of CHOP translation by a peptide encoded by an open reading frame localized in the chop 5'UTR

1 reference

https://pubmed.ncbi.nlm.nih.gov/23354059

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The mechanism of eukaryotic translation initiation and principles of its regulation

1 reference

https://pubmed.ncbi.nlm.nih.gov/23354059

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

NADPH oxidase links endoplasmic reticulum stress, oxidative stress, and PKR activation to induce apoptosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/23354059

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Activating transcription factor 3 is integral to the eukaryotic initiation factor 2 kinase stress response

1 reference

https://pubmed.ncbi.nlm.nih.gov/23354059

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Regulated translation initiation controls stress-induced gene expression in mammalian cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/23354059

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Translation initiation control by heme-regulated eukaryotic initiation factor 2alpha kinase in erythroid cells under cytoplasmic stresses

1 reference

https://pubmed.ncbi.nlm.nih.gov/23354059

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Domain stabilities in protein kinase R (PKR): evidence for weak interdomain interactions

1 reference

https://pubmed.ncbi.nlm.nih.gov/23354059

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Regulation of autophagy by ATF4 in response to severe hypoxia.

1 reference

https://pubmed.ncbi.nlm.nih.gov/23354059

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A global map of p53 transcription-factor binding sites in the human genome

1 reference

https://pubmed.ncbi.nlm.nih.gov/23354059

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Heme-regulated eIF2alpha kinase (HRI) is required for translational regulation and survival of erythroid precursors in iron deficiency

1 reference

https://pubmed.ncbi.nlm.nih.gov/23354059

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Involvement of Double-stranded RNA-activated Protein Kinase in the Synergistic Activation of Nuclear Factor-κB by Tumor Necrosis Factor-α and γ-Interferon in Preneuronal Cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/23354059

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

PKR is not a universal target of tumor suppressor p53 in response to genotoxic stress

1 reference

https://pubmed.ncbi.nlm.nih.gov/23354059

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Gadd153 sensitizes cells to endoplasmic reticulum stress by down-regulating Bcl2 and perturbing the cellular redox state

1 reference

https://pubmed.ncbi.nlm.nih.gov/23354059

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Kinetic studies on the successive reaction of neuronal nitric oxide synthase from L-arginine to nitric oxide and L-citrulline

1 reference

https://pubmed.ncbi.nlm.nih.gov/23354059

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

CHOP is implicated in programmed cell death in response to impaired function of the endoplasmic reticulum

1 reference

https://pubmed.ncbi.nlm.nih.gov/23354059

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The eIF2alpha kinases PERK and PKR activate glycogen synthase kinase 3 to promote the proteasomal degradation of p53.

1 reference

https://pubmed.ncbi.nlm.nih.gov/23354059

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Phosphorylation of the alpha-subunit of the eukaryotic initiation factor-2 (eIF2alpha) reduces protein synthesis and enhances apoptosis in response to proteasome inhibition

1 reference

https://pubmed.ncbi.nlm.nih.gov/23354059

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Glucose limitation induces GCN4 translation by activation of Gcn2 protein kinase

1 reference

https://pubmed.ncbi.nlm.nih.gov/23354059

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Divergent effects of PERK and IRE1 signaling on cell viability

1 reference

https://pubmed.ncbi.nlm.nih.gov/23354059

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

PERK-dependent regulation of lipogenesis during mouse mammary gland development and adipocyte differentiation

1 reference

https://pubmed.ncbi.nlm.nih.gov/23354059

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Gcn4p, a master regulator of gene expression, is controlled at multiple levels by diverse signals of starvation and stress

1 reference

https://pubmed.ncbi.nlm.nih.gov/23354059

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

An RNA-dependent protein kinase is involved in tunicamycin-induced apoptosis and Alzheimer's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/23354059

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

5' untranslated sequences are required for the translational control of a yeast regulatory gene

1 reference

https://pubmed.ncbi.nlm.nih.gov/23354059

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Unactivated PKR exists in an open conformation capable of binding nucleotides

1 reference

https://pubmed.ncbi.nlm.nih.gov/23354059

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Protein kinase PKR is required for platelet-derived growth factor signaling of c-fos gene expression via Erks and Stat3.

1 reference

https://pubmed.ncbi.nlm.nih.gov/23354059

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Analysis of PKR structure by small-angle scattering

1 reference

https://pubmed.ncbi.nlm.nih.gov/23354059

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Activators and target genes of Rel/NF-kappaB transcription factors

1 reference

https://pubmed.ncbi.nlm.nih.gov/23354059

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Double-stranded-RNA-activated protein kinase PKR enhances transcriptional activation by tumor suppressor p53

1 reference

https://pubmed.ncbi.nlm.nih.gov/23354059

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Ribosomal stress couples the unfolded protein response to p53-dependent cell cycle arrest

1 reference

https://pubmed.ncbi.nlm.nih.gov/23354059

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Antiviral effect of the mammalian translation initiation factor 2alpha kinase GCN2 against RNA viruses

1 reference

https://pubmed.ncbi.nlm.nih.gov/23354059

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The GCN2-ATF4 pathway is critical for tumour cell survival and proliferation in response to nutrient deprivation.

1 reference

https://pubmed.ncbi.nlm.nih.gov/23354059

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The Nrf2-antioxidant response element signaling pathway and its activation by oxidative stress

1 reference

https://pubmed.ncbi.nlm.nih.gov/23354059

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Two distinct stress signaling pathways converge upon the CHOP promoter during the mammalian unfolded protein response

1 reference

https://pubmed.ncbi.nlm.nih.gov/23354059

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

PERK EIF2AK3 control of pancreatic beta cell differentiation and proliferation is required for postnatal glucose homeostasis.

1 reference

https://pubmed.ncbi.nlm.nih.gov/23354059

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Calcineurin interacts with PERK and dephosphorylates calnexin to relieve ER stress in mammals and frogs

1 reference

https://pubmed.ncbi.nlm.nih.gov/23354059

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Double-stranded RNA-dependent protein kinase activates transcription factor NF-kappa B by phosphorylating I kappa B.

1 reference

https://pubmed.ncbi.nlm.nih.gov/23354059

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Phosphorylation of eIF2 Facilitates Ribosomal Bypass of an Inhibitory Upstream ORF to Enhance CHOP Translation

1 reference

https://pubmed.ncbi.nlm.nih.gov/23354059

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

PACT and PKR: turning on NF-kappa B in the absence of virus

1 reference

https://pubmed.ncbi.nlm.nih.gov/23354059

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Translation attenuation through eIF2alpha phosphorylation prevents oxidative stress and maintains the differentiated state in beta cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/23354059

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Phosphorylation of eIF2alpha in response to 26S proteasome inhibition is mediated by the haem-regulated inhibitor (HRI) kinase.

1 reference

https://pubmed.ncbi.nlm.nih.gov/23354059

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Hepatic CYP3A suppression by high concentrations of proteasomal inhibitors: a consequence of endoplasmic reticulum (ER) stress induction, activation of RNA-dependent protein kinase-like ER-bound eukaryotic initiation factor 2alpha (eIF2alpha)-kinase

1 reference

https://pubmed.ncbi.nlm.nih.gov/23354059

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Functional characterization of Drosophila melanogaster PERK eukaryotic initiation factor 2alpha (eIF2alpha) kinase.

1 reference

https://pubmed.ncbi.nlm.nih.gov/23354059

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Human breast cancer cells contain elevated levels and activity of the protein kinase, PKR.

1 reference

https://pubmed.ncbi.nlm.nih.gov/23354059

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mechanisms of ER Stress-Mediated Mitochondrial Membrane Permeabilization

1 reference

https://pubmed.ncbi.nlm.nih.gov/23354059

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Requirement for kinase-induced conformational change in eukaryotic initiation factor 2alpha (eIF2alpha) restricts phosphorylation of Ser51.

1 reference

https://pubmed.ncbi.nlm.nih.gov/23354059

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Two heme-binding domains of heme-regulated eukaryotic initiation factor-2alpha kinase. N terminus and kinase insertion

1 reference

https://pubmed.ncbi.nlm.nih.gov/23354059

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identification of activating transcription factor 4 (ATF4) as an Nrf2-interacting protein. Implication for heme oxygenase-1 gene regulation

1 reference

https://pubmed.ncbi.nlm.nih.gov/23354059

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Growth arrest and DNA damage-inducible protein GADD34 targets protein phosphatase 1 alpha to the endoplasmic reticulum and promotes dephosphorylation of the alpha subunit of eukaryotic translation initiation factor 2

1 reference

https://pubmed.ncbi.nlm.nih.gov/23354059

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Deficiency of heme-regulated eIF2alpha kinase decreases hepcidin expression and splenic iron in HFE-/- mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/23354059

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Upstream open reading frames: molecular switches in (patho)physiology

1 reference

https://pubmed.ncbi.nlm.nih.gov/23354059

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mechanisms of ferriheme reduction by nitric oxide: nitrite and general base catalysis

1 reference

https://pubmed.ncbi.nlm.nih.gov/23354059

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Homologous Regions of the α Subunit of Eukaryotic Translational Initiation Factor 2 (eIF2α) and the Vaccinia Virus K3L Gene Product Interact with the Same Domain within the dsRNA‐Activated Protein Kinase (PKR)

1 reference

https://pubmed.ncbi.nlm.nih.gov/23354059

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cross-family dimerization of transcription factors Fos/Jun and ATF/CREB alters DNA binding specificity

1 reference

https://pubmed.ncbi.nlm.nih.gov/23354059

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Translational regulation of GCN4 and the general amino acid control of yeast

1 reference

https://pubmed.ncbi.nlm.nih.gov/23354059

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Translational repression mediates activation of nuclear factor kappa B by phosphorylated translation initiation factor 2

1 reference

https://pubmed.ncbi.nlm.nih.gov/23354059

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Nucleophosmin interacts with and inhibits the catalytic function of eukaryotic initiation factor 2 kinase PKR

1 reference

https://pubmed.ncbi.nlm.nih.gov/23354059

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

An essential role for the interferon-inducible, double-stranded RNA-activated protein kinase PKR in the tumor necrosis factor-induced apoptosis in U937 cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/23354059

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Higher-Order Substrate Recognition of eIF2α by the RNA-Dependent Protein Kinase PKR

1 reference

https://pubmed.ncbi.nlm.nih.gov/23354059

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Thalassemia: pathophysiology of red cell changes

1 reference

https://pubmed.ncbi.nlm.nih.gov/23354059

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

PERK and GCN2 contribute to eIF2alpha phosphorylation and cell cycle arrest after activation of the unfolded protein response pathway

1 reference

https://pubmed.ncbi.nlm.nih.gov/23354059

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

PI(3)king apart PTEN's role in cancer.

1 reference

https://pubmed.ncbi.nlm.nih.gov/23354059

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Impaired dexamethasone-mediated induction of tryptophan 2,3-dioxygenase in heme-deficient rat hepatocytes: translational control by a hepatic eIF2alpha kinase, the heme-regulated inhibitor

1 reference

https://pubmed.ncbi.nlm.nih.gov/23354059

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Autophosphorylation of threonine 485 in the activation loop is essential for attaining eIF2alpha kinase activity of HRI

1 reference

https://pubmed.ncbi.nlm.nih.gov/23354059

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Central Role of Double-Stranded RNA-Activated Protein Kinase in Microbial Induction of Nitric Oxide Synthase

1 reference

https://pubmed.ncbi.nlm.nih.gov/23354059

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Regulation of c-myc expression by IFN-gamma through Stat1-dependent and -independent pathways.

1 reference

https://pubmed.ncbi.nlm.nih.gov/23354059

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Double-stranded RNA-activated protein kinase is required for the LPS-induced activation of STAT1 inflammatory signaling in rat brain glial cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/23354059

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

EIF2AK3, encoding translation initiation factor 2-alpha kinase 3, is mutated in patients with Wolcott-Rallison syndrome

1 reference

https://pubmed.ncbi.nlm.nih.gov/23354059

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Induction of apoptosis by double-stranded-RNA-dependent protein kinase (PKR) involves the alpha subunit of eukaryotic translation initiation factor 2 and NF-kappaB.

1 reference

https://pubmed.ncbi.nlm.nih.gov/23354059

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The murine double-stranded RNA-dependent protein kinase PKR is required for resistance to vesicular stomatitis virus.

1 reference

https://pubmed.ncbi.nlm.nih.gov/23354059

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

ERAD inhibitors integrate ER stress with an epigenetic mechanism to activate BH3-only protein NOXA in cancer cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/23354059

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inhibition of RNA-dependent protein kinase (PKR) leads to cancer cell death and increases chemosensitivity

1 reference

https://pubmed.ncbi.nlm.nih.gov/23354059

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

PACT, a stress-modulated cellular activator of interferon-induced double-stranded RNA-activated protein kinase, PKR.

1 reference

https://pubmed.ncbi.nlm.nih.gov/23354059

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Akt determines cell fate through inhibition of the PERK-eIF2α phosphorylation pathway

1 reference

https://pubmed.ncbi.nlm.nih.gov/23354059

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mutations in the alpha subunit of eukaryotic translation initiation factor 2 (eIF-2 alpha) that overcome the inhibitory effect of eIF-2 alpha phosphorylation on translation initiation

1 reference

https://pubmed.ncbi.nlm.nih.gov/23354059

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Tyrosine phosphorylation acts as a molecular switch to full-scale activation of the eIF2alpha RNA-dependent protein kinase

1 reference

https://pubmed.ncbi.nlm.nih.gov/23354059

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Amino acid limitation regulates the expression of genes involved in several specific biological processes through GCN2-dependent and GCN2-independent pathways

1 reference

https://pubmed.ncbi.nlm.nih.gov/23354059

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

PKR; a sentinel kinase for cellular stress

1 reference

https://pubmed.ncbi.nlm.nih.gov/23354059

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Brain ischemia and reperfusion activates the eukaryotic initiation factor 2alpha kinase, PERK.

1 reference

https://pubmed.ncbi.nlm.nih.gov/23354059

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Serine 577 is phosphorylated and negatively affects the tRNA binding and eIF2alpha kinase activities of GCN2.

1 reference

https://pubmed.ncbi.nlm.nih.gov/23354059

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Chemical genetics identify eIF2α kinase heme-regulated inhibitor as an anticancer target

1 reference

https://pubmed.ncbi.nlm.nih.gov/23354059

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Nrf2 signaling and cell survival

1 reference

https://pubmed.ncbi.nlm.nih.gov/23354059

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Neoplastic progression in melanoma and colon cancer is associated with increased expression and activity of the interferon-inducible protein kinase, PKR

1 reference

https://pubmed.ncbi.nlm.nih.gov/23354059

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The protein kinase PKR is required for p38 MAPK activation and the innate immune response to bacterial endotoxin

1 reference

https://pubmed.ncbi.nlm.nih.gov/23354059

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Phosphorylation of Eukaryotic Translation Initiation Factor 2 Mediates Apoptosis in Response to Activation of the Double-stranded RNA-dependent Protein Kinase

1 reference

https://pubmed.ncbi.nlm.nih.gov/23354059

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Role of protein kinase R in double-stranded RNA-induced expression of nitric oxide synthase in human astroglia

1 reference

https://pubmed.ncbi.nlm.nih.gov/23354059

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Activating transcription factor 4.

1 reference

https://pubmed.ncbi.nlm.nih.gov/23354059

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mechanism of activation of the double-stranded-RNA-dependent protein kinase, PKR: role of dimerization and cellular localization in the stimulation of PKR phosphorylation of eukaryotic initiation factor-2 (eIF2).

1 reference

https://pubmed.ncbi.nlm.nih.gov/23354059

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

ER stress disrupts Ca2+-signaling complexes and Ca2+ regulation in secretory and muscle cells from PERK-knockout mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/23354059

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

RAX, a cellular activator for double-stranded RNA-dependent protein kinase during stress signaling

1 reference

https://pubmed.ncbi.nlm.nih.gov/23354059

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Adenoviral transfer of the melanoma differentiation-associated gene 7 (mda7) induces apoptosis of lung cancer cells via up-regulation of the double-stranded RNA-dependent protein kinase (PKR).

1 reference

https://pubmed.ncbi.nlm.nih.gov/23354059

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inhibition of the double-stranded RNA-dependent protein kinase PKR by mammalian ribosomes

1 reference

https://pubmed.ncbi.nlm.nih.gov/23354059

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Eukaryotic translation initiation factors and regulators

1 reference

https://pubmed.ncbi.nlm.nih.gov/23354059

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

An upstream open reading frame regulates translation of GADD34 during cellular stresses that induce eIF2alpha phosphorylation

1 reference

https://pubmed.ncbi.nlm.nih.gov/23354059

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Intrinsic capacities of molecular sensors of the unfolded protein response to sense alternate forms of endoplasmic reticulum stress

1 reference

https://pubmed.ncbi.nlm.nih.gov/23354059

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Erythroid expression of the heme-regulated eIF-2 alpha kinase

1 reference

https://pubmed.ncbi.nlm.nih.gov/23354059

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The function of heme-regulated eIF2alpha kinase in murine iron homeostasis and macrophage maturation

1 reference

https://pubmed.ncbi.nlm.nih.gov/23354059

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A dynamically tuned double-stranded RNA binding mechanism for the activation of antiviral kinase PKR.

1 reference

https://pubmed.ncbi.nlm.nih.gov/23354059

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

PERK promotes cancer cell proliferation and tumor growth by limiting oxidative DNA damage

1 reference

https://pubmed.ncbi.nlm.nih.gov/23354059

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Translational control by TOR and TAP42 through dephosphorylation of eIF2alpha kinase GCN2.

1 reference

https://pubmed.ncbi.nlm.nih.gov/23354059

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Uncharged tRNA and sensing of amino acid deficiency in mammalian piriform cortex.

1 reference

https://pubmed.ncbi.nlm.nih.gov/23354059

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

PERK mediates cell-cycle exit during the mammalian unfolded protein response

1 reference

https://pubmed.ncbi.nlm.nih.gov/23354059

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The dsRNA protein kinase PKR: virus and cell control

1 reference

https://pubmed.ncbi.nlm.nih.gov/23354059

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

UPR induces transient burst of apoptosis in islets of early lactating rats through reduced AKT phosphorylation via ATF4/CHOP stimulation of TRB3 expression.

1 reference

https://pubmed.ncbi.nlm.nih.gov/23354059

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The GCN2 eIF2alpha kinase is required for adaptation to amino acid deprivation in mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/23354059

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

S-nitrosylated protein-disulphide isomerase links protein misfolding to neurodegeneration

1 reference

https://pubmed.ncbi.nlm.nih.gov/23354059

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

PERK in beta cell biology and insulin biogenesis

1 reference

https://pubmed.ncbi.nlm.nih.gov/23354059

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

ER stress triggers apoptosis by activating BH3-only protein Bim

1 reference

https://pubmed.ncbi.nlm.nih.gov/23354059

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Increased susceptibility of breast cancer cells to stress mediated inhibition of protein synthesis.

1 reference

https://pubmed.ncbi.nlm.nih.gov/23354059

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

eIF2alpha kinases GCN2 and PERK modulate transcription and translation of distinct sets of mRNAs in mouse liver

1 reference

https://pubmed.ncbi.nlm.nih.gov/23354059

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A synthetic peptide substrate for initiation factor-2 kinases

1 reference

https://pubmed.ncbi.nlm.nih.gov/23354059

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The role of p58IPK in protecting the stressed endoplasmic reticulum

1 reference

https://pubmed.ncbi.nlm.nih.gov/23354059

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Critical role of endogenous Akt/IAPs and MEK1/ERK pathways in counteracting endoplasmic reticulum stress-induced cell death

1 reference

https://pubmed.ncbi.nlm.nih.gov/23354059

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Phosphorylation of eIF2 directs ATF5 translational control in response to diverse stress conditions

1 reference

https://pubmed.ncbi.nlm.nih.gov/23354059

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

P58IPK, a novel endoplasmic reticulum stress-inducible protein and potential negative regulator of eIF2alpha signaling

1 reference

https://pubmed.ncbi.nlm.nih.gov/23354059

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The unfolded protein response protects human tumor cells during hypoxia through regulation of the autophagy genes MAP1LC3B and ATG5.

1 reference

https://pubmed.ncbi.nlm.nih.gov/23354059

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Impaired tissue growth is mediated by checkpoint kinase 1 (CHK1) in the integrated stress response

1 reference

https://pubmed.ncbi.nlm.nih.gov/23354059

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

RNA dimerization promotes PKR dimerization and activation

1 reference

https://pubmed.ncbi.nlm.nih.gov/23354059

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Dimerization is required for activation of eIF2 kinase Gcn2 in response to diverse environmental stress conditions

1 reference

https://pubmed.ncbi.nlm.nih.gov/23354059

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Nutritional control of gene expression: how mammalian cells respond to amino acid limitation

1 reference

https://pubmed.ncbi.nlm.nih.gov/23354059

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Molecular cloning and characterization of the human double-stranded RNA-activated protein kinase induced by interferon

1 reference

https://pubmed.ncbi.nlm.nih.gov/23354059

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

PACT, a protein activator of the interferon-induced protein kinase, PKR.

1 reference

https://pubmed.ncbi.nlm.nih.gov/23354059

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The double-stranded RNA activated protein kinase PKR physically associates with the tumor suppressor p53 protein and phosphorylates human p53 on serine 392 in vitro

1 reference

https://pubmed.ncbi.nlm.nih.gov/23354059

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Regulation of G(1) arrest and apoptosis in hypoxia by PERK and GCN2-mediated eIF2alpha phosphorylation

1 reference

https://pubmed.ncbi.nlm.nih.gov/23354059

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Translational control of inducible nitric oxide synthase expression by arginine can explain the arginine paradox

1 reference

https://pubmed.ncbi.nlm.nih.gov/23354059

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

GCN2 phosphorylation of eIF2alpha activates NF-kappaB in response to UV irradiation

1 reference

https://pubmed.ncbi.nlm.nih.gov/23354059

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Diabetes mellitus and exocrine pancreatic dysfunction in perk-/- mice reveals a role for translational control in secretory cell survival

1 reference

https://pubmed.ncbi.nlm.nih.gov/23354059

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Regulation of protein synthesis by the heme-regulated eIF2alpha kinase: relevance to anemias

1 reference

https://pubmed.ncbi.nlm.nih.gov/23354059

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Perk is essential for translational regulation and cell survival during the unfolded protein response

1 reference

https://pubmed.ncbi.nlm.nih.gov/23354059

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

PERK (EIF2AK3) regulates proinsulin trafficking and quality control in the secretory pathway

1 reference

https://pubmed.ncbi.nlm.nih.gov/23354059

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

IRE1α Disruption Causes Histological Abnormality of Exocrine Tissues, Increase of Blood Glucose Level, and Decrease of Serum Immunoglobulin Level

1 reference

https://pubmed.ncbi.nlm.nih.gov/23354059

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Role of ERO1-alpha-mediated stimulation of inositol 1,4,5-triphosphate receptor activity in endoplasmic reticulum stress-induced apoptosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/23354059

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Activation of heme-regulated eukaryotic initiation factor 2alpha kinase by nitric oxide is induced by the formation of a five-coordinate NO-heme complex: optical absorption, electron spin resonance, and resonance raman spectral studies

1 reference

https://pubmed.ncbi.nlm.nih.gov/23354059

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Tumour hypoxia, chemotherapeutic resistance and hypoxia-related therapies.

1 reference

https://pubmed.ncbi.nlm.nih.gov/23354059

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

JNK2 and IKKbeta are required for activating the innate response to viral infection

1 reference

https://pubmed.ncbi.nlm.nih.gov/23354059

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Control of activating transcription factor 4 (ATF4) persistence by multisite phosphorylation impacts cell cycle progression and neurogenesis.

1 reference

https://pubmed.ncbi.nlm.nih.gov/23354059

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

RNA granules: the good, the bad and the ugly

1 reference

https://pubmed.ncbi.nlm.nih.gov/23354059

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

GCN2 whets the appetite for amino acids

1 reference

https://pubmed.ncbi.nlm.nih.gov/23354059

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

CHOP is involved in endoplasmic reticulum stress-induced apoptosis by enhancing DR5 expression in human carcinoma cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/23354059

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Nitric oxide and endoplasmic reticulum stress

1 reference

https://pubmed.ncbi.nlm.nih.gov/23354059

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Nitric oxide: from a mysterious labile factor to the molecule of the Nobel Prize. Recent progress in nitric oxide research

1 reference

https://pubmed.ncbi.nlm.nih.gov/23354059

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Viral control of mitochondrial apoptosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/23354059

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Ribosome-binding Domain of Eukaryotic Initiation Factor-2 Kinase GCN2 Facilitates Translation Control

1 reference

https://pubmed.ncbi.nlm.nih.gov/23354059

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Feedback inhibition of the unfolded protein response by GADD34-mediated dephosphorylation of eIF2alpha

1 reference

https://pubmed.ncbi.nlm.nih.gov/23354059

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Regulation of endoplasmic reticulum stress-induced cell death by ATF4 in neuroectodermal tumor cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/23354059

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Regulation of the protein kinase PKR by the vaccinia virus pseudosubstrate inhibitor K3L is dependent on residues conserved between the K3L protein and the PKR substrate eIF2alpha.

1 reference

https://pubmed.ncbi.nlm.nih.gov/23354059

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Myxoma virus immunomodulatory protein M156R is a structural mimic of eukaryotic translation initiation factor eIF2alpha

1 reference

https://pubmed.ncbi.nlm.nih.gov/23354059

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Different effect of proteasome inhibition on vesicular stomatitis virus and poliovirus replication

1 reference

https://pubmed.ncbi.nlm.nih.gov/23354059

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Both Transcriptional Regulation and Translational Control of ATF4 Are Central to the Integrated Stress Response

1 reference

https://pubmed.ncbi.nlm.nih.gov/23354059

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The unfolded protein response signals through high-order assembly of Ire1

1 reference

https://pubmed.ncbi.nlm.nih.gov/23354059

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pancreatic eukaryotic initiation factor-2alpha kinase (PEK) homologues in humans, Drosophila melanogaster and Caenorhabditis elegans that mediate translational control in response to endoplasmic reticulum stress

1 reference

https://pubmed.ncbi.nlm.nih.gov/23354059

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Modulation of the eukaryotic initiation factor 2 alpha-subunit kinase PERK by tyrosine phosphorylation

1 reference

https://pubmed.ncbi.nlm.nih.gov/23354059

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Defects in translational regulation mediated by the alpha subunit of eukaryotic initiation factor 2 inhibit antiviral activity and facilitate the malignant transformation of human fibroblasts

1 reference

https://pubmed.ncbi.nlm.nih.gov/23354059

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Evidence for translational regulation of the activator of general amino acid control in yeast

1 reference

https://pubmed.ncbi.nlm.nih.gov/23354059

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Heme-regulated eIF2alpha kinase modifies the phenotypic severity of murine models of erythropoietic protoporphyria and beta-thalassemia

1 reference

https://pubmed.ncbi.nlm.nih.gov/23354059

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1007/S00018-012-1252-6

1 reference

Europe PubMed Central

PubMed publication ID

28 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

28 August 2017

ResearchGate publication ID

0 references

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