(Q37171815)

18 August 2017

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title

Multiple roles for lipids in the Hedgehog signalling pathway (English)

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18 August 2017

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Suzanne Eaton

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18 August 2017

publication date

1 June 2008

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Nature Reviews Molecular Cell Biology

18 August 2017

published in

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18 August 2017

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18 August 2017

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18 August 2017

page(s)

437-445

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Growth-inhibitory effects of vitamin D analogues and retinoids on human pancreatic cancer cells

18 August 2017

cites work

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Vitamin D receptors and anti-proliferative effects of vitamin D derivatives in human pancreatic carcinoma cells in vivo and in vitro

21 January 2018

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Oxysterol biosynthetic enzymes

21 January 2018

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START domain proteins and the intracellular trafficking of cholesterol in steroidogenic cells

21 January 2018

1 reference

Lipid and cholesterol trafficking in NPC.

21 January 2018

1 reference

Hedgehog signaling in development and homeostasis of the gastrointestinal tract

21 January 2018

1 reference

Sonic hedgehog controls stem cell behavior in the postnatal and adult brain

31 March 2020

1 reference

Sonic hedgehog signalling in T-cell development and activation

31 March 2020

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A defective response to Hedgehog signaling in disorders of cholesterol biosynthesis

31 March 2020

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Human developmental disorders and the Sonic hedgehog pathway

31 March 2020

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Widespread requirement for Hedgehog ligand stimulation in growth of digestive tract tumours

31 March 2020

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Sonic Hedgehog signaling in advanced prostate cancer

31 March 2020

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Sonic hedgehog in normal and neoplastic proliferation: insight gained from human tumors and animal models

31 March 2020

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Gli and hedgehog in cancer: tumours, embryos and stem cells.

31 March 2020

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Cholesterol modification of hedgehog signaling proteins in animal development

31 March 2020

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Hedgehog patterning activity: role of a lipophilic modification mediated by the carboxy-terminal autoprocessing domain

31 March 2020

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Identification of a palmitic acid-modified form of human Sonic hedgehog

31 March 2020

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Skinny hedgehog, an acyltransferase required for palmitoylation and activity of the hedgehog signal

31 March 2020

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Sightless has homology to transmembrane acyltransferases and is required to generate active Hedgehog protein

31 March 2020

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Cholesterol modification of hedgehog is required for trafficking and movement, revealing an asymmetric cellular response to hedgehog

31 March 2020

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Cholesterol modification is necessary for controlled planar long-range activity of Hedgehog in Drosophila epithelia

31 March 2020

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Palmitoylation is required for the production of a soluble multimeric Hedgehog protein complex and long-range signaling in vertebrates

31 March 2020

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An acylatable residue of Hedgehog is differentially required in Drosophila and mouse limb development

31 March 2020

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Association of sterol- and glycosylphosphatidylinositol-linked proteins with Drosophila raft lipid microdomains.

31 March 2020

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Effects of oncogenic mutations in Smoothened and Patched can be reversed by cyclopamine

31 March 2020

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Synergistic and antagonistic roles of the Sonic hedgehog N- and C-terminal lipids

31 March 2020

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Dispatched, a novel sterol-sensing domain protein dedicated to the release of cholesterol-modified hedgehog from signaling cells

31 March 2020

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Hedgehog-mediated patterning of the mammalian embryo requires transporter-like function of dispatched

31 March 2020

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Multidrug-resistance efflux pumps - not just for resistance

31 March 2020

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Cholesterol sensing, trafficking, and esterification.

31 March 2020

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A freely diffusible form of Sonic hedgehog mediates long-range signalling

31 March 2020

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Hedgehog lipid modifications are required for Hedgehog stabilization in the extracellular matrix

31 March 2020

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Lipoprotein particles are required for Hedgehog and Wingless signalling

31 March 2020

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Alternative lipid mobilization: the insect shuttle system

31 March 2020

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Lipid storage and mobilization in insects: current status and future directions

31 March 2020

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Molecular characterization and developmental expression of a retinoid- and fatty acid-binding glycoprotein from Drosophila. A putative lipophorin

31 March 2020

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Apolipophorin II/I, apolipoprotein B, vitellogenin, and microsomal triglyceride transfer protein genes are derived from a common ancestor.

31 March 2020

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Lipoprotein-heparan sulfate interactions in the Hh pathway

31 March 2020

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Cholesterol modification restricts the spread of Shh gradient in the limb bud.

31 March 2020

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Hedgehog movement is regulated through tout velu-dependent synthesis of a heparan sulfate proteoglycan

31 March 2020

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Three Drosophila EXT genes shape morphogen gradients through synthesis of heparan sulfate proteoglycans

31 March 2020

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Drosophila glypicans control the cell-to-cell movement of Hedgehog by a dynamin-independent process.

31 March 2020

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Patched acts catalytically to suppress the activity of Smoothened

31 March 2020

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Inhibition of Hedgehog signaling by direct binding of cyclopamine to Smoothened

31 March 2020

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Teratogen-mediated inhibition of target tissue response to Shh signaling

31 March 2020

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Small-molecule modulators of Hedgehog signaling: identification and characterization of Smoothened agonists and antagonists

31 March 2020

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Small molecule modulation of Smoothened activity

31 March 2020

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Mutations in the sterol-sensing domain of Patched suggest a role for vesicular trafficking in Smoothened regulation

31 March 2020

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Inborn errors of sterol biosynthesis

31 March 2020

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Human malformation syndromes due to inborn errors of cholesterol synthesis

31 March 2020

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Cholesterol homeostasis in development: the role of Xenopus 7-dehydrocholesterol reductase (Xdhcr7) in neural development.

31 March 2020

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Severe facial clefting in Insig-deficient mouse embryos caused by sterol accumulation and reversed by lovastatin

31 March 2020

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Biochemical, phenotypic and neurophysiological characterization of a genetic mouse model of RSH/Smith--Lemli--Opitz syndrome

31 March 2020

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Repression of smoothened by patched-dependent (pro-)vitamin D3 secretion

31 March 2020

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Metabolism and Mechanism of Action of Vitamin D

31 March 2020

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Human plasma transport of vitamin D after its endogenous synthesis

31 March 2020

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31 March 2020

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Functions of 1alpha,25-dihydroxyvitamin D(3) in mammary gland: from normal development to breast cancer

31 March 2020

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Oxysterols regulate differentiation of mesenchymal stem cells: pro-bone and anti-fat

31 March 2020

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Oxysterols are novel activators of the hedgehog signaling pathway in pluripotent mesenchymal cells

31 March 2020

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Oxysterols stimulate Sonic hedgehog signal transduction and proliferation of medulloblastoma cells

31 March 2020

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Medulloblastoma growth inhibition by hedgehog pathway blockade

31 March 2020

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NPC1 and NPC2 Regulate Cellular Cholesterol Homeostasis through Generation of Low Density Lipoprotein Cholesterol-derived Oxysterols

31 March 2020

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Patched1 regulates hedgehog signaling at the primary cilium

31 March 2020

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The LXRs: a new class of oxysterol receptors

31 March 2020

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Emerging roles of the oxysterol-binding protein family in metabolism, transport, and signaling.

31 March 2020

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31 March 2020

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Sterol-regulated transport of SREBPs from endoplasmic reticulum to Golgi: oxysterols block transport by binding to Insig

31 March 2020

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Intracellular cholesterol transport

31 March 2020

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Cellular cholesterol trafficking and compartmentalization

31 March 2020

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Transmembrane molecular pump activity of Niemann-Pick C1 protein

31 March 2020

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Nonvesicular sterol transport: two protein families and a sterol sensor?

31 March 2020

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The Niemann-Pick C proteins and trafficking of cholesterol through the late endosomal/lysosomal system

31 March 2020

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Niemann-Pick type C disease and intracellular cholesterol trafficking

31 March 2020

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Oxysterol-activated LXRalpha/RXR induces hSR-BI-promoter activity in hepatoma cells and preadipocytes

31 March 2020

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Control of cellular cholesterol efflux by the nuclear oxysterol receptor LXR alpha

31 March 2020

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A Drosophila model of the Niemann-Pick type C lysosome storage disease: dnpc1a is required for molting and sterol homeostasis

31 March 2020

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Mutations of a Drosophila NPC1 gene confer sterol and ecdysone metabolic defects

31 March 2020

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NCR-1 and NCR-2, the C. elegans homologs of the human Niemann-Pick type C1 disease protein, function upstream of DAF-9 in the dauer formation pathways

31 March 2020

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Niemann-Pick type C disease involves disrupted neurosteroidogenesis and responds to allopregnanolone

31 March 2020

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Cholesterol substrate pools and steroid hormone levels are normal in the face of mutational inactivation of NPC1 protein

31 March 2020

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Cholesterol uptake in adrenal and gonadal tissues: the SR-BI and 'selective' pathway connection

31 March 2020

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Adrenal cholesterol utilization

31 March 2020

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Hormone-sensitive lipase is required for high-density lipoprotein cholesteryl ester-supported adrenal steroidogenesis

31 March 2020

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Interaction of hormone-sensitive lipase with steroidogenic acute regulatory protein: facilitation of cholesterol transfer in adrenal

31 March 2020

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Hormone-sensitive lipase deficiency in mice causes lipid storage in the adrenal cortex and impaired corticosterone response to corticotropin stimulation

31 March 2020

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Pathways for kidney-specific uptake of the steroid hormone 25-hydroxyvitamin D3.

31 March 2020

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Novel regulators of vitamin D action and metabolism: Lessons learned at the Los Angeles zoo

31 March 2020

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Response element binding proteins and intracellular vitamin D binding proteins: novel regulators of vitamin D trafficking, action and metabolism

31 March 2020

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Regulation of 1,25-Dihydroxyvitamin D Synthesis by Intracellular Vitamin D Binding Protein-1

31 March 2020

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Intracellular vitamin D binding proteins: novel facilitators of vitamin D-directed transactivation

31 March 2020

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Cyclopamine inhibition of Sonic hedgehog signal transduction is not mediated through effects on cholesterol transport.

31 March 2020

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Megalin functions as an endocytic sonic hedgehog receptor

31 March 2020

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Epithelial trafficking of Sonic hedgehog by megalin

31 March 2020

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Defective forebrain development in mice lacking gp330/megalin

31 March 2020

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ABCA1 mediates high-affinity uptake of 25-hydroxycholesterol by membrane vesicles and rapid efflux of oxysterol by intact cells

31 March 2020

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Hedgehog induces opposite changes in turnover and subcellular localization of patched and smoothened

31 March 2020

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Altered localization of Drosophila Smoothened protein activates Hedgehog signal transduction

31 March 2020

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Cilia and Hedgehog responsiveness in the mouse

31 March 2020

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Extensive phosphorylation of Smoothened in Hedgehog pathway activation

31 March 2020

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Drosophila Smoothened phosphorylation sites essential for Hedgehog signal transduction

31 March 2020

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Hedgehog regulates smoothened activity by inducing a conformational switch

31 March 2020

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The Hedgehog response network: sensors, switches, and routers

31 March 2020

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Signaling from Smo to Ci/Gli: conservation and divergence of Hedgehog pathways from Drosophila to vertebrates

31 March 2020

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31 March 2020

Identifiers

DOI

10.1038/NRM2414

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release_h6di4dhxbzbmfmh4evodunli4y

18 August 2017

Fatcat ID

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Fatcat

https://api.fatcat.wiki/v0/release/h6di4dhxbzbmfmh4evodunli4y

mapped directly with Wikidata item

24 November 2022

based on heuristic

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