(Q37576139)

21 August 2017

Apelin gene therapy increases myocardial vascular density and ameliorates diabetic cardiomyopathy via upregulation of sirtuin 3. (English)

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21 August 2017

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diabetic cardiomyopathy

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Heng Zeng

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21 August 2017

Xiaochen He

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21 August 2017

Xuwei Hou

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21 August 2017

Lanfang Li

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21 August 2017

Jian-Xiong Chen

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21 August 2017

20 December 2013

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American Journal of Physiology Heart and Circulatory Physiology

21 August 2017

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21 August 2017

306

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21 August 2017

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21 August 2017

H585-97

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describes a project that uses

21 August 2017

ImageJ

1 reference

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC3920238/fullTextXML

inferred from PubMed Central ID database lookup

cites work

Myocardial injection of apelin-overexpressing bone marrow cells improves cardiac repair via upregulation of Sirt3 after myocardial infarction

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Sirtuin 3 regulates mouse pancreatic beta cell function and is suppressed in pancreatic islets isolated from human type 2 diabetic patients

23 August 2017

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Apelin-13 increases myocardial progenitor cells and improves repair postmyocardial infarction

23 August 2017

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Overexpression of angiopoietin-1 increases CD133+/c-kit+ cells and reduces myocardial apoptosis in db/db mouse infarcted hearts

23 August 2017

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Overexpression of angiopoietin-2 impairs myocardial angiogenesis and exacerbates cardiac fibrosis in the diabetic db/db mouse model

23 August 2017

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Emerging characterization of the role of SIRT3-mediated mitochondrial protein deacetylation in the heart

23 August 2017

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SIRT3 deficiency and mitochondrial protein hyperacetylation accelerate the development of the metabolic syndrome

23 August 2017

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Mitochondrial SIRT3 and heart disease

23 August 2017

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Diabetic cardiomyopathy--to take a long story serious

23 August 2017

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Diet and exercise signals regulate SIRT3 and activate AMPK and PGC-1alpha in skeletal muscle

23 August 2017

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SIRT3 is a mitochondria-localized tumor suppressor required for maintenance of mitochondrial integrity and metabolism during stress

23 August 2017

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Apelin is necessary for the maintenance of insulin sensitivity

23 August 2017

1 reference

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Sirt3 blocks the cardiac hypertrophic response by augmenting Foxo3a-dependent antioxidant defense mechanisms in mice

23 August 2017

1 reference

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Ang-1 gene therapy inhibits hypoxia-inducible factor-1alpha (HIF-1alpha)-prolyl-4-hydroxylase-2, stabilizes HIF-1alpha expression, and normalizes immature vasculature in db/db mice

23 August 2017

1 reference

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Endurance exercise as a countermeasure for aging

23 August 2017

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SIRT3 is a stress-responsive deacetylase in cardiomyocytes that protects cells from stress-mediated cell death by deacetylation of Ku70

23 August 2017

1 reference

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Diabetic cardiomyopathy revisited

23 August 2017

1 reference

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Paracrine and autocrine mechanisms of apelin signaling govern embryonic and tumor angiogenesis

23 August 2017

1 reference

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Apelin and its receptor control heart field formation during zebrafish gastrulation

23 August 2017

1 reference

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NADPH oxidase modulates myocardial Akt, ERK1/2 activation, and angiogenesis after hypoxia-reoxygenation

23 August 2017

1 reference

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Nucleocytoplasmic shuttling of the NAD+-dependent histone deacetylase SIRT1

23 August 2017

1 reference

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Apelin, the ligand for the endothelial G-protein-coupled receptor, APJ, is a potent angiogenic factor required for normal vascular development of the frog embryo

23 August 2017

1 reference

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Vascular endothelial growth factor blockade promotes the transition from compensatory cardiac hypertrophy to failure in response to pressure overload

23 August 2017

1 reference

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Epidemiology of the diabetic heart

23 August 2017

1 reference

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A novel VNTR enhancer within the SIRT3 gene, a human homologue of SIR2, is associated with survival at oldest ages.

23 August 2017

1 reference

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Apelin, the novel endogenous ligand of the orphan receptor APJ, regulates cardiac contractility

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3920238

Myocardial infarction in diabetic rats: role of hyperglycaemia on infarct size and early expression of hypoxia-inducible factor 1

23 August 2017

1 reference

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Characterization of apelin, the ligand for the APJ receptor

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3920238

New model of tumor angiogenesis: dynamic balance between vessel regression and growth mediated by angiopoietins and VEGF.

23 August 2017

1 reference

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Isolation and characterization of a novel endogenous peptide ligand for the human APJ receptor

23 August 2017

1 reference

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Requisite role of angiopoietin-1, a ligand for the TIE2 receptor, during embryonic angiogenesis

23 August 2017

1 reference

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Inhibition of protein tyrosine phosphatase improves angiogenesis via enhancing Ang-1/Tie-2 signaling in diabetes

23 August 2017

1 reference

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Reduced mitochondrial function in obesity-associated fatty liver: SIRT3 takes on the fat

6 September 2017

1 reference

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Disruption of Ang-1/Tie-2 signaling contributes to the impaired myocardial vascular maturation and angiogenesis in type II diabetic mice

25 June 2018

1 reference

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SIRT3 weighs heavily in the metabolic balance: a new role for SIRT3 in metabolic syndrome

25 June 2018

1 reference

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Activation of catalase by apelin prevents oxidative stress-linked cardiac hypertrophy

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3920238

Apelin protects heart against ischemia/reperfusion injury in rat.

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3920238

Cardiac aldosterone overexpression prevents harmful effects of diabetes in the mouse heart by preserving capillary density

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3920238

Critical role of the NADPH oxidase subunit p47phox on vascular TLR expression and neointimal lesion formation in high-fat diet-induced obesity

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3920238

Critical role of angiopoietins/Tie-2 in hyperglycemic exacerbation of myocardial infarction and impaired angiogenesis

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3920238

Disruption of coordinated cardiac hypertrophy and angiogenesis contributes to the transition to heart failure

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3920238

Progressive attenuation of myocardial vascular endothelial growth factor expression is a seminal event in diabetic cardiomyopathy: restoration of microvascular homeostasis and recovery of cardiac function in diabetic cardiomyopathy after replenishme

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3920238

Expression of angiogenic factors during acute coronary syndromes in human type 2 diabetes

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3920238

Immunocytochemical localization of the endogenous vasoactive peptide apelin to human vascular and endocardial endothelial cells

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3920238

Variability of the SIRT3 gene, human silent information regulator Sir2 homologue, and survivorship in the elderly

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3920238

Circulating and cardiac levels of apelin, the novel ligand of the orphan receptor APJ, in patients with heart failure

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3920238

Vessel cooption, regression, and growth in tumors mediated by angiopoietins and VEGF.

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3920238

Effect of diabetes mellitus on formation of coronary collateral vessels

1 September 2018

1 reference

12 December 2020

Angiopoietin-1-induced angiogenesis is modulated by endothelial NADPH oxidase

1 reference

12 December 2020

Apelin modulates aortic vascular tone via endothelial nitric oxide synthase phosphorylation pathway in diabetic mice

1 reference

12 December 2020

Impaired angiogenesis after hindlimb ischemia in type 2 diabetes mellitus: differential regulation of vascular endothelial growth factor receptor 1 and soluble vascular endothelial growth factor receptor 1

1 reference

12 December 2020

The novel peptide apelin regulates intrarenal artery tone in diabetic mice

1 reference

12 December 2020

Decreased cardiac expression of vascular endothelial growth factor and its receptors in insulin-resistant and diabetic States: a possible explanation for impaired collateral formation in cardiac tissue

1 reference

12 December 2020

HSP90 and Akt modulate Ang-1-induced angiogenesis via NO in coronary artery endothelium

1 reference

12 December 2020

10.1152/AJPHEART.00821.2013

Identifiers

DOI

1 reference

21 August 2017

1 reference

21 August 2017

PubMed publication ID

24363305

1 reference