(Q37602631)

21 August 2017

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title

Genetic basis of multidrug resistance of tumor cells (English)

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21 August 2017

main subject

multiple drug resistance

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Kane SE

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21 August 2017

Pastan I

series ordinal

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21 August 2017

Gottesman MM

series ordinal

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21 August 2017

publication date

1 August 1990

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Journal of Bioenergetics and Biomembranes

21 August 2017

published in

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21 August 2017

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21 August 2017

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21 August 2017

page(s)

593-618

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Structure and expression of the human MDR (P-glycoprotein) gene family

21 August 2017

cites work

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12 December 2020

Identification of the multidrug resistance-related membrane glycoprotein as an acceptor for calcium channel blockers.

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12 December 2020

Transport defects as the physiological basis for eye color mutants of Drosophila melanogaster

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12 December 2020

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12 December 2020

Human multidrug-resistant cell lines: increased mdr1 expression can precede gene amplification

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12 December 2020

Deletion and insertion mutants of the multidrug transporter.

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12 December 2020

An altered pattern of cross-resistance in multidrug-resistant human cells results from spontaneous mutations in the mdr1 (P-glycoprotein) gene

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12 December 2020

Characterization of the ATPase activity of the Mr 170,000 to 180,000 membrane glycoprotein (P-glycoprotein) associated with multidrug resistance in K562/ADM cells

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12 December 2020

Discrete mutations introduced in the predicted nucleotide-binding sites of the mdr1 gene abolish its ability to confer multidrug resistance

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12 December 2020

Vinblastine photoaffinity labeling of a high molecular weight surface membrane glycoprotein specific for multidrug-resistant cells

1 reference

12 December 2020

The nucleotide sequences of the rbsD, rbsA, and rbsC genes of Escherichia coli K12.

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12 December 2020

Acylation of monocyte and glomerular mesangial cell proteins. Myristyl acylation of the interleukin 1 precursors

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12 December 2020

Identification of the cystic fibrosis gene: cloning and characterization of complementary DNA

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12 December 2020

Multidrug resistance during chemical carcinogenesis: a mechanism revealed?

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12 December 2020

Complete nucleotide sequence and identification of membrane components of the histidine transport operon of S. typhimurium

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12 December 2020

Immunohistochemical localization in normal tissues of different epitopes in the multidrug transport protein P170: evidence for localization in brain capillaries and crossreactivity of one antibody with a muscle protein

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12 December 2020

Localization of the human multiple drug resistance gene, MDR1, to 7q21.1

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12 December 2020

Transepithelial transport of drugs by the multidrug transporter in cultured Madin-Darby canine kidney cell epithelia

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12 December 2020

Cytoplasmic orientation and two-domain structure of the multidrug transporter, P-glycoprotein, demonstrated with sequence-specific antibodies

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12 December 2020

Molecular cloning of cDNA for rat liver gap junction protein

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12 December 2020

Expression of the mdr (P-glycoprotein) gene in Chinese hamster digestive tracts

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12 December 2020

Adenylyl cyclase amino acid sequence: possible channel- or transporter-like structure

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12 December 2020

Sequence of mdr3 cDNA encoding a human P-glycoprotein

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12 December 2020

Active outward transport of daunomycin in resistant Ehrlich ascites tumor cells

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12 December 2020

Membrane vesicles from multidrug-resistant human cancer cells contain a specific 150- to 170-kDa protein detected by photoaffinity labeling

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12 December 2020

Expression of a multidrug resistance gene in human cancers

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12 December 2020

Isolation of human mdr DNA sequences amplified in multidrug-resistant KB carcinoma cells

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12 December 2020

Reconstitution of a bacterial periplasmic permease in proteoliposomes and demonstration of ATP hydrolysis concomitant with transport

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12 December 2020

Tissue distribution of P-glycoprotein encoded by a multidrug-resistant gene as revealed by a monoclonal antibody, MRK 16

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12 December 2020

Clinical trials of agents that reverse multidrug-resistance

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12 December 2020

Reduced drug accumulation in multiply drug-resistant human KB carcinoma cell lines.

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12 December 2020

Purine transport by Malpighian tubules of pteridine-deficient eye color mutants of Drosophila melanogaster

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12 December 2020

Drug-resistance in multiple myeloma and non-Hodgkin's lymphoma: detection of P-glycoprotein and potential circumvention by addition of verapamil to chemotherapy.

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12 December 2020

Differential overexpression of three mdr gene family members in multidrug-resistant J774.2 mouse cells. Evidence that distinct P-glycoprotein precursors are encoded by unique mdr genes

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12 December 2020

Amplification of the multidrug resistance gene in some chloroquine-resistant isolates of P. falciparum

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12 December 2020

The human mdr3 gene encodes a novel P-glycoprotein homologue and gives rise to alternatively spliced mRNAs in liver

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12 December 2020

The nodI gene product of Rhizobium leguminosarum is closely related to ATP-binding bacterial transport proteins; nucleotide sequence analysis of the nodI and nodJ genes.

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12 December 2020

Photoaffinity labeling of the multidrug-resistance-related P-glycoprotein with photoactive analogs of verapamil

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12 December 2020

Amplification of a gene related to mammalian mdr genes in drug-resistant Plasmodium falciparum.

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12 December 2020

Photosensitized labeling of a functional multidrug transporter in living drug-resistant tumor cells.

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12 December 2020

MDR1 gene expression in lung cancer.

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12 December 2020

DNA sequence of the white locus of Drosophila melanogaster.

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12 December 2020

Cellular localization of the multidrug-resistance gene product P-glycoprotein in normal human tissues

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12 December 2020

Cloning and characterization of human and rat liver cDNAs coding for a gap junction protein

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12 December 2020

Reversal mechanism of multidrug resistance by verapamil: direct binding of verapamil to P-glycoprotein on specific sites and transport of verapamil outward across the plasma membrane of K562/ADM cells

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12 December 2020

Simultaneous expression of two P-glycoprotein genes in drug-sensitive Chinese hamster ovary cells

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12 December 2020

Intrinsic drug resistance in human kidney cancer is associated with expression of a human multidrug-resistance gene.

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12 December 2020

Homology between P-glycoprotein and a bacterial haemolysin transport protein suggests a model for multidrug resistance

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12 December 2020

Secretion of cyclolysin, the calmodulin-sensitive adenylate cyclase-haemolysin bifunctional protein of Bordetella pertussis

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12 December 2020

The multidrug transporter, a double-edged sword

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12 December 2020

Isolation and expression of a complementary DNA that confers multidrug resistance

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12 December 2020

The function of Gp170, the multidrug resistance gene product, in rat liver canalicular membrane vesicles.

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12 December 2020

Expression of a multidrug resistance-adenosine deaminase fusion gene.

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12 December 2020

Expression of a drug resistance gene in human neuroblastoma cell lines: modulation by retinoic acid-induced differentiation

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12 December 2020

Physical mapping, amplification, and overexpression of the mouse mdr gene family in multidrug-resistant cells

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12 December 2020

Multidrug-resistance gene (P-glycoprotein) is expressed by endothelial cells at blood-brain barrier sites

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12 December 2020

Progesterone interacts with P-glycoprotein in multidrug-resistant cells and in the endometrium of gravid uterus

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12 December 2020

Heat shock and arsenite increase expression of the multidrug resistance (MDR1) gene in human renal carcinoma cells

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12 December 2020

Essential features of the P-glycoprotein pharmacophore as defined by a series of reserpine analogs that modulate multidrug resistance

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12 December 2020

Prediction of doxorubicin resistance in vitro in myeloma, lymphoma, and breast cancer by P-glycoprotein staining

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12 December 2020

The brown protein of Drosophila melanogaster is similar to the white protein and to components of active transport complexes

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12 December 2020

The yeast STE6 gene encodes a homologue of the mammalian multidrug resistance P-glycoprotein

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12 December 2020

Two different regions of P-glycoprotein [corrected] are photoaffinity-labeled by azidopine.

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12 December 2020

Overcoming of vincristine resistance in P388 leukemia in vivo and in vitro through enhanced cytotoxicity of vincristine and vinblastine by verapamil

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12 December 2020

High-level, unstable adriamycin resistance in a Chinese hamster mutant cell line with double minute chromosomes.

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12 December 2020

Nucleotide binding by membrane components of bacterial periplasmic binding protein-dependent transport systems

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12 December 2020

Detection of P-glycoprotein in multidrug-resistant cell lines by monoclonal antibodies

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12 December 2020

A new cell division operon in Escherichia coli

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12 December 2020

Mammalian and bacterial sugar transport proteins are homologous

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12 December 2020

Differential amplification and disproportionate expression of five genes in three multidrug-resistant Chinese hamster lung cell lines

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12 December 2020

Structure and function of voltage-sensitive ion channels

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12 December 2020

Expression of the multidrug-resistant gene in hepatocarcinogenesis and regenerating rat liver.

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12 December 2020

Genomic organization of the human multidrug resistance (MDR1) gene and origin of P-glycoproteins

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12 December 2020

Expression of the multidrug resistance gene in myeloid leukemias.

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12 December 2020

Cloning, nucleotide sequence, and characterization of genes encoding the secretion function of the Pasteurella haemolytica leukotoxin determinant.

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12 December 2020

Use of a cloned multidrug resistance gene for coamplification and overproduction of major excreted protein, a transformation-regulated secreted acid protease

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12 December 2020

Expression of the mdr-1/P-170 gene in patients with acute lymphoblastic leukemia.

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12 December 2020

Physical-chemical properties shared by compounds that modulate multidrug resistance in human leukemic cells.

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12 December 2020

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12 December 2020

Mammalian multidrug resistance gene: complete cDNA sequence indicates strong homology to bacterial transport proteins

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12 December 2020

P-glycoprotein gene (MDR1) cDNA from human adrenal: normal P-glycoprotein carries Gly185 with an altered pattern of multidrug resistance

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12 December 2020

Isolation and genetic characterization of human KB cell lines resistant to multiple drugs

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12 December 2020

A new vector using the human multidrug resistance gene as a selectable marker enables overexpression of foreign genes in eukaryotic cells

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12 December 2020

The three mouse multidrug resistance (mdr) genes are expressed in a tissue-specific manner in normal mouse tissues

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12 December 2020

Expression of a human multidrug resistance cDNA (MDR1) in the bone marrow of transgenic mice: resistance to daunomycin-induced leukopenia

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12 December 2020

Molecular characterization of the oligopeptide permease of Salmonella typhimurium

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12 December 2020

Amplification of DNA sequences in human multidrug-resistant KB carcinoma cells

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12 December 2020

The ndvA gene product of Rhizobium meliloti is required for beta-(1----2)glucan production and has homology to the ATP-binding export protein HlyB.

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12 December 2020

Apparent stronger expression in the human adrenal cortex than in the human adrenal medulla of Mr 170,000-180,000 P-glycoprotein

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12 December 2020

Cellular resistance to actinomycin D in Chinese hamster cells in vitro: cross-resistance, radioautographic, and cytogenetic studies

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12 December 2020

Effects of indole alkaloids on multidrug resistance and labeling of P-glycoprotein by a photoaffinity analog of vinblastine

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12 December 2020

Isolation and sequence of the promoter region of the human multidrug-resistance (P-glycoprotein) gene.

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12 December 2020

Measurement of Multidrug-Resistance Messenger RNA in Urogenital Cancers; Elevated Expression in Renal Cell Carcinoma is Associated with Intrinsic Drug Resistance

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12 December 2020

Internal duplication and homology with bacterial transport proteins in the mdr1 (P-glycoprotein) gene from multidrug-resistant human cells.

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12 December 2020

The gene encoding multidrug resistance is induced and expressed at high levels during pregnancy in the secretory epithelium of the uterus

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12 December 2020

Bacterial periplasmic transport systems: structure, mechanism, and evolution

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12 December 2020

Expression of a multidrug-resistance gene in human tumors and tissues

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12 December 2020

Structure of Saccharomyces cerevisiae mating hormone a-factor. Identification of S-farnesyl cysteine as a structural component

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12 December 2020

Genetics of multidrug resistance

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12 December 2020

Saccharomyces cerevisiae STE6 gene product: a novel pathway for protein export in eukaryotic cells

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12 December 2020

Primary structure of the receptor for calcium channel blockers from skeletal muscle

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12 December 2020

A surface glycoprotein modulating drug permeability in Chinese hamster ovary cell mutants

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12 December 2020

The biochemistry of P-glycoprotein-mediated multidrug resistance

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12 December 2020

Is there a common design for cell membrane channels?

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12 December 2020

Nucleotide sequence of an Escherichia coli chromosomal hemolysin

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12 December 2020

Phosphate-specific transport system of Escherichia coli: nucleotide sequence and gene-polypeptide relationships

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12 December 2020

Action of calcium antagonists on multidrug resistant cells. Specific cytotoxicity independent of increased cancer drug accumulation.

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12 December 2020

Expression of a full-length cDNA for the human "MDR1" gene confers resistance to colchicine, doxorubicin, and vinblastine

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12 December 2020

Overexpression and amplification of five genes in a multidrug-resistant Chinese hamster ovary cell line

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12 December 2020

Cloning and characterization of a second member of the mouse mdr gene family

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12 December 2020

Identification of members of the P-glycoprotein multigene family

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12 December 2020

Transport proteins. Export-import family expands

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12 December 2020

Regulation of the multidrug resistance gene in regenerating rat liver.

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12 December 2020

Certain calcium channel blockers bind specifically to multidrug-resistant human KB carcinoma membrane vesicles and inhibit drug binding to P-glycoprotein

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12 December 2020

Sequence and structure of a human glucose transporter

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12 December 2020

Single cell analysis of daunomycin uptake and efflux in multidrug-resistant and -sensitive KB cells: effects of verapamil and other drugs.

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12 December 2020

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12 December 2020

Freeze-fracture study of plasma membranes in wild type and daunorubicin-resistant Ehrlich ascites tumor and P388 leukemia cells

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12 December 2020

ATP-dependent transport of vinblastine in vesicles from human multidrug-resistant cells

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12 December 2020

MDR1 RNA levels in human renal cell carcinomas: correlation with grade and prediction of reversal of doxorubicin resistance by quinidine in tumor explants

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12 December 2020

Sequence of the malK gene in E.coli K12

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12 December 2020

Purification of the 170- to 180-kilodalton membrane glycoprotein associated with multidrug resistance. 170- to 180-kilodalton membrane glycoprotein is an ATPase.

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12 December 2020

The tissue dependent expression of hamster P-glycoprotein genes

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12 December 2020

Mammalian multidrug-resistance gene: correlation of exon organization with structural domains and duplication of an ancestral gene

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12 December 2020

Identifiers

DOI

10.1007/BF00762963

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21 August 2017

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