(Q37548226)

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Heat shock protein 27 phosphorylation: kinases, phosphatases, functions and pathology

scientific article published on 11 July 2009

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Europe PubMed Central

PubMed publication ID

21 August 2017

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Europe PubMed Central

Heat shock protein 27 phosphorylation: kinases, phosphatases, functions and pathology (English)

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Europe PubMed Central

PubMed publication ID

21 August 2017

phosphorylation

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2

object named as

Ugo Moens

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Europe PubMed Central

PubMed publication ID

21 August 2017

Sergiy Kostenko

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object named as

Sergiy Kostenko

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Europe PubMed Central

PubMed publication ID

21 August 2017

publication date

11 July 2009

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Europe PubMed Central

PubMed publication ID

21 August 2017

Cellular and Molecular Life Sciences

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Europe PubMed Central

PubMed publication ID

21 August 2017

66

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Europe PubMed Central

PubMed publication ID

21 August 2017

20

1 reference

Europe PubMed Central

PubMed publication ID

21 August 2017

3289-3307

1 reference

Europe PubMed Central

PubMed publication ID

21 August 2017

Cytoskeletal changes in hypoxic pulmonary endothelial cells are dependent on MAPK-activated protein kinase MK2.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19593530

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Both binding and activation of p38 mitogen-activated protein kinase (MAPK) play essential roles in regulation of the nucleocytoplasmic distribution of MAPK-activated protein kinase 5 by cellular stress

1 reference

https://pubmed.ncbi.nlm.nih.gov/19593530

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Structure and properties of small heat shock proteins (sHsp) and their interaction with cytoskeleton proteins

1 reference

https://pubmed.ncbi.nlm.nih.gov/19593530

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Rapid protein phosphorylation induced by phorbol ester in HL-60 cells. Unique alkali-stable phosphorylation of a 17,000-dalton protein detected by two-dimensional gel electrophoresis

1 reference

https://pubmed.ncbi.nlm.nih.gov/19593530

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

HSP27 phosphorylation is correlated with ADP-induced platelet granule secretion

1 reference

https://pubmed.ncbi.nlm.nih.gov/19593530

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mechanism of activation of protein kinase B by insulin and IGF-1

1 reference

https://pubmed.ncbi.nlm.nih.gov/19593530

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The actin cytoskeleton response to oxidants: from small heat shock protein phosphorylation to changes in the redox state of actin itself

1 reference

https://pubmed.ncbi.nlm.nih.gov/19593530

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identification of the phosphorylation sites of the murine small heat shock protein hsp25

1 reference

https://pubmed.ncbi.nlm.nih.gov/19593530

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Neuronal expression of constitutive heat shock proteins: implications for neurodegenerative diseases

1 reference

https://pubmed.ncbi.nlm.nih.gov/19593530

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

AKT-dependent HspB1 (Hsp27) activity in epidermal differentiation

1 reference

https://pubmed.ncbi.nlm.nih.gov/19593530

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

MAPKAP kinases - MKs - two's company, three's a crowd

1 reference

https://pubmed.ncbi.nlm.nih.gov/19593530

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identification of MAPKAP kinase 2 as a major enzyme responsible for the phosphorylation of the small mammalian heat shock proteins

1 reference

https://pubmed.ncbi.nlm.nih.gov/19593530

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Regulation of Hsp27 oligomerization, chaperone function, and protective activity against oxidative stress/tumor necrosis factor alpha by phosphorylation

1 reference

https://pubmed.ncbi.nlm.nih.gov/19593530

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mutant small heat-shock protein 27 causes axonal Charcot-Marie-Tooth disease and distal hereditary motor neuropathy

1 reference

https://pubmed.ncbi.nlm.nih.gov/19593530

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Hypo-osmotic cell swelling activates the p38 MAP kinase signalling cascade

1 reference

https://pubmed.ncbi.nlm.nih.gov/19593530

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Akt regulates thrombin-induced HSP27 phosphorylation in aortic smooth muscle cells: function at a point downstream from p38 MAP kinase

1 reference

https://pubmed.ncbi.nlm.nih.gov/19593530

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Binding of non-native protein to Hsp25 during heat shock creates a reservoir of folding intermediates for reactivation.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19593530

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A 25-kD inhibitor of actin polymerization is a low molecular mass heat shock protein

1 reference

https://pubmed.ncbi.nlm.nih.gov/19593530

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The role of stress proteins in prostate cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/19593530

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Protein kinase D is a key regulator of cardiomyocyte lipoprotein lipase secretion after diabetes

1 reference

https://pubmed.ncbi.nlm.nih.gov/19593530

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The human genome encodes 10 alpha-crystallin-related small heat shock proteins: HspB1-10

1 reference

https://pubmed.ncbi.nlm.nih.gov/19593530

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Epstein-Barr virus upregulates phosphorylated heat shock protein 27 kDa in carcinoma cells using the phosphoinositide 3-kinase/Akt pathway

1 reference

https://pubmed.ncbi.nlm.nih.gov/19593530

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The role of Hsp27 and actin in the regulation of movement in human cancer cells responding to heat shock

1 reference

https://pubmed.ncbi.nlm.nih.gov/19593530

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effect of protein kinase inhibitors on activity of mammalian small heat-shock protein (HSP25) kinase

1 reference

https://pubmed.ncbi.nlm.nih.gov/19593530

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

MAP-kinase-activated protein kinase 2 expression and activity is induced after neuronal depolarization.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19593530

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mitogen-activated 3p kinase is active in the nucleus

1 reference

https://pubmed.ncbi.nlm.nih.gov/19593530

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Heat shock protein 27 is the major differentially phosphorylated protein involved in renal epithelial cellular stress response and controls focal adhesion organization and apoptosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/19593530

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A role for the p38 mitogen-activated protein kinase/Hsp 27 pathway in cholecystokinin-induced changes in the actin cytoskeleton in rat pancreatic acini

1 reference

https://pubmed.ncbi.nlm.nih.gov/19593530

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Relative contribution of mutations in genes for autosomal dominant distal hereditary motor neuropathies: a genotype-phenotype correlation study

1 reference

https://pubmed.ncbi.nlm.nih.gov/19593530

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Structural and functional diversities between members of the human HSPB, HSPH, HSPA, and DNAJ chaperone families.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19593530

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inhibition of TNFalpha-induced activation of nuclear factor kappaB by kava (Piper methysticum) derivatives

1 reference

https://pubmed.ncbi.nlm.nih.gov/19593530

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identification of constitutive and gamma-interferon- and interleukin 4-regulated proteins in the human renal carcinoma cell line ACHN.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19593530

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Analysis of the role of Hsp25 phosphorylation reveals the importance of the oligomerization state of this small heat shock protein in its protective function against TNFalpha- and hydrogen peroxide-induced cell death

1 reference

https://pubmed.ncbi.nlm.nih.gov/19593530

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

AKAP mediated signal transduction

1 reference

https://pubmed.ncbi.nlm.nih.gov/19593530

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Crosstalk between p38, Hsp25 and Akt in spinal motor neurons after sciatic nerve injury

1 reference

https://pubmed.ncbi.nlm.nih.gov/19593530

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Heat shock protein is a unique marker of growth arrest during macrophage differentiation of HL-60 cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/19593530

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Attenuated phosphorylation of heat shock protein 27 correlates with tumor progression in patients with hepatocellular carcinoma

1 reference

https://pubmed.ncbi.nlm.nih.gov/19593530

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Prostaglandin D2 induces nuclear import of the sex-determining factor SOX9 via its cAMP-PKA phosphorylation

1 reference

https://pubmed.ncbi.nlm.nih.gov/19593530

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Comparison of tumor growth betweenHSP25- andHSP27-transfected murine L929 cells in nude mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/19593530

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Conformational changes resulting from pseudophosphorylation of mammalian small heat shock proteins--a two-hybrid study

1 reference

https://pubmed.ncbi.nlm.nih.gov/19593530

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Elimination of protein kinase MK5/PRAK activity by targeted homologous recombination

1 reference

https://pubmed.ncbi.nlm.nih.gov/19593530

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A systematic MS-based approach for identifying in vitro substrates of PKA and PKG in rat uteri

1 reference

https://pubmed.ncbi.nlm.nih.gov/19593530

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Tumor necrosis factor-alpha induces the phosphorylation of 28kDa stress proteins in endothelial cells: possible role in protection against cytotoxicity?

1 reference

https://pubmed.ncbi.nlm.nih.gov/19593530

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Characterization of 45-kDa/54-kDa HSP27 kinase, a stress-sensitive kinase which may activate the phosphorylation-dependent protective function of mammalian 27-kDa heat-shock protein HSP27.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19593530

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

HSP27 multimerization mediated by phosphorylation-sensitive intermolecular interactions at the amino terminus

1 reference

https://pubmed.ncbi.nlm.nih.gov/19593530

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Heat shock proteins in cancer: chaperones of tumorigenesis

1 reference

https://pubmed.ncbi.nlm.nih.gov/19593530

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Glucose and diabetes: effects on podocyte and glomerular p38MAPK, heat shock protein 25, and actin cytoskeleton

1 reference

https://pubmed.ncbi.nlm.nih.gov/19593530

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Characterization of an autoinhibitory domain in human mitogen-activated protein kinase-activated protein kinase 2.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19593530

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Autoantibodies in the autoimmune disease pemphigus foliaceus induce blistering via p38 mitogen-activated protein kinase-dependent signaling in the skin

1 reference

https://pubmed.ncbi.nlm.nih.gov/19593530

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identification of mitogen-activated protein (MAP) kinase-activated protein kinase-3, a novel substrate of CSBP p38 MAP kinase

1 reference

https://pubmed.ncbi.nlm.nih.gov/19593530

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Hsp27 knockdown using nucleotide-based therapies inhibit tumor growth and enhance chemotherapy in human bladder cancer cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/19593530

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cell-cycle dependent phosphorylation of HSP28 by TGF beta 1 and H2O2 in normal mouse osteoblastic cells (MC3T3-E1), but not in their ras-transformants

1 reference

https://pubmed.ncbi.nlm.nih.gov/19593530

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

MAP kinases p38 and JNK are activated by the steroid hormone 1alpha,25(OH)2-vitamin D3 in the C2C12 muscle cell line

1 reference

https://pubmed.ncbi.nlm.nih.gov/19593530

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Small heat-shock protein family: function in health and disease.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19593530

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Role of p38 MAP kinase in endothelial cell alignment induced by fluid shear stress

1 reference

https://pubmed.ncbi.nlm.nih.gov/19593530

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

PKA-induced F-actin rearrangement requires phosphorylation of Hsp27 by the MAPKAP kinase MK5.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19593530

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Heat shock protein 27 kDa expression and phosphorylation regulates endothelial cell migration

1 reference

https://pubmed.ncbi.nlm.nih.gov/19593530

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Induction of p38MAPK and HSP27 phosphorylation in pemphigus patient skin

1 reference

https://pubmed.ncbi.nlm.nih.gov/19593530

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Quantitation of protein phosphorylation in pregnant rat uteri using stable isotope dimethyl labeling coupled with IMAC.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19593530

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Desmosome signaling. Inhibition of p38MAPK prevents pemphigus vulgaris IgG-induced cytoskeleton reorganization

1 reference

https://pubmed.ncbi.nlm.nih.gov/19593530

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A phosphorylation state-specific antibody recognizes Hsp27, a novel substrate of protein kinase D.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19593530

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Heat-shock proteins and platelet function

1 reference

https://pubmed.ncbi.nlm.nih.gov/19593530

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Modulation of F-actin rearrangement by the cyclic AMP/cAMP-dependent protein kinase (PKA) pathway is mediated by MAPK-activated protein kinase 5 and requires PKA-induced nuclear export of MK5.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19593530

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

SAPK2/p38-dependent F-actin reorganization regulates early membrane blebbing during stress-induced apoptosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/19593530

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Hsp27 protects against ischemic brain injury via attenuation of a novel stress-response cascade upstream of mitochondrial cell death signaling

1 reference

https://pubmed.ncbi.nlm.nih.gov/19593530

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Two distinct forms of MAPKAP kinase-2 in adult cardiac ventricular myocytes.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19593530

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Protein kinase C delta regulates the phosphorylation of heat shock protein 27 in human hepatocellular carcinoma

1 reference

https://pubmed.ncbi.nlm.nih.gov/19593530

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Transient activation of a distinct serine protein kinase is responsible for 27-kDa heat shock protein phosphorylation in mitogen-stimulated and heat-shocked cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/19593530

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Small heat shock proteins are molecular chaperones.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19593530

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Getting to know protein kinase D.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19593530

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Protein kinase D enzymes are dispensable for proliferation, survival and antigen receptor-regulated NFkappaB activity in vertebrate B-cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/19593530

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Decreased heat- and tumor necrosis factor-mediated hsp28 phosphorylation in thermotolerant HeLa cells.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19593530

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Heat shock protein 1 and the mitogen-activated protein kinase 14 pathway are important for mouse trophoblast stem cell differentiation.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19593530

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

MK2 and MK3--a pair of isoenzymes?

1 reference

https://pubmed.ncbi.nlm.nih.gov/19593530

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identification of a protein transiently phosphorylated by activators of endothelial cell function as the heat-shock protein HSP27. A possible role for protein kinase C

1 reference

https://pubmed.ncbi.nlm.nih.gov/19593530

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

p38 MAP kinase activation by vascular endothelial growth factor mediates actin reorganization and cell migration in human endothelial cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/19593530

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Heat shock protein 27 prevents cellular polyglutamine toxicity and suppresses the increase of reactive oxygen species caused by huntingtin

1 reference

https://pubmed.ncbi.nlm.nih.gov/19593530

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cell-free phosphorylation of the murine small heat-shock protein hsp25 by an endogenous kinase from Ehrlich ascites tumor cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/19593530

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inhibition of Daxx-mediated apoptosis by heat shock protein 27

1 reference

https://pubmed.ncbi.nlm.nih.gov/19593530

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Stress-mediated signaling in PC12 cells - the role of the small heat shock protein, Hsp27, and Akt in protecting cells from heat stress and nerve growth factor withdrawal

1 reference

https://pubmed.ncbi.nlm.nih.gov/19593530

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Phosphorylated HSP27 essential for acetylcholine-induced association of RhoA with PKCα

1 reference

https://pubmed.ncbi.nlm.nih.gov/19593530

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Phosphorylation of an Mr = 29,000 protein by IL-1 is susceptible to partial down-regulation after endothelial cell activation

1 reference

https://pubmed.ncbi.nlm.nih.gov/19593530

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Oxidative stress-induced actin reorganization mediated by the p38 mitogen-activated protein kinase/heat shock protein 27 pathway in vascular endothelial cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/19593530

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Heat shock proteins 27 and 70: anti-apoptotic proteins with tumorigenic properties

1 reference

https://pubmed.ncbi.nlm.nih.gov/19593530

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Activation of p38 has opposing effects on the proliferation and migration of endothelial cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/19593530

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mitogen activated protein kinase activated protein kinase 2 regulates actin polymerization and vascular leak in ventilator associated lung injury

1 reference

https://pubmed.ncbi.nlm.nih.gov/19593530

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

CXCL12 and C5a trigger cell migration via a PAK1/2-p38α MAPK-MAPKAP-K2-HSP27 pathway

1 reference

https://pubmed.ncbi.nlm.nih.gov/19593530

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

SB 203580 is a specific inhibitor of a MAP kinase homologue which is stimulated by cellular stresses and interleukin-1

1 reference

https://pubmed.ncbi.nlm.nih.gov/19593530

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Phosphorylation of the 27-kDa heat shock protein via p38 MAP kinase and MAPKAP kinase in smooth muscle

1 reference

https://pubmed.ncbi.nlm.nih.gov/19593530

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Heat shock protein 27 functions in inflammatory gene expression and transforming growth factor-beta-activated kinase-1 (TAK1)-mediated signaling.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19593530

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Altered expression of glomerular heat shock protein 27 in experimental nephrotic syndrome

1 reference

https://pubmed.ncbi.nlm.nih.gov/19593530

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Hsp27 regulates Akt activation and polymorphonuclear leukocyte apoptosis by scaffolding MK2 to Akt signal complex

1 reference

https://pubmed.ncbi.nlm.nih.gov/19593530

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

MAPKAPK5, a Novel Mitogen-Activated Protein Kinase (MAPK)-Activated Protein Kinase, Is a Substrate of the Extracellular-Regulated Kinase (ERK) and p38 Kinase

1 reference

https://pubmed.ncbi.nlm.nih.gov/19593530

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

CaM Kinase II-dependent pathophysiological signalling in endothelial cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/19593530

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Overexpression of heat shock protein Hsp27 protects against cerulein-induced pancreatitis

1 reference

https://pubmed.ncbi.nlm.nih.gov/19593530

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Characterization of heat shock protein 27 phosphorylation sites in renal cell carcinoma.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19593530

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A comparison of the substrate specificity of MAPKAP kinase-2 and MAPKAP kinase-3 and their activation by cytokines and cellular stress

1 reference

https://pubmed.ncbi.nlm.nih.gov/19593530

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

14-3-3epsilon inhibits MK5-mediated cell migration by disrupting F-actin polymerization

1 reference

https://pubmed.ncbi.nlm.nih.gov/19593530

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

HSP27 phosphorylation-mediated resistance against actin fragmentation and cell death induced by oxidative stress

1 reference

https://pubmed.ncbi.nlm.nih.gov/19593530

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

PKD, PKD2, and p38 MAPK mediate Hsp27 serine-82 phosphorylation induced by neurotensin in pancreatic cancer PANC-1 cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/19593530

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Modulation of vimentin containing intermediate filament distribution and phosphorylation in living fibroblasts by the cAMP-dependent protein kinase

1 reference

https://pubmed.ncbi.nlm.nih.gov/19593530

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

MAPKAP kinase-2; a novel protein kinase activated by mitogen-activated protein kinase

1 reference

https://pubmed.ncbi.nlm.nih.gov/19593530

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

HSP27 regulates p53 transcriptional activity in doxorubicin-treated fibroblasts and cardiac H9c2 cells: p21 upregulation and G2/M phase cell cycle arrest

1 reference

https://pubmed.ncbi.nlm.nih.gov/19593530

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Interleukin-1-induced intracellular signaling pathways converge in the activation of mitogen-activated protein kinase and mitogen-activated protein kinase-activated protein kinase 2 and the subsequent phosphorylation of the 27-kilodalton heat shock

1 reference

https://pubmed.ncbi.nlm.nih.gov/19593530

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Self-association of a small heat shock protein

1 reference

https://pubmed.ncbi.nlm.nih.gov/19593530

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

HSP27 is involved in the pathogenesis of kidney tubulointerstitial fibrosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/19593530

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Protein kinase D mediates a stress-induced NF-kappaB activation and survival pathway

1 reference

https://pubmed.ncbi.nlm.nih.gov/19593530

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Recruitment of protein phosphatase 2A to dorsal ruffles by platelet-derived growth factor in smooth muscle cells: dephosphorylation of Hsp27.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19593530

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Induction of Chinese hamster HSP27 gene expression in mouse cells confers resistance to heat shock. HSP27 stabilization of the microfilament organization

1 reference

https://pubmed.ncbi.nlm.nih.gov/19593530

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Stress- and mitogen-induced phosphorylation of the small heat shock protein Hsp25 by MAPKAP kinase 2 is not essential for chaperone properties and cellular thermoresistance

1 reference

https://pubmed.ncbi.nlm.nih.gov/19593530

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Dephosphorylation of the small heat shock protein Hsp27 in vivo by protein phosphatase 2A.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19593530

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Heat shock protein 27: its potential role in vascular disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/19593530

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

P38 Mitogen Activated Protein Kinase Regulates Endothelial VCAM-1 Expression at the Post-transcriptional Level

1 reference

https://pubmed.ncbi.nlm.nih.gov/19593530

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

p38 Kinase-dependent MAPKAPK-2 activation functions as 3-phosphoinositide-dependent kinase-2 for Akt in human neutrophils

1 reference

https://pubmed.ncbi.nlm.nih.gov/19593530

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The transcriptional regulation and cell-specific expression of the MAPK-activated protein kinase MK5.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19593530

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

PMA-induced activation of the p42/44ERK- and p38RK-MAP kinase cascades in HL-60 cells is PKC dependent but not essential for differentiation to the macrophage-like phenotype

1 reference

https://pubmed.ncbi.nlm.nih.gov/19593530

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pyrrolopyridine inhibitors of mitogen-activated protein kinase-activated protein kinase 2 (MK-2)

1 reference

https://pubmed.ncbi.nlm.nih.gov/19593530

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Hsp27 upregulation and phosphorylation is required for injured sensory and motor neuron survival

1 reference

https://pubmed.ncbi.nlm.nih.gov/19593530

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Phosphorylation and supramolecular organization of murine small heat shock protein HSP25 abolish its actin polymerization-inhibiting activity

1 reference

https://pubmed.ncbi.nlm.nih.gov/19593530

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A novel kinase cascade triggered by stress and heat shock that stimulates MAPKAP kinase-2 and phosphorylation of the small heat shock proteins

1 reference

https://pubmed.ncbi.nlm.nih.gov/19593530

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Protein phosphatase inhibitors and heat preconditioning prevent Hsp27 dephosphorylation, F-actin disruption and deterioration of morphology in ATP-depleted endothelial cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/19593530

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Possible involvement of phosphatidylinositol 3-kinase/Akt signal pathway in vasopressin-induced HSP27 phosphorylation in aortic smooth muscle A10 cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/19593530

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Protein kinase inhibitors can suppress stress-induced dissociation of Hsp27

1 reference

https://pubmed.ncbi.nlm.nih.gov/19593530

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inhibition of colony formation of NIH 3T3 cells by the expression of the small molecular weight heat shock protein HSP27: involvement of its phosphorylation and aggregation at the C-terminal region

1 reference

https://pubmed.ncbi.nlm.nih.gov/19593530

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inhibition of HSP27 phosphorylation by a cell-permeant MAPKAP Kinase 2 inhibitor

1 reference

https://pubmed.ncbi.nlm.nih.gov/19593530

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Regulation of the 28 kDa heat shock protein by retinoic acid during differentiation of human leukemic HL-60 cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/19593530

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Hereditary motor neuropathy and heat shock proteins: a shocking transformation

1 reference

https://pubmed.ncbi.nlm.nih.gov/19593530

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A Role for p38MAPK/HSP27 Pathway in Smooth Muscle Cell Migration

1 reference

https://pubmed.ncbi.nlm.nih.gov/19593530

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

3pK, a new mitogen-activated protein kinase-activated protein kinase located in the small cell lung cancer tumor suppressor gene region

1 reference

https://pubmed.ncbi.nlm.nih.gov/19593530

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inhibition of heat shock induction of heat shock protein 70 and enhancement of heat shock protein 27 phosphorylation by quercetin derivatives

1 reference

https://pubmed.ncbi.nlm.nih.gov/19593530

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Vascular endothelial growth factor induces heat shock protein (HSP) 27 serine 82 phosphorylation and endothelial tubulogenesis via protein kinase D and independent of p38 kinase

1 reference

https://pubmed.ncbi.nlm.nih.gov/19593530

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

cGMP and cGMP-dependent protein kinase in platelets and blood cells.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19593530

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pyrrolo-pyrimidones: a novel class of MK2 inhibitors with potent cellular activity.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19593530

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Differential expression levels of the heat shock protein 27 isoforms in pediatric normal, nonleukemic and common acute lymphoblastic leukemia B-cell precursors.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19593530

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Biphasic activation of p38MAPK suggests that apoptosis is a downstream event in pemphigus acantholysis

1 reference

https://pubmed.ncbi.nlm.nih.gov/19593530

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Hsp27 (HspB1) and alphaB-crystallin (HspB5) as therapeutic targets.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19593530

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cyclic GMP-dependent and -independent regulation of MAP kinases by sodium nitroprusside in isolated cardiomyocytes

1 reference

https://pubmed.ncbi.nlm.nih.gov/19593530

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Stat3 modulates heat shock 27kDa protein expression in breast epithelial cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/19593530

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Can you hear me now? Regulating transcriptional activators by phosphorylation

1 reference

https://pubmed.ncbi.nlm.nih.gov/19593530

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Heterooligomeric complexes formed by human small heat shock proteins HspB1 (Hsp27) and HspB6 (Hsp20).

1 reference

https://pubmed.ncbi.nlm.nih.gov/19593530

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Increased expression of the M(r) 27,000 heat shock protein (hsp27) in in vitro differentiated normal human keratinocytes

1 reference

https://pubmed.ncbi.nlm.nih.gov/19593530

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Heat-shock protein-25/27 phosphorylation by the delta isoform of protein kinase C.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19593530

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Modulation of cellular thermoresistance and actin filament stability accompanies phosphorylation-induced changes in the oligomeric structure of heat shock protein 27

1 reference

https://pubmed.ncbi.nlm.nih.gov/19593530

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Heat Shock Protein 27 Controls Apoptosis by Regulating Akt Activation

1 reference

https://pubmed.ncbi.nlm.nih.gov/19593530

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Activation of protein kinase B (Akt/RAC‐protein kinase) by cellular stress and its association with heat shock protein Hsp27

1 reference

https://pubmed.ncbi.nlm.nih.gov/19593530

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Human HSP27 is phosphorylated at serines 78 and 82 by heat shock and mitogen-activated kinases that recognize the same amino acid motif as S6 kinase II

1 reference

https://pubmed.ncbi.nlm.nih.gov/19593530

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Hsp27 modulates p53 signaling and suppresses cellular senescence

1 reference

https://pubmed.ncbi.nlm.nih.gov/19593530

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Overexpression of wild-type heat shock protein 27 and a nonphosphorylatable heat shock protein 27 mutant protects against ischemia/reperfusion injury in a transgenic mouse model

1 reference

https://pubmed.ncbi.nlm.nih.gov/19593530

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Interleukin 1 signal transduction

1 reference

https://pubmed.ncbi.nlm.nih.gov/19593530

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Role of heat shock protein 27 phosphorylation in migration of vascular smooth muscle cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/19593530

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Heat shock protein expression in diabetic nephropathy

1 reference

https://pubmed.ncbi.nlm.nih.gov/19593530

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Deletion of MK2 signalling in vivo inhibits small Hsp phosphorylation but not diabetic nephropathy

1 reference

https://pubmed.ncbi.nlm.nih.gov/19593530

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Heat shock proteins in renal cell carcinomas

1 reference

https://pubmed.ncbi.nlm.nih.gov/19593530

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Hsp27: novel regulator of intracellular redox state

1 reference

https://pubmed.ncbi.nlm.nih.gov/19593530

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

HSP25 inhibits protein kinase C delta-mediated cell death through direct interaction

1 reference

https://pubmed.ncbi.nlm.nih.gov/19593530

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Heat shock protein 27 is a substrate of cGMP-dependent protein kinase in intact human platelets: phosphorylation-induced actin polymerization caused by HSP27 mutants

1 reference

https://pubmed.ncbi.nlm.nih.gov/19593530

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

PRAK, a novel protein kinase regulated by the p38 MAP kinase

1 reference

https://pubmed.ncbi.nlm.nih.gov/19593530

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mutations in the HSP27 (HSPB1) gene cause dominant, recessive, and sporadic distal HMN/CMT type 2

1 reference

https://pubmed.ncbi.nlm.nih.gov/19593530

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Role of F-actin organization in p38 MAP kinase-mediated apoptosis and necrosis in neonatal rat cardiomyocytes subjected to simulated ischemia and reoxygenation

1 reference

https://pubmed.ncbi.nlm.nih.gov/19593530

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Dephosphorylation of the small heat shock protein hsp25 by calcium/calmodulin-dependent (type 2B) protein phosphatase

1 reference

https://pubmed.ncbi.nlm.nih.gov/19593530

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Adenovirus-activated PKA and p38/MAPK pathways boost microtubule-mediated nuclear targeting of virus

1 reference

https://pubmed.ncbi.nlm.nih.gov/19593530

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Heat shock proteins: stress proteins with Janus-like properties in cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/19593530

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Roles and regulation of stat family transcription factors in human breast cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/19593530

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The expression of the growth-related 25kDa protein (p25) of Ehrlich ascites tumor cells is increased by hyperthermic treatment (heat shock).

1 reference

https://pubmed.ncbi.nlm.nih.gov/19593530

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The cellular "networking" of mammalian Hsp27 and its functions in the control of protein folding, redox state and apoptosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/19593530

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Phosphorylated heat shock protein 27 represses growth of hepatocellular carcinoma via inhibition of extracellular signal-regulated kinase

1 reference

https://pubmed.ncbi.nlm.nih.gov/19593530

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The protein kinase inhibitor SB203580 uncouples PMA-induced differentiation of HL-60 cells from phosphorylation of Hsp27.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19593530

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Phosphoproteome study reveals Hsp27 as a novel signaling molecule involved in GDNF-induced neurite outgrowth

1 reference

https://pubmed.ncbi.nlm.nih.gov/19593530

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Modulation of actin microfilament dynamics and fluid phase pinocytosis by phosphorylation of heat shock protein 27.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19593530

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Acute diabetes moderates trafficking of cardiac lipoprotein lipase through p38 mitogen-activated protein kinase-dependent actin cytoskeleton organization

1 reference

https://pubmed.ncbi.nlm.nih.gov/19593530

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Sequence and organization of genes encoding the human 27 kDa heat shock protein

1 reference

https://pubmed.ncbi.nlm.nih.gov/19593530

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

MAPK and heat shock protein 27 activation are associated with respiratory syncytial virus induction of human bronchial epithelial monolayer disruption

1 reference

https://pubmed.ncbi.nlm.nih.gov/19593530

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Blocking tumor cell migration and invasion with biphenyl isoxazole derivative KRIBB3, a synthetic molecule that inhibits Hsp27 phosphorylation

1 reference

https://pubmed.ncbi.nlm.nih.gov/19593530

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Phosphorylation-dependent cellular localization and thermoprotective role of heat shock protein 25 in hippocampal progenitor cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/19593530

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Chaperone Hsp27, a novel subunit of AUF1 protein complexes, functions in AU-rich element-mediated mRNA decay

1 reference

https://pubmed.ncbi.nlm.nih.gov/19593530

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inhibitors of signal transduction protein kinases as targets for cancer therapy

1 reference

https://pubmed.ncbi.nlm.nih.gov/19593530

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

3pK, a novel mitogen-activated protein (MAP) kinase-activated protein kinase, is targeted by three MAP kinase pathways

1 reference

https://pubmed.ncbi.nlm.nih.gov/19593530

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Differential estrogenic regulation of small M(r) heat shock protein expression in osteoblasts

1 reference

https://pubmed.ncbi.nlm.nih.gov/19593530

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Regulation of cyclooxygenase 2 mRNA stability by the mitogen-activated protein kinase p38 signaling cascade

1 reference

https://pubmed.ncbi.nlm.nih.gov/19593530

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Molecular cloning, sequencing and expression in Escherichia coli of the 25-kDa growth-related protein of Ehrlich ascites tumor and its homology to mammalian stress proteins

1 reference

https://pubmed.ncbi.nlm.nih.gov/19593530

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

MAPKAPK-2-mediated LIM-kinase activation is critical for VEGF-induced actin remodeling and cell migration

1 reference

https://pubmed.ncbi.nlm.nih.gov/19593530

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Role of protein phosphatase 2A in the regulation of endothelial cell cytoskeleton structure.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19593530

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Signal-transduction pathways that regulate visceral smooth muscle function. III. Coupling of muscarinic receptors to signaling kinases and effector proteins in gastrointestinal smooth muscles

1 reference

https://pubmed.ncbi.nlm.nih.gov/19593530

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1007/S00018-009-0086-3

1 reference

Europe PubMed Central

PubMed publication ID

21 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

21 August 2017

ResearchGate publication ID

0 references

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