(Q37626406)

21 August 2017

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title

Generating specificity and diversity in the transcriptional response to hypoxia (English)

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21 August 2017

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21 August 2017

Kian Leong Lee

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21 August 2017

Henry Yang

series ordinal

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21 August 2017

Lorenz Poellinger

series ordinal

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21 August 2017

publication date

3 November 2009

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21 August 2017

published in

Nature Reviews Genetics

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21 August 2017

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21 August 2017

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21 August 2017

page(s)

821-832

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Targeting HIF-1 for cancer therapy

21 August 2017

cites work

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The human side of hypoxia-inducible factor

31 March 2020

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31 March 2020

Biology of HIF-1alpha

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Hypoxia-induced signaling in the cardiovascular system

31 March 2020

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HIF gene expression in cancer therapy

31 March 2020

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Hypoxia--a key regulatory factor in tumour growth

31 March 2020

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Hypoxia, HIF1 and glucose metabolism in the solid tumour

31 March 2020

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Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension

31 March 2020

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Transcriptional repression of human cad gene by hypoxia inducible factor-1alpha

31 March 2020

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Regulation of iron homeostasis by the hypoxia-inducible transcription factors (HIFs).

31 March 2020

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Genome-wide association of hypoxia-inducible factor (HIF)-1alpha and HIF-2alpha DNA binding with expression profiling of hypoxia-inducible transcripts

31 March 2020

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Constitutive function of the basic helix-loop-helix/PAS factor Arnt. Regulation of target promoters via the E box motif

31 March 2020

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Possible function of Ah receptor nuclear translocator (Arnt) homodimer in transcriptional regulation

31 March 2020

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Role of the PAS domain in regulation of dimerization and DNA binding specificity of the dioxin receptor

31 March 2020

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Role of CBP in regulating HIF-1-mediated activation of transcription.

31 March 2020

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Redox-regulated recruitment of the transcriptional coactivators CREB-binding protein and SRC-1 to hypoxia-inducible factor 1alpha

31 March 2020

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Histone deacetylase 7 associates with hypoxia-inducible factor 1alpha and increases transcriptional activity

31 March 2020

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FIH-1: a novel protein that interacts with HIF-1alpha and VHL to mediate repression of HIF-1 transcriptional activity

31 March 2020

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Activation of hypoxia-inducible factor 1alpha: posttranscriptional regulation and conformational change by recruitment of the Arnt transcription factor

31 March 2020

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Hypoxia-inducible factor 1alpha (HIF-1alpha) protein is rapidly degraded by the ubiquitin-proteasome system under normoxic conditions. Its stabilization by hypoxia depends on redox-induced changes

31 March 2020

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Regulation of hypoxia-inducible factor 1alpha is mediated by an O2-dependent degradation domain via the ubiquitin-proteasome pathway

31 March 2020

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Signal transduction in hypoxic cells: inducible nuclear translocation and recruitment of the CBP/p300 coactivator by the hypoxia-inducible factor-1alpha

31 March 2020

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Regulation of the hypoxia-inducible transcription factor 1alpha by the ubiquitin-proteasome pathway

31 March 2020

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Structure of the VHL-ElonginC-ElonginB complex: implications for VHL tumor suppressor function

31 March 2020

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Mechanism of regulation of the hypoxia-inducible factor-1 alpha by the von Hippel-Lindau tumor suppressor protein

31 March 2020

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Ubiquitination of hypoxia-inducible factor requires direct binding to the beta-domain of the von Hippel-Lindau protein

31 March 2020

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Hypoxia inducible factor-alpha binding and ubiquitylation by the von Hippel-Lindau tumor suppressor protein

31 March 2020

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HIFalpha targeted for VHL-mediated destruction by proline hydroxylation: implications for O2 sensing

31 March 2020

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Targeting of HIF-alpha to the von Hippel-Lindau ubiquitylation complex by O2-regulated prolyl hydroxylation

31 March 2020

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C. elegans EGL-9 and mammalian homologs define a family of dioxygenases that regulate HIF by prolyl hydroxylation

31 March 2020

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A conserved family of prolyl-4-hydroxylases that modify HIF

31 March 2020

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Asparagine hydroxylation of the HIF transactivation domain a hypoxic switch

31 March 2020

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FIH-1 is an asparaginyl hydroxylase enzyme that regulates the transcriptional activity of hypoxia-inducible factor

31 March 2020

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Hypoxia-inducible factor (HIF) asparagine hydroxylase is identical to factor inhibiting HIF (FIH) and is related to the cupin structural family

31 March 2020

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RSUME, a small RWD-containing protein, enhances SUMO conjugation and stabilizes HIF-1alpha during hypoxia

31 March 2020

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SUMO-specific protease 1 is essential for stabilization of HIF1alpha during hypoxia

31 March 2020

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Identification of an alternative mechanism of degradation of the hypoxia-inducible factor-1alpha

31 March 2020

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The aryl hydrocarbon receptor nuclear transporter is modulated by the SUMO-1 conjugation system

31 March 2020

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Circadian clock control by SUMOylation of BMAL1.

31 March 2020

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Regulation of HIF-1alpha stability through S-nitrosylation

31 March 2020

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Functional interference between hypoxia and dioxin signal transduction pathways: competition for recruitment of the Arnt transcription factor

31 March 2020

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RACK1 competes with HSP90 for binding to HIF-1alpha and is required for O(2)-independent and HSP90 inhibitor-induced degradation of HIF-1alpha

31 March 2020

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Inhibition of PPAR gamma 2 gene expression by the HIF-1-regulated gene DEC1/Stra13: a mechanism for regulation of adipogenesis by hypoxia

31 March 2020

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Epidermal sensing of oxygen is essential for systemic hypoxic response

31 March 2020

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Stabilization of HIF-1alpha is critical to improve wound healing in diabetic mice

31 March 2020

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Cellular and developmental control of O2 homeostasis by hypoxia-inducible factor 1α

31 March 2020

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HIF-1 alpha is required for solid tumor formation and embryonic vascularization.

31 March 2020

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Role of HIF-1alpha in hypoxia-mediated apoptosis, cell proliferation and tumour angiogenesis

31 March 2020

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Abnormal angiogenesis and responses to glucose and oxygen deprivation in mice lacking the protein ARNT.

31 March 2020

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The hypoxia-responsive transcription factor EPAS1 is essential for catecholamine homeostasis and protection against heart failure during embryonic development

31 March 2020

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The transcription factor EPAS-1/hypoxia-inducible factor 2alpha plays an important role in vascular remodeling

31 March 2020

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Loss of HIF-2alpha and inhibition of VEGF impair fetal lung maturation, whereas treatment with VEGF prevents fatal respiratory distress in premature mice

31 March 2020

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Multiple organ pathology, metabolic abnormalities and impaired homeostasis of reactive oxygen species in Epas1-/- mice

31 March 2020

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HLF/HIF-2alpha is a key factor in retinopathy of prematurity in association with erythropoietin

31 March 2020

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HIF-1alpha is essential for myeloid cell-mediated inflammation

31 March 2020

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NF-kappaB links innate immunity to the hypoxic response through transcriptional regulation of HIF-1alpha

31 March 2020

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Abnormal heart development and lung remodeling in mice lacking the hypoxia-inducible factor-related basic helix-loop-helix PAS protein NEPAS

31 March 2020

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Activation of a HIF1alpha-PPARgamma axis underlies the integration of glycolytic and lipid anabolic pathways in pathologic cardiac hypertrophy.

31 March 2020

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A family with erythrocytosis establishes a role for prolyl hydroxylase domain protein 2 in oxygen homeostasis

31 March 2020

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A gain-of-function mutation in the HIF2A gene in familial erythrocytosis

31 March 2020

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Disruption of oxygen homeostasis underlies congenital Chuvash polycythemia

31 March 2020

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Oxygen sensing by HIF hydroxylases

31 March 2020

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Hypoxia-induced retinal angiogenesis in zebrafish as a model to study retinopathy

31 March 2020

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Transcriptome analysis of the response to chronic constant hypoxia in zebrafish hearts.

31 March 2020

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Gene expression profile of zebrafish exposed to hypoxia during development

31 March 2020

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Zebrafish mutants in the von Hippel-Lindau tumor suppressor display a hypoxic response and recapitulate key aspects of Chuvash polycythemia

31 March 2020

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Distinct mechanisms underlying tolerance to intermittent and constant hypoxia in Drosophila melanogaster

31 March 2020

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Mechanisms underlying hypoxia tolerance in Drosophila melanogaster: hairy as a metabolic switch

31 March 2020

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Experimental selection for Drosophila survival in extremely low O(2) environment

31 March 2020

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Roles of the HIF-1 hypoxia-inducible factor during hypoxia response in Caenorhabditis elegans.

31 March 2020

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Genetic analysis of pathways regulated by the von Hippel-Lindau tumor suppressor in Caenorhabditis elegans

31 March 2020

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A predictive model of the oxygen and heme regulatory network in yeast

31 March 2020

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Heme levels switch the function of Hap1 of Saccharomyces cerevisiae between transcriptional activator and transcriptional repressor

31 March 2020

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The enduring hypoxic response of Mycobacterium tuberculosis

31 March 2020

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Rv3133c/dosR is a transcription factor that mediates the hypoxic response of Mycobacterium tuberculosis

31 March 2020

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Regulation of the Mycobacterium tuberculosis hypoxic response gene encoding α-crystallin

31 March 2020

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A central integrator of transcription networks in plant stress and energy signalling.

31 March 2020

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A genome-wide analysis of the effects of sucrose on gene expression in Arabidopsis seedlings under anoxia

31 March 2020

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Gene expression programs in response to hypoxia: cell type specificity and prognostic significance in human cancers

31 March 2020

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An integrative genomics approach identifies Hypoxia Inducible Factor-1 (HIF-1)-target genes that form the core response to hypoxia.

31 March 2020

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A novel normalization method for effective removal of systematic variation in microarray data

31 March 2020

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Integrative analysis of HIF binding and transactivation reveals its role in maintaining histone methylation homeostasis

31 March 2020

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Regulation of Jumonji-domain-containing histone demethylases by hypoxia-inducible factor (HIF)-1alpha

31 March 2020

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The histone demethylases JMJD1A and JMJD2B are transcriptional targets of hypoxia-inducible factor HIF.

31 March 2020

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Gene expression profiling of hypoxia signaling in human hepatocellular carcinoma cells

31 March 2020

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MicroRNAs: genomics, biogenesis, mechanism, and function

31 March 2020

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The widespread impact of mammalian MicroRNAs on mRNA repression and evolution

31 March 2020

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MicroRNAs: small RNAs with a big role in gene regulation

31 March 2020

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A microRNA signature of hypoxia

31 March 2020

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MiRNA-directed regulation of VEGF and other angiogenic factors under hypoxia

31 March 2020

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MicroRNA regulation of DNA repair gene expression in hypoxic stress

31 March 2020

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Epigenetics: a landscape takes shape

31 March 2020

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How chromatin-binding modules interpret histone modifications: lessons from professional pocket pickers

31 March 2020

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The putative oncogene GASC1 demethylates tri- and dimethylated lysine 9 on histone H3

31 March 2020

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Reversal of histone lysine trimethylation by the JMJD2 family of histone demethylases

31 March 2020

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JHDM2A, a JmjC-containing H3K9 demethylase, facilitates transcription activation by androgen receptor

31 March 2020

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Expanding chemical biology of 2-oxoglutarate oxygenases

31 March 2020

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Recruitment of HIF-1α and HIF-2α to common target genes is differentially regulated in neuroblastoma: HIF-2α promotes an aggressive phenotype

31 March 2020

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Contrasting properties of hypoxia-inducible factor 1 (HIF-1) and HIF-2 in von Hippel-Lindau-associated renal cell carcinoma.

31 March 2020

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HIF-1alpha induces cell cycle arrest by functionally counteracting Myc.

31 March 2020

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HIF-2alpha promotes hypoxic cell proliferation by enhancing c-myc transcriptional activity

31 March 2020

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Transcriptional up-regulation of inhibitory PAS domain protein gene expression by hypoxia-inducible factor 1 (HIF-1): a negative feedback regulatory circuit in HIF-1-mediated signaling in hypoxic cells

31 March 2020

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The human HIF (hypoxia-inducible factor)-3alpha gene is a HIF-1 target gene and may modulate hypoxic gene induction

31 March 2020

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Inhibitory PAS domain protein (IPAS) is a hypoxia-inducible splicing variant of the hypoxia-inducible factor-3alpha locus

31 March 2020

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Inhibitory PAS domain protein is a negative regulator of hypoxia-inducible gene expression

31 March 2020

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Jmjd6 catalyses lysyl-hydroxylation of U2AF65, a protein associated with RNA splicing

31 March 2020

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ARDent about acetylation and deacetylation in hypoxia signalling.

31 March 2020

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Regulation of hypoxia-inducible factor 2alpha signaling by the stress-responsive deacetylase sirtuin 1.

31 March 2020

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Sirtuin functions in health and disease

31 March 2020

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The Rpd3/Hda1 family of lysine deacetylases: from bacteria and yeast to mice and men

31 March 2020

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Crossing paths with Notch in the hyper-network

31 March 2020

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Jade-1 inhibits Wnt signalling by ubiquitylating beta-catenin and mediates Wnt pathway inhibition by pVHL

31 March 2020

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Hypoxia signalling through mTOR and the unfolded protein response in cancer

31 March 2020

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Involvement of estrogen-related receptors in transcriptional response to hypoxia and growth of solid tumors

31 March 2020

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HIF-independent regulation of VEGF and angiogenesis by the transcriptional coactivator PGC-1α

31 March 2020

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Transcriptional regulation and transformation by Myc proteins

31 March 2020

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HIF-1alpha induces genetic instability by transcriptionally downregulating MutSalpha expression.

31 March 2020

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HIF-1 inhibits mitochondrial biogenesis and cellular respiration in VHL-deficient renal cell carcinoma by repression of C-MYC activity

31 March 2020

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HIF-1alpha induces MXI1 by alternate promoter usage in human neuroblastoma cells.

31 March 2020

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An amino-terminal domain of Mxi1 mediates anti-Myc oncogenic activity and interacts with a homolog of the yeast transcriptional repressor SIN3

31 March 2020

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HIF-alpha effects on c-Myc distinguish two subtypes of sporadic VHL-deficient clear cell renal carcinoma

31 March 2020

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Delta-like 4 Notch ligand regulates tumor angiogenesis, improves tumor vascular function, and promotes tumor growth in vivo.

31 March 2020

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Hypoxia-mediated activation of Dll4-Notch-Hey2 signaling in endothelial progenitor cells and adoption of arterial cell fate

31 March 2020

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Notch signaling mediates hypoxia-induced tumor cell migration and invasion

31 March 2020

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Hypoxia requires notch signaling to maintain the undifferentiated cell state

31 March 2020

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Heterozygosity for hypoxia inducible factor 1alpha decreases the incidence of thymic lymphomas in a p53 mutant mouse model

31 March 2020

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Asparaginyl hydroxylation of the Notch ankyrin repeat domain by factor inhibiting hypoxia-inducible factor

31 March 2020

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Interaction with factor inhibiting HIF-1 defines an additional mode of cross-coupling between the Notch and hypoxia signaling pathways

31 March 2020

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Differences in hydroxylation and binding of Notch and HIF-1alpha demonstrate substrate selectivity for factor inhibiting HIF-1 (FIH-1).

31 March 2020

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Proteomics-based identification of novel factor inhibiting hypoxia-inducible factor (FIH) substrates indicates widespread asparaginyl hydroxylation of ankyrin repeat domain-containing proteins.

31 March 2020

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Ero1L, a thiol oxidase, is required for Notch signaling through cysteine bridge formation of the Lin12-Notch repeats in Drosophila melanogaster

31 March 2020

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Continuous hypoxic culturing maintains activation of Notch and allows long-term propagation of human embryonic stem cells without spontaneous differentiation

31 March 2020

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Hypoxia alters gene expression in human neuroblastoma cells toward an immature and neural crest-like phenotype

31 March 2020

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Oxygen sensing by metazoans: the central role of the HIF hydroxylase pathway

31 March 2020

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Epidithiodiketopiperazines block the interaction between hypoxia-inducible factor-1alpha (HIF-1alpha) and p300 by a zinc ejection mechanism

31 March 2020

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HIF-2alpha regulates Oct-4: effects of hypoxia on stem cell function, embryonic development, and tumor growth.

31 March 2020

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12 December 2020

Molecular characterization and chromosomal localization of a third alpha-class hypoxia inducible factor subunit, HIF3alpha

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12 December 2020

Protein-protein interaction via PAS domains: role of the PAS domain in positive and negative regulation of the bHLH/PAS dioxin receptor-Arnt transcription factor complex

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12 December 2020

Oxygen-regulated beta(2)-adrenergic receptor hydroxylation by EGLN3 and ubiquitylation by pVHL

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12 December 2020

Integration of oxygen signaling at the consensus HRE.

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12 December 2020

Repression of alpha-fetoprotein gene expression under hypoxic conditions in human hepatoma cells: characterization of a negative hypoxia response element that mediates opposite effects of hypoxia inducible factor-1 and c-Myc

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12 December 2020

Identifiers

DOI

10.1038/NRG2665

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Dimensions Publication ID

21 August 2017

1045717479

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