(Q37127240)

18 August 2017

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title

Enabling personalized cancer medicine through analysis of gene-expression patterns (English)

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18 August 2017

René Bernards

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Laura J van't Veer

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18 August 2017

language of work or name

English

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publication date

1 April 2008

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18 August 2017

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18 August 2017

volume

452

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18 August 2017

issue

7187

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18 August 2017

page(s)

564-570

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Gene-expression profiles to predict distant metastasis of lymph-node-negative primary breast cancer

18 August 2017

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Light-directed, spatially addressable parallel chemical synthesis

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Gene expression profiling predicts clinical outcome of breast cancer

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Linking oncogenic pathways with therapeutic opportunities

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Oncogenic pathway signatures in human cancers as a guide to targeted therapies

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A multigene assay to predict recurrence of tamoxifen-treated, node-negative breast cancer

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Gene expression patterns of breast carcinomas distinguish tumor subclasses with clinical implications

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Repeated observation of breast tumor subtypes in independent gene expression data sets

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Distinct types of diffuse large B-cell lymphoma identified by gene expression profiling

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Thousands of samples are needed to generate a robust gene list for predicting outcome in cancer

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Strong time dependence of the 76-gene prognostic signature for node-negative breast cancer patients in the TRANSBIG multicenter independent validation series

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Validation and clinical utility of a 70-gene prognostic signature for women with node-negative breast cancer

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Concordance among gene-expression-based predictors for breast cancer

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Pathway analysis of gene signatures predicting metastasis of node-negative primary breast cancer

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A genomic strategy to refine prognosis in early-stage non-small-cell lung cancer.

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The HOXB13:IL17BR expression index is a prognostic factor in early-stage breast cancer

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Predictors of resistance to preoperative trastuzumab and vinorelbine for HER2-positive early breast cancer

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Gene expression profiles of multiple breast cancer phenotypes and response to neoadjuvant chemotherapy

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Poor prognosis in carcinoma is associated with a gene expression signature of aberrant PTEN tumor suppressor pathway activity.

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Functional discovery via a compendium of expression profiles

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The Connectivity Map: using gene-expression signatures to connect small molecules, genes, and disease

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7 January 2021

Gene expression signature-based chemical genomic prediction identifies a novel class of HSP90 pathway modulators

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7 January 2021

Gene expression-based chemical genomics identifies rapamycin as a modulator of MCL1 and glucocorticoid resistance

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7 January 2021

Efficacy and safety of trastuzumab as a single agent in first-line treatment of HER2-overexpressing metastatic breast cancer

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A functional genetic approach identifies the PI3K pathway as a major determinant of trastuzumab resistance in breast cancer

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7 January 2021

PTEN activation contributes to tumor inhibition by trastuzumab, and loss of PTEN predicts trastuzumab resistance in patients.

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7 January 2021

Regulators of mitotic arrest and ceramide metabolism are determinants of sensitivity to paclitaxel and other chemotherapeutic drugs.

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7 January 2021

Synthetic lethal screen identification of chemosensitizer loci in cancer cells

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Targeting the DNA repair defect in BRCA mutant cells as a therapeutic strategy

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7 January 2021

Specific killing of BRCA2-deficient tumours with inhibitors of poly(ADP-ribose) polymerase

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7 January 2021

The MicroArray Quality Control (MAQC) project shows inter- and intraplatform reproducibility of gene expression measurements

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7 January 2021

TAILORx: trial assigning individualized options for treatment (Rx)

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7 January 2021

A gene-expression signature as a predictor of survival in breast cancer

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7 January 2021

American Society of Clinical Oncology 2007 update of recommendations for the use of tumor markers in breast cancer

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7 January 2021

Reliability of immunohistochemical demonstration of oestrogen receptors in routine practice: interlaboratory variance in the sensitivity of detection and evaluation of scoring systems

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7 January 2021

Robust interlaboratory reproducibility of a gene expression signature measurement consistent with the needs of a new generation of diagnostic tools

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7 January 2021

Identifiers

DOI

10.1038/NATURE06915

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Dimensions Publication ID

18 August 2017

1043830331

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1 reference