(Q37056216)

18 August 2017

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title

Many roads lead to oncogene-induced senescence (English)

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18 August 2017

S Courtois-Cox

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18 August 2017

S L Jones

series ordinal

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18 August 2017

K Cichowski

series ordinal

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18 August 2017

language of work or name

English

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publication date

14 January 2008

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18 August 2017

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18 August 2017

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18 August 2017

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18 August 2017

page(s)

2801-2809

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Remodeling of chromatin structure in senescent cells and its potential impact on tumor suppression and aging

18 August 2017

cites work

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210950

Oncogene-induced senescence is part of the tumorigenesis barrier imposed by DNA damage checkpoints

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210950

Aberrant regulation of ras proteins in malignant tumour cells from type 1 neurofibromatosis patients

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1210950

Role of phosphoinositide 3-kinase regulatory isoforms in development and actin rearrangement

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1210950

Oncogene-induced senescence as an initial barrier in lymphoma development

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210950

Germline loss-of-function mutations in SPRED1 cause a neurofibromatosis 1-like phenotype

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210950

The role of apoptosis in cancer development and treatment response

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210950

Molecular analysis of H2O2-induced senescent-like growth arrest in normal human fibroblasts: p53 and Rb control G1 arrest but not cell replication

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210950

Crucial role of p53-dependent cellular senescence in suppression of Pten-deficient tumorigenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210950

Tumour biology: senescence in premalignant tumours

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210950

A negative feedback signaling network underlies oncogene-induced senescence

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210950

A new mouse model to explore the initiation, progression, and therapy of BRAFV600E-induced lung tumors

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210950

Abnormal regulation of mammalian p21ras contributes to malignant tumor growth in von Recklinghausen (type 1) neurofibromatosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210950

Transforming genes of human bladder and lung carcinoma cell lines are homologous to the ras genes of Harvey and Kirsten sarcoma viruses

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210950

Oncogene-induced senescence is a DNA damage response triggered by DNA hyper-replication

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210950

Role of K-ras and Pten in the development of mouse models of endometriosis and endometrioid ovarian cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210950

p38alpha MAP kinase as a sensor of reactive oxygen species in tumorigenesis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210950

Cell cycle regulation in H(2)O(2)-induced premature senescence of human diploid fibroblasts and regulatory control exerted by the papilloma virus E6 and E7 proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210950

Tumor induction by an endogenous K-ras oncogene is highly dependent on cellular context

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210950

Oncogenes and senescence: breaking down in the fast lane

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210950

Trp53R172H and KrasG12D cooperate to promote chromosomal instability and widely metastatic pancreatic ductal adenocarcinoma in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210950

Differentially expressed genes in neurofibromatosis 1-associated neurofibromas and malignant peripheral nerve sheath tumors

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210950

Mouse models of human non-small-cell lung cancer: raising the bar.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210950

Modulation of signalling by Sprouty: a developing story

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210950

Tumorigenic conversion of primary embryo fibroblasts requires at least two cooperating oncogenes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210950

Deregulated E2F activity induces hyperplasia and senescence-like features in the mouse pituitary gland

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210950

Sprouty and cancer: the first terms report.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210950

c-Jun-deficient cells undergo premature senescence as a result of spontaneous DNA damage accumulation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210950

The DNA damage signaling pathway connects oncogenic stress to cellular senescence.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210950

The DNA damage signaling pathway is a critical mediator of oncogene-induced senescence.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210950

The RAS/RAF/MEK/ERK and PI3K/AKT signaling pathways present molecular targets for the effective treatment of advanced melanoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210950

BRAFE600-associated senescence-like cell cycle arrest of human naevi

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210950

Akt negatively regulates the in vitro lifespan of human endothelial cells via a p53/p21-dependent pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210950

A novel role for high-mobility group a proteins in cellular senescence and heterochromatin formation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210950

Rb-mediated heterochromatin formation and silencing of E2F target genes during cellular senescence

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210950

FoxOs are lineage-restricted redundant tumor suppressors and regulate endothelial cell homeostasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210950

Human EJ bladder carcinoma oncogene is homologue of Harvey sarcoma virus ras gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210950

Oxygen sensitivity severely limits the replicative lifespan of murine fibroblasts

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210950

Loss of Apc allows phenotypic manifestation of the transforming properties of an endogenous K-ras oncogene in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210950

Dose-dependent oncogene-induced senescence in vivo and its evasion during mammary tumorigenesis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210950

Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210950

Repression of c-fos transcription and an altered genetic program in senescent human fibroblasts

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210950

Sprouty-2 regulates oncogenic K-ras in lung development and tumorigenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210950

PRAK is essential for ras-induced senescence and tumor suppression

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210950

Identification of a tumour suppressor network opposing nuclear Akt function

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210950

Pten dose dictates cancer progression in the prostate

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210950

Endogenous oncogenic K-ras(G12D) stimulates proliferation and widespread neoplastic and developmental defects.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210950

Restoration of p53 function leads to tumour regression in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210950

Regulation of cellular response to oncogenic and oxidative stress by Seladin-1

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210950

Senescence and tumour clearance is triggered by p53 restoration in murine liver carcinomas

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210950

Downregulation of Wnt signaling is a trigger for formation of facultative heterochromatin and onset of cell senescence in primary human cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210950

Regulation of a senescence checkpoint response by the E2F1 transcription factor and p14(ARF) tumor suppressor

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210950

7 January 2021

The role of apoptosis in cancer cell survival and therapeutic outcome

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210950

7 January 2021

Ras proteins induce senescence by altering the intracellular levels of reactive oxygen species

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210950

7 January 2021

Ras induces vascular smooth muscle cell senescence and inflammation in human atherosclerosis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210950

7 January 2021

MYC can induce DNA breaks in vivo and in vitro independent of reactive oxygen species

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210950

7 January 2021

Identifiers

DOI

10.1038/SJ.ONC.1210950

1 reference

release_q2xdytzytva4ppoo4ittlbtjgi

18 August 2017

Fatcat ID

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/q2xdytzytva4ppoo4ittlbtjgi

24 November 2022

mapped directly with Wikidata item

1 reference