(Q37596589)

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Perforin and Fas act together in the induction of apoptosis, and both are critical in the clearance of lymphocytic choriomeningitis virus infection

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Europe PubMed Central

PMC publication ID

21 August 2017

Perforin and Fas act together in the induction of apoptosis, and both are critical in the clearance of lymphocytic choriomeningitis virus infection (English)

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Europe PubMed Central

PMC publication ID

21 August 2017

apoptotic process

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lymphocytic choriomeningitis

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Thomas Stehle

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Europe PubMed Central

PMC publication ID

21 August 2017

author name string

Miriam Rode

1

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Europe PubMed Central

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21 August 2017

Sandra Balkow

2

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Europe PubMed Central

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21 August 2017

Vera Sobek

3

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Europe PubMed Central

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21 August 2017

Reina Brehm

4

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Europe PubMed Central

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21 August 2017

Praxedis Martin

5

1 reference

Europe PubMed Central

PMC publication ID

21 August 2017

Astrid Kersten

6

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Europe PubMed Central

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21 August 2017

Tilman Dumrese

7

1 reference

Europe PubMed Central

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21 August 2017

Arno Müllbacher

9

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Europe PubMed Central

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21 August 2017

Reinhard Wallich

10

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21 August 2017

Markus M Simon

11

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21 August 2017

language of work or name

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publication date

1 November 2004

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Europe PubMed Central

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21 August 2017

Journal of Virology

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Europe PubMed Central

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21 August 2017

78

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Europe PubMed Central

PMC publication ID

21 August 2017

22

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Europe PubMed Central

PMC publication ID

21 August 2017

12395-12405

1 reference

Europe PubMed Central

PMC publication ID

21 August 2017

Granzyme B activates procaspase-3 which signals a mitochondrial amplification loop for maximal apoptosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=525048

23 August 2017

Tumor suppressor NM23-H1 is a granzyme A-activated DNase during CTL-mediated apoptosis, and the nucleosome assembly protein SET is its inhibitor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=525048

23 August 2017

Cleaving the oxidative repair protein Ape1 enhances cell death mediated by granzyme A

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=525048

23 August 2017

Functional significance of the perforin/granzyme cell death pathway

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=525048

23 August 2017

Cytotoxic T lymphocytes: all roads lead to death

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=525048

23 August 2017

Lack of both Fas ligand and perforin protects from flavivirus-mediated encephalitis in mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=525048

23 August 2017

Lymphocyte-mediated cytotoxicity.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=525048

23 August 2017

Concerted action of the FasL/Fas and perforin/granzyme A and B pathways is mandatory for the development of early viral hepatitis but not for recovery from viral infection

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=525048

23 August 2017

Granzyme A and B-deficient killer lymphocytes are defective in eliciting DNA fragmentation but retain potent in vivo anti-tumor capacity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=525048

23 August 2017

Apoptotic DNA fragmentation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=525048

23 August 2017

Contributions of Fas-Fas ligand interactions to the pathogenesis of mouse hepatitis virus in the central nervous system

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=525048

23 August 2017

Granzyme A, a noncytolytic component of CD8(+) cell granules, restricts the spread of herpes simplex virus in the peripheral nervous systems of experimentally infected mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=525048

23 August 2017

Granzymes are the essential downstream effector molecules for the control of primary virus infections by cytolytic leukocytes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=525048

23 August 2017

Noncytopathic clearance of lymphocytic choriomeningitis virus from the hepatocyte.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=525048

23 August 2017

Mitochondria-dependent and -independent regulation of Granzyme B-induced apoptosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=525048

23 August 2017

The regulation of reactive oxygen species production during programmed cell death

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=525048

23 August 2017

In Vitro– and Ex Vivo–derived Cytolytic Leukocytes from Granzyme A × B Double Knockout Mice Are Defective in Granule-mediated Apoptosis but not Lysis of Target Cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=525048

23 August 2017

The central executioner of apoptosis: multiple connections between protease activation and mitochondria in Fas/APO-1/CD95- and ceramide-induced apoptosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=525048

23 August 2017

Decreased tumor surveillance in perforin-deficient mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=525048

23 August 2017

Long-range disruption of gene expression by a selectable marker cassette

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=525048

23 August 2017

Bcl-2 inhibits the mitochondrial release of an apoptogenic protease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=525048

23 August 2017

Phenotypic analysis of antigen-specific T lymphocytes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=525048

23 August 2017

Differential inhibition of the Fas- and granule-mediated cytolysis pathways by the orthopoxvirus cytokine response modifier A/SPI-2 and SPI-1 protein

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=525048

23 August 2017

Enhanced and accelerated lymphoproliferation in Fas-null mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=525048

23 August 2017

Cytotoxicity mediated by T cells and natural killer cells is greatly impaired in perforin-deficient mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=525048

23 August 2017

Granzyme A-deficient mice retain potent cell-mediated cytotoxicity.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=525048

23 August 2017

Immune function in mice lacking the perforin gene

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=525048

23 August 2017

Fas and perforin pathways as major mechanisms of T cell-mediated cytotoxicity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=525048

23 August 2017

Redox regulation of signal transduction: tyrosine phosphorylation and calcium influx

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=525048

23 August 2017

Glucocorticoid-induced thymocyte apoptosis is associated with endogenous endonuclease activation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=525048

23 August 2017

Induction of target cell DNA release by the cytotoxic T lymphocyte granule protease granzyme A.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=525048

23 August 2017

Purification and characterization of a cytolytic pore-forming protein from granules of cloned lymphocytes with natural killer activity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=525048

23 August 2017

Purification of three cytotoxic lymphocyte granule serine proteases that induce apoptosis through distinct substrate and target cell interactions

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=525048

23 August 2017

Granzyme B-induced apoptosis requires both direct caspase activation and relief of caspase inhibition

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=525048

6 September 2017

Molecular mechanisms of cytolysis by complement and by cytolytic lymphocytes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=525048

6 September 2017

Caspase activation by granzyme B is indirect, and caspase autoprocessing requires the release of proapoptotic mitochondrial factors.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=525048

14 September 2017

Fas and Fas ligand: lpr and gld mutations

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=525048

14 September 2017

Mechanism of lymphocyte-mediated cytotoxicity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=525048

14 September 2017

Granzyme B induces BID-mediated cytochrome c release and mitochondrial permeability transition

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=525048

28 September 2017

Cytotoxic T cells specifically induce Fas on target cells, thereby facilitating exocytosis-independent induction of apoptosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=525048

28 September 2017

Poxvirus-encoded serpins do not prevent cytolytic T cell-mediated recovery from primary infections.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=525048

28 September 2017

A comparative study of apoptosis and necrosis in HepG2 cells: oxidant-induced caspase inactivation leads to necrosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=525048

28 September 2017

CrmA, a poxvirus-encoded serpin, inhibits cytotoxic T-lymphocyte-mediated apoptosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=525048

28 September 2017

Effector CD4+ and CD8+ T-cell mechanisms in the control of respiratory virus infections.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=525048

25 June 2018

Residual Cytotoxicity and Granzyme K Expression in Granzyme A-deficient Cytotoxic Lymphocytes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=525048

25 June 2018

Mechanism of recovery from acute virus infection. I. Role of T lymphocytes in the clearance of lymphocytic choriomeningitis virus from spleens of mice.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=525048

25 June 2018

Quantification of lymphocytic choriomeningitis virus with an immunological focus assay in 24- or 96-well plates

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=525048

25 June 2018

A natural killer cell granule protein that induces DNA fragmentation and apoptosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=525048

25 June 2018

Cutting edge: granzymes A and B are not essential for perforin-mediated tumor rejection

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=525048

1 September 2018

Potentiation of Fas-mediated apoptosis by attenuated production of mitochondria-derived reactive oxygen species

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=525048

1 September 2018

Concerted action of perforin and granzymes is critical for the elimination of Trypanosoma cruzi from mouse tissues, but prevention of early host death is in addition dependent on the FasL/Fas pathway

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=525048

1 September 2018

Granzymes are essential for natural killer cell-mediated and perf-facilitated tumor control

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=525048

1 September 2018

Antigen-induced cell death of T effector cells in vitro proceeds via the Fas pathway, requires endogenous interferon-gamma and is independent of perforin and granzymes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=525048

1 September 2018

The differential contribution of granzyme A and granzyme B in cytotoxic T lymphocyte-mediated apoptosis is determined by the quality of target cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=525048

1 September 2018

Granzyme A initiates an alternative pathway for granule-mediated apoptosis.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=525048

1 September 2018

Perforin dependence of natural killer cell-mediated tumor control in vivo

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=525048

1 September 2018

Murine hepatitis caused by lymphocytic choriomeningitis virus. I. The hepatic lesions.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=525048

1 September 2018

Cytotoxic lymphocytes require granzyme B for the rapid induction of DNA fragmentation and apoptosis in allogeneic target cells.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=525048

1 September 2018

Targeted mutation in the Fas gene causes hyperplasia in peripheral lymphoid organs and liver

1 reference

https://pubmed.ncbi.nlm.nih.gov/15507626

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Fas mediates apoptosis in human monocytes by a reactive oxygen intermediate dependent pathway

1 reference

https://pubmed.ncbi.nlm.nih.gov/15507626

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Rapid and specific efflux of reduced glutathione during apoptosis induced by anti-Fas/APO-1 antibody

1 reference

https://pubmed.ncbi.nlm.nih.gov/15507626

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Fas-induced programmed cell death is mediated by a Ras-regulated O2- synthesis

1 reference

https://pubmed.ncbi.nlm.nih.gov/15507626

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Aged murine killer T-cell clones acquire specific cytotoxicity for P815 mastocytoma cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/15507626

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Murine cytomegalovirus replication in salivary glands is controlled by both perforin and granzymes during acute infection

1 reference

https://pubmed.ncbi.nlm.nih.gov/15507626

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

NKT cells and tumor immunity—a double-edged sword

1 reference

https://pubmed.ncbi.nlm.nih.gov/15507626

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1128/JVI.78.22.12395-12405.2004

1 reference

Europe PubMed Central

PMC publication ID

21 August 2017

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

21 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

21 August 2017

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