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Molecular pathways of motor neuron injury in amyotrophic lateral sclerosis

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Europe PubMed Central

PubMed publication ID

25 August 2017

Molecular pathways of motor neuron injury in amyotrophic lateral sclerosis (English)

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Europe PubMed Central

PubMed publication ID

25 August 2017

amyotrophic lateral sclerosis

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Andrew Grierson

3

object named as

Andrew J Grierson

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Europe PubMed Central

PubMed publication ID

25 August 2017

Laura Ferraiuolo

object named as

Laura Ferraiuolo

1

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object named as

Janine Kirby

2

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Michael Sendtner

object named as

Michael Sendtner

4

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object named as

Pamela J Shaw

5

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publication date

1 November 2011

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Europe PubMed Central

PubMed publication ID

25 August 2017

Nature Reviews Neurology

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Europe PubMed Central

PubMed publication ID

25 August 2017

7

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Europe PubMed Central

PubMed publication ID

25 August 2017

11

1 reference

Europe PubMed Central

PubMed publication ID

25 August 2017

616-630

1 reference

Europe PubMed Central

PubMed publication ID

25 August 2017

Motor neurone disease: a practical update on diagnosis and management

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2011.152

21 January 2018

Neuronal death in amyotrophic lateral sclerosis is apoptosis: possible contribution of a programmed cell death mechanism

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2011.152

21 January 2018

Amyotrophic lateral sclerosis: current issues in classification, pathogenesis and molecular pathology

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2011.152

21 January 2018

Amyotrophic lateral sclerosis associated with genetic abnormalities in the gene encoding Cu/Zn superoxide dismutase: molecular pathology of five new cases, and comparison with previous reports and 73 sporadic cases of ALS.

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2011.152

21 January 2018

Ubiquitinated TDP-43 in frontotemporal lobar degeneration and amyotrophic lateral sclerosis

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2011.152

21 January 2018

Non-cell autonomous toxicity in neurodegenerative disorders: ALS and beyond

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2011.152

21 January 2018

Mutant SOD1 alters the motor neuronal transcriptome: implications for familial ALS.

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2011.152

21 January 2018

Phosphatase and tensin homologue/protein kinase B pathway linked to motor neuron survival in human superoxide dismutase 1-related amyotrophic lateral sclerosis

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2011.152

21 January 2018

VEGF protects spinal motor neurons against chronic excitotoxic degeneration in vivo by activation of PI3-K pathway and inhibition of p38MAPK.

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2011.152

21 January 2018

Downregulation of genes with a function in axon outgrowth and synapse formation in motor neurones of the VEGFdelta/delta mouse model of amyotrophic lateral sclerosis

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2011.152

21 January 2018

Review: neuromuscular synaptic vulnerability in motor neurone disease: amyotrophic lateral sclerosis and spinal muscular atrophy

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2011.152

21 January 2018

ALS drug development: reflections from the past and a way forward

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2011.152

21 January 2018

Genetics of sporadic amyotrophic lateral sclerosis.

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2011.152

21 January 2018

Whole-genome analysis of sporadic amyotrophic lateral sclerosis

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2011.152

21 January 2018

ITPR2 as a susceptibility gene in sporadic amyotrophic lateral sclerosis: a genome-wide association study

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2011.152

21 January 2018

Genetic variation in DPP6 is associated with susceptibility to amyotrophic lateral sclerosis

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2011.152

21 January 2018

Chromosome 9p21 in amyotrophic lateral sclerosis in Finland: a genome-wide association study

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2011.152

21 January 2018

Chromosome 9p21 in sporadic amyotrophic lateral sclerosis in the UK and seven other countries: a genome-wide association study

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2011.152

21 January 2018

Ataxin-2 intermediate-length polyglutamine expansions are associated with increased risk for ALS

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2011.152

21 January 2018

Clinical genetics of amyotrophic lateral sclerosis: what do we really know?

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2011.152

21 January 2018

Presence of 4-hydroxynonenal in cerebrospinal fluid of patients with sporadic amyotrophic lateral sclerosis

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2011.152

21 January 2018

Increased lipid peroxidation in sera of ALS patients: a potential biomarker of disease burden

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2011.152

21 January 2018

Oxidative stress biomarkers in sporadic ALS

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2011.152

21 January 2018

Morphological evidence for lipid peroxidation and protein glycoxidation in spinal cords from sporadic amyotrophic lateral sclerosis patients

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2011.152

21 January 2018

Messenger RNA oxidation occurs early in disease pathogenesis and promotes motor neuron degeneration in ALS

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2011.152

21 January 2018

Oxidative stress in ALS: key role in motor neuron injury and therapeutic target

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2011.152

21 January 2018

Mutant TAR DNA-binding protein-43 induces oxidative injury in motor neuron-like cell

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2011.152

21 January 2018

The inflammatory NADPH oxidase enzyme modulates motor neuron degeneration in amyotrophic lateral sclerosis mice

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2011.152

21 January 2018

Redox modifier genes in amyotrophic lateral sclerosis in mice.

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2011.152

21 January 2018

Nuclear erythroid 2-related factor 2-antioxidative response element signaling pathway in motor cortex and spinal cord in amyotrophic lateral sclerosis

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2011.152

21 January 2018

Excitotoxic and oxidative cross-talk between motor neurons and glia in ALS pathogenesis

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2011.152

21 January 2018

Review: The role of mitochondria in the pathogenesis of amyotrophic lateral sclerosis.

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2011.152

21 January 2018

Protein aggregation in motor neurone disorders.

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2011.152

21 January 2018

ER stress and unfolded protein response in amyotrophic lateral sclerosis

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2011.152

21 January 2018

Astrocyte function and role in motor neuron disease: a future therapeutic target?

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2011.152

21 January 2018

Microglia as potential contributors to motor neuron injury in amyotrophic lateral sclerosis

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2011.152

21 January 2018

Lost in translation: treatment trials in the SOD1 mouse and in human ALS.

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2011.152

21 January 2018

An adverse property of a familial ALS-linked SOD1 mutation causes motor neuron disease characterized by vacuolar degeneration of mitochondria

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2011.152

21 January 2018

Toxicity of familial ALS-linked SOD1 mutants from selective recruitment to spinal mitochondria.

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2011.152

21 January 2018

Amyotrophic lateral sclerosis-associated SOD1 mutant proteins bind and aggregate with Bcl-2 in spinal cord mitochondria

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2011.152

21 January 2018

Selective association of misfolded ALS-linked mutant SOD1 with the cytoplasmic face of mitochondria.

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2011.152

21 January 2018

Mitochondrial DNA and respiratory chain function in spinal cords of ALS patients

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2011.152

21 January 2018

Mutated human SOD1 causes dysfunction of oxidative phosphorylation in mitochondria of transgenic mice

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2011.152

21 January 2018

Neural mitochondrial Ca2+ capacity impairment precedes the onset of motor symptoms in G93A Cu/Zn-superoxide dismutase mutant mice

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2011.152

21 January 2018

Calcium dysregulation in amyotrophic lateral sclerosis

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2011.152

21 January 2018

Characterization of the caspase cascade in a cell culture model of SOD1-related familial amyotrophic lateral sclerosis: expression, activation and therapeutic effects of inhibition.

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2011.152

21 January 2018

Mitochondrial dysfunction in a cell culture model of familial amyotrophic lateral sclerosis

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2011.152

21 January 2018

Familial amyotrophic lateral sclerosis-linked SOD1 mutants perturb fast axonal transport to reduce axonal mitochondria content

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2011.152

21 January 2018

Role of axonal transport in neurodegenerative diseases

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2011.152

21 January 2018

Identification and characterization of cholest-4-en-3-one, oxime (TRO19622), a novel drug candidate for amyotrophic lateral sclerosis

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2011.152

21 January 2018

Excitotoxicity and amyotrophic lateral sclerosis.

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2011.152

21 January 2018

Molecular mechanisms of calcium-dependent neurodegeneration in excitotoxicity

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2011.152

21 January 2018

Excitotoxicity mediated by non-NMDA receptors causes distal axonopathy in long-term cultured spinal motor neurons.

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2011.152

21 January 2018

Calcium-permeable alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptors: a molecular determinant of selective vulnerability in amyotrophic lateral sclerosis

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2011.152

21 January 2018

Parvalbumin and calbindin D-28k in the human motor system and in motor neuron disease

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2011.152

21 January 2018

CSF and plasma amino acid levels in motor neuron disease: elevation of CSF glutamate in a subset of patients

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2011.152

21 January 2018

Decreased glutamate transport by the brain and spinal cord in amyotrophic lateral sclerosis

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2011.152

21 January 2018

Selective loss of glial glutamate transporter GLT‐1 in amyotrophic lateral sclerosis

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2011.152

21 January 2018

The expression of the glial glutamate transporter protein EAAT2 in motor neuron disease: an immunohistochemical study.

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2011.152

21 January 2018

Glutamate transporters and the excitotoxic path to motor neuron degeneration in amyotrophic lateral sclerosis

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2011.152

21 January 2018

Cortical hyperexcitability may precede the onset of familial amyotrophic lateral sclerosis

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2011.152

21 January 2018

Novel threshold tracking techniques suggest that cortical hyperexcitability is an early feature of motor neuron disease

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2011.152

21 January 2018

AMPA receptor-mediated neuronal death in sporadic ALS.

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2011.152

21 January 2018

Familial amyotrophic lateral sclerosis is associated with a mutation in D-amino acid oxidase

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2011.152

21 January 2018

Caspase-3 cleaves and inactivates the glutamate transporter EAAT2.

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2011.152

21 January 2018

Abnormal exocytotic release of glutamate in a mouse model of amyotrophic lateral sclerosis.

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2011.152

21 January 2018

Reduction in the motoneuron inhibitory/excitatory synaptic ratio in an early-symptomatic mouse model of amyotrophic lateral sclerosis

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2011.152

21 January 2018

Astrocytes regulate GluR2 expression in motor neurons and their vulnerability to excitotoxicity

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2011.152

21 January 2018

Riluzole, neuroprotection and amyotrophic lateral sclerosis.

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2011.152

21 January 2018

Clinical trials for neuroprotection in ALS.

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2011.152

21 January 2018

TDP-43 redistribution is an early event in sporadic amyotrophic lateral sclerosis.

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2011.152

21 January 2018

TDP-43 mutations in familial and sporadic amyotrophic lateral sclerosis

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2011.152

21 January 2018

An immunological epitope selective for pathological monomer-misfolded SOD1 in ALS.

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2011.152

21 January 2018

Wild-type and mutant SOD1 share an aberrant conformation and a common pathogenic pathway in ALS

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2011.152

21 January 2018

FUS mutations in familial amyotrophic lateral sclerosis in the Netherlands.

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2011.152

21 January 2018

Novel FUS/TLS mutations and pathology in familial and sporadic amyotrophic lateral sclerosis.

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2011.152

21 January 2018

Glutamate slows axonal transport of neurofilaments in transfected neurons

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2011.152

21 January 2018

Neurofilament heavy chain side arm phosphorylation regulates axonal transport of neurofilaments.

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2011.152

21 January 2018

Exome sequencing reveals VCP mutations as a cause of familial ALS

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2011.152

21 January 2018

TDP-43 mediates degeneration in a novel Drosophila model of disease caused by mutations in VCP/p97.

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2011.152

21 January 2018

Mutations in UBQLN2 cause dominant X-linked juvenile and adult-onset ALS and ALS/dementia

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2011.152

21 January 2018

The gene encoding alsin, a protein with three guanine-nucleotide exchange factor domains, is mutated in a form of recessive amyotrophic lateral sclerosis

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2011.152

21 January 2018

Amyotrophic lateral sclerosis 2-deficiency leads to neuronal degeneration in amyotrophic lateral sclerosis through altered AMPA receptor trafficking

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2011.152

21 January 2018

A mutation in the vesicle-trafficking protein VAPB causes late-onset spinal muscular atrophy and amyotrophic lateral sclerosis

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2011.152

21 January 2018

Mutations of optineurin in amyotrophic lateral sclerosis

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2011.152

21 January 2018

ALS phenotypes with mutations in CHMP2B (charged multivesicular body protein 2B)

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2011.152

21 January 2018

Mutations in CHMP2B in lower motor neuron predominant amyotrophic lateral sclerosis (ALS).

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2011.152

21 January 2018

Deleterious variants of FIG4, a phosphoinositide phosphatase, in patients with ALS.

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2011.152

21 January 2018

A protein complex that regulates PtdIns(3,5)P2 levels

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2011.152

21 January 2018

A mutation in dynein rescues axonal transport defects and extends the life span of ALS mice

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2011.152

21 January 2018

Slowing of axonal transport is a very early event in the toxicity of ALS-linked SOD1 mutants to motor neurons

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2011.152

21 January 2018

Deficits in axonal transport precede ALS symptoms in vivo

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2011.152

21 January 2018

Axonal mitochondrial transport and potential are correlated

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2011.152

21 January 2018

Tumor necrosis factor induces hyperphosphorylation of kinesin light chain and inhibits kinesin-mediated transport of mitochondria

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2011.152

21 January 2018

p38alpha stress-activated protein kinase phosphorylates neurofilaments and is associated with neurofilament pathology in amyotrophic lateral sclerosis.

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2011.152

21 January 2018

Persistent activation of p38 mitogen-activated protein kinase in a mouse model of familial amyotrophic lateral sclerosis correlates with disease progression.

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2011.152

21 January 2018

Association of missense and 5'-splice-site mutations in tau with the inherited dementia FTDP-17

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2011.152

21 January 2018

A frameshift deletion in peripherin gene associated with amyotrophic lateral sclerosis

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2011.152

21 January 2018

Presence of dendritic cells, MCP-1, and activated microglia/macrophages in amyotrophic lateral sclerosis spinal cord tissue

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2011.152

21 January 2018

Increased levels of inflammatory chemokines in amyotrophic lateral sclerosis.

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2011.152

21 January 2018

Immune system alterations in sporadic amyotrophic lateral sclerosis patients suggest an ongoing neuroinflammatory process

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2011.152

21 January 2018

Dual effect of CD4+CD25+ regulatory T cells in neurodegeneration: a dialogue with microglia

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2011.152

21 January 2018

CD4+ T cells support glial neuroprotection, slow disease progression, and modify glial morphology in an animal model of inherited ALS.

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2011.152

21 January 2018

Microarray analysis of the cellular pathways involved in the adaptation to and progression of motor neuron injury in the SOD1 G93A mouse model of familial ALS.

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2011.152

21 January 2018

Toxicity from different SOD1 mutants dysregulates the complement system and the neuronal regenerative response in ALS motor neurons

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2011.152

21 January 2018

Innate and adaptive immunity in amyotrophic lateral sclerosis: evidence of complement activation.

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2011.152

21 January 2018

Primary glia expressing the G93A-SOD1 mutation present a neuroinflammatory phenotype and provide a cellular system for studies of glial inflammation

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2011.152

21 January 2018

Human embryonic stem cell-derived motor neurons are sensitive to the toxic effect of glial cells carrying an ALS-causing mutation

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2011.152

21 January 2018

Non-cell-autonomous effect of human SOD1 G37R astrocytes on motor neurons derived from human embryonic stem cells

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2011.152

21 January 2018

Orchestrating the unfolded protein response in health and disease

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2011.152

21 January 2018

An in vitro model for Lewy body-like hyaline inclusion/astrocytic hyaline inclusion: induction by ER stress with an ALS-linked SOD1 mutation

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2011.152

21 January 2018

Involvement of caspase-4 in endoplasmic reticulum stress-induced apoptosis and Abeta-induced cell death

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2011.152

21 January 2018

Induction of the unfolded protein response in familial amyotrophic lateral sclerosis and association of protein-disulfide isomerase with superoxide dismutase 1.

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2011.152

21 January 2018

Endoplasmic reticulum stress and induction of the unfolded protein response in human sporadic amyotrophic lateral sclerosis

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2011.152

21 January 2018

A role for motoneuron subtype-selective ER stress in disease manifestations of FALS mice

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2011.152

21 January 2018

Evidence of endoplasmic reticular stress in the spinal motor neurons exposed to CSF from sporadic amyotrophic lateral sclerosis patients

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2011.152

21 January 2018

XBP-1 deficiency in the nervous system protects against amyotrophic lateral sclerosis by increasing autophagy

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2011.152

21 January 2018

The VAP protein family: from cellular functions to motor neuron disease

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2011.152

21 January 2018

Characterization of the Properties of a Novel Mutation in VAPB in Familial Amyotrophic Lateral Sclerosis

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2011.152

21 January 2018

Identification and characterization of a spinal muscular atrophy-determining gene

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2011.152

21 January 2018

Spinal muscular atrophy: why do low levels of survival motor neuron protein make motor neurons sick?

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2011.152

21 January 2018

TDP-43 and FUS in amyotrophic lateral sclerosis and frontotemporal dementia

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2011.152

21 January 2018

Tar DNA Binding Protein-43 (TDP-43) Associates with Stress Granules: Analysis of Cultured Cells and Pathological Brain Tissue

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2011.152

21 January 2018

Nuclear transport impairment of amyotrophic lateral sclerosis-linked mutations in FUS/TLS.

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2011.152

21 January 2018

ALS-associated fused in sarcoma (FUS) mutations disrupt Transportin-mediated nuclear import

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2011.152

21 January 2018

Identification of neuronal RNA targets of TDP-43-containing ribonucleoprotein complexes

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2011.152

21 January 2018

Long pre-mRNA depletion and RNA missplicing contribute to neuronal vulnerability from loss of TDP-43.

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2011.152

21 January 2018

Characterizing the RNA targets and position-dependent splicing regulation by TDP-43.

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2011.152

21 January 2018

RNA targets of TDP-43 identified by UV-CLIP are deregulated in ALS.

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2011.152

21 January 2018

TDP-43-Based Animal Models of Neurodegeneration: New Insights into ALS Pathology and Pathophysiology

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2011.152

21 January 2018

ANG mutations segregate with familial and 'sporadic' amyotrophic lateral sclerosis

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2011.152

21 January 2018

Control of motoneuron survival by angiogenin.

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2011.152

21 January 2018

DNA/RNA helicase gene mutations in a form of juvenile amyotrophic lateral sclerosis (ALS4)

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2011.152

21 January 2018

Wild-Type Nonneuronal Cells Extend Survival of SOD1 Mutant Motor Neurons in ALS Mice

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2011.152

21 January 2018

Onset and progression in inherited ALS determined by motor neurons and microglia

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2011.152

21 January 2018

Astrocytes as determinants of disease progression in inherited amyotrophic lateral sclerosis

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2011.152

21 January 2018

Astrocytes expressing ALS-linked mutated SOD1 release factors selectively toxic to motor neurons

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2011.152

21 January 2018

Schwann cells expressing dismutase active mutant SOD1 unexpectedly slow disease progression in ALS mice.

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2011.152

21 January 2018

Dysregulation of astrocyte-motoneuron cross-talk in mutant superoxide dismutase 1-related amyotrophic lateral sclerosis

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2011.152

21 January 2018

Intrinsic differences in brain and spinal cord mitochondria: Implication for therapeutic interventions.

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2011.152

21 January 2018

Metabolic and functional differences between brain and spinal cord mitochondria underlie different predisposition to pathology

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2011.152

21 January 2018

Axonal excitability properties in amyotrophic lateral sclerosis

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2011.152

21 January 2018

Energy metabolism in amyotrophic lateral sclerosis

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2011.152

21 January 2018

Identification of active loci of a human endogenous retrovirus in neurons of patients with amyotrophic lateral sclerosis

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2011.152

21 January 2018

SPATACSIN mutations cause autosomal recessive juvenile amyotrophic lateral sclerosis

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2011.152

21 January 2018

Sigma nonopioid intracellular receptor 1 mutations cause frontotemporal lobar degeneration-motor neuron disease.

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2011.152

21 January 2018

Optimised and rapid pre-clinical screening in the SOD1(G93A) transgenic mouse model of amyotrophic lateral sclerosis (ALS).

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2011.152

21 January 2018

Neonatal neuronal circuitry shows hyperexcitable disturbance in a mouse model of the adult-onset neurodegenerative disease amyotrophic lateral sclerosis

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2011.152

21 January 2018

Early vacuolization and mitochondrial damage in motor neurons of FALS mice are not associated with apoptosis or with changes in cytochrome oxidase histochemical reactivity.

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2011.152

21 January 2018

A genetic model of amyotrophic lateral sclerosis in zebrafish displays phenotypic hallmarks of motoneuron disease

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2011.152

21 January 2018

Mutations in the FUS/TLS gene on chromosome 16 cause familial amyotrophic lateral sclerosis

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2011.152

21 January 2018

Mutations in FUS, an RNA processing protein, cause familial amyotrophic lateral sclerosis type 6

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2011.152

21 January 2018

A novel locus for familial amyotrophic lateral sclerosis, on chromosome 18q

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2011.152

21 January 2018

Identification of two novel loci for dominantly inherited familial amyotrophic lateral sclerosis

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2011.152

21 January 2018

Sporadic amyotrophic lateral sclerosis: two pathological patterns shown by analysis of distribution of TDP-43-immunoreactive neuronal and glial cytoplasmic inclusions

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2011.152

31 March 2020

TDP-43-immunoreactive neuronal and glial inclusions in the neostriatum in amyotrophic lateral sclerosis with and without dementia

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2011.152

31 March 2020

Neuroscience: Standard model

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2011.152

31 March 2020

Linkage of familial amyotrophic lateral sclerosis with frontotemporal dementia to chromosome 9q21-q22

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2011.152

31 March 2020

Erratum: Mutations in Cu/Zn superoxide dismutase gene are associated with familial amyotrophic lateral sclerosis

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2011.152

31 March 2020

Oxidative damage to protein in sporadic motor neuron disease spinal cord

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2011.152

31 March 2020

Protein oxidative damage in a transgenic mouse model of familial amyotrophic lateral sclerosis

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2011.152

31 March 2020

Mutant SOD1 causes motor neuron disease independent of copper chaperone-mediated copper loading

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2011.152

31 March 2020

Antioxidant treatment for amyotrophic lateral sclerosis or motor neuron disease

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2011.152

31 March 2020

Mitochondrial alterations in the spinal cord of patients with sporadic amyotrophic lateral sclerosis

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2011.152

31 March 2020

Motor neurons are selectively vulnerable to AMPA/kainate receptor-mediated injury in vitro

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2011.152

31 March 2020

Intrinsic properties of lumbar motor neurones in the adult G127insTGGG superoxide dismutase-1 mutant mouse in vivo: evidence for increased persistent inward currents

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2011.152

31 March 2020

Dose-ranging study of riluzole in amyotrophic lateral sclerosis. Amyotrophic Lateral Sclerosis/Riluzole Study Group II

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2011.152

31 March 2020

Phosphorylated high molecular weight neurofilament protein in lower motor neurons in amyotrophic lateral sclerosis and other neurodegenerative diseases involving ventral horn cells

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2011.152

31 March 2020

Bunina bodies in amyotrophic lateral sclerosis immunostained with rabbit anti-cystatin C serum

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2011.152

31 March 2020

Cu/Zn superoxide dismutase-like immunoreactivity in Lewy body-like inclusions of sporadic amyotrophic lateral sclerosis

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2011.152

31 March 2020

Matrix metalloproteinase-9 regulates TNF-alpha and FasL expression in neuronal, glial cells and its absence extends life in a transgenic mouse model of amyotrophic lateral sclerosis

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2011.152

31 March 2020

Variants of the heavy neurofilament subunit are associated with the development of amyotrophic lateral sclerosis

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2011.152

31 March 2020

Selective vulnerability and pruning of phasic motoneuron axons in motoneuron disease alleviated by CNTF

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2011.152

31 March 2020

Amyotrophic lateral sclerosis is a distal axonopathy: evidence in mice and man

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2011.152

31 March 2020

From transcriptome analysis to therapeutic anti-CD40L treatment in the SOD1 model of amyotrophic lateral sclerosis

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2011.152

31 March 2020

XBP-1 deficiency in the nervous system reveals a homeostatic switch to activate autophagy

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2011.152

31 March 2020

Angiogenin inhibits nuclear translocation of apoptosis inducing factor in a Bcl‐2‐dependent manner

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2011.152

31 March 2020

Restricted expression of G86R Cu/Zn superoxide dismutase in astrocytes results in astrocytosis but does not cause motoneuron degeneration

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2011.152

31 March 2020

Neuron-specific expression of mutant superoxide dismutase 1 in transgenic mice does not lead to motor impairment.

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2011.152

31 March 2020

Neuron-specific expression of mutant superoxide dismutase is sufficient to induce amyotrophic lateral sclerosis in transgenic mice

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2011.152

31 March 2020

Dismutase-competent SOD1 mutant accumulation in myelinating Schwann cells is not detrimental to normal or transgenic ALS model mice

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2011.152

31 March 2020

Contrasting effects of cerebrospinal fluid from motor neuron disease patients on the survival of primary motor neurons cultured with or without glia

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2011.152

31 March 2020

A mutation in sigma‐1 receptor causes juvenile amyotrophic lateral sclerosis

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2011.152

31 March 2020

Early electrophysiological abnormalities in lumbar motoneurons in a transgenic mouse model of amyotrophic lateral sclerosis

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2011.152

31 March 2020

A hexanucleotide repeat expansion in C9ORF72 is the cause of chromosome 9p21-linked ALS-FTD

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2011.152

31 March 2020

Expanded GGGGCC hexanucleotide repeat in noncoding region of C9ORF72 causes chromosome 9p-linked FTD and ALS

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2011.152

31 March 2020

SOD1 and TDP-43 animal models of amyotrophic lateral sclerosis: recent advances in understanding disease toward the development of clinical treatments

1 reference

https://pubmed.ncbi.nlm.nih.gov/22051914

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Differential cellular phosphorylation of neurofilament heavy side-arms by glycogen synthase kinase-3 and cyclin-dependent kinase-5.

1 reference

https://pubmed.ncbi.nlm.nih.gov/22051914

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Molecular factors underlying selective vulnerability of motor neurons to neurodegeneration in amyotrophic lateral sclerosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/22051914

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Selective neuronal vulnerability to oxidative stress in the brain

1 reference

https://pubmed.ncbi.nlm.nih.gov/22051914

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Evidence for DNA damage in amyotrophic lateral sclerosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/22051914

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

SOD1 mutations disrupt redox-sensitive Rac regulation of NADPH oxidase in a familial ALS model

1 reference

https://pubmed.ncbi.nlm.nih.gov/22051914

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Phosphorylation of neurofilament heavy chain side-arms by stress activated protein kinase-1b/Jun N-terminal kinase-3

1 reference

https://pubmed.ncbi.nlm.nih.gov/22051914

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Neuropathology with clinical correlations of sporadic amyotrophic lateral sclerosis: 102 autopsy cases examined between 1962 and 2000.

1 reference

https://pubmed.ncbi.nlm.nih.gov/22051914

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1038/NRNEUROL.2011.152

1 reference

Europe PubMed Central

PubMed publication ID

25 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

25 August 2017

ResearchGate publication ID

0 references

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