(Q37959015)

25 August 2017

title

Preclinical perspective of urinary biomarkers for the detection of nephrotoxicity: what we know and what we need to know (English)

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25 August 2017

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Tobias Christian Fuchs

series ordinal

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25 August 2017

Philip Hewitt

series ordinal

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25 August 2017

publication date

1 December 2011

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25 August 2017

published in

Biomarkers in Medicine

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25 August 2017

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25 August 2017

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25 August 2017

page(s)

763-779

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A history of diabetes mellitus or how a disease of the kidneys evolved into a kidney disease.

25 August 2017

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Evaluation of a urinary kidney biomarker panel in rat models of acute and subchronic nephrotoxicity

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Evaluation of novel biomarkers of nephrotoxicity in two strains of rat treated with Cisplatin

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Human clusterin gene expression is confined to surviving cells during in vitro programmed cell death

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Differential effects of clusterin/apolipoprotein J on cellular growth and survival.

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Clusterin and DNA repair: a new function in cancer for a key player in apoptosis and cell cycle control

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Measurement of urinary clusterin as an index of nephrotoxicity

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Urinary clusterin levels in the rat correlate with the severity of tubular damage and may help to differentiate between glomerular and tubular injuries

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Localization of proliferating cell nuclear antigen, vimentin, c-Fos, and clusterin in the postischemic kidney. Evidence for a heterogenous genetic response among nephron segments, and a large pool of mitotically active and dedifferentiated cells.

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Urinary beta2-microglobulin as a possible sensitive marker for renal injury caused by tenofovir disoproxil fumarate.

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Beta-2-microglobulin is superior to N-acetyl-beta-glucosaminidase in predicting prognosis in idiopathic membranous nephropathy

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Evaluation of putative biomarkers of nephrotoxicity after exposure to ochratoxin a in vivo and in vitro

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Assessment of renal injury in vivo

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Measurement of cystatin-C and creatinine in urine

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Serum cystatin C concentration as a marker of renal dysfunction in the elderly

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Cystatin C--a new marker of glomerular filtration rate in children independent of age and height

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Urinary cystatin C as a specific marker of tubular dysfunction

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Immunology: hepatitis A virus link to atopic disease

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Regulation of T cell dependent immune responses by TIM family members

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The role of the T-cell costimulatory molecule Tim-1 in the immune response.

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Cell contact-dependent signaling

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Integrin cytoplasmic domains: mediators of cytoskeletal linkages and extra- and intracellular initiated transmembrane signaling

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Kidney injury molecule-1 (KIM-1), a putative epithelial cell adhesion molecule containing a novel immunoglobulin domain, is up-regulated in renal cells after injury

21 January 2018

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Shedding of kidney injury molecule-1, a putative adhesion protein involved in renal regeneration

21 January 2018

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Release of soluble ICAM-1 from human lung fibroblasts, aortic smooth muscle cells, dermal microvascular endothelial cells, bronchial epithelial cells, and keratinocytes

21 January 2018

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Matrix metalloproteinase stromelysin-1 triggers a cascade of molecular alterations that leads to stable epithelial-to-mesenchymal conversion and a premalignant phenotype in mammary epithelial cells

21 January 2018

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Effects of methotrexate on trophoblast proliferation and local immune responses

21 January 2018

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Involvement of the cell surface-bound mucin, episialin/MUC1, in progression of human carcinomas

21 January 2018

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Reversible disruption of cell-matrix and cell-cell interactions by overexpression of sialomucin complex

21 January 2018

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A mechanism for inhibition of E-cadherin-mediated cell-cell adhesion by the membrane-associated mucin episialin/MUC1.

21 January 2018

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Episialin (MUC1) overexpression inhibits integrin-mediated cell adhesion to extracellular matrix components

21 January 2018

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Kidney injury molecule-1 is a phosphatidylserine receptor that confers a phagocytic phenotype on epithelial cells

21 January 2018

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Biological markers of acute kidney injury

21 January 2018

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Renal papillary necrosis--40 years on.

21 January 2018

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Characterization of renal papillary antigen 1 (RPA-1), a biomarker of renal papillary necrosis

21 January 2018

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Structure of mammalian trefoil factors and functional insights

21 January 2018

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Pleiotropic effects of Trefoil Factor 1 deficiency

21 January 2018

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Cell type specific expression of secretory TFF peptides: colocalization with mucins and synthesis in the brain

21 January 2018

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Transcription factor NF-kappaB signals antianoikic function of trefoil factor 3 on intestinal epithelial cells

21 January 2018

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Distinct pathways of cell migration and antiapoptotic response to epithelial injury: structure-function analysis of human intestinal trefoil factor

21 January 2018

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Intestinal trefoil factor confers colonic epithelial resistance to apoptosis

21 January 2018

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Trefoil peptides promote epithelial migration through a transforming growth factor beta-independent pathway

21 January 2018

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Trefoil factor family-peptides promote migration of human bronchial epithelial cells: synergistic effect with epidermal growth factor

21 January 2018

1 reference

Urine proteomics: the present and future of measuring urinary protein components in disease

21 January 2018

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Pattern of urinary proteins in experimental diabetes.

21 January 2018

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Relationship between albuminuria and total proteinuria in systemic lupus erythematosus nephritis: diagnostic and therapeutic implications

21 January 2018

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Serum and urinary amino acid levels in sickle cell disease

21 January 2018

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Cross-study and cross-omics comparisons of three nephrotoxic compounds reveal mechanistic insights and new candidate biomarkers

21 January 2018

1 reference

Structure and sequence relationships in the lipocalins and related proteins

21 January 2018

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The lipocalin protein family: structural and sequence overview

21 January 2018

1 reference

The neutrophil lipocalin NGAL is a bacteriostatic agent that interferes with siderophore-mediated iron acquisition

21 January 2018

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Lipocalin 2 mediates an innate immune response to bacterial infection by sequestrating iron

21 January 2018

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NGAL: a biomarker of acute kidney injury and other systemic conditions.

21 January 2018

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Human neutrophil gelatinase-associated lipocalin and homologous proteins in rat and mouse.

21 January 2018

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Molecular characterization and pattern of tissue expression of the gene for neutrophil gelatinase-associated lipocalin from humans.

21 January 2018

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Neutrophil gelatinase-associated lipocalin: a novel early urinary biomarker for cisplatin nephrotoxicity

21 January 2018

1 reference

The Ngal reporter mouse detects the response of the kidney to injury in real time

21 January 2018

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Urine NGAL predicts severity of acute kidney injury after cardiac surgery: a prospective study

21 January 2018

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Urinary neutrophil gelatinase-associated lipocalin and acute kidney injury after cardiac surgery

21 January 2018

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Cloning and sequence analysis of rat bone sialoprotein (osteopontin) cDNA reveals an Arg-Gly-Asp cell-binding sequence

21 January 2018

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Expression and distribution of osteopontin in human tissues: widespread association with luminal epithelial surfaces.

21 January 2018

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Expression of osteopontin in gentamicin-induced acute tubular necrosis and its recovery process

21 January 2018

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Osteopontin is a critical inhibitor of calcium oxalate crystal formation and retention in renal tubules

21 January 2018

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Osteopontin--a molecule for all seasons

21 January 2018

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Prediction of nephrotoxicant action and identification of candidate toxicity-related biomarkers.

21 January 2018

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Validation of putative genomic biomarkers of nephrotoxicity in rats

21 January 2018

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Osteopontin as an injury marker expressing in epithelial hyperplasia lesions helpful in prognosis of focal segmental glomerulosclerosis

21 January 2018

1 reference

Tissue inhibitors of metalloproteinases: evolution, structure and function

21 January 2018

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TIMPs as multifacial proteins

21 January 2018

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TIMP-1 overexpression promotes tumorigenesis of MDA-MB-231 breast cancer cells and alters expression of a subset of cancer promoting genes in vivo distinct from those observed in vitro

21 January 2018

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Balance between matrix synthesis and degradation: a determinant of glomerulosclerosis

21 January 2018

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Elevation of serum and urine levels of TIMP-1 and tenascin in patients with renal disease

21 January 2018

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Application of antibody array technology in the analysis of urinary cytokine profiles in patients with chronic kidney disease.

21 January 2018

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Increased expression of extracellular matrix regulators TIMP1 and MMP1 in deteriorating heart failure.

21 January 2018

1 reference

Plasma glutathione S-transferase measurements after paracetamol overdose: evidence for early hepatocellular damage

21 January 2018

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Pathological excretion patterns of urinary proteins in miners highly exposed to dinitrotoluene

21 January 2018

1 reference

Early proximal tubule injury in experimental aristolochic acid nephropathy: functional and histological studies

21 January 2018

1 reference

Kidney injury molecule-1: a tissue and urinary biomarker for nephrotoxicant-induced renal injury

21 January 2018

1 reference

Acute kidney injury, mortality, length of stay, and costs in hospitalized patients

21 January 2018

1 reference

Clusterin protects renal tubular epithelial cells from gentamicin-mediated cytotoxicity

21 January 2018

1 reference

Renal biomarker qualification submission: a dialog between the FDA-EMEA and Predictive Safety Testing Consortium

21 January 2018

1 reference

21 January 2018

Identifiers

DOI

10.2217/BMM.11.86

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25 August 2017

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