(Q37992965)

26 August 2017

title

MicroRNAs and their targets: recognition, regulation and an emerging reciprocal relationship (English)

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26 August 2017

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Amy E Pasquinelli

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26 August 2017

language of work or name

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13 March 2012

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26 August 2017

published in

Nature Reviews Genetics

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26 August 2017

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26 August 2017

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26 August 2017

page(s)

271-282

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miRBase: integrating microRNA annotation and deep-sequencing data

26 August 2017

cites work

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MicroRNAs: target recognition and regulatory functions

21 January 2018

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New tricks for animal microRNAS: targeting of amino acid coding regions at conserved and nonconserved sites

21 January 2018

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MicroRNAs in development and disease

21 January 2018

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Gene silencing by microRNAs: contributions of translational repression and mRNA decay

21 January 2018

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Small RNAs and their roles in plant development.

21 January 2018

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Translational inhibition by microRNAs in plants

21 January 2018

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Endogenous siRNA and miRNA targets identified by sequencing of the Arabidopsis degradome

21 January 2018

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Global identification of microRNA-target RNA pairs by parallel analysis of RNA ends

21 January 2018

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Cleavage of Scarecrow-like mRNA targets directed by a class of Arabidopsis miRNA

21 January 2018

1 reference

Computational analysis of miRNA targets in plants: current status and challenges

21 January 2018

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MicroRNA-directed cleavage of HOXB8 mRNA

21 January 2018

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Specificity of microRNA target selection in translational repression

21 January 2018

1 reference

The 21-nucleotide let-7 RNA regulates developmental timing in Caenorhabditis elegans

21 January 2018

1 reference

The lin-41 RBCC gene acts in the C. elegans heterochronic pathway between the let-7 regulatory RNA and the LIN-29 transcription factor

21 January 2018

1 reference

The C. elegans microRNA let-7 binds to imperfect let-7 complementary sites from the lin-41 3'UTR

21 January 2018

1 reference

Expanding the microRNA targeting code: functional sites with centered pairing

21 January 2018

1 reference

MicroRNAs to Nanog, Oct4 and Sox2 coding regions modulate embryonic stem cell differentiation

21 January 2018

1 reference

Experimental strategies for microRNA target identification

21 January 2018

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Got target? Computational methods for microRNA target prediction and their extension

21 January 2018

1 reference

Transcriptome-wide identification of RNA-binding protein and microRNA target sites by PAR-CLIP

21 January 2018

1 reference

Genome-wide identification of Ago2 binding sites from mouse embryonic stem cells with and without mature microRNAs.

21 January 2018

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Comprehensive discovery of endogenous Argonaute binding sites in Caenorhabditis elegans

21 January 2018

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The impact of microRNAs on protein output

21 January 2018

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Microarray analysis shows that some microRNAs downregulate large numbers of target mRNAs

21 January 2018

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Widespread changes in protein synthesis induced by microRNAs

21 January 2018

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mRNA degradation by miRNAs and GW182 requires both CCR4:NOT deadenylase and DCP1:DCP2 decapping complexes

21 January 2018

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GW182 proteins directly recruit cytoplasmic deadenylase complexes to miRNA targets

21 January 2018

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miRNA repression involves GW182-mediated recruitment of CCR4-NOT through conserved W-containing motifs

21 January 2018

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miRNA-mediated deadenylation is orchestrated by GW182 through two conserved motifs that interact with CCR4-NOT

21 January 2018

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Zebrafish MiR-430 promotes deadenylation and clearance of maternal mRNAs

21 January 2018

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MicroRNAs direct rapid deadenylation of mRNA

21 January 2018

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MicroRNAs control translation initiation by inhibiting eukaryotic initiation factor 4E/cap and poly(A) tail function

21 January 2018

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Evidence that microRNAs are associated with translating messenger RNAs in human cells

21 January 2018

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Human let-7a miRNA blocks protein production on actively translating polyribosomes

21 January 2018

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The lin-4 regulatory RNA controls developmental timing in Caenorhabditis elegans by blocking LIN-14 protein synthesis after the initiation of translation

21 January 2018

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Short RNAs repress translation after initiation in mammalian cells.

21 January 2018

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Inhibition of translational initiation by Let-7 MicroRNA in human cells

21 January 2018

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Two genetic circuits repress the Caenorhabditis elegans heterochronic gene lin-28 after translation initiation

21 January 2018

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MicroRNA-10a binds the 5'UTR of ribosomal protein mRNAs and enhances their translation

21 January 2018

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Switching from repression to activation: microRNAs can up-regulate translation

21 January 2018

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Posttranscriptional activation of gene expression in Xenopus laevis oocytes by microRNA-protein complexes (microRNPs).

21 January 2018

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Pervasive and cooperative deadenylation of 3'UTRs by embryonic microRNA families.

21 January 2018

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Concordant regulation of translation and mRNA abundance for hundreds of targets of a human microRNA

21 January 2018

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Genome-wide analysis in vivo of translation with nucleotide resolution using ribosome profiling

21 January 2018

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Mammalian microRNAs predominantly act to decrease target mRNA levels

21 January 2018

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A parsimonious model for gene regulation by miRNAs.

21 January 2018

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MicroRNA targeting specificity in mammals: determinants beyond seed pairing

21 January 2018

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Biological basis for restriction of microRNA targets to the 3' untranslated region in mammalian mRNAs

21 January 2018

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The impact of miRNA target sites in coding sequences and in 3'UTRs

21 January 2018

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Argonaute protein identity and pairing geometry determine cooperativity in mammalian RNA silencing.

21 January 2018

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Distance constraints between microRNA target sites dictate efficacy and cooperativity

21 January 2018

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Molecular architecture of a miRNA-regulated 3' UTR

21 January 2018

1 reference

Properties of the Regulatory RNA-Binding Protein HuR and its Role in Controlling miRNA Repression

21 January 2018

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Relief of microRNA-mediated translational repression in human cells subjected to stress

21 January 2018

1 reference

Transcriptome-wide analysis of regulatory interactions of the RNA-binding protein HuR.

21 January 2018

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Integrative regulatory mapping indicates that the RNA-binding protein HuR couples pre-mRNA processing and mRNA stability

21 January 2018

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HuR recruits let-7/RISC to repress c-Myc expression

21 January 2018

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RNA-binding protein Dnd1 inhibits microRNA access to target mRNA

21 January 2018

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Differential regulation of germline mRNAs in soma and germ cells by zebrafish miR-430.

21 January 2018

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A novel repeat domain that is often associated with RING finger and B-box motifs.

21 January 2018

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TRIM/RBCC, a novel class of 'single protein RING finger' E3 ubiquitin ligases

21 January 2018

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The let-7 target gene mouse lin-41 is a stem cell specific E3 ubiquitin ligase for the miRNA pathway protein Ago2

21 January 2018

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Active turnover modulates mature microRNA activity in Caenorhabditis elegans

21 January 2018

1 reference

Dual role for argonautes in microRNA processing and posttranscriptional regulation of microRNA expression.

21 January 2018

1 reference

Mei-P26 regulates microRNAs and cell growth in the Drosophila ovarian stem cell lineage

21 January 2018

1 reference

nhl-2 Modulates microRNA activity in Caenorhabditis elegans

21 January 2018

1 reference

Translation repression in human cells by microRNA-induced gene silencing requires RCK/p54

21 January 2018

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Target-specific requirements for enhancers of decapping in miRNA-mediated gene silencing

21 January 2018

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The TRIM-NHL protein TRIM32 activates microRNAs and prevents self-renewal in mouse neural progenitors

21 January 2018

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Lin-28B transactivation is necessary for Myc-mediated let-7 repression and proliferation

21 January 2018

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Prolyl 4-hydroxylation regulates Argonaute 2 stability

21 January 2018

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Hypoxia potentiates microRNA-mediated gene silencing through posttranslational modification of Argonaute2.

21 January 2018

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Phosphorylation of human Argonaute proteins affects small RNA binding.

21 January 2018

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Poly(ADP-ribose) regulates stress responses and microRNA activity in the cytoplasm.

21 January 2018

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Genes and mechanisms related to RNA interference regulate expression of the small temporal RNAs that control C. elegans developmental timing

21 January 2018

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Target-mediated protection of endogenous microRNAs in C. elegans

21 January 2018

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Target RNA-directed trimming and tailing of small silencing RNAs

21 January 2018

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Post-transcriptional generation of miRNA variants by multiple nucleotidyl transferases contributes to miRNA transcriptome complexity

21 January 2018

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MicroRNA assassins: factors that regulate the disappearance of miRNAs.

21 January 2018

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Kinetic analysis reveals the fate of a microRNA following target regulation in mammalian cells

21 January 2018

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Down-regulation of a host microRNA by a Herpesvirus saimiri noncoding RNA

21 January 2018

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Target mimicry provides a new mechanism for regulation of microRNA activity

21 January 2018

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Regulation of gene expression in plants through miRNA inactivation

21 January 2018

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A collection of target mimics for comprehensive analysis of microRNA function in Arabidopsis thaliana

21 January 2018

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A long noncoding RNA controls muscle differentiation by functioning as a competing endogenous RNA

21 January 2018

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In vivo identification of tumor- suppressive PTEN ceRNAs in an oncogenic BRAF-induced mouse model of melanoma

21 January 2018

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A coding-independent function of gene and pseudogene mRNAs regulates tumour biology

21 January 2018

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A ceRNA hypothesis: the Rosetta Stone of a hidden RNA language?

21 January 2018

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Redefining microRNA targets

21 January 2018

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An extensive microRNA-mediated network of RNA-RNA interactions regulates established oncogenic pathways in glioblastoma

21 January 2018

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Coding-independent regulation of the tumor suppressor PTEN by competing endogenous mRNAs

21 January 2018

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SIP1/ZEB2 induces EMT by repressing genes of different epithelial cell-cell junctions

21 January 2018

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Evolution and functions of long noncoding RNAs

21 January 2018

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MicroRNA sponges: competitive inhibitors of small RNAs in mammalian cells

21 January 2018

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MicroRNA sponges: progress and possibilities

21 January 2018

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A feedback loop comprising lin-28 and let-7 controls pre-let-7 maturation during neural stem-cell commitment

21 January 2018

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Expression of distinct RNAs from 3' untranslated regions

21 January 2018

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Identification of human microRNA targets from isolated argonaute protein complexes

21 January 2018

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Isolation of microRNA targets by miRNP immunopurification

21 January 2018

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Systematic identification of mRNAs recruited to argonaute 2 by specific microRNAs and corresponding changes in transcript abundance

21 January 2018

1 reference

A biochemical approach to identifying microRNA targets

21 January 2018

1 reference

Molecular characterization of human Argonaute-containing ribonucleoprotein complexes and their bound target mRNAs

21 January 2018

1 reference

Systematic identification of C. elegans miRISC proteins, miRNAs, and mRNA targets by their interactions with GW182 proteins AIN-1 and AIN-2.

21 January 2018

1 reference

A quantitative targeted proteomics approach to validate predicted microRNA targets in C. elegans

21 January 2018

1 reference

Posttranscriptional regulation of the heterochronic gene lin-14 by lin-4 mediates temporal pattern formation in C. elegans

21 January 2018

1 reference

The mechanism of eukaryotic translation initiation and principles of its regulation

21 January 2018

1 reference

Posttranslational modification of Argonautes and their role in small RNA-mediated gene regulation

21 January 2018

1 reference

Molecular biology. Paring miRNAs through pairing

21 January 2018

1 reference

Emerging Roles for Natural MicroRNA Sponges

21 January 2018

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The widespread regulation of microRNA biogenesis, function and decay

21 January 2018

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Argonaute HITS-CLIP decodes microRNA-mRNA interaction maps

31 March 2020

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Assaying the polyadenylation state of mRNAs

31 March 2020

1 reference

The therapeutic potential of microRNA modulation.

31 March 2020

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22411466

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Properties of the regulatory RNA-binding protein HuR and its role in controlling miRNA repression.

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22411466

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1038/NRG3162

1 reference

26 August 2017

1 reference