(Q37587994)

English

SF3B1/Hsh155 HEAT motif mutations affect interaction with the spliceosomal ATPase Prp5, resulting in altered branch site selectivity in pre-mRNA splicing

scientific article published on December 2016

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scholarly article

1 reference

Europe PubMed Central

PMC publication ID

21 August 2017

SF3B1/Hsh155 HEAT motif mutations affect interaction with the spliceosomal ATPase Prp5, resulting in altered branch site selectivity in pre-mRNA splicing (English)

1 reference

Europe PubMed Central

PMC publication ID

21 August 2017

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author name string

Qing Tang

1

1 reference

Europe PubMed Central

PMC publication ID

21 August 2017

Susana Rodriguez-Santiago

2

1 reference

Europe PubMed Central

PMC publication ID

21 August 2017

Jing Wang

3

1 reference

Europe PubMed Central

PMC publication ID

21 August 2017

Jia Pu

4

1 reference

Europe PubMed Central

PMC publication ID

21 August 2017

Andrea Yuste

5

1 reference

Europe PubMed Central

PMC publication ID

21 August 2017

Varun Gupta

6

1 reference

Europe PubMed Central

PMC publication ID

21 August 2017

Alberto Moldón

7

1 reference

Europe PubMed Central

PMC publication ID

21 August 2017

Yong-Zhen Xu

8

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Europe PubMed Central

PMC publication ID

21 August 2017

Charles C Query

9

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Europe PubMed Central

PMC publication ID

21 August 2017

publication date

1 December 2016

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Europe PubMed Central

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21 August 2017

Genes & Development

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Europe PubMed Central

PMC publication ID

21 August 2017

30

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Europe PubMed Central

PMC publication ID

21 August 2017

24

1 reference

Europe PubMed Central

PMC publication ID

21 August 2017

2710-2723

1 reference

Europe PubMed Central

PMC publication ID

21 August 2017

Molecular Architecture of SF3b and Structural Consequences of Its Cancer-Related Mutations

1 reference

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23 August 2017

Molecular architecture of the Saccharomyces cerevisiae activated spliceosome

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5238730

23 August 2017

Cancer-associated SF3B1 mutants recognize otherwise inaccessible cryptic 3' splice sites within RNA secondary structures

1 reference

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23 August 2017

Cryo-EM structure of the spliceosome immediately after branching

1 reference

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Structure of a yeast catalytic step I spliceosome at 3.4 Å resolution

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5238730

23 August 2017

Structure of a yeast activated spliceosome at 3.5 Å resolution

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5238730

23 August 2017

Spliceosomal DEAH-Box ATPases Remodel Pre-mRNA to Activate Alternative Splice Sites

1 reference

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23 August 2017

Cancer-associated SF3B1 mutations affect alternative splicing by promoting alternative branchpoint usage

1 reference

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Aberrant RNA splicing in cancer; expression changes and driver mutations of splicing factor genes

1 reference

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23 August 2017

Transcriptome sequencing reveals potential mechanism of cryptic 3' splice site selection in SF3B1-mutated cancers

1 reference

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A novel mechanism for Prp5 function in prespliceosome formation and proofreading the branch site sequence

1 reference

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23 August 2017

Rare SF3B1 R625 mutations in cutaneous melanoma.

1 reference

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23 August 2017

Misregulation of pre-mRNA alternative splicing in cancer

1 reference

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23 August 2017

SF3B1 mutations are associated with alternative splicing in uveal melanoma

1 reference

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23 August 2017

Splicing fidelity: DEAD/H-box ATPases as molecular clocks

1 reference

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23 August 2017

SF3B1 mutations in chronic lymphocytic leukemia

1 reference

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23 August 2017

Splicing proofreading at 5' splice sites by ATPase Prp28p

1 reference

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23 August 2017

Evolution and impact of subclonal mutations in chronic lymphocytic leukemia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5238730

23 August 2017

Spliceosome database: a tool for tracking components of the spliceosome

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5238730

23 August 2017

Pancreatic cancer genomes reveal aberrations in axon guidance pathway genes

1 reference

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23 August 2017

SF3B1 haploinsufficiency leads to formation of ring sideroblasts in myelodysplastic syndromes

1 reference

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23 August 2017

Whole-genome analysis informs breast cancer response to aromatase inhibition

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23 August 2017

The spliceosome: a flexible, reversible macromolecular machine

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5238730

23 August 2017

Exome sequencing identifies recurrent mutations of the splicing factor SF3B1 gene in chronic lymphocytic leukemia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5238730

23 August 2017

SF3B1 and other novel cancer genes in chronic lymphocytic leukemia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5238730

23 August 2017

A U1-U2 snRNP interaction network during intron definition

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5238730

23 August 2017

Mutations of the SF3B1 splicing factor in chronic lymphocytic leukemia: association with progression and fludarabine-refractoriness

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5238730

23 August 2017

Clinical significance of SF3B1 mutations in myelodysplastic syndromes and myelodysplastic/myeloproliferative neoplasms

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5238730

23 August 2017

Somatic SF3B1 mutation in myelodysplasia with ring sideroblasts

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5238730

23 August 2017

Frequent pathway mutations of splicing machinery in myelodysplasia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5238730

23 August 2017

Spliceosome Structure and Function

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5238730

23 August 2017

The Genome Analysis Toolkit: A MapReduce framework for analyzing next-generation DNA sequencing data

1 reference

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23 August 2017

A systematic CEN library of the Saccharomyces cerevisiae genome

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5238730

23 August 2017

Reconstitution of both steps of Saccharomyces cerevisiae splicing with purified spliceosomal components

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5238730

23 August 2017

Fast and accurate short read alignment with Burrows-Wheeler transform

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5238730

23 August 2017

The spliceosome: design principles of a dynamic RNP machine

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5238730

23 August 2017

Alternative splicing and disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5238730

23 August 2017

Exon ligation is proofread by the DExD/H-box ATPase Prp22p

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5238730

23 August 2017

Crystal structure of a core spliceosomal protein interface

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5238730

23 August 2017

Insights into the mechanisms of splicing: more lessons from the ribosome

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5238730

23 August 2017

The Isy1p component of the NineTeen complex interacts with the ATPase Prp16p to regulate the fidelity of pre-mRNA splicing

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5238730

23 August 2017

Major Conformational Change in the Complex SF3b upon Integration into the Spliceosomal U11/U12 di-snRNP as Revealed by Electron Cryomicroscopy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5238730

23 August 2017

Prp5 bridges U1 and U2 snRNPs and enables stable U2 snRNP association with intron RNA

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5238730

23 August 2017

Spatial organization of protein-RNA interactions in the branch site-3' splice site region during pre-mRNA splicing in yeast

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5238730

23 August 2017

Molecular Architecture of the Multiprotein Splicing Factor SF3b

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5238730

23 August 2017

A novel U2 and U11/U12 snRNP protein that associates with the pre-mRNA branch site.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5238730

23 August 2017

Comparison of ARM and HEAT protein repeats

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5238730

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HEAT repeats associated with condensins, cohesins, and other complexes involved in chromosome-related functions

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5238730

23 August 2017

Structure of importin-beta bound to the IBB domain of importin-alpha

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5238730

23 August 2017

The structure of the protein phosphatase 2A PR65/A subunit reveals the conformation of its 15 tandemly repeated HEAT motifs

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5238730

23 August 2017

A potential role for U2AF-SAP 155 interactions in recruiting U2 snRNP to the branch site

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5238730

23 August 2017

Phosphorylation of spliceosomal protein SAP 155 coupled with splicing catalysis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5238730

23 August 2017

Mechanical Devices of the Spliceosome: Motors, Clocks, Springs, and Things

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5238730

23 August 2017

The Saccharomyces cerevisiae Prp5 protein has RNA-dependent ATPase activity with specificity for U2 small nuclear RNA.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5238730

23 August 2017

Mutational analysis of pre-mRNA splicing in Saccharomyces cerevisiae using a sensitive new reporter gene, CUP1

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5238730

23 August 2017

A putative ATP binding protein influences the fidelity of branchpoint recognition in yeast splicing

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5238730

23 August 2017

The spliceosome as an indicted conspirator in myeloid malignancies

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5238730

6 September 2017

Cancer-Associated SF3B1 Hotspot Mutations Induce Cryptic 3' Splice Site Selection through Use of a Different Branch Point

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5238730

14 September 2017

Beat the clock: paradigms for NTPases in the maintenance of biological fidelity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5238730

28 September 2017

Crystal structure of Prp5p reveals interdomain interactions that impact spliceosome assembly

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5238730

25 June 2018

Recurrent mutations at codon 625 of the splicing factor SF3B1 in uveal melanoma.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5238730

25 June 2018

Distinct patterns of novel gene mutations in poor-prognostic stereotyped subsets of chronic lymphocytic leukemia: the case of SF3B1 and subset #2.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5238730

1 September 2018

Release of SF3 from the intron branchpoint activates the first step of pre-mRNA splicing

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5238730

1 September 2018

Competition between the ATPase Prp5 and branch region-U2 snRNA pairing modulates the fidelity of spliceosome assembly

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5238730

1 September 2018

Biochemical and NMR analyses of an SF3b155-p14-U2AF-RNA interaction network involved in branch point definition during pre-mRNA splicing

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5238730

1 September 2018

Suppression of multiple substrate mutations by spliceosomal prp8 alleles suggests functional correlations with ribosomal ambiguity mutants

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5238730

1 September 2018

Spliceosome mutations in hematopoietic malignancies

1 reference

https://pubmed.ncbi.nlm.nih.gov/28087715

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Four yeast spliceosomal proteins (PRP5, PRP9, PRP11, and PRP21) interact to promote U2 snRNP binding to pre-mRNA

1 reference

https://pubmed.ncbi.nlm.nih.gov/28087715

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1101/GAD.291872.116

1 reference

Europe PubMed Central

PMC publication ID

21 August 2017

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

21 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

21 August 2017

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