(Q37353862)

19 August 2017

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title

Detecting shared pathogenesis from the shared genetics of immune-related diseases (English)

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19 August 2017

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19 August 2017

Alexandra Zhernakova

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Cleo C van Diemen

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19 August 2017

publication date

1 January 2009

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19 August 2017

published in

Nature Reviews Genetics

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19 August 2017

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19 August 2017

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19 August 2017

page(s)

43-55

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Cloning and characterization of human Lnk, an adaptor protein with pleckstrin homology and Src homology 2 domains that can inhibit T cell activation

19 August 2017

cites work

1 reference

CD40L: a multi-functional ligand

21 January 2018

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Immunological tolerance and the autoimmune response

21 January 2018

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New perspectives on mechanisms underlying chronic allergic inflammation and asthma in 2007.

31 March 2020

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The genetics and immunopathogenesis of inflammatory bowel disease

31 March 2020

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Autoimmune diseases co-occurring within individuals and within families: a systematic review

31 March 2020

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Occurrence of celiac disease after onset of type 1 diabetes: a 6-year prospective longitudinal study

31 March 2020

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Genome-wide association studies: a new window into immune-mediated diseases

31 March 2020

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Defining the role of the MHC in autoimmunity: a review and pooled analysis

31 March 2020

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Genetic determinants of diabetes are similarly associated with other immune-mediated diseases

31 March 2020

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Association of the T-cell regulatory gene CTLA4 with susceptibility to autoimmune disease

31 March 2020

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Clustering of non-major histocompatibility complex susceptibility candidate loci in human autoimmune diseases

31 March 2020

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The common variants/multiple disease hypothesis of common complex genetic disorders

31 March 2020

1 reference

Genetics of Crohn disease, an archetypal inflammatory barrier disease

31 March 2020

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A second generation human haplotype map of over 3.1 million SNPs

31 March 2020

1 reference

A HapMap harvest of insights into the genetics of common disease

31 March 2020

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The haplotype structure of the human major histocompatibility complex

31 March 2020

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Localization of type 1 diabetes susceptibility to the MHC class I genes HLA-B and HLA-A

31 March 2020

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Induction and effector functions of T(H)17 cells.

31 March 2020

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Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease

31 March 2020

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A large-scale genetic association study confirms IL12B and leads to the identification of IL23R as psoriasis-risk genes

31 March 2020

1 reference

Sequence variants in IL10, ARPC2 and multiple other loci contribute to ulcerative colitis susceptibility

31 March 2020

1 reference

Human regulatory T cells: role in autoimmune disease and therapeutic opportunities

31 March 2020

1 reference

Regulatory T cells and immune tolerance

31 March 2020

1 reference

Generalized autoimmune disease in interleukin-2-deficient mice is triggered by an uncontrolled activation and proliferation of CD4+ T cells

31 March 2020

1 reference

Ulcerative colitis-like disease in mice with a disrupted interleukin-2 gene

31 March 2020

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Interleukin-2 gene variation impairs regulatory T cell function and causes autoimmunity

31 March 2020

1 reference

Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls

31 March 2020

1 reference

Association scan of 14,500 nonsynonymous SNPs in four diseases identifies autoimmunity variants

31 March 2020

1 reference

Large-scale genetic fine mapping and genotype-phenotype associations implicate polymorphism in the IL2RA region in type 1 diabetes.

31 March 2020

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Robust associations of four new chromosome regions from genome-wide analyses of type 1 diabetes

31 March 2020

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A genome-wide association study for celiac disease identifies risk variants in the region harboring IL2 and IL21

31 March 2020

1 reference

Localization of a type 1 diabetes locus in the IL2RA/CD25 region by use of tag single-nucleotide polymorphisms

31 March 2020

1 reference

Interleukin 21 contributes to the mucosal T helper cell type 1 response in coeliac disease

31 March 2020

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Interleukin-21 (IL-21) controls inflammatory pathways in the gut.

31 March 2020

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Interleukin-21: a critical regulator of the balance between effector and regulatory T-cell responses

31 March 2020

1 reference

Regulation of immune responses by T cells

31 March 2020

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T-cell signalling and autoimmunity: molecular mechanisms of disease

31 March 2020

1 reference

Genome-wide association scan in women with systemic lupus erythematosus identifies susceptibility variants in ITGAM, PXK, KIAA1542 and other loci

31 March 2020

1 reference

Newly identified genetic risk variants for celiac disease related to the immune response

31 March 2020

1 reference

Cytotoxic T-lymphocyte associated antigen 4 gene polymorphisms and autoimmune thyroid disease: a meta-analysis

31 March 2020

1 reference

Mechanisms of genetic susceptibility to type I diabetes: beyond HLA.

31 March 2020

1 reference

Protein tyrosine phosphatase PTPN22 in human autoimmunity

31 March 2020

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Protein tyrosine phosphatases in autoimmunity.

31 March 2020

1 reference

The adaptor molecule Lnk negatively regulates tumor necrosis factor-alpha-dependent VCAM-1 expression in endothelial cells through inhibition of the ERK1 and -2 pathways

31 March 2020

1 reference

Fifty years of anti-ds DNA antibodies: are we approaching journey's end?

31 March 2020

1 reference

Systemic lupus erythematosus.

31 March 2020

1 reference

Antibodies as predictors of complex autoimmune diseases

31 March 2020

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Emerging patterns of risk factor make-up enable subclassification of rheumatoid arthritis

31 March 2020

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Common variants at CD40 and other loci confer risk of rheumatoid arthritis

31 March 2020

1 reference

Generation of memory B cells and plasma cells in vitro.

31 March 2020

1 reference

Development of Autoantibodies before the Clinical Onset of Systemic Lupus Erythematosus

31 March 2020

1 reference

Aberrant intestinal expression and allelic variants of mucin genes associated with inflammatory bowel disease

31 March 2020

1 reference

Role of mucins in inflammatory bowel disease: important lessons from experimental models

31 March 2020

1 reference

Muc2-deficient mice spontaneously develop colitis, indicating that MUC2 is critical for colonic protection

31 March 2020

1 reference

Associations with tight junction genes PARD3 and MAGI2 in Dutch patients point to a common barrier defect for coeliac disease and ulcerative colitis

31 March 2020

1 reference

A chromosome 8 gene-cluster polymorphism with low human beta-defensin 2 gene copy number predisposes to Crohn disease of the colon

31 March 2020

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Psoriasis is associated with increased beta-defensin genomic copy number

31 March 2020

1 reference

Getting under the skin: the immunogenetics of psoriasis

31 March 2020

1 reference

Unveiling the roles of autophagy in innate and adaptive immunity

31 March 2020

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Autophagy-dependent viral recognition by plasmacytoid dendritic cells

31 March 2020

1 reference

Systemic lupus erythematosus arising during interferon-alpha therapy for cryoglobulinemic vasculitis associated with hepatitis C.

31 March 2020

1 reference

Targeting interferon-alpha: a promising approach for systemic lupus erythematosus therapy.

31 March 2020

1 reference

An increased prevalence of Epstein-Barr virus infection in young patients suggests a possible etiology for systemic lupus erythematosus

31 March 2020

1 reference

Single nucleotide polymorphisms in TNFSF15 confer susceptibility to Crohn's disease

31 March 2020

1 reference

TL1A (TNFSF15) regulates the development of chronic colitis by modulating both T-helper 1 and T-helper 17 activation.

31 March 2020

1 reference

Deubiquitylation and regulation of the immune response

31 March 2020

1 reference

The ubiquitin-modifying enzyme A20 is required for termination of Toll-like receptor responses

31 March 2020

1 reference

Failure to regulate TNF-induced NF-kappaB and cell death responses in A20-deficient mice

31 March 2020

1 reference

Homeostatic MyD88-dependent signals cause lethal inflamMation in the absence of A20.

31 March 2020

1 reference

Viral exploitation and subversion of the immune system through chemokine mimicry

31 March 2020

1 reference

Epstein-Barr virus antibodies and risk of multiple sclerosis: a prospective study

31 March 2020

1 reference

A specific viral cause of multiple sclerosis: one virus, one disease

31 March 2020

1 reference

Innate immunity and intestinal microbiota in the development of Type 1 diabetes

31 March 2020

1 reference

Interleukin 7 receptor alpha chain (IL7R) shows allelic and functional association with multiple sclerosis

31 March 2020

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Distinct regulation of effector and memory T-cell differentiation.

31 March 2020

1 reference

Self- and nonself-recognition by C-type lectins on dendritic cells

31 March 2020

1 reference

Insulin expression in human thymus is modulated by INS VNTR alleles at the IDDM2 locus.

31 March 2020

1 reference

Rotavirus infection frequency and risk of celiac disease autoimmunity in early childhood: a longitudinal study

31 March 2020

1 reference

Drug-induced systemic lupus erythematosus associated with etanercept therapy

31 March 2020

1 reference

Selective abrogation of Th1 response by STA-5326, a potent IL-12/IL-23 inhibitor

31 March 2020

1 reference

Molecular prediction of disease risk and severity in a large Dutch Crohn's disease cohort

31 March 2020

1 reference

Clustering of autoimmune diseases in families with a high-risk for multiple sclerosis: a descriptive study.

31 March 2020

1 reference

HLA Dr-Dq haplotypes and the TNFA-308 polymorphism: associations with asthma and allergy

31 March 2020

1 reference

The HLA gene complex in thyroid autoimmunity: from epidemiology to etiology

31 March 2020

1 reference

Identification of two independent risk factors for lupus within the MHC in United Kingdom families

31 March 2020

1 reference

Risk alleles for multiple sclerosis identified by a genomewide study

31 March 2020

1 reference

A genome-wide association study of psoriasis and psoriatic arthritis identifies new disease loci

31 March 2020

1 reference

Recent advances in the genetics of RA susceptibility

31 March 2020

1 reference

Genetic determinants of ulcerative colitis include the ECM1 locus and five loci implicated in Crohn's disease

31 March 2020

1 reference

The clustering of other chronic inflammatory diseases in inflammatory bowel disease: a population-based study

31 March 2020

1 reference

Celiac disease in North Italian patients with autoimmune thyroid diseases

31 March 2020

1 reference

Clinical, subclinical and potential autoimmune diseases in an Italian population of children with coeliac disease

31 March 2020

1 reference

Could TH1 and TH2 diseases coexist? Evaluation of asthma incidence in children with coeliac disease, type 1 diabetes, or rheumatoid arthritis: a register study

31 March 2020

1 reference

Celiac disease and autoimmune thyroid disease.

31 March 2020

1 reference

Clustering of inflammatory bowel disease with immune mediated diseases among members of a northern california-managed care organization

31 March 2020

1 reference

Prevalence of systemic lupus erythematosus and associated comorbidities in Puerto Rico

31 March 2020

1 reference

Clinical review: Type 1 diabetes-associated autoimmunity: natural history, genetic associations, and screening

31 March 2020

1 reference

Variations in the C3, C3a receptor, and C5 genes affect susceptibility to bronchial asthma

31 March 2020

1 reference

Genetic variants regulating ORMDL3 expression contribute to the risk of childhood asthma

31 March 2020

1 reference

A genome-wide association study identifies IL23R as an inflammatory bowel disease gene

31 March 2020

1 reference

Systematic association mapping identifies NELL1 as a novel IBD disease gene

31 March 2020

1 reference

Replication of signals from recent studies of Crohn's disease identifies previously unknown disease loci for ulcerative colitis

31 March 2020

1 reference

A genome-wide association scan of nonsynonymous SNPs identifies a susceptibility variant for Crohn disease in ATG16L1

31 March 2020

1 reference

Loci on 20q13 and 21q22 are associated with pediatric-onset inflammatory bowel disease

31 March 2020

1 reference

Novel Crohn disease locus identified by genome-wide association maps to a gene desert on 5p13.1 and modulates expression of PTGER4

31 March 2020

1 reference

Sequence variants in the autophagy gene IRGM and multiple other replicating loci contribute to Crohn's disease susceptibility

31 March 2020

1 reference

Genome-wide association study for Crohn's disease in the Quebec Founder Population identifies multiple validated disease loci

31 March 2020

1 reference

Genome-wide association study identifies new susceptibility loci for Crohn disease and implicates autophagy in disease pathogenesis

31 March 2020

1 reference

ATG16L1andIL23RAre Associated With Inflammatory Bowel Diseases but Not With Celiac Disease in The Netherlands

31 March 2020

1 reference

Genetic analysis of innate immunity in Crohn's disease and ulcerative colitis identifies two susceptibility loci harboring CARD9 and IL18RAP.

31 March 2020

1 reference

An insertion-deletion polymorphism in the interferon regulatory Factor 5 (IRF5) gene confers risk of inflammatory bowel diseases

31 March 2020

1 reference

Identification of ZNF313/RNF114 as a novel psoriasis susceptibility gene

31 March 2020

1 reference

Novel association in chromosome 4q27 region with rheumatoid arthritis and confirmation of type 1 diabetes point to a general risk locus for autoimmune diseases

31 March 2020

1 reference

STAT4 and the risk of rheumatoid arthritis and systemic lupus erythematosus

31 March 2020

1 reference

TRAF1-C5 as a risk locus for rheumatoid arthritis--a genomewide study

31 March 2020

1 reference

A functional variant in FCRL3, encoding Fc receptor-like 3, is associated with rheumatoid arthritis and several autoimmunities

31 March 2020

1 reference

Rheumatoid arthritis association at 6q23.

31 March 2020

1 reference

Interleukin-18 gene polymorphism, but not interleukin-2 gene polymorphism, is associated with rheumatoid arthritis

31 March 2020

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Two independent alleles at 6q23 associated with risk of rheumatoid arthritis

31 March 2020

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Association of interferon regulatory factor 5 haplotypes, similar to that found in systemic lupus erythematosus, in a large subgroup of patients with rheumatoid arthritis

31 March 2020

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Association of LY9 in UK and Canadian SLE families

31 March 2020

1 reference

Association of systemic lupus erythematosus with C8orf13-BLK and ITGAM-ITGAX

31 March 2020

1 reference

Functional variants in the B-cell gene BANK1 are associated with systemic lupus erythematosus

31 March 2020

1 reference

A nonsynonymous functional variant in integrin-αM (encoded by ITGAM) is associated with systemic lupus erythematosus

31 March 2020

1 reference

A risk haplotype of STAT4 for systemic lupus erythematosus is over-expressed, correlates with anti-dsDNA and shows additive effects with two risk alleles of IRF5.

31 March 2020

1 reference

Polymorphism at the TNF superfamily gene TNFSF4 confers susceptibility to systemic lupus erythematosus

31 March 2020

1 reference

A genome-wide association study identifies KIAA0350 as a type 1 diabetes gene

31 March 2020

1 reference

A novel susceptibility locus for type 1 diabetes on Chr12q13 identified by a genome-wide association study

31 March 2020

1 reference

A genome-wide association study of nonsynonymous SNPs identifies a type 1 diabetes locus in the interferon-induced helicase (IFIH1) region

31 March 2020

1 reference

New susceptibility genes for ulcerative colitis

31 March 2020

1 reference

WEB-based GEne SeT AnaLysis Toolkit (WebGestalt): update 2013

31 March 2020

1 reference

12 December 2020

Inflammatory eye, skin, and bowel disease in spondyloarthritis: genetic, phenotypic, and environmental factors

1 reference

12 December 2020

Adult celiac disease followed by onset of systemic lupus erythematosus

1 reference

12 December 2020

Serum levels of interferons in patients with systemic lupus erythematosus

1 reference

12 December 2020

DAVID: Database for Annotation, Visualization, and Integrated Discovery

1 reference

12 December 2020

Increased occurrence of psoriasis in patients with Crohn's disease and their relatives

1 reference

12 December 2020

Prevalence and distribution of autoimmune diseases in 368 rheumatoid arthritis families.

1 reference

12 December 2020

High prevalence of celiac disease among patients with insulin-dependent (type I) diabetes mellitus.

1 reference

12 December 2020

Identifiers

DOI

10.1038/NRG2489

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19 August 2017

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