(Q37863862)

24 August 2017

1 reference

title

Modulating stress responses by the UPRosome: a matter of life and death (English)

1 reference

24 August 2017

Modulating stress responses by the UPRosome: A matter of life and death (English)

1 reference

https://api.crossref.org/works/10.1016/J.TIBS.2011.03.001

29 November 2024

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A21482118

29 November 2024

Ute Woehlbier

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A21482118

29 November 2024

Claudio Hetz

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A21482118

29 November 2024

language of work or name

English

1 reference

National Center for Biotechnology Information

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=21482118

29 November 2024

publication date

7 April 2011

1 reference

full work available at URL

24 August 2017

1 reference

inferred from page(s)

https://api.elsevier.com/content/article/PII:S0968000411000454?httpAccept=text/xml

1 reference

https://api.crossref.org/works/10.1016/J.TIBS.2011.03.001

https://api.elsevier.com/content/article/PII:S0968000411000454?httpAccept=text/plain

29 November 2024

1 reference

https://api.crossref.org/works/10.1016/J.TIBS.2011.03.001

Trends in Biochemical Sciences

29 November 2024

published in

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24 August 2017

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24 August 2017

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24 August 2017

page(s)

329-337

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Caspase-12 mediates endoplasmic-reticulum-specific apoptosis and cytotoxicity by amyloid-beta

24 August 2017

cites work

1 reference

COCI

https://opencitations.net/index/coci/api/v1/citations/10.1038/47513

The mammalian unfolded protein response

15 July 2023

1 reference

https://api.crossref.org/works/10.1016/J.TIBS.2011.03.001

Signal integration in the endoplasmic reticulum unfolded protein response

29 November 2024

1 reference

https://api.crossref.org/works/10.1016/J.TIBS.2011.03.001

Fine-tuning of the unfolded protein response: Assembling the IRE1alpha interactome

29 November 2024

1 reference

https://api.crossref.org/works/10.1016/J.TIBS.2011.03.001

Integrating stress signals at the endoplasmic reticulum: The BCL-2 protein family rheostat.

29 November 2024

1 reference

https://api.crossref.org/works/10.1016/J.TIBS.2011.03.001

Protein folding stress in neurodegenerative diseases: a glimpse into the ER

29 November 2024

1 reference

https://api.crossref.org/works/10.1016/J.TIBS.2011.03.001

IRE1 couples endoplasmic reticulum load to secretory capacity by processing the XBP-1 mRNA

29 November 2024

1 reference

https://api.crossref.org/works/10.1016/J.TIBS.2011.03.001

IRE1-mediated unconventional mRNA splicing and S2P-mediated ATF6 cleavage merge to regulate XBP1 in signaling the unfolded protein response

29 November 2024

1 reference

https://api.crossref.org/works/10.1016/J.TIBS.2011.03.001

XBP1 mRNA is induced by ATF6 and spliced by IRE1 in response to ER stress to produce a highly active transcription factor

29 November 2024

1 reference

https://api.crossref.org/works/10.1016/J.TIBS.2011.03.001

Dynamic interaction of BiP and ER stress transducers in the unfolded-protein response

29 November 2024

1 reference

https://api.crossref.org/works/10.1016/J.TIBS.2011.03.001

Dissociation of Kar2p/BiP from an ER sensory molecule, Ire1p, triggers the unfolded protein response in yeast

29 November 2024

1 reference

https://api.crossref.org/works/10.1016/J.TIBS.2011.03.001

Genetic evidence for a role of BiP/Kar2 that regulates Ire1 in response to accumulation of unfolded proteins.

29 November 2024

1 reference

https://api.crossref.org/works/10.1016/J.TIBS.2011.03.001

On the mechanism of sensing unfolded protein in the endoplasmic reticulum

29 November 2024

1 reference

https://api.crossref.org/works/10.1016/J.TIBS.2011.03.001

Two regulatory steps of ER-stress sensor Ire1 involving its cluster formation and interaction with unfolded proteins

29 November 2024

1 reference

https://api.crossref.org/works/10.1016/J.TIBS.2011.03.001

A role for BiP as an adjustor for the endoplasmic reticulum stress-sensing protein Ire1.

29 November 2024

1 reference

https://api.crossref.org/works/10.1016/J.TIBS.2011.03.001

Activation of mammalian IRE1alpha upon ER stress depends on dissociation of BiP rather than on direct interaction with unfolded proteins

29 November 2024

1 reference

https://api.crossref.org/works/10.1016/J.TIBS.2011.03.001

The crystal structure of human IRE1 luminal domain reveals a conserved dimerization interface required for activation of the unfolded protein response

29 November 2024

1 reference

https://api.crossref.org/works/10.1016/J.TIBS.2011.03.001

BiP binding to the ER-stress sensor Ire1 tunes the homeostatic behavior of the unfolded protein response

29 November 2024

1 reference

https://api.crossref.org/works/10.1016/J.TIBS.2011.03.001

Ligand-independent dimerization activates the stress response kinases IRE1 and PERK in the lumen of the endoplasmic reticulum

29 November 2024

1 reference

https://api.crossref.org/works/10.1016/J.TIBS.2011.03.001

Protein translation and folding are coupled by an endoplasmic-reticulum-resident kinase

29 November 2024

1 reference

https://api.crossref.org/works/10.1016/J.TIBS.2011.03.001

Activating transcription factor 4.

29 November 2024

1 reference

https://api.crossref.org/works/10.1016/J.TIBS.2011.03.001

An integrated stress response regulates amino acid metabolism and resistance to oxidative stress

29 November 2024

1 reference

https://api.crossref.org/works/10.1016/J.TIBS.2011.03.001

ATF4 is an oxidative stress-inducible, prodeath transcription factor in neurons in vitro and in vivo

29 November 2024

1 reference

https://api.crossref.org/works/10.1016/J.TIBS.2011.03.001

Analysis of ATF6 activation in Site-2 protease-deficient Chinese hamster ovary cells.

29 November 2024

1 reference

https://api.crossref.org/works/10.1016/J.TIBS.2011.03.001

Stable binding of ATF6 to BiP in the endoplasmic reticulum stress response

29 November 2024

1 reference

https://api.crossref.org/works/10.1016/J.TIBS.2011.03.001

Mammalian transcription factor ATF6 is synthesized as a transmembrane protein and activated by proteolysis in response to endoplasmic reticulum stress

29 November 2024

1 reference

https://api.crossref.org/works/10.1016/J.TIBS.2011.03.001

Rationalizing translation attenuation in the network architecture of the unfolded protein response.

29 November 2024

1 reference

https://api.crossref.org/works/10.1016/J.TIBS.2011.03.001

Decay of endoplasmic reticulum-localized mRNAs during the unfolded protein response.

29 November 2024

1 reference

https://api.crossref.org/works/10.1016/J.TIBS.2011.03.001

Regulated Ire1-dependent decay of messenger RNAs in mammalian cells

29 November 2024

1 reference

https://api.crossref.org/works/10.1016/J.TIBS.2011.03.001

IRE1alpha kinase activation modes control alternate endoribonuclease outputs to determine divergent cell fates.

29 November 2024

1 reference

https://api.crossref.org/works/10.1016/J.TIBS.2011.03.001

Messenger RNA targeting to endoplasmic reticulum stress signalling sites.

29 November 2024

1 reference

https://api.crossref.org/works/10.1016/J.TIBS.2011.03.001

Chemical biology investigation of cell death pathways activated by endoplasmic reticulum stress reveals cytoprotective modulators of ASK1.

29 November 2024

1 reference

https://api.crossref.org/works/10.1016/J.TIBS.2011.03.001

ASK1 is essential for endoplasmic reticulum stress-induced neuronal cell death triggered by expanded polyglutamine repeats

29 November 2024

1 reference

https://api.crossref.org/works/10.1016/J.TIBS.2011.03.001

Coupling of stress in the ER to activation of JNK protein kinases by transmembrane protein kinase IRE1

29 November 2024

1 reference

https://api.crossref.org/works/10.1016/J.TIBS.2011.03.001

The inositol trisphosphate receptor in the control of autophagy

29 November 2024

1 reference

https://api.crossref.org/works/10.1016/J.TIBS.2011.03.001

Autophagy is activated for cell survival after endoplasmic reticulum stress

29 November 2024

1 reference

https://api.crossref.org/works/10.1016/J.TIBS.2011.03.001

Transcriptional induction of mammalian ER quality control proteins is mediated by single or combined action of ATF6alpha and XBP1

29 November 2024

1 reference

https://api.crossref.org/works/10.1016/J.TIBS.2011.03.001

ER stress triggers apoptosis by activating BH3-only protein Bim

29 November 2024

1 reference

https://api.crossref.org/works/10.1016/J.TIBS.2011.03.001

Adaptive suppression of the ATF4-CHOP branch of the unfolded protein response by toll-like receptor signalling

29 November 2024

1 reference

https://api.crossref.org/works/10.1016/J.TIBS.2011.03.001

Gadd153 sensitizes cells to endoplasmic reticulum stress by down-regulating Bcl2 and perturbing the cellular redox state

29 November 2024

1 reference

https://api.crossref.org/works/10.1016/J.TIBS.2011.03.001

CHOP induces death by promoting protein synthesis and oxidation in the stressed endoplasmic reticulum

29 November 2024

1 reference

https://api.crossref.org/works/10.1016/J.TIBS.2011.03.001

Divergent effects of PERK and IRE1 signaling on cell viability

29 November 2024

1 reference

https://api.crossref.org/works/10.1016/J.TIBS.2011.03.001

IRE1 signaling affects cell fate during the unfolded protein response

29 November 2024

1 reference

https://api.crossref.org/works/10.1016/J.TIBS.2011.03.001

Cell death: critical control points

29 November 2024

1 reference

https://api.crossref.org/works/10.1016/J.TIBS.2011.03.001

Mitochondria and cell death: outer membrane permeabilization and beyond

29 November 2024

1 reference

https://api.crossref.org/works/10.1016/J.TIBS.2011.03.001

BAX and BAK regulation of endoplasmic reticulum Ca2+: a control point for apoptosis

29 November 2024

1 reference

https://api.crossref.org/works/10.1016/J.TIBS.2011.03.001

Bax and Bak can localize to the endoplasmic reticulum to initiate apoptosis

29 November 2024

1 reference

https://api.crossref.org/works/10.1016/J.TIBS.2011.03.001

Proapoptotic BAX and BAK: a requisite gateway to mitochondrial dysfunction and death

29 November 2024

1 reference

https://api.crossref.org/works/10.1016/J.TIBS.2011.03.001

Neuronal apoptosis induced by endoplasmic reticulum stress is regulated by ATF4-CHOP-mediated induction of the Bcl-2 homology 3-only member PUMA

29 November 2024

1 reference

https://api.crossref.org/works/10.1016/J.TIBS.2011.03.001

Involvement of caspase-4 in endoplasmic reticulum stress-induced apoptosis and Abeta-induced cell death

29 November 2024

1 reference

https://api.crossref.org/works/10.1016/J.TIBS.2011.03.001

Coupling endoplasmic reticulum stress to the cell death program. An Apaf-1-independent intrinsic pathway

29 November 2024

1 reference

https://api.crossref.org/works/10.1016/J.TIBS.2011.03.001

Proapoptotic BAX and BAK modulate the unfolded protein response by a direct interaction with IRE1alpha

29 November 2024

1 reference

https://api.crossref.org/works/10.1016/J.TIBS.2011.03.001

AIP1 is critical in transducing IRE1-mediated endoplasmic reticulum stress response

29 November 2024

1 reference

https://api.crossref.org/works/10.1016/J.TIBS.2011.03.001

HSP72 protects cells from ER stress-induced apoptosis via enhancement of IRE1alpha-XBP1 signaling through a physical interaction

29 November 2024

1 reference

https://api.crossref.org/works/10.1016/J.TIBS.2011.03.001

BAX inhibitor-1 is a negative regulator of the ER stress sensor IRE1alpha

29 November 2024

1 reference

https://api.crossref.org/works/10.1016/J.TIBS.2011.03.001

Protein-tyrosine phosphatase 1B potentiates IRE1 signaling during endoplasmic reticulum stress

29 November 2024

1 reference

https://api.crossref.org/works/10.1016/J.TIBS.2011.03.001

Ire1p: a kinase and site-specific endoribonuclease

29 November 2024

1 reference

https://api.crossref.org/works/10.1016/J.TIBS.2011.03.001

Mammalian endoplasmic reticulum stress sensor IRE1 signals by dynamic clustering

29 November 2024

1 reference

https://api.crossref.org/works/10.1016/J.TIBS.2011.03.001

Bax inhibitor-1 regulates endoplasmic reticulum stress-associated reactive oxygen species and heme oxygenase-1 expression

29 November 2024

1 reference

https://api.crossref.org/works/10.1016/J.TIBS.2011.03.001

Hepatic Bax inhibitor-1 inhibits IRE1alpha and protects from obesity-associated insulin resistance and glucose intolerance

29 November 2024

1 reference

https://api.crossref.org/works/10.1016/J.TIBS.2011.03.001

Cytoprotective gene bi-1 is required for intrinsic protection from endoplasmic reticulum stress and ischemia-reperfusion injury

29 November 2024

1 reference

https://api.crossref.org/works/10.1016/J.TIBS.2011.03.001

Bifunctional Apoptosis Regulator (BAR), an Endoplasmic Reticulum (ER)-associated E3 Ubiquitin Ligase, Modulates BI-1 Protein Stability and Function in ER Stress

29 November 2024

1 reference

https://api.crossref.org/works/10.1016/J.TIBS.2011.03.001

Feedback inhibition of the unfolded protein response by GADD34-mediated dephosphorylation of eIF2alpha

29 November 2024

1 reference

https://api.crossref.org/works/10.1016/J.TIBS.2011.03.001

Growth arrest and DNA damage-inducible protein GADD34 targets protein phosphatase 1 alpha to the endoplasmic reticulum and promotes dephosphorylation of the alpha subunit of eukaryotic translation initiation factor 2

29 November 2024

1 reference

https://api.crossref.org/works/10.1016/J.TIBS.2011.03.001

The function of GADD34 is a recovery from a shutoff of protein synthesis induced by ER stress: elucidation by GADD34-deficient mice

29 November 2024

1 reference

https://api.crossref.org/works/10.1016/J.TIBS.2011.03.001

Delineation of a negative feedback regulatory loop that controls protein translation during endoplasmic reticulum stress

29 November 2024

1 reference

https://api.crossref.org/works/10.1016/J.TIBS.2011.03.001

Activation of the unfolded protein response and alternative splicing of ATF6α in HLA-B27 positive lymphocytes

29 November 2024

1 reference

https://api.crossref.org/works/10.1016/J.TIBS.2011.03.001

ER stress contributes to ischemia-induced cardiomyocyte apoptosis

29 November 2024

1 reference

https://api.crossref.org/works/10.1016/J.TIBS.2011.03.001

A crucial role for RACK1 in the regulation of glucose-stimulated IRE1alpha activation in pancreatic beta cells

29 November 2024

1 reference

https://api.crossref.org/works/10.1016/J.TIBS.2011.03.001

Heat shock protein 90 modulates the unfolded protein response by stabilizing IRE1alpha

29 November 2024

1 reference

https://api.crossref.org/works/10.1016/J.TIBS.2011.03.001

Cdc37 has distinct roles in protein kinase quality control that protect nascent chains from degradation and promote posttranslational maturation

29 November 2024

1 reference

https://api.crossref.org/works/10.1016/J.TIBS.2011.03.001

Nck-dependent activation of extracellular signal-regulated kinase-1 and regulation of cell survival during endoplasmic reticulum stress

29 November 2024

1 reference

https://api.crossref.org/works/10.1016/J.TIBS.2011.03.001

Activation of caspase-12, an endoplastic reticulum (ER) resident caspase, through tumor necrosis factor receptor-associated factor 2-dependent mechanism in response to the ER stress

29 November 2024

1 reference

https://api.crossref.org/works/10.1016/J.TIBS.2011.03.001

JAB1 participates in unfolded protein responses by association and dissociation with IRE1

29 November 2024

1 reference

https://api.crossref.org/works/10.1016/J.TIBS.2011.03.001

A role for presenilin-1 in nuclear accumulation of Ire1 fragments and induction of the mammalian unfolded protein response

29 November 2024

1 reference

https://api.crossref.org/works/10.1016/J.TIBS.2011.03.001

Regulation of unfolded protein response modulator XBP1s by acetylation and deacetylation

29 November 2024

1 reference

https://api.crossref.org/works/10.1016/J.TIBS.2011.03.001

SUMO modification regulates the transcriptional activity of XBP1

29 November 2024

1 reference

https://api.crossref.org/works/10.1016/J.TIBS.2011.03.001

pXBP1(U) encoded in XBP1 pre-mRNA negatively regulates unfolded protein response activator pXBP1(S) in mammalian ER stress response

29 November 2024

1 reference

https://api.crossref.org/works/10.1016/J.TIBS.2011.03.001

Translational Pausing Ensures Membrane Targeting and Cytoplasmic Splicing of XBP1u mRNA

29 November 2024

1 reference

https://api.crossref.org/works/10.1016/J.TIBS.2011.03.001

The role of the unfolded protein response in tumour development: friend or foe?

29 November 2024

1 reference

https://api.crossref.org/works/10.1016/J.TIBS.2011.03.001

Targeting the endoplasmic reticulum-stress response as an anticancer strategy

29 November 2024

1 reference

https://api.crossref.org/works/10.1016/J.TIBS.2011.03.001

Targeting XBP-1 as a novel anti-cancer strategy.

29 November 2024

1 reference

https://api.crossref.org/works/10.1016/J.TIBS.2011.03.001

XBP1 is essential for survival under hypoxic conditions and is required for tumor growth.

29 November 2024

1 reference

https://api.crossref.org/works/10.1016/J.TIBS.2011.03.001

Endoplasmic reticulum stress and the inflammatory basis of metabolic disease

29 November 2024

1 reference

https://api.crossref.org/works/10.1016/J.TIBS.2011.03.001

The role of IRE1alpha in the degradation of insulin mRNA in pancreatic beta-cells

29 November 2024

1 reference

https://api.crossref.org/works/10.1016/J.TIBS.2011.03.001

Endoplasmic reticulum stress-induced apoptosis and auto-immunity in diabetes

29 November 2024

1 reference

https://api.crossref.org/works/10.1016/J.TIBS.2011.03.001

Endoplasmic reticulum stress links obesity, insulin action, and type 2 diabetes

29 November 2024

1 reference

https://api.crossref.org/works/10.1016/J.TIBS.2011.03.001

Regulation of innate immunity by signaling pathways emerging from the endoplasmic reticulum

29 November 2024

1 reference

https://api.crossref.org/works/10.1016/J.TIBS.2011.03.001

An essential role for XBP-1 in host protection against immune activation in C. elegans

29 November 2024

1 reference

https://api.crossref.org/works/10.1016/J.TIBS.2011.03.001

The endoplasmic reticulum stress response in immunity and autoimmunity

29 November 2024

1 reference

https://api.crossref.org/works/10.1016/J.TIBS.2011.03.001

The unfolded protein response in familial amyotrophic lateral sclerosis

29 November 2024

1 reference

https://api.crossref.org/works/10.1016/J.TIBS.2011.03.001

A role for motoneuron subtype-selective ER stress in disease manifestations of FALS mice

29 November 2024

1 reference

https://api.crossref.org/works/10.1016/J.TIBS.2011.03.001

XBP-1 deficiency in the nervous system protects against amyotrophic lateral sclerosis by increasing autophagy

29 November 2024

1 reference

https://api.crossref.org/works/10.1016/J.TIBS.2011.03.001

Unfolded protein response transcription factor XBP-1 does not influence prion replication or pathogenesis.

29 November 2024

1 reference

https://api.crossref.org/works/10.1016/J.TIBS.2011.03.001

Caspase-12 and endoplasmic reticulum stress mediate neurotoxicity of pathological prion protein.

29 November 2024

1 reference

https://api.crossref.org/works/10.1016/J.TIBS.2011.03.001

Flavonol Activation Defines an Unanticipated Ligand-Binding Site in the Kinase-RNase Domain of IRE1

29 November 2024

1 reference

https://api.crossref.org/works/10.1016/J.TIBS.2011.03.001

Endoplasmic reticulum stress responses

29 November 2024

series ordinal

100

1 reference

https://api.crossref.org/works/10.1016/J.TIBS.2011.03.001

29 November 2024

Identifiers

1 reference

24 August 2017

1 reference