(Q37996420)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22443084%20AND%20SRC:MED&resulttype=core&format=json

26 January 2020

title

The RAS/RAF/MEK/ERK and the PI3K/AKT signalling pathways: role in cancer pathogenesis and implications for therapeutic approaches (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22443084%20AND%20SRC:MED&resulttype=core&format=json

26 January 2020

0 references

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22443084%20AND%20SRC:MED&resulttype=core&format=json

26 January 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22443084%20AND%20SRC:MED&resulttype=core&format=json

26 January 2020

Monica Rosaria Maiello

series ordinal

object named as

Monica R Maiello

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22443084%20AND%20SRC:MED&resulttype=core&format=json

26 January 2020

Amelia D'Alessio

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22443084%20AND%20SRC:MED&resulttype=core&format=json

26 January 2020

Maria Pergameno

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22443084%20AND%20SRC:MED&resulttype=core&format=json

26 January 2020

language of work or name

English

0 references

publication date

23 March 2012

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22443084%20AND%20SRC:MED&resulttype=core&format=json

Expert Opinion on Therapeutic Targets

26 January 2020

published in

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22443084%20AND%20SRC:MED&resulttype=core&format=json

26 January 2020

volume

16 Suppl 2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22443084%20AND%20SRC:MED&resulttype=core&format=json

26 January 2020

page(s)

S17-27

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22443084%20AND%20SRC:MED&resulttype=core&format=json

The PI3K pathway as drug target in human cancer

26 January 2020

cites work

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Targeting the mitogen-activated protein kinase pathway: physiological feedback and drug response

21 January 2018

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Targeting the phosphoinositide 3-kinase pathway in cancer

21 January 2018

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AKT inhibition relieves feedback suppression of receptor tyrosine kinase expression and activity

21 January 2018

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PI3K inhibition results in enhanced HER signaling and acquired ERK dependency in HER2-overexpressing breast cancer

21 January 2018

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Ras, PI(3)K and mTOR signalling controls tumour cell growth

21 January 2018

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Regulation of MAPKs by growth factors and receptor tyrosine kinases

21 January 2018

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Targeting RAS signalling pathways in cancer therapy

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PI3K pathway alterations in cancer: variations on a theme

21 January 2018

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The evolution of phosphatidylinositol 3-kinases as regulators of growth and metabolism

21 January 2018

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Phosphatidylinositol-3-OH kinase as a direct target of Ras

21 January 2018

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Akt Phosphorylation of BAD Couples Survival Signals to the Cell-Intrinsic Death Machinery

21 January 2018

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Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor

21 January 2018

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NF-kappaB activation by tumour necrosis factor requires the Akt serine-threonine kinase

21 January 2018

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A phosphatidylinositol 3-kinase/Akt pathway promotes translocation of Mdm2 from the cytoplasm to the nucleus

21 January 2018

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Defining the role of mTOR in cancer

21 January 2018

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TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling

21 January 2018

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Implications for KRAS status and EGFR-targeted therapies in metastatic CRC.

21 January 2018

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Mutations of the BRAF gene in human cancer

21 January 2018

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Mechanism of activation of the RAF-ERK signaling pathway by oncogenic mutations of B-RAF

21 January 2018

1 reference

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The RAF proteins take centre stage

21 January 2018

1 reference

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Mutations of C-RAF are rare in human cancer because C-RAF has a low basal kinase activity compared with B-RAF

21 January 2018

1 reference

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MEK1 mutations, but not ERK2 mutations, occur in melanomas and colon carcinomas, but none in thyroid carcinomas

21 January 2018

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Rational, biologically based treatment of EGFR-mutant non-small-cell lung cancer

21 January 2018

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Helical domain and kinase domain mutations in p110alpha of phosphatidylinositol 3-kinase induce gain of function by different mechanisms

21 January 2018

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Frequent PIK3CA gene amplification and its clinical significance in colorectal cancer.

21 January 2018

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A transforming mutation in the pleckstrin homology domain of AKT1 in cancer

21 January 2018

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A novel AKT3 mutation in melanoma tumours and cell lines

21 January 2018

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Colorectal cancer: mutations in a signalling pathway

21 January 2018

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Molecular alterations in AKT1, AKT2 and AKT3 detected in breast and prostatic cancer by FISH.

21 January 2018

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The role of PTEN signaling perturbations in cancer and in targeted therapy

21 January 2018

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Pten is essential for embryonic development and tumour suppression

21 January 2018

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Non-genomic loss of PTEN function in cancer: not in my genes.

21 January 2018

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The oncogenic mutation in the pleckstrin homology domain of AKT1 in endometrial carcinomas

21 January 2018

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Comprehensive genomic characterization defines human glioblastoma genes and core pathways

21 January 2018

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Cell signaling by receptor tyrosine kinases

21 January 2018

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Function, regulation and pathological roles of the Gab/DOS docking proteins

21 January 2018

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mTORC1-activated S6K1 phosphorylates Rictor on threonine 1135 and regulates mTORC2 signaling

21 January 2018

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https://api.crossref.org/works/10.1517%2F14728222.2011.639361

The TSC1-2 tumor suppressor controls insulin-PI3K signaling via regulation of IRS proteins

21 January 2018

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https://api.crossref.org/works/10.1517%2F14728222.2011.639361

mTOR inhibition induces upstream receptor tyrosine kinase signaling and activates Akt

21 January 2018

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https://api.crossref.org/works/10.1517%2F14728222.2011.639361

Prolonged rapamycin treatment inhibits mTORC2 assembly and Akt/PKB

21 January 2018

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Phosphorylation and functional inactivation of TSC2 by Erk implications for tuberous sclerosis and cancer pathogenesis

21 January 2018

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Tumor-promoting phorbol esters and activated Ras inactivate the tuberous sclerosis tumor suppressor complex via p90 ribosomal S6 kinase

21 January 2018

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Oncogenic MAPK signaling stimulates mTORC1 activity by promoting RSK-mediated raptor phosphorylation

21 January 2018

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ERK1/2 phosphorylate Raptor to promote Ras-dependent activation of mTOR complex 1 (mTORC1).

21 January 2018

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21 January 2018

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The MEK/MAPK pathway is involved in the resistance of breast cancer cells to the EGFR tyrosine kinase inhibitor gefitinib

21 January 2018

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4E-BP1 is a key effector of the oncogenic activation of the AKT and ERK signaling pathways that integrates their function in tumors

21 January 2018

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Effective use of PI3K and MEK inhibitors to treat mutant Kras G12D and PIK3CA H1047R murine lung cancers

21 January 2018

1 reference

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PIK3CA mutation uncouples tumor growth and cyclin D1 regulation from MEK/ERK and mutant KRAS signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.639361

Improved survival with vemurafenib in melanoma with BRAF V600E mutation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.639361

Recovery of phospho-ERK activity allows melanoma cells to escape from BRAF inhibitor therapy.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.639361

Activity of XL184 (Cabozantinib), an oral tyrosine kinase inhibitor, in patients with medullary thyroid cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.639361

Clinical Implications of the Cancer Genome

21 January 2018

1 reference

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10.1517/14728222.2011.639361

21 January 2018

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22443084%20AND%20SRC:MED&resulttype=core&format=json

release_2pn6fi633javdfmhko3ck7lcwy

26 January 2020

Fatcat ID

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/2pn6fi633javdfmhko3ck7lcwy

mapped directly with Wikidata item

24 November 2022

based on heuristic

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22443084%20AND%20SRC:MED&resulttype=core&format=json