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English
Core binding factor at the crossroads: determining the fate of the HSC.
scientific article published on January 2010
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scholarly article
1 reference
stated in
Europe PubMed Central
PMC publication ID
2812028
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19813271%20AND%20SRC:MED&resulttype=core&format=json
retrieved
9 February 2020
review article
1 reference
stated in
Europe PubMed Central
title
Core binding factor at the crossroads: determining the fate of the HSC
(English)
1 reference
stated in
Europe PubMed Central
PMC publication ID
2812028
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19813271%20AND%20SRC:MED&resulttype=core&format=json
retrieved
9 February 2020
author
Fu-Sheng Chou
series ordinal
2
1 reference
stated in
Europe PubMed Central
PMC publication ID
2812028
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19813271%20AND%20SRC:MED&resulttype=core&format=json
retrieved
9 February 2020
author name string
Kevin A Link
series ordinal
1
1 reference
stated in
Europe PubMed Central
PMC publication ID
2812028
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19813271%20AND%20SRC:MED&resulttype=core&format=json
retrieved
9 February 2020
James C Mulloy
series ordinal
3
1 reference
stated in
Europe PubMed Central
PMC publication ID
2812028
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19813271%20AND%20SRC:MED&resulttype=core&format=json
retrieved
9 February 2020
publication date
1 January 2010
1 reference
stated in
Europe PubMed Central
PMC publication ID
2812028
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19813271%20AND%20SRC:MED&resulttype=core&format=json
retrieved
9 February 2020
published in
Journal of Cellular Physiology
1 reference
stated in
Europe PubMed Central
PMC publication ID
2812028
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19813271%20AND%20SRC:MED&resulttype=core&format=json
retrieved
9 February 2020
volume
222
1 reference
stated in
Europe PubMed Central
PMC publication ID
2812028
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19813271%20AND%20SRC:MED&resulttype=core&format=json
retrieved
9 February 2020
issue
1
1 reference
stated in
Europe PubMed Central
PMC publication ID
2812028
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19813271%20AND%20SRC:MED&resulttype=core&format=json
retrieved
9 February 2020
page(s)
50-56
1 reference
stated in
Europe PubMed Central
PMC publication ID
2812028
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19813271%20AND%20SRC:MED&resulttype=core&format=json
retrieved
9 February 2020
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t(8;21)(q22;q22) Fusion proteins preferentially bind to duplicated AML1/RUNX1 DNA-binding sequences to differentially regulate gene expression
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AML1/Runx1 negatively regulates quiescent hematopoietic stem cells in adult hematopoiesis.
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23 August 2017
p53 signaling in response to increased DNA damage sensitizes AML1-ETO cells to stress-induced death
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23 August 2017
Structural basis for recognition of SMRT/N-CoR by the MYND domain and its contribution to AML1/ETO's activity
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The p21Waf1 pathway is involved in blocking leukemogenesis by the t(8;21) fusion protein AML1-ETO.
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23 August 2017
CBFB-MYH11 hinders early T-cell development and induces massive cell death in the thymus
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23 August 2017
The tetramer structure of the Nervy homology two domain, NHR2, is critical for AML1/ETO's activity
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Loss of Runx1 perturbs adult hematopoiesis and is associated with a myeloproliferative phenotype.
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23 August 2017
Deletion of an AML1-ETO C-terminal NcoR/SMRT-interacting region strongly induces leukemia development
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Stem cell expression of the AML1/ETO fusion protein induces a myeloproliferative disorder in mice.
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23 August 2017
E protein silencing by the leukemogenic AML1-ETO fusion protein
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23 August 2017
AML-1 is required for megakaryocytic maturation and lymphocytic differentiation, but not for maintenance of hematopoietic stem cells in adult hematopoiesis
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23 August 2017
Role of RUNX1 in adult hematopoiesis: analysis of RUNX1-IRES-GFP knock-in mice reveals differential lineage expression
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23 August 2017
The ETO (MTG8) gene family
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23 August 2017
The inv(16) fusion protein associates with corepressors via a smooth muscle myosin heavy-chain domain
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23 August 2017
The core-binding factor beta subunit is required for bone formation and hematopoietic maturation
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23 August 2017
AML1 and the AML1-ETO fusion protein in the pathogenesis of t(8;21) AML.
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23 August 2017
ETO, a target of t(8;21) in acute leukemia, makes distinct contacts with multiple histone deacetylases and binds mSin3A through its oligomerization domain
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23 August 2017
Oligomerization of ETO is obligatory for corepressor interaction
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23 August 2017
A mechanism of repression by acute myeloid leukemia-1, the target of multiple chromosomal translocations in acute leukemia
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23 August 2017
Helix-loop-helix proteins: regulators of transcription in eucaryotic organisms
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23 August 2017
Biological characteristics of the leukemia-associated transcriptional factor AML1 disclosed by hematopoietic rescue of AML1-deficient embryonic stem cells by using a knock-in strategy
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23 August 2017
The leukemic protein core binding factor beta (CBFbeta)-smooth-muscle myosin heavy chain sequesters CBFalpha2 into cytoskeletal filaments and aggregates
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23 August 2017
ETO, a target of t(8;21) in acute leukemia, interacts with the N-CoR and mSin3 corepressors
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23 August 2017
ETO, fusion partner in t(8;21) acute myeloid leukemia, represses transcription by interaction with the human N-CoR/mSin3/HDAC1 complex
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23 August 2017
Absence of fetal liver hematopoiesis in mice deficient in transcriptional coactivator core binding factor beta
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23 August 2017
Core binding factor beta-smooth muscle myosin heavy chain chimeric protein involved in acute myeloid leukemia forms unusual nuclear rod-like structures in transformed NIH 3T3 cells
1 reference
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23 August 2017
Deficiencies in progenitor cells of multiple hematopoietic lineages and defective megakaryocytopoiesis in mice lacking the thrombopoietic receptor c-Mpl
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23 August 2017
Disruption of the Cbfa2 gene causes necrosis and hemorrhaging in the central nervous system and blocks definitive hematopoiesis
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23 August 2017
AML1, the target of multiple chromosomal translocations in human leukemia, is essential for normal fetal liver hematopoiesis
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PubMed Central
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23 August 2017
Transcriptional upregulation of p21/WAF/Cip1 in myeloid leukemic blasts expressing AML1-ETO.
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6 September 2017
Human CD34+ cells expressing the inv(16) fusion protein exhibit a myelomonocytic phenotype with greatly enhanced proliferative ability
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6 September 2017
VWRPY motif–dependent and –independent roles of AML1/Runx1 transcription factor in murine hematopoietic development
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6 September 2017
Expression of a conditional AML1-ETO oncogene bypasses embryonic lethality and establishes a murine model of human t(8;21) acute myeloid leukemia
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6 September 2017
Cytoplasmic sequestration of the polyomavirus enhancer binding protein 2 (PEBP2)/core binding factor alpha (CBFalpha) subunit by the leukemia-related PEBP2/CBFbeta-SMMHC fusion protein inhibits PEBP2/CBF-mediated transactivation
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6 September 2017
Multimerization via its myosin domain facilitates nuclear localization and inhibition of core binding factor (CBF) activities by the CBFbeta-smooth muscle myosin heavy chain myeloid leukemia oncoprotein
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14 September 2017
Hematopoietic stem cell expansion and distinct myeloid developmental abnormalities in a murine model of the AML1-ETO translocation
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2812028
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14 September 2017
Aberrant recruitment of the nuclear receptor corepressor-histone deacetylase complex by the acute myeloid leukemia fusion partner ETO.
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PubMed Central
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14 September 2017
Thrombopoietin/MPL signaling regulates hematopoietic stem cell quiescence and interaction with the osteoblastic niche.
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14 September 2017
A previously unidentified alternatively spliced isoform of t(8;21) transcript promotes leukemogenesis
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14 September 2017
The transcriptionally active form of AML1 is required for hematopoietic rescue of the AML1-deficient embryonic para-aortic splanchnopleural (P-Sp) region
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14 September 2017
Molecular basis for a dominant inactivation of RUNX1/AML1 by the leukemogenic inversion 16 chimera
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PubMed Central
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14 September 2017
The AML1-ETO fusion protein promotes the expansion of human hematopoietic stem cells
1 reference
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2812028
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28 September 2017
AML1 mutations induced MDS and MDS/AML in a mouse BMT model
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2812028
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25 June 2018
Repression of interleukin-4 in T helper type 1 cells by Runx/Cbf beta binding to the Il4 silencer
1 reference
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2812028
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25 June 2018
Runx1 is expressed in adult mouse hematopoietic stem cells and differentiating myeloid and lymphoid cells, but not in maturing erythroid cells
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2812028
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25 June 2018
Cbfa2 is required for the formation of intra-aortic hematopoietic clusters.
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2812028
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25 June 2018
Thrombopoietin promotes the survival of murine hematopoietic long-term reconstituting cells: comparison with the effects of FLT3/FLK-2 ligand and interleukin-6.
1 reference
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2812028
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25 June 2018
Oncogenic transcription factors in the human acute leukemias
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2812028
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25 June 2018
Embryonic lethality and impairment of haematopoiesis in mice heterozygous for an AML1-ETO fusion gene.
1 reference
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2812028
retrieved
25 June 2018
The CBFbeta subunit is essential for CBFalpha2 (AML1) function in vivo
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2812028
retrieved
25 June 2018
Cell-cycle restriction limits DNA damage and maintains self-renewal of leukaemia stem cells
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2812028
retrieved
1 September 2018
RUNX1 DNA-binding mutants, associated with minimally differentiated acute myelogenous leukemia, disrupt myeloid differentiation.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2812028
retrieved
1 September 2018
A Limited role for p21Cip1/Waf1 in maintaining normal hematopoietic stem cell functioning.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2812028
retrieved
1 September 2018
T-lymphoid, megakaryocyte, and granulocyte development are sensitive to decreases in CBFbeta dosage
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2812028
retrieved
1 September 2018
The t(8;21) translocation converts AML1 into a constitutive transcriptional repressor
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2812028
retrieved
1 September 2018
Maintaining the self-renewal and differentiation potential of human CD34+ hematopoietic cells using a single genetic element.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2812028
retrieved
1 September 2018
Differential requirements for Runx proteins in CD4 repression and epigenetic silencing during T lymphocyte development.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2812028
retrieved
1 September 2018
The AML1-ETO fusion gene promotes extensive self-renewal of human primary erythroid cells
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2812028
retrieved
1 September 2018
Expression of a knocked-in AML1-ETO leukemia gene inhibits the establishment of normal definitive hematopoiesis and directly generates dysplastic hematopoietic progenitors.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2812028
retrieved
1 September 2018
Failure of embryonic hematopoiesis and lethal hemorrhages in mouse embryos heterozygous for a knocked-in leukemia gene CBFB-MYH11.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2812028
retrieved
1 September 2018
PU.1 is a major downstream target of AML1 (RUNX1) in adult mouse hematopoiesis
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2812028
retrieved
3 December 2018
Haploinsufficiency of AML1 results in a decrease in the number of LTR-HSCs while simultaneously inducing an increase in more mature progenitors
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/19813271
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Cbf beta-SMMHC induces distinct abnormal myeloid progenitors able to develop acute myeloid leukemia
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/19813271
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Hematopoietic stem cell quiescence maintained by p21cip1/waf1
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/19813271
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Cooperative function of Aml1-ETO corepressor recruitment domains in the expansion of primary bone marrow cells
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/19813271
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Identifiers
DOI
10.1002/JCP.21950
1 reference
stated in
Europe PubMed Central
PMC publication ID
2812028
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19813271%20AND%20SRC:MED&resulttype=core&format=json
retrieved
9 February 2020
PMC publication ID
2812028
1 reference
stated in
Europe PubMed Central
PMC publication ID
2812028
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19813271%20AND%20SRC:MED&resulttype=core&format=json
retrieved
9 February 2020
PubMed publication ID
19813271
1 reference
stated in
Europe PubMed Central
PMC publication ID
2812028
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19813271%20AND%20SRC:MED&resulttype=core&format=json
retrieved
9 February 2020
ResearchGate publication ID
26880016
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