(Q37756527)

22 August 2017

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title

Nicotine addiction and nicotinic receptors: lessons from genetically modified mice (English)

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22 August 2017

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Jean-Pierre Changeux

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22 August 2017

language of work or name

English

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publication date

1 June 2010

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Nature Reviews Neuroscience

22 August 2017

published in

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22 August 2017

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22 August 2017

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22 August 2017

page(s)

389-401

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Smoking, nicotine and neuropsychiatric disorders

22 August 2017

cites work

1 reference

Nicotinic receptors: allosteric transitions and therapeutic targets in the nervous system

31 March 2020

1 reference

Abnormal avoidance learning in mice lacking functional high-affinity nicotine receptor in the brain

31 March 2020

1 reference

Differential contribution of genetic variation in multiple brain nicotinic cholinergic receptors to nicotine dependence: recent progress and emerging open questions

31 March 2020

1 reference

Mice homozygous for the L250T mutation in the alpha7 nicotinic acetylcholine receptor show increased neuronal apoptosis and die within 1 day of birth

31 March 2020

1 reference

Nicotine activation of alpha4* receptors: sufficient for reward, tolerance, and sensitization

31 March 2020

1 reference

Conditional expression in corticothalamic efferents reveals a developmental role for nicotinic acetylcholine receptors in modulation of passive avoidance behavior.

31 March 2020

1 reference

Nicotine reinforcement and cognition restored by targeted expression of nicotinic receptors

31 March 2020

1 reference

Interplay of beta2* nicotinic receptors and dopamine pathways in the control of spontaneous locomotion

31 March 2020

1 reference

Involvement of alpha6 nicotinic receptor subunit in nicotine-elicited locomotion, demonstrated by in vivo antisense oligonucleotide infusion

31 March 2020

1 reference

Hierarchical control of dopamine neuron-firing patterns by nicotinic receptors

31 March 2020

1 reference

Behavioral sequence analysis reveals a novel role for beta2* nicotinic receptors in exploration

31 March 2020

1 reference

Structural and functional diversity of native brain neuronal nicotinic receptors

31 March 2020

1 reference

A study of the desensitization produced by acetylcholine at the motor end-plate

31 March 2020

1 reference

Nicotine-induced upregulation of nicotinic receptors: underlying mechanisms and relevance to nicotine addiction

31 March 2020

1 reference

A role for brain stress systems in addiction

31 March 2020

1 reference

Hippocampal nAChRs mediate nicotine withdrawal-related learning deficits

31 March 2020

1 reference

Nicotinic receptors in the habenulo-interpeduncular system are necessary for nicotine withdrawal in mice

31 March 2020

1 reference

The hidden island of addiction: the insula

31 March 2020

1 reference

Brain activation by short-term nicotine exposure in anesthetized wild-type and beta2-nicotinic receptors knockout mice: a BOLD fMRI study.

31 March 2020

1 reference

Neural systems of reinforcement for drug addiction: from actions to habits to compulsion

31 March 2020

1 reference

Review. Neurobiological mechanisms for opponent motivational processes in addiction

31 March 2020

1 reference

Nicotine self-administration acutely activates brain reward systems and induces a long-lasting increase in reward sensitivity

31 March 2020

1 reference

A neurocomputational hypothesis for nicotine addiction

31 March 2020

1 reference

The neurobiology of tobacco dependence: a preclinical perspective on the role of the dopamine projections to the nucleus accumbens [corrected].

31 March 2020

1 reference

Effects of nicotinic stimulation on cognitive performance

31 March 2020

1 reference

Nicotinic receptor subtypes and cognitive function

31 March 2020

1 reference

Dissociations between the locomotor stimulant and depressant effects of nicotinic agonists in rats

31 March 2020

1 reference

Nicotinic actions on neuronal networks for cognition: general principles and long-term consequences

31 March 2020

1 reference

Fear conditioning and latent inhibition in mice lacking the high affinity subclass of nicotinic acetylcholine receptors in the brain

31 March 2020

1 reference

Executive and social behaviors under nicotinic receptor regulation

31 March 2020

1 reference

Effects of nicotine in the dopaminergic system of mice lacking the alpha4 subunit of neuronal nicotinic acetylcholine receptors.

31 March 2020

1 reference

Point mutant mice with hypersensitive alpha 4 nicotinic receptors show dopaminergic deficits and increased anxiety.

31 March 2020

1 reference

The beta3 nicotinic receptor subunit: a component of alpha-conotoxin MII-binding nicotinic acetylcholine receptors that modulate dopamine release and related behaviors.

31 March 2020

1 reference

The alpha3 and beta4 nicotinic acetylcholine receptor subunits are necessary for nicotine-induced seizures and hypolocomotion in mice

31 March 2020

1 reference

Performance deficit of alpha7 nicotinic receptor knockout mice in a delayed matching-to-place task suggests a mild impairment of working/episodic-like memory

31 March 2020

1 reference

Amygdala modulation of memory consolidation: interaction with other brain systems

31 March 2020

1 reference

Nicotine improves sustained attention in mice: evidence for involvement of the alpha7 nicotinic acetylcholine receptor

31 March 2020

1 reference

Impaired passive avoidance learning in mice lacking central neuronal nicotinic acetylcholine receptors

31 March 2020

1 reference

Nicotine self-administration in animals as a dependence model

31 March 2020

1 reference

Crucial role of alpha4 and alpha6 nicotinic acetylcholine receptor subunits from ventral tegmental area in systemic nicotine self-administration

31 March 2020

1 reference

Reinforcing effects of nicotine microinjections into the ventral tegmental area of mice: dependence on cholinergic nicotinic and dopaminergic D1 receptors

31 March 2020

1 reference

Acetylcholine receptors containing the beta2 subunit are involved in the reinforcing properties of nicotine

31 March 2020

1 reference

Assessment of nicotinic acetylcholine receptor subunit contributions to nicotine self-administration in mutant mice

31 March 2020

1 reference

Molecular and physiological diversity of nicotinic acetylcholine receptors in the midbrain dopaminergic nuclei

31 March 2020

1 reference

The beta2 but not alpha7 subunit of the nicotinic acetylcholine receptor is required for nicotine-conditioned place preference in mice

31 March 2020

1 reference

The role of nicotinic receptor alpha 7 subunits in nicotine discrimination

31 March 2020

1 reference

The role of alpha6-containing nicotinic acetylcholine receptors in nicotine reward and withdrawal

31 March 2020

1 reference

Nicotinic alpha7- or beta2-containing receptor knockout: effects on radial-arm maze learning and long-term nicotine consumption in mice

31 March 2020

1 reference

Sensitization of the mesoaccumbens dopamine response to nicotine

31 March 2020

1 reference

Neural mechanisms underlying nicotine addiction: acute positive reinforcement and withdrawal

31 March 2020

1 reference

Burst firing in midbrain dopaminergic neurons

31 March 2020

1 reference

Afferent modulation of dopamine neuron firing patterns

31 March 2020

1 reference

The control of firing pattern in nigral dopamine neurons: single spike firing

31 March 2020

1 reference

Burst stimulation of the medial forebrain bundle selectively increases Fos-like immunoreactivity in the limbic forebrain of the rat

31 March 2020

1 reference

Increased expression of NGFI-A mRNA in the rat striatum following burst stimulation of the medial forebrain bundle

31 March 2020

1 reference

Getting formal with dopamine and reward

31 March 2020

1 reference

Cholinergic modulation of dopaminergic reward areas: upstream and downstream targets of nicotine addiction

31 March 2020

1 reference

Afferent modulation of dopamine neuron firing differentially regulates tonic and phasic dopamine transmission

31 March 2020

1 reference

The hippocampus modulates dopamine neuron responsivity by regulating the intensity of phasic neuron activation

31 March 2020

1 reference

Nicotine amplifies reward-related dopamine signals in striatum

31 March 2020

1 reference

Frequency-dependent modulation of dopamine release by nicotine

31 March 2020

1 reference

Endogenous nicotinic cholinergic activity regulates dopamine release in the striatum

31 March 2020

1 reference

Alpha6-containing nicotinic acetylcholine receptors dominate the nicotine control of dopamine neurotransmission in nucleus accumbens.

31 March 2020

1 reference

Meaningful silences: how dopamine listens to the ACh pause

31 March 2020

1 reference

Dopamine signaling differences in the nucleus accumbens and dorsal striatum exploited by nicotine

31 March 2020

1 reference

Synaptic mechanisms underlie nicotine-induced excitability of brain reward areas

31 March 2020

1 reference

A versatile system for the neuronal subtype specific expression of lentiviral vectors

31 March 2020

1 reference

Nicotinic effects on cognitive function: behavioral characterization, pharmacological specification, and anatomic localization

31 March 2020

1 reference

Cholinergic mediation of attention: contributions of phasic and tonic increases in prefrontal cholinergic activity

31 March 2020

1 reference

Mice Deficient in the α7 Neuronal Nicotinic Acetylcholine Receptor Lack α-Bungarotoxin Binding Sites and Hippocampal Fast Nicotinic Currents

31 March 2020

1 reference

Nicotinic and muscarinic modulations of excitatory synaptic transmission in the rat prefrontal cortex in vitro

31 March 2020

1 reference

Nicotine induces glutamate release from thalamocortical terminals in prefrontal cortex

31 March 2020

1 reference

Distributed network actions by nicotine increase the threshold for spike-timing-dependent plasticity in prefrontal cortex

31 March 2020

1 reference

Gating of information flow within the limbic system and the pathophysiology of schizophrenia

31 March 2020

1 reference

Critical role of the prefrontal cortex in the regulation of hippocampus-accumbens information flow

31 March 2020

1 reference

Nicotinic mechanisms influencing synaptic plasticity in the hippocampus

31 March 2020

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Activation of nicotinic acetylcholine receptors induces long-term potentiation in vivo in the intact mouse dentate gyrus.

31 March 2020

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Chronic nicotine cell specifically upregulates functional alpha 4* nicotinic receptors: basis for both tolerance in midbrain and enhanced long-term potentiation in perforant path.

31 March 2020

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Nicotine activates immature "silent" connections in the developing hippocampus

31 March 2020

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Nicotinic modulation of network and synaptic transmission in the immature hippocampus investigated with genetically modified mice

31 March 2020

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Dopamine enables in vivo synaptic plasticity associated with the addictive drug nicotine

31 March 2020

1 reference

Distribution of alpha 2, alpha 3, alpha 4, and beta 2 neuronal nicotinic receptor subunit mRNAs in the central nervous system: a hybridization histochemical study in the rat.

31 March 2020

1 reference

Comparison of alpha2 nicotinic acetylcholine receptor subunit mRNA expression in the central nervous system of rats and mice

31 March 2020

1 reference

Alpha2 nicotine receptors function as a molecular switch to continuously excite a subset of interneurons in rat hippocampal circuits

31 March 2020

1 reference

Presynaptic type III neuregulin 1 is required for sustained enhancement of hippocampal transmission by nicotine and for axonal targeting of alpha7 nicotinic acetylcholine receptors

31 March 2020

1 reference

Immunocytochemical localization of a neuronal nicotinic receptor: the beta 2-subunit.

31 March 2020

1 reference

Molecular cloning, functional properties, and distribution of rat brain alpha 7: a nicotinic cation channel highly permeable to calcium

31 March 2020

1 reference

Facilitation of cortico-amygdala synapses by nicotine: activity-dependent modulation of glutamatergic transmission

31 March 2020

1 reference

Desensitization of the nicotine-induced mesolimbic dopamine responses during constant infusion with nicotine

31 March 2020

1 reference

Psychostimulant-induced behavioral sensitization depends on nicotinic receptor activation.

31 March 2020

1 reference

Sensitization, drug addiction and psychopathology in animals and humans

31 March 2020

1 reference

Voluntary nicotine consumption triggers in vivo potentiation of cortical excitatory drives to midbrain dopaminergic neurons.

31 March 2020

1 reference

Cell autonomy, receptor autonomy, and thermodynamics in nicotine receptor up-regulation

31 March 2020

1 reference

An extracellular protein microdomain controls up-regulation of neuronal nicotinic acetylcholine receptors by nicotine

31 March 2020

1 reference

Nicotine upregulates its own receptors through enhanced intracellular maturation

31 March 2020

1 reference

Nicotine as a modulator of behavior: beyond the inverted U.

31 March 2020

1 reference

Exposure to nicotine and sensitization of nicotine-induced behaviors

31 March 2020

1 reference

Long-term effects of chronic nicotine exposure on brain nicotinic receptors

31 March 2020

1 reference

Cellular and molecular mechanisms of drug dependence

31 March 2020

1 reference

Disruption of NMDAR-dependent burst firing by dopamine neurons provides selective assessment of phasic dopamine-dependent behavior.

31 March 2020

1 reference

Severity of withdrawal symptoms as a predictor of outcome of an attempt to quit smoking.

31 March 2020

1 reference

Differential role of nicotinic acetylcholine receptor subunits in physical and affective nicotine withdrawal signs

31 March 2020

1 reference

Decreased brain reward function during nicotine withdrawal in C57BL6 mice: evidence from intracranial self-stimulation (ICSS) studies

31 March 2020

1 reference

The antinociceptive effects of alpha7 nicotinic agonists in an acute pain model

31 March 2020

1 reference

Decreased signs of nicotine withdrawal in mice null for the beta4 nicotinic acetylcholine receptor subunit

31 March 2020

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Decreased withdrawal symptoms but normal tolerance to nicotine in mice null for the alpha7 nicotinic acetylcholine receptor subunit

31 March 2020

1 reference

Genetic dissociation of two behaviors associated with nicotine addiction: beta-2 containing nicotinic receptors are involved in nicotine reinforcement but not in withdrawal syndrome.

31 March 2020

1 reference

Nicotine relieves anxiogenic-like behavior in mice that overexpress the read-through variant of acetylcholinesterase but not in wild-type mice

31 March 2020

1 reference

Beta2 subunit containing acetylcholine receptors mediate nicotine withdrawal deficits in the acquisition of contextual fear conditioning

31 March 2020

1 reference

Diversity and distribution of nicotinic acetylcholine receptors in the locus ceruleus neurons.

31 March 2020

1 reference

Distribution and pharmacology of alpha 6-containing nicotinic acetylcholine receptors analyzed with mutant mice

31 March 2020

1 reference

Demonstration of functional alpha4-containing nicotinic receptors in the medial habenula

31 March 2020

1 reference

Anti-addictive actions of an iboga alkaloid congener: a novel mechanism for a novel treatment

31 March 2020

1 reference

Lateral habenula as a source of negative reward signals in dopamine neurons

31 March 2020

1 reference

Habenula: crossroad between the basal ganglia and the limbic system

31 March 2020

1 reference

Supplementing high-density SNP microarrays for additional coverage of disease-related genes: addiction as a paradigm

31 March 2020

1 reference

New insights into the genetics of addiction

31 March 2020

1 reference

Neural processes underlying conscious perception: experimental findings and a global neuronal workspace framework

31 March 2020

1 reference

Timing of the brain events underlying access to consciousness during the attentional blink

31 March 2020

1 reference

Brain dynamics underlying the nonlinear threshold for access to consciousness

31 March 2020

1 reference

Damage to the insula disrupts addiction to cigarette smoking

31 March 2020

1 reference

Inactivation of the interoceptive insula disrupts drug craving and malaise induced by lithium

31 March 2020

1 reference

The prefrontal cortex and cognitive control

31 March 2020

1 reference

Repeated high-frequency transcranial magnetic stimulation over the dorsolateral prefrontal cortex reduces cigarette craving and consumption

31 March 2020

1 reference

Reduced frontal white matter integrity in cocaine dependence: a controlled diffusion tensor imaging study

31 March 2020

1 reference

Disrupted white matter integrity in heroin dependence: a controlled study utilizing diffusion tensor imaging

31 March 2020

1 reference

Prenatal and adolescent exposure to tobacco smoke modulates the development of white matter microstructure.

31 March 2020

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Differential regulation of neocortical synapses by neuromodulators and activity

31 March 2020

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Evidence for "preterminal" nicotinic receptors on GABAergic axons in the rat interpeduncular nucleus.

31 March 2020

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Nicotinic control of axon excitability regulates thalamocortical transmission

31 March 2020

1 reference

Insular hypocretin transmission regulates nicotine reward

31 March 2020

1 reference

The effects of chronic versus acute desipramine on nicotine withdrawal and nicotine self-administration in the rat.

31 March 2020

1 reference

Nicotinic receptors, allosteric proteins and medicine.

31 March 2020

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The putative role of extra-synaptic mesolimbic dopamine in the neurobiology of nicotine dependence

31 March 2020

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The neuronal pathways mediating the behavioral and addictive properties of nicotine

31 March 2020

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Role of dopamine in the behavioural actions of nicotine related to addiction

31 March 2020

1 reference

Neuronal systems underlying behaviors related to nicotine addiction: neural circuits and molecular genetics.

31 March 2020

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The cholinergic mesopontine tegmentum is a relatively neglected nicotinic master modulator of the dopaminergic system: relevance to drugs of abuse and pathology

31 March 2020

1 reference

31 March 2020

Identifiers

DOI

10.1038/NRN2849

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22 August 2017

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