(Q37606286)

21 August 2017

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title

Tumour-initiating cells: challenges and opportunities for anticancer drug discovery (English)

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21 August 2017

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Bin-Bing S Zhou

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21 August 2017

Haiying Zhang

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21 August 2017

Marc Damelin

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21 August 2017

Kenneth G Geles

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21 August 2017

Justin C Grindley

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21 August 2017

Peter B Dirks

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21 August 2017

publication date

1 October 2009

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Nature Reviews Drug Discovery

21 August 2017

published in

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21 August 2017

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21 August 2017

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21 August 2017

page(s)

806-823

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Pathways to tumorigenesis--modeling mutation acquisition in stem cells and their progeny

21 August 2017

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Environmental restrictions within tumor ecosystems select for a convergent, hypoxia-resistant phenotype of cancer stem cells

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Three-dimensional tissue cytometer based on high-speed multiphoton microscopy

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The initial clinical trial of nitrogen mustard

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Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cell

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Prospective identification of tumorigenic breast cancer cells

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Identification of human brain tumour initiating cells

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A human colon cancer cell capable of initiating tumour growth in immunodeficient mice

31 March 2020

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Identification and expansion of human colon-cancer-initiating cells

31 March 2020

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Identification of pancreatic cancer stem cells

31 March 2020

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Identification of cells initiating human melanomas

31 March 2020

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Significance of CD90+ cancer stem cells in human liver cancer

31 March 2020

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Stem cells, cancer, and cancer stem cells

31 March 2020

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Applying the principles of stem-cell biology to cancer

31 March 2020

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Cancer stem cells--perspectives on current status and future directions: AACR Workshop on cancer stem cells

31 March 2020

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Tumor growth need not be driven by rare cancer stem cells

31 March 2020

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Efficient tumour formation by single human melanoma cells

31 March 2020

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Comment on "Tumor Growth Need Not Be Driven by Rare Cancer Stem Cells"

31 March 2020

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A cell initiating human acute myeloid leukaemia after transplantation into SCID mice

31 March 2020

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AML1/ETO-expressing nonleukemic stem cells in acute myelogenous leukemia with 8;21 chromosomal translocation

31 March 2020

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Identifying cancer stem cells in solid tumors: case not proven

31 March 2020

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N-cadherin expression level distinguishes reserved versus primed states of hematopoietic stem cells

31 March 2020

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CD24 and Siglec-10 selectively repress tissue damage-induced immune responses.

31 March 2020

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Stem cell marker CD133 affects clinical outcome in glioma patients.

31 March 2020

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MLL-GAS7 transforms multipotent hematopoietic progenitors and induces mixed lineage leukemias in mice

31 March 2020

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Expression of BCR/ABL and BCL-2 in myeloid progenitors leads to myeloid leukemias

31 March 2020

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MOZ-TIF2, but not BCR-ABL, confers properties of leukemic stem cells to committed murine hematopoietic progenitors.

31 March 2020

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Identification of tumorsphere- and tumor-initiating cells in HER2/Neu-induced mammary tumors

31 March 2020

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Isolation and molecular characterization of cancer stem cells in MMTV-Wnt-1 murine breast tumors

31 March 2020

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Identification of CD15 as a marker for tumor-propagating cells in a mouse model of medulloblastoma

31 March 2020

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Crypt stem cells as the cells-of-origin of intestinal cancer

31 March 2020

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Prominin 1 marks intestinal stem cells that are susceptible to neoplastic transformation

31 March 2020

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Multipotent CD15+ cancer stem cells in patched-1-deficient mouse medulloblastoma

31 March 2020

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Comprehensive genomic characterization defines human glioblastoma genes and core pathways

31 March 2020

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Core signaling pathways in human pancreatic cancers revealed by global genomic analyses

31 March 2020

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An integrated genomic analysis of human glioblastoma multiforme

31 March 2020

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Concepts of human leukemic development.

31 March 2020

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Deciphering the signaling events that promote melanoma tumor cell vasculogenic mimicry and their link to embryonic vasculogenesis: role of the Eph receptors

31 March 2020

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Tissue repair and stem cell renewal in carcinogenesis

31 March 2020

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Bmi-1 is required for maintenance of adult self-renewing haematopoietic stem cells

31 March 2020

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Bmi-1 determines the proliferative capacity of normal and leukaemic stem cells

31 March 2020

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Loss of beta-catenin impairs the renewal of normal and CML stem cells in vivo

31 March 2020

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Cutaneous cancer stem cell maintenance is dependent on beta-catenin signalling

31 March 2020

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Hedgehog signaling maintains a tumor stem cell compartment in multiple myeloma

31 March 2020

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Hedgehog signalling is essential for maintenance of cancer stem cells in myeloid leukaemia

31 March 2020

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Wnt signalling in stem cells and cancer

31 March 2020

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Transformation from committed progenitor to leukaemia stem cell initiated by MLL-AF9.

31 March 2020

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Long-term haematopoietic reconstitution by Trp53-/-p16Ink4a-/-p19Arf-/- multipotent progenitors

31 March 2020

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Imaging hematopoietic precursor division in real time

31 March 2020

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Detection, isolation, and stimulation of quiescent primitive leukemic progenitor cells from patients with acute myeloid leukemia (AML).

31 March 2020

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Medulloblastoma can be initiated by deletion of Patched in lineage-restricted progenitors or stem cells

31 March 2020

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PTEN-deficient intestinal stem cells initiate intestinal polyposis

31 March 2020

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Opinion: migrating cancer stem cells - an integrated concept of malignant tumour progression

31 March 2020

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Most early disseminated cancer cells detected in bone marrow of breast cancer patients have a putative breast cancer stem cell phenotype

31 March 2020

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Distinct populations of cancer stem cells determine tumor growth and metastatic activity in human pancreatic cancer

31 March 2020

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Epithelial-mesenchymal transitions in tumour progression

31 March 2020

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Notch promotes epithelial-mesenchymal transition during cardiac development and oncogenic transformation

31 March 2020

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let-7 regulates self renewal and tumorigenicity of breast cancer cells

31 March 2020

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The epithelial-mesenchymal transition generates cells with properties of stem cells

31 March 2020

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Stem cells and their niches

31 March 2020

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Identification of the haematopoietic stem cell niche and control of the niche size

31 March 2020

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Osteoblastic cells regulate the haematopoietic stem cell niche

31 March 2020

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Normal stem cells and cancer stem cells: the niche matters

31 March 2020

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A microenvironment-induced myeloproliferative syndrome caused by retinoic acid receptor gamma deficiency

31 March 2020

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In vivo imaging of specialized bone marrow endothelial microdomains for tumour engraftment

31 March 2020

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A perivascular niche for brain tumor stem cells

31 March 2020

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PI3K pathway regulates survival of cancer stem cells residing in the perivascular niche following radiation in medulloblastoma in vivo

31 March 2020

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Stem cell-like glioma cells promote tumor angiogenesis through vascular endothelial growth factor

31 March 2020

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Cancer stem cells in nervous system tumors

31 March 2020

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Therapeutic implications of cancer stem cells.

31 March 2020

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High stem cell frequency in acute myeloid leukemia at diagnosis predicts high minimal residual disease and poor survival

31 March 2020

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Molecular definition of breast tumor heterogeneity

31 March 2020

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Intrinsic resistance of tumorigenic breast cancer cells to chemotherapy

31 March 2020

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Mechanisms of cancer drug resistance

31 March 2020

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The ABC transporter Bcrp1/ABCG2 is expressed in a wide variety of stem cells and is a molecular determinant of the side-population phenotype

31 March 2020

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Regulation of oxidative stress by ATM is required for self-renewal of haematopoietic stem cells

31 March 2020

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Glioma stem cells promote radioresistance by preferential activation of the DNA damage response

31 March 2020

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Association of reactive oxygen species levels and radioresistance in cancer stem cells

31 March 2020

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Regulation and significance of apoptosis in the stem cells of the gastrointestinal epithelium

31 March 2020

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Bcr-Abl is a "molecular switch" for the decision for growth and differentiation in hematopoietic stem cells

31 March 2020

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Primitive, quiescent, Philadelphia-positive stem cells from patients with chronic myeloid leukemia are insensitive to STI571 in vitro

31 March 2020

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Frequency of major molecular responses to imatinib or interferon alfa plus cytarabine in newly diagnosed chronic myeloid leukemia

31 March 2020

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Persistence of malignant hematopoietic progenitors in chronic myelogenous leukemia patients in complete cytogenetic remission following imatinib mesylate treatment

31 March 2020

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BCR-ABL activity and its response to drugs can be determined in CD34+ CML stem cells by CrkL phosphorylation status using flow cytometry.

31 March 2020

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BCR–ABL1 lymphoblastic leukaemia is characterized by the deletion of Ikaros

31 March 2020

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The paradox of response and survival in cancer therapeutics

31 March 2020

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Cancer stem cells: an old idea--a paradigm shift

31 March 2020

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HER2 regulates the mammary stem/progenitor cell population driving tumorigenesis and invasion.

31 March 2020

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Tumor-initiating cells of HER2-positive carcinoma cell lines express the highest oncoprotein levels and are sensitive to trastuzumab

31 March 2020

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Mechanisms of disease: understanding resistance to HER2-targeted therapy in human breast cancer

31 March 2020

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Cancer stem cells: controversial or just misunderstood?

31 March 2020

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HedgehogandBmpGenes Are Coexpressed at Many Diverse Sites of Cell–Cell Interaction in the Mouse Embryo

31 March 2020

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Secreted antagonists of the Wnt signalling pathway

31 March 2020

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Epigenetic inactivation of SFRP genes allows constitutive WNT signaling in colorectal cancer

31 March 2020

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Small-molecule antagonists of the oncogenic Tcf/beta-catenin protein complex

31 March 2020

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A small molecule inhibitor of beta-catenin/CREB-binding protein transcription [corrected]

31 March 2020

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An anti-Wnt-2 monoclonal antibody induces apoptosis in malignant melanoma cells and inhibits tumor growth.

31 March 2020

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Inhibition of Wnt-2-mediated signaling induces programmed cell death in non-small-cell lung cancer cells.

31 March 2020

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Inhibition of prostate cancer proliferation by interference with SONIC HEDGEHOG-GLI1 signaling

31 March 2020

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Suppression of the Shh pathway using a small molecule inhibitor eliminates medulloblastoma in Ptc1(+/-)p53(-/-) mice.

31 March 2020

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Widespread requirement for Hedgehog ligand stimulation in growth of digestive tract tumours

31 March 2020

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Hedgehog is an early and late mediator of pancreatic cancer tumorigenesis

31 March 2020

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Hedgehog signalling within airway epithelial progenitors and in small-cell lung cancer

31 March 2020

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Inhibition of smoothened signaling prevents ultraviolet B-induced basal cell carcinomas through regulation of Fas expression and apoptosis

31 March 2020

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Tumor stem cells derived from glioblastomas cultured in bFGF and EGF more closely mirror the phenotype and genotype of primary tumors than do serum-cultured cell lines

31 March 2020

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Shh pathway activity is down-regulated in cultured medulloblastoma cells: implications for preclinical studies

31 March 2020

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Hedgehog signaling promotes prostate xenograft tumor growth

31 March 2020

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A paracrine requirement for hedgehog signalling in cancer

31 March 2020

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Activation of Notch-1 signaling maintains the neoplastic phenotype in human Ras-transformed cells

31 March 2020

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Notch-1 induction, a novel activity of SV40 required for growth of SV40-transformed human mesothelial cells

31 March 2020

1 reference

Activating mutations of NOTCH1 in human T cell acute lymphoblastic leukemia

31 March 2020

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Notch/gamma-secretase inhibition turns proliferative cells in intestinal crypts and adenomas into goblet cells

31 March 2020

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Notch pathway inhibition depletes stem-like cells and blocks engraftment in embryonal brain tumors

31 March 2020

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Inhibition of Dll4 signalling inhibits tumour growth by deregulating angiogenesis

31 March 2020

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Blockade of Dll4 inhibits tumour growth by promoting non-productive angiogenesis

31 March 2020

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Modulation of Notch signaling by antibodies specific for the extracellular negative regulatory region of NOTCH3

31 March 2020

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Preferential induction of apoptosis for primary human leukemic stem cells

31 March 2020

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Chemical genetics reveals a complex functional ground state of neural stem cells

31 March 2020

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Increased Wnt signaling triggers oncogenic conversion of human breast epithelial cells by a Notch-dependent mechanism

31 March 2020

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Mutational loss of PTEN induces resistance to NOTCH1 inhibition in T-cell leukemia

31 March 2020

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Bone morphogenetic proteins inhibit the tumorigenic potential of human brain tumour-initiating cells.

31 March 2020

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31 March 2020

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Polycomb silencers control cell fate, development and cancer

31 March 2020

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Epigenetic-mediated dysfunction of the bone morphogenetic protein pathway inhibits differentiation of glioblastoma-initiating cells

31 March 2020

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The Polycomb group proteins bind throughout the INK4A-ARF locus and are disassociated in senescent cells

31 March 2020

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Downregulation of EZH2 decreases growth of estrogen receptor-negative invasive breast carcinoma and requires BRCA1

31 March 2020

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Colon cancer stem cells dictate tumor growth and resist cell death by production of interleukin-4.

31 March 2020

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Activation of the PTEN/mTOR/STAT3 pathway in breast cancer stem-like cells is required for viability and maintenance

31 March 2020

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Cell-cycle restriction limits DNA damage and maintains self-renewal of leukaemia stem cells

31 March 2020

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The DNA damage response: putting checkpoints in perspective

31 March 2020

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The ever-lengthening arm of p53

31 March 2020

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Growth-inhibitory and tumor- suppressive functions of p53 depend on its repression of CD44 expression

31 March 2020

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Primitive acute myeloid leukemia cells with long-term proliferative ability in vitro and in vivo lack surface expression of c-kit (CD117)

31 March 2020

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The interleukin-3 receptor alpha chain is a unique marker for human acute myelogenous leukemia stem cells

31 March 2020

1 reference

Monoclonal antibody therapy of cancer

31 March 2020

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Co-expression of the toleragenic glycoprotein, CD200, with markers for cancer stem cells

31 March 2020

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Arming antibodies: prospects and challenges for immunoconjugates

31 March 2020

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Effective relief of malignant ascites in patients with advanced ovarian cancer by a trifunctional anti-EpCAM x anti-CD3 antibody: a phase I/II study.

31 March 2020

1 reference

Targeting multidrug resistance in cancer

31 March 2020

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Chemotherapy-resistant human AML stem cells home to and engraft within the bone-marrow endosteal region.

31 March 2020

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Targeting of CD44 eradicates human acute myeloid leukemic stem cells

31 March 2020

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SLAM family receptors distinguish hematopoietic stem and progenitor cells and reveal endothelial niches for stem cells

31 March 2020

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Vascular niche for adult hippocampal neurogenesis

31 March 2020

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LeX/ssea-1 is expressed by adult mouse CNS stem cells, identifying them as nonependymal

31 March 2020

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Coordinated interaction of neurogenesis and angiogenesis in the adult songbird brain.

31 March 2020

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Pten dependence distinguishes haematopoietic stem cells from leukaemia-initiating cells

31 March 2020

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PTEN maintains haematopoietic stem cells and acts in lineage choice and leukaemia prevention

31 March 2020

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First-in-class, first-in-human phase I results of targeted agents: highlights of the 2008 American society of clinical oncology meeting

31 March 2020

1 reference

Targeting the Notch1 and mTOR pathways in a mouse T-ALL model

31 March 2020

1 reference

Cytotoxic effects induced by a combination of cyclopamine and gefitinib, the selective hedgehog and epidermal growth factor receptor signaling inhibitors, in prostate cancer cells

31 March 2020

1 reference

Phosphoinositide 3-kinase and Akt are essential for Sonic Hedgehog signaling

31 March 2020

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PML targeting eradicates quiescent leukaemia-initiating cells

31 March 2020

1 reference

PTEN/PI3K/Akt pathway regulates the side population phenotype and ABCG2 activity in glioma tumor stem-like cells

31 March 2020

1 reference

Inhibition of Hedgehog signaling enhances delivery of chemotherapy in a mouse model of pancreatic cancer

31 March 2020

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A direct pancreatic cancer xenograft model as a platform for cancer stem cell therapeutic development.

31 March 2020

1 reference

Persistence of a small subpopulation of cancer stem-like cells in the C6 glioma cell line

31 March 2020

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Human breast cancer cell lines contain stem-like cells that self-renew, give rise to phenotypically diverse progeny and survive chemotherapy

31 March 2020

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Breast cancer cell lines contain functional cancer stem cells with metastatic capacity and a distinct molecular signature

31 March 2020

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A distinct "side population" of cells with high drug efflux capacity in human tumor cells

31 March 2020

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Side population is enriched in tumorigenic, stem-like cancer cells, whereas ABCG2+ and ABCG2- cancer cells are similarly tumorigenic

31 March 2020

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Isolation and in vitro propagation of tumorigenic breast cancer cells with stem/progenitor cell properties

31 March 2020

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Glioma stem cell lines expanded in adherent culture have tumor-specific phenotypes and are suitable for chemical and genetic screens

31 March 2020

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ALDH1 is a marker of normal and malignant human mammary stem cells and a predictor of poor clinical outcome

31 March 2020

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Generation of neurons and astrocytes from isolated cells of the adult mammalian central nervous system

31 March 2020

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Transformation of different human breast epithelial cell types leads to distinct tumor phenotypes.

31 March 2020

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Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal niche

31 March 2020

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High-throughput analysis of signals regulating stem cell fate and function

31 March 2020

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Sonic hedgehog induces the proliferation of primitive human hematopoietic cells via BMP regulation

31 March 2020

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Notch signalling regulates stem cell numbers in vitro and in vivo

31 March 2020

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Low O2 tensions and the prevention of differentiation of hES cells

31 March 2020

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Self-renewal of embryonic stem cells by a small molecule

31 March 2020

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High-throughput screening assay for the identification of compounds regulating self-renewal and differentiation in human embryonic stem cells

31 March 2020

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High-throughput identification of genes promoting neuron formation and lineage choice in mouse embryonic stem cells

31 March 2020

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A phenotypic small-molecule screen identifies an orphan ligand-receptor pair that regulates neural stem cell differentiation

31 March 2020

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High-throughput screening for modulators of stem cell differentiation

31 March 2020

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Reproducible, ultra high-throughput formation of multicellular organization from single cell suspension-derived human embryonic stem cell aggregates

31 March 2020

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Lentivector-mediated clonal tracking reveals intrinsic heterogeneity in the human hematopoietic stem cell compartment and culture-induced stem cell impairment

31 March 2020

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Identification of selective inhibitors of cancer stem cells by high-throughput screening

31 March 2020

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The fuzzy math of solid tumor stem cells: a perspective

31 March 2020

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Isolation and characterization of tumorigenic, stem-like neural precursors from human glioblastoma

31 March 2020

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Human short-term repopulating stem cells are efficiently detected following intrafemoral transplantation into NOD/SCID recipients depleted of CD122+ cells

31 March 2020

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Transplantation of Human Tumors in Nude Mice23

31 March 2020

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Noninvasive MR imaging of magnetically labeled stem cells to directly identify neovasculature in a glioma model

31 March 2020

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In vivo imaging, tracking, and targeting of cancer stem cells

31 March 2020

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Detection of functional haematopoietic stem cell niche using real-time imaging.

31 March 2020

1 reference

The prognostic role of a gene signature from tumorigenic breast-cancer cells.

31 March 2020

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Isolation of rare circulating tumour cells in cancer patients by microchip technology

31 March 2020

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Cancer. Addiction to oncogenes--the Achilles heal of cancer

31 March 2020

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CD44 targeting reduces tumour growth and prevents post-chemotherapy relapse of human breast cancers xenografts.

31 March 2020

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The clonal evolution of tumor cell populations

31 March 2020

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CD133(+) and CD133(-) glioblastoma-derived cancer stem cells show differential growth characteristics and molecular profiles

31 March 2020

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Modeling the initiation and progression of human acute leukemia in mice

31 March 2020

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Contributions of human tumor xenografts to anticancer drug development

31 March 2020

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Prevalence of CD44+/CD24-/low cells in breast cancer may not be associated with clinical outcome but may favor distant metastasis

31 March 2020

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12 December 2020

Stem cells: the real culprits in cancer?

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12 December 2020

High level engraftment of NOD/SCID mice by primitive normal and leukemic hematopoietic cells from patients with chronic myeloid leukemia in chronic phase.

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12 December 2020

Branching morphogenesis of the lung: new models for a classical problem

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12 December 2020

Beyond DNA cross-linking: history and prospects of DNA-targeted cancer treatment--fifteenth Bruce F. Cain Memorial Award Lecture.

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12 December 2020

Isolation of a highly quiescent subpopulation of primitive leukemic cells in chronic myeloid leukemia.

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12 December 2020

Identification of a cancer stem cell in human brain tumors

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12 December 2020

Induction of the differentiation and apoptosis of tumor cells in vivo with efficiency and selectivity

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12 December 2020

BCR-ABL gene rearrangement and expression of primitive hematopoietic progenitors in chronic myeloid leukemia.

1 reference

12 December 2020

Comment on "Tumor growth need not be driven by rare cancer stem cells".

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12 December 2020

Context, tissue plasticity, and cancer: are tumor stem cells also regulated by the microenvironment?

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12 December 2020

Lack of expression of Thy-1 (CD90) on acute myeloid leukemia cells with long-term proliferative ability in vitro and in vivo.

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12 December 2020

Identifiers

DOI

10.1038/NRD2137

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Dimensions Publication ID

21 August 2017

1047880637

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