(Q37731911)

22 August 2017

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title

Store-operated CRAC channels: function in health and disease (English)

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22 August 2017

Anant B Parekh

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22 August 2017

publication date

16 April 2010

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Nature Reviews Drug Discovery

22 August 2017

published in

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22 August 2017

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22 August 2017

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22 August 2017

page(s)

399-410

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Calcium signalling: dynamics, homeostasis and remodelling

22 August 2017

cites work

1 reference

31 March 2020

1 reference

Calcium and apoptosis: facts and hypotheses

31 March 2020

1 reference

Vesicle pools and Ca2+ microdomains: new tools for understanding their roles in neurotransmitter release

31 March 2020

1 reference

Microdomains of intracellular Ca2+: molecular determinants and functional consequences.

31 March 2020

1 reference

Inositol trisphosphate and calcium signalling

31 March 2020

1 reference

A model for receptor-regulated calcium entry

31 March 2020

1 reference

Depletion of intracellular calcium stores activates a calcium current in mast cells

31 March 2020

1 reference

Mitogen-regulated Ca2+ current of T lymphocytes is activated by depletion of intracellular Ca2+ stores

31 March 2020

1 reference

Calcium release-activated calcium current in rat mast cells

31 March 2020

1 reference

Calcium-dependent potentiation of store-operated calcium channels in T lymphocytes

31 March 2020

1 reference

Calcium and barium permeation through calcium release-activated calcium (CRAC) channels

31 March 2020

1 reference

Substantial depletion of the intracellular Ca2+ stores is required for macroscopic activation of the Ca2+ release-activated Ca2+ current in rat basophilic leukaemia cells

31 March 2020

1 reference

Monovalent cation permeability and Ca(2+) block of the store-operated Ca(2+) current I(CRAC )in rat basophilic leukemia cells

31 March 2020

1 reference

Permeation through store-operated CRAC channels in divalent-free solution: potential problems and implications for putative CRAC channel genes

31 March 2020

1 reference

Regulation of CRAC channel activity by recruitment of silent channels to a high open-probability gating mode

31 March 2020

1 reference

A store-operated calcium channel in Drosophila S2 cells

31 March 2020

1 reference

The molecular choreography of a store-operated calcium channel

31 March 2020

1 reference

Store-operated calcium channels

31 March 2020

1 reference

Transient receptor potential cation channels in disease

31 March 2020

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The TRP ion channel family.

31 March 2020

1 reference

STIM1, an essential and conserved component of store-operated Ca2+ channel function

31 March 2020

1 reference

STIM is a Ca2+ sensor essential for Ca2+-store-depletion-triggered Ca2+ influx

31 March 2020

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STIMulating store-operated Ca(2+) entry

31 March 2020

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Biochemical properties and cellular localisation of STIM proteins

31 March 2020

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STIM1 has a plasma membrane role in the activation of store-operated Ca(2+) channels

31 March 2020

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Large store-operated calcium selective currents due to co-expression of Orai1 or Orai2 with the intracellular calcium sensor, Stim1

31 March 2020

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Ca2+ store depletion causes STIM1 to accumulate in ER regions closely associated with the plasma membrane

31 March 2020

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Structural and mechanistic insights into STIM1-mediated initiation of store-operated calcium entry

31 March 2020

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STIM1 is a Ca2+ sensor that activates CRAC channels and migrates from the Ca2+ store to the plasma membrane

31 March 2020

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A severe defect in CRAC Ca2+ channel activation and altered K+ channel gating in T cells from immunodeficient patients

31 March 2020

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A mutation in Orai1 causes immune deficiency by abrogating CRAC channel function

31 March 2020

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CRACM1 is a plasma membrane protein essential for store-operated Ca2+ entry

31 March 2020

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Genome-wide RNAi screen of Ca(2+) influx identifies genes that regulate Ca(2+) release-activated Ca(2+) channel activity

31 March 2020

1 reference

Molecular determinants of Ca2+ selectivity and ion permeation in L-type Ca2+ channels

31 March 2020

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Orai1 is an essential pore subunit of the CRAC channel

31 March 2020

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CRACM1 multimers form the ion-selective pore of the CRAC channel.

31 March 2020

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Molecular identification of the CRAC channel by altered ion selectivity in a mutant of Orai

31 March 2020

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Amplification of CRAC current by STIM1 and CRACM1 (Orai1)

31 March 2020

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31 March 2020

A CRAC current tango.

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Orai1 and STIM reconstitute store-operated calcium channel function

31 March 2020

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Acetylcholine receptor channel structure probed in cysteine-substitution mutants.

31 March 2020

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Structural determinants of ion permeation in CRAC channels

31 March 2020

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Atomic structure of a voltage-dependent K+ channel in a lipid membrane-like environment

31 March 2020

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Biochemical and functional characterization of Orai proteins

31 March 2020

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CRACM1, CRACM2, and CRACM3 are store-operated Ca2+ channels with distinct functional properties.

31 March 2020

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Calcium inhibition and calcium potentiation of Orai1, Orai2, and Orai3 calcium release-activated calcium channels

31 March 2020

1 reference

Murine ORAI2 splice variants form functional Ca2+ release-activated Ca2+ (CRAC) channels

31 March 2020

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STIM2 protein mediates distinct store-dependent and store-independent modes of CRAC channel activation

31 March 2020

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STIM2 is a feedback regulator that stabilizes basal cytosolic and endoplasmic reticulum Ca2+ levels

31 March 2020

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STIM1 is a calcium sensor specialized for digital signaling

31 March 2020

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Live-cell imaging reveals sequential oligomerization and local plasma membrane targeting of stromal interaction molecule 1 after Ca2+ store depletion.

31 March 2020

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Visualization and Manipulation of Plasma Membrane-Endoplasmic Reticulum Contact Sites Indicates the Presence of Additional Molecular Components within the STIM1-Orai1 Complex

31 March 2020

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Oligomerization of STIM1 couples ER calcium depletion to CRAC channel activation

31 March 2020

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Aggregation of STIM1 underneath the plasma membrane induces clustering of Orai1

31 March 2020

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A Cytosolic Homomerization and a Modulatory Domain within STIM1 C Terminus Determine Coupling to ORAI1 Channels

31 March 2020

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SOAR and the polybasic STIM1 domains gate and regulate Orai channels

31 March 2020

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A minimal regulatory domain in the C terminus of STIM1 binds to and activates ORAI1 CRAC channels

31 March 2020

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The CRAC channel consists of a tetramer formed by Stim-induced dimerization of Orai dimers

31 March 2020

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Orai1 subunit stoichiometry of the mammalian CRAC channel pore.

31 March 2020

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Functional stoichiometry of the unitary calcium-release-activated calcium channel

31 March 2020

1 reference

Calcium signaling: a tale for all seasons

31 March 2020

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Ca2+ signaling and calcium binding chaperones of the endoplasmic reticulum

31 March 2020

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Functional consequences of activating store-operated CRAC channels

31 March 2020

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Ca2+ microdomains near plasma membrane Ca2+ channels: impact on cell function

31 March 2020

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Signalling to transcription: store-operated Ca2+ entry and NFAT activation in lymphocytes.

31 March 2020

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Calcium oscillations increase the efficiency and specificity of gene expression

31 March 2020

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Ca2+ flow via tunnels in polarized cells: recharging of apical Ca2+ stores by focal Ca2+ entry through basal membrane patch.

31 March 2020

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Modulation of plasma membrane calcium-ATPase activity by local calcium microdomains near CRAC channels in human T cells

31 March 2020

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Organization and Ca2+ regulation of adenylyl cyclases in cAMP microdomains

31 March 2020

1 reference

Cysteinyl leukotrienes: multi-functional mediators in allergic rhinitis

31 March 2020

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Leukotriene receptors in rhinitis and sinusitis

31 March 2020

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Close functional coupling between Ca2+ release-activated Ca2+ channels, arachidonic acid release, and leukotriene C4 secretion.

31 March 2020

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Local Ca2+ influx through Ca2+ release-activated Ca2+ (CRAC) channels stimulates production of an intracellular messenger and an intercellular pro-inflammatory signal.

31 March 2020

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Intercellular Ca2+ wave propagation involving positive feedback between CRAC channels and cysteinyl leukotrienes

31 March 2020

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Lymphocyte calcium signaling from membrane to nucleus

31 March 2020

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Coupling of Ca(2+) microdomains to spatially and temporally distinct cellular responses by the tyrosine kinase Syk.

31 March 2020

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Decoding of cytoplasmic Ca(2+) oscillations through the spatial signature drives gene expression

31 March 2020

1 reference

Defective mast cell effector functions in mice lacking the CRACM1 pore subunit of store-operated calcium release-activated calcium channels

31 March 2020

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Essential function for the calcium sensor STIM1 in mast cell activation and anaphylactic responses

31 March 2020

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Hair loss and defective T- and B-cell function in mice lacking ORAI1

31 March 2020

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STIM1 signalling controls store-operated calcium entry required for development and contractile function in skeletal muscle

31 March 2020

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The calcium sensor STIM1 is an essential mediator of arterial thrombosis and ischemic brain infarction

31 March 2020

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Severe combined immunodeficiency due to defective binding of the nuclear factor of activated T cells in T lymphocytes of two male siblings

31 March 2020

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ORAI1 and STIM1 deficiency in human and mice: roles of store-operated Ca2+ entry in the immune system and beyond.

31 March 2020

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ORAI1 deficiency and lack of store-operated Ca2+ entry cause immunodeficiency, myopathy, and ectodermal dysplasia

31 March 2020

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STIM1 mutation associated with a syndrome of immunodeficiency and autoimmunity

31 March 2020

1 reference

Quality of life in nasal polyposis.

31 March 2020

1 reference

Nasal polyps: still more questions than answers

31 March 2020

1 reference

Nasal polyposis: an update: editorial review

31 March 2020

1 reference

Targeting Ca2+ release-activated Ca2+ channel channels and leukotriene receptors provides a novel combination strategy for treating nasal polyposis

31 March 2020

1 reference

A Pyrazole Derivative, YM-58483, Potently Inhibits Store-Operated Sustained Ca2+ Influx and IL-2 Production in T Lymphocytes

31 March 2020

1 reference

The suppressive effects of YM-58483/BTP-2, a store-operated Ca2+ entry blocker, on inflammatory mediator release in vitro and airway responses in vivo

31 March 2020

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YM-58483, a selective CRAC channel inhibitor, prevents antigen-induced airway eosinophilia and late phase asthmatic responses via Th2 cytokine inhibition in animal models

31 March 2020

1 reference

ORAI and store-operated calcium influx in human airway smooth muscle cells

31 March 2020

1 reference

Reactivity of infiltrating T lymphocytes with microbial antigens in Crohn's disease

31 March 2020

1 reference

Inflammatory bowel disease: etiology and pathogenesis

31 March 2020

1 reference

Ca2+ signaling in identified T-lymphocytes from human intestinal mucosa. Relation to hyporeactivity, proliferation, and inflammatory bowel disease

31 March 2020

1 reference

Sustained activation of the tyrosine kinase Syk by antigen in mast cells requires local Ca2+ influx through Ca2+ release-activated Ca2+ channels

31 March 2020

1 reference

Targeting gut T cell Ca2+ release-activated Ca2+ channels inhibits T cell cytokine production and T-box transcription factor T-bet in inflammatory bowel disease

31 March 2020

1 reference

Orai1 and STIM1 are critical for breast tumor cell migration and metastasis

31 March 2020

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Bcl-2-dependent modulation of Ca(2+) homeostasis and store-operated channels in prostate cancer cells

31 March 2020

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Ion channels in death and differentiation of prostate cancer cells.

31 March 2020

1 reference

Non-specific effects of calcium entry antagonists in mast cells

31 March 2020

1 reference

3,5-Bis(trifluoromethyl)pyrazoles: a novel class of NFAT transcription factor regulator

31 March 2020

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Potent inhibition of NFAT activation and T cell cytokine production by novel low molecular weight pyrazole compounds

31 March 2020

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Potent inhibition of Ca2+ release-activated Ca2+ channels and T-lymphocyte activation by the pyrazole derivative BTP2.

31 March 2020

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A pyrazole derivative potently inhibits lymphocyte Ca2+ influx and cytokine production by facilitating transient receptor potential melastatin 4 channel activity.

31 March 2020

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A functional link between store-operated and TRPC channels revealed by the 3,5-bis(trifluoromethyl)pyrazole derivative, BTP2.

31 March 2020

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The Ca2+ release-activated Ca2+ current (I(CRAC)) mediates store-operated Ca2+ entry in rat microglia

31 March 2020

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Thapsigargin-induced gene expression in nonexcitable cells is dependent on calcium influx

31 March 2020

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Phase II trial of carboxyamidotriazole in patients with relapsed epithelial ovarian cancer

31 March 2020

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Carboxyamidotriazole-induced inhibition of mitochondrial calcium import blocks capacitative calcium entry and cell proliferation in HEK-293 cells

31 March 2020

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Store-operated Ca2+ entry depends on mitochondrial Ca2+ uptake

31 March 2020

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Respiring mitochondria determine the pattern of activation and inactivation of the store-operated Ca(2+) current I(CRAC).

31 March 2020

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Mitochondrial control of calcium-channel gating: a mechanism for sustained signaling and transcriptional activation in T lymphocytes

31 March 2020

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Mitochondrial regulation of store-operated CRAC channels

31 March 2020

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Complex actions of 2-aminoethyldiphenyl borate on store-operated calcium entry

31 March 2020

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2-Aminoethoxydiphenyl borate directly facilitates and indirectly inhibits STIM1-dependent gating of CRAC channels

31 March 2020

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Store-dependent and -independent modes regulating Ca2+ release-activated Ca2+ channel activity of human Orai1 and Orai3

31 March 2020

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2-aminoethoxydiphenyl borate alters selectivity of Orai3 channels by increasing their pore size.

31 March 2020

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STIM1-Orai1 interactions and Orai1 conformational changes revealed by live-cell FRET microscopy

31 March 2020

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Store-operated cyclic AMP signalling mediated by STIM1.

31 March 2020

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Dual functions for the endoplasmic reticulum calcium sensors STIM1 and STIM2 in T cell activation and tolerance

31 March 2020

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Pharmacology of capacitative calcium entry.

31 March 2020

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12 December 2020

Ca2+ influx through CRAC channels activates cytosolic phospholipase A2, leukotriene C4 secretion, and expression of c-fos through ERK-dependent and -independent pathways in mast cells

1 reference

12 December 2020

Diethylstilbestrol is a potent inhibitor of store-operated channels and capacitative Ca(2+) influx

1 reference

12 December 2020

A phase I trial of carboxyamido-triazole and paclitaxel for relapsed solid tumors: potential efficacy of the combination and demonstration of pharmacokinetic interaction.

1 reference

12 December 2020

STIM1 clusters and activates CRAC channels via direct binding of a cytosolic domain to Orai1

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12 December 2020

A primary T-cell immunodeficiency associated with defective transmembrane calcium influx

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12 December 2020

The calcium current activated by T cell receptor and store depletion in human lymphocytes is absent in a primary immunodeficiency.

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12 December 2020

Identifiers

DOI

10.1038/NRD3136

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22 August 2017

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