(Q36936660)

17 August 2017

1 reference

title

Glutathione deficiency produced by inhibition of its synthesis, and its reversal; applications in research and therapy (English)

1 reference

17 August 2017

Glutathione deficiency produced by inhibition of its synthesis, and its reversal; Applications in research and therapy (English)

1 reference

https://api.crossref.org/works/10.1016/0163-7258(91)90076-X

22 November 2022

1 reference

1 reference

https://api.crossref.org/works/10.1016/0163-7258(91)90076-X

22 November 2022

A. Meister

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A1784629

22 November 2022

language of work or name

English

1 reference

National Center for Biotechnology Information

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=1784629

22 November 2022

publication date

1 January 1991

1 reference

full work available at URL

17 August 2017

https://api.elsevier.com/content/article/PII:016372589190076X?httpAccept=text/xml

1 reference

https://api.crossref.org/works/10.1016/0163-7258(91)90076-X

https://api.elsevier.com/content/article/PII:016372589190076X?httpAccept=text/plain

22 November 2022

1 reference

https://api.crossref.org/works/10.1016/0163-7258(91)90076-X

Pharmacology & Therapeutics

22 November 2022

published in

1 reference

17 August 2017

1 reference

17 August 2017

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17 August 2017

page(s)

155-194

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Intrahepatic transport and utilization of biliary glutathione and its metabolites

17 August 2017

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22 November 2022

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22 November 2022

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22 November 2022

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22 November 2022

Glutathione monoesters

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Direct evidence for inter-organ transport of glutathione and that the non-filtration renal mechanism for glutathione utilization involves gamma-glutamyl transpeptidase

22 November 2022

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22 November 2022

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22 November 2022

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22 November 2022

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22 November 2022

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22 November 2022

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22 November 2022

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22 November 2022

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22 November 2022

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22 November 2022

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22 November 2022

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Nonprotein thiols and the radiation response of A549 human lung carcinoma cells

22 November 2022

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Increasing chemosensitivity to cisplatin by glutathione depletion with buthionine sulfoximine. In vitro and in vivo studies with a human squamous cell cancer line

22 November 2022

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Quantitative nutritional studies with water-soluble, chemically defined diets. III. Individual amino acids as sources of non-essential nitrogen

22 November 2022

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An enzyme from rat liver catalysing conjugations with glutathione

22 November 2022

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The mitochondrial generation of hydrogen peroxide. General properties and effect of hyperbaric oxygen

22 November 2022

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The cellular production of hydrogen peroxide

22 November 2022

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Buthionine sulfoximine inhibition of cystine uptake and glutathione biosynthesis in human lung carcinoma cells

22 November 2022

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Role of glutathione in the radiation response of mammalian cells in vitro and in vivo

22 November 2022

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TUMOUR SULPHYDRYL LEVELS AND SENSITIVITY TO THE NITROGEN MUSTARD MEROPHAN

22 November 2022

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Near-total glutathione depletion and age-specific cataracts induced by buthionine sulfoximine in mice

22 November 2022

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Long-term home use of acetylcysteine in chronic bronchitis

22 November 2022

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Blood-brain barrier restriction of peptides and the low uptake of enkephalins

22 November 2022

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Enzymic Formation of Pyrrolidone Carboxylic Acid from γ-Glutamyl Peptides

22 November 2022

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Protection against the toxicity of alkylating agents by thiols: The mechanism of protection and its relevance to cancer chemotherapy

22 November 2022

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Effect of diethylmaleate and other glutathione depletors on protein synthesis

22 November 2022

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Gastrointestinal metabolism of N-acetylcysteine in the rat, including an assay for sulfite in biological systems

22 November 2022

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No penetration of orally administered N-acetylcysteine into bronchoalveolar lavage fluid

22 November 2022

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The pulmonary effects of buthionine sulfoximine treatment and glutathione depletion in rats

22 November 2022

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Glutathione depletion as a determinant of sensitivity of human leukemia cells to cyclophosphamide

22 November 2022

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The replacement by thiazolidinecarboxylic acid of exogenous cystine and cysteine

22 November 2022

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Importance and regulation of hepatic glutathione

22 November 2022

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Glutathione metabolism in cultured Sertoli cells and spermatogenic cells from hamsters

22 November 2022

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Regulation of cellular glutathione

22 November 2022

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Toxic effects of extended glutathione depletion by buthionine sulfoximine on murine mammary carcinoma cells

22 November 2022

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Glutathione export by human lymphoid cells: depletion of glutathione by inhibition of its synthesis decreases export and increases sensitivity to irradiation

22 November 2022

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Antioxidant and co-antioxidant activity of vitamin C. The effect of vitamin C, either alone or in the presence of vitamin E or a water-soluble vitamin E analogue, upon the peroxidation of aqueous multilamellar phospholipid liposomes

22 November 2022

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Role of the glutathione-glutathione peroxidase cycle in the cytotoxicity of the anticancer quinones

22 November 2022

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The effects of buthionine sulphoximine (BSO) on glutathione depletion and xenobiotic biotransformation

22 November 2022

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Transport of glutathione across the small intestine of the rat in vitro

22 November 2022

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Extraction of glutathione by the isolated perfused rabbit kidney

22 November 2022

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Increased melphalan activity in intracranial human medulloblastoma and glioma xenografts following buthionine sulfoximine-mediated glutathione depletion.

22 November 2022

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Reversal of age-associated decline in immune responsiveness by dietary glutathione supplementation in mice

22 November 2022

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22 November 2022

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Computer analysis of the active site of glutamine synthetase

22 November 2022

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Influence of a cysteine prodrug, L-2-oxothiazolidine-4-carboxylic acid, on the urinary elimination of mercapturic acids of ethylene oxide, dibromoethane, and acrylonitrile: a dose-effect study.

22 November 2022

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Potentiation of melphalan cytotoxicity in human ovarian cancer cell lines by glutathione depletion

22 November 2022

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Potent and specific inhibition of glutathione synthesis by buthionine sulfoximine (S-n-butyl homocysteine sulfoximine)

22 November 2022

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Origin and turnover of mitochondrial glutathione

22 November 2022

104

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Thiol groups of biological importance

22 November 2022

107

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Assessment of the kidney function in maintenance of plasma glutathione concentration and redox state in anaesthetized rats

22 November 2022

108

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Transepithelial transport of glutathione in vascularly perfused small intestine of rat

22 November 2022

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22 November 2022

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22 November 2022

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Augmentation of adriamycin, melphalan, and cisplatin cytotoxicity in drug-resistant and -sensitive human ovarian carcinoma cell lines by buthionine sulfoximine mediated glutathione depletion.

22 November 2022

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Synthesis of Peptides in Enzymic Reactions involving Glutathione

22 November 2022

116

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Experimental production of renal glycosuria, phosphaturia, and aminoaciduria by injection of maleic acid

22 November 2022

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On an Autoxidisable Constituent of the Cell

22 November 2022

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Some relations between ascorbic acid and glutathione

22 November 2022

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The influence of thiol-groups in the activity of dehydrogenases

22 November 2022

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Absorption of glutathione from the gastro-intestinal tract

22 November 2022

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22 November 2022

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22 November 2022

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Enhancement of cisplatin toxicity by buthionine sulfoximine, a glutathione-depleting agent, in mice

22 November 2022

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Glutathione deficiency leads to mitochondrial damage in brain

22 November 2022

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Some properties of mitochondrial glutathione

22 November 2022

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Evidence for carrier-mediated transport of glutathione across the blood-brain barrier in the rat

22 November 2022

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Morphological changes in rat brain induced by L-cysteine injection in newborn animals

22 November 2022

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Direct evidence of intercellular sharing of glutathione via metabolic cooperation

22 November 2022

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Lest I Forget Thee, Glutathione …

22 November 2022

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The effect of glutathione (GSH) depletion in vivo by buthionine sulfoximine (BSO) on the radiosensitization of SR 2508

22 November 2022

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Transport of glutathione across the mitochondrial membranes

22 November 2022

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Effect of glutathione on DNA repair in cisplatin-resistant human ovarian cancer cell lines.

22 November 2022

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Oxidative stress in isolated rat renal proximal and distal tubular cells

22 November 2022

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Exogenous glutathione protects intestinal epithelial cells from oxidative injury

22 November 2022

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Depletion of tumour versus normal tissue glutathione by buthionine sulfoximine

22 November 2022

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Changes in cellular glutathione content during adriamycin treatment in human ovarian cancer--a possible indicator of chemosensitivity

22 November 2022

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The effect of glutathione on the vitamin E requirement for inhibition of liver microsomal lipid peroxidation

22 November 2022

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Spermatogenic cell-somatic cell interactions are required for maintenance of spermatogenic cell glutathione

22 November 2022

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22 November 2022

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22 November 2022

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22 November 2022

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Oral N-acetylcysteine and exacerbation rates in patients with chronic bronchitis and severe airways obstruction. British Thoracic Society Research Committee

22 November 2022

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Identification of L-methionine S-sulfoximine as the diastereoisomer of L-methionine SR-sulfoximine that inhibits glutamine synthetase

22 November 2022

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The reduction of glutathione by plant tissues

22 November 2022

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Glutathione metabolism in the lung: inhibition of its synthesis leads to lamellar body and mitochondrial defects

22 November 2022

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Glutathione ester prevents buthionine sulfoximine-induced cataracts and lens epithelial cell damage

22 November 2022

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Glutathione is required for intestinal function

22 November 2022

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22 November 2022

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Effect of glutathione depletion on morphine toxicity in mice

22 November 2022

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The interorgan metabolism of glutathione

22 November 2022

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On the enzymology of amino acid transport

22 November 2022

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Selective modification of glutathione metabolism

22 November 2022

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Methods for the selective modification of glutathione metabolism and study of glutathione transport

22 November 2022

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The fall and rise of cellular glutathione levels: enzyme-based approaches

22 November 2022

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22 November 2022

Glutathione

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Intracellular cysteine and glutathione delivery systems.

22 November 2022

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Administration of L-2-oxothiazolidine-4-carboxylate increases glutathione levels in rat brain

22 November 2022

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Glutathione depletion in tissues after administration of buthionine sulphoximine

22 November 2022

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Mechanism of action of paracetamol protective agents in mice in vivo

22 November 2022

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Historical aspects of glutathione and cancer chemotherapy

22 November 2022

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Role of glutathione and other endogenous thiols in radiation protection

22 November 2022

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Acetaminophen-induced hepatic necrosis. I. Role of drug metabolism

22 November 2022

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Acetaminophen-induced hepatic necrosis. IV. Protective role of glutathione

22 November 2022

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Increased capacity for glutathione synthesis enhances resistance to radiation in Escherichia coli: a possible model for mammalian cell protection

22 November 2022

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Cellular glutathione as a determinant of sensitivity to mercuric chloride toxicity. Prevention of toxicity by giving glutathione monoester

22 November 2022

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Prodrugs of L-cysteine as liver-protective agents. 2(RS)-Methylthiazolidine-4(R)-carboxylic acid, a latent cysteine.

22 November 2022

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2-Substituted thiazolidine-4(R)-carboxylic acids as prodrugs of L-cysteine. Protection of mice against acetaminophen hepatotoxicity

22 November 2022

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Tumor cell anti-oxidant defenses. Inhibition of the glutathione redox cycle enhances macrophage-mediated cytolysis

22 November 2022

218

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Cytotoxicity of cysteine in culture media

22 November 2022

221

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Translocation of amino acids and glutathione studied with the perfused kidney and isolated renal cells

22 November 2022

226

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Enhanced melphalan cytotoxicity in human ovarian cancer in vitro and in tumor-bearing nude mice by buthionine sulfoximine depletion of glutathione

22 November 2022

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Direct observation of a free radical interaction between vitamin E and vitamin C

22 November 2022

230

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Decrease in glutathione levels of kidney and liver after injection of methionine sulfoximine into rats

22 November 2022

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Resistance to alkylating agents and cisplatin: insights from ovarian carcinoma model systems

22 November 2022

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Modification of SR 2508 sensitization in hypoxic V79 cells by manipulation of glutathione levels

22 November 2022

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Marked reduction of rat brain glutathione following intracerebroventricular administration of the glutathione synthesis inhibitor L-buthionine sulfoximine

22 November 2022

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22 November 2022

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Reduction of brain glutathione by L-buthionine sulfoximine potentiates the dopamine-depleting action of 6-hydroxydopamine in rat striatum

22 November 2022

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Reversal of experimental paracetamol toxicosis with N-acetylcysteine

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Chemical depletion of glutathione in vivo

22 November 2022

238

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https://api.crossref.org/works/10.1016/0163-7258(91)90076-X

Hepatic efflux and renal extraction of plasma glutathione: marked differences between healthy subjects and the rat.

22 November 2022

241

1 reference

https://api.crossref.org/works/10.1016/0163-7258(91)90076-X

In vivo formation of methionine sulfoximine phosphate, a protein-bound metabolite of methionine sulfoximine

22 November 2022

242

1 reference

https://api.crossref.org/works/10.1016/0163-7258(91)90076-X

The Action of Formaldehyde upon Cysteine

22 November 2022

243

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https://api.crossref.org/works/10.1016/0163-7258(91)90076-X

Vitamin E dependent reduced glutathione inhibition of rat liver microsomal lipid peroxidation.

22 November 2022

244

1 reference

https://api.crossref.org/works/10.1016/0163-7258(91)90076-X

Chemically-induced glutathione depletion and lipid peroxidation

22 November 2022

245

1 reference

https://api.crossref.org/works/10.1016/0163-7258(91)90076-X

Schedule dependence of buthionine sulfoximine in reversing resistance to cisplatin.

22 November 2022

248

1 reference

https://api.crossref.org/works/10.1016/0163-7258(91)90076-X

Subcellular glutathione contents in isolated hepatocytes treated with L-buthionine sulfoximine

22 November 2022

250

1 reference

https://api.crossref.org/works/10.1016/0163-7258(91)90076-X

Phosphorylation of methionine sulfoximine by glutamine synthetase

22 November 2022

251

1 reference

https://api.crossref.org/works/10.1016/0163-7258(91)90076-X

Studies on the mechanism of inhibition of glutamine synthetase by methionine sulfoximine

22 November 2022

252

1 reference

https://api.crossref.org/works/10.1016/0163-7258(91)90076-X

Maleic acid-induced inhibition of amino acid transport in rat kidney

22 November 2022

253

1 reference

https://api.crossref.org/works/10.1016/0163-7258(91)90076-X

Identification of L-methionine-S-sulfoximine as the convulsant isomer of methionine sulfoximine

22 November 2022

254

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Inhibition of glutamine synthetase by methionine sulfoximine. Studies on methionine sulfoximine phosphate

22 November 2022

255

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https://api.crossref.org/works/10.1016/0163-7258(91)90076-X

Radiation response of Chinese hamster cells after elevation of intracellular glutathione levels

22 November 2022

256

1 reference

https://api.crossref.org/works/10.1016/0163-7258(91)90076-X

Potentiation and protection of doxorubicin cytotoxicity by cellular glutathione modulation

22 November 2022

257

1 reference

https://api.crossref.org/works/10.1016/0163-7258(91)90076-X

The effects of cellular glutathione elevation on the oxygen enhancement ratio.

22 November 2022

258

1 reference

https://api.crossref.org/works/10.1016/0163-7258(91)90076-X

Selective modulation of glutathione levels in human normal versus tumor cells and subsequent differential response to chemotherapy drugs

22 November 2022

259

1 reference

https://api.crossref.org/works/10.1016/0163-7258(91)90076-X

In vivo modulation of glutathione by buthionine sulfoximine: effect on marrow response to melphalan

22 November 2022

260

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Effects of glutathione depletion by buthionine sulfoximine on radiosensitization by oxygen and misonidazole in vitro.

22 November 2022

266

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Glutathione, a first line of defense against cadmium toxicity

22 November 2022

268

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Buthionine sulfoximine-mediated depletion of glutathione in intracranial human glioma-derived xenografts.

22 November 2022

270

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Depletion of Brain Glutathione in Preweanling Mice by L-Buthionine Sulfoximine

22 November 2022

271

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https://api.crossref.org/works/10.1016/0163-7258(91)90076-X

Glutathione catabolism by the ischemic rat kidney

22 November 2022

272

1 reference

https://api.crossref.org/works/10.1016/0163-7258(91)90076-X

Efficacy of oral N-acetylcysteine in the treatment of acetaminophen overdose. Analysis of the national multicenter study (1976 to 1985)

22 November 2022

273

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https://api.crossref.org/works/10.1016/0163-7258(91)90076-X

Does elevated glutathione protect the cell from H2O2 insult?

22 November 2022

275

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https://api.crossref.org/works/10.1016/0163-7258(91)90076-X

Transport into brain of buthionine sulfoximine, an inhibitor of glutathione synthesis, is facilitated by esterification and administration of dimethylsulfoxide

22 November 2022

276

1 reference

https://api.crossref.org/works/10.1016/0163-7258(91)90076-X

Effects of the long-term depletion of reduced glutathione in mice administered L-buthionine-S,R-sulfoximine

22 November 2022

278

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Glutathione regulates activation-dependent DNA synthesis in highly purified normal human T lymphocytes stimulated via the CD2 and CD3 antigens

22 November 2022

279

1 reference

https://api.crossref.org/works/10.1016/0163-7258(91)90076-X

Reduction in glutathione content of L-PAM resistant L1210 Cells confers drug sensitivity.

22 November 2022

280

1 reference

https://api.crossref.org/works/10.1016/0163-7258(91)90076-X

Dechlorination of L-phenylalanine mustard by sensitive and resistant tumor cells and its relationship to intracellular glutathione content.

22 November 2022

281

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Observations on the function of peroxidase systems and the chemistry of the adrenal cortex: Description of a new carbohydrate derivative

22 November 2022

282

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https://api.crossref.org/works/10.1016/0163-7258(91)90076-X

Studies on the regulation of glutathione level in rat liver

22 November 2022

285

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https://api.crossref.org/works/10.1016/0163-7258(91)90076-X

Rat Liver Glutathione: Possible Role as a Reservoir of Cysteine

22 November 2022

286

1 reference

https://api.crossref.org/works/10.1016/0163-7258(91)90076-X

Glutathione monoethyl ester can selectively protect liver from high dose BCNU or cyclophosphamide

22 November 2022

287

1 reference

https://api.crossref.org/works/10.1016/0163-7258(91)90076-X

Metabolic activation and hepatotoxicity. Effect of cysteine, N-acetylcysteine, and methionine on glutathione biosynthesis and bromobenzene toxicity in isolated rat hepatocytes

22 November 2022

290

1 reference

https://api.crossref.org/works/10.1016/0163-7258(91)90076-X

Modulation of endothelial GSH concentrations: effect of exogenous GSH and GSH monoethyl ester

22 November 2022

291

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https://api.crossref.org/works/10.1016/0163-7258(91)90076-X

Chemosensitization by buthionine sulfoximine in vivo

22 November 2022

292

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https://api.crossref.org/works/10.1016/0163-7258(91)90076-X

Glutathione enhancement in various mouse organs and protection by glutathione isopropyl ester against liver injury

22 November 2022

293

1 reference

https://api.crossref.org/works/10.1016/0163-7258(91)90076-X

Purification from pig liver of a protein which protects liposomes and biomembranes from peroxidative degradation and exhibits glutathione peroxidase activity on phosphatidylcholine hydroperoxides

22 November 2022

294

1 reference

https://api.crossref.org/works/10.1016/0163-7258(91)90076-X

Effect of oral glutathione on hepatic glutathione levels in rats and mice.

22 November 2022

296

1 reference

https://api.crossref.org/works/10.1016/0163-7258(91)90076-X

Glutathione-mediated transport across intestinal brush-border membranes

22 November 2022

297

1 reference

https://api.crossref.org/works/10.1016/0163-7258(91)90076-X

Cytotoxicity as an indicator for transport mechanism. Evidence that melphalan is transported by two leucine-preferring carrier systems in the L1210 murine leukemia cell

22 November 2022

298

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https://api.crossref.org/works/10.1016/0163-7258(91)90076-X

Cellular pharmacokinetics of the phenylalanine mustards

22 November 2022

299

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Endogenous versus exogenous thiols in radioprotection

22 November 2022

301

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Hepatic mitochondrial and cytosolic glutathione content and the subcellular distribution of GSH-S-transferases

22 November 2022

302

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https://api.crossref.org/works/10.1016/0163-7258(91)90076-X

The protection by ascorbate and glutathione against microsomal lipid peroxidation is dependent on vitamin E.

22 November 2022

303

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https://api.crossref.org/works/10.1016/0163-7258(91)90076-X

The level and half-life of glutathione in human plasma

22 November 2022

307

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Drug-induced lipid peroxidation in mice--III. Glutathione content of liver, kidney and spleen after intravenous administration of free and liposomally entrapped glutathione

22 November 2022

308

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https://api.crossref.org/works/10.1016/0163-7258(91)90076-X

Stimulation of hepatic glutathione formation by administration of L-2-oxothiazolidine-4-carboxylate, a 5-oxo-L-prolinase substrate

22 November 2022

309

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https://api.crossref.org/works/10.1016/0163-7258(91)90076-X

Selective effects of N-acetylcysteine stereoisomers on hepatic glutathione and plasma sulfate in mice

22 November 2022

314

1 reference

https://api.crossref.org/works/10.1016/0163-7258(91)90076-X

Effects of phorone (diisopropylidene acetone), a glutathione (GSH) depletor, on hepatic enzymes involved in drug and heme metabolism in rats: evidence that phorone is a potent inducer of heme oxygenase

22 November 2022

315

1 reference

https://api.crossref.org/works/10.1016/0163-7258(91)90076-X

Transport of L-cysteine and reduced glutathione through biological membranes

22 November 2022

316

1 reference

https://api.crossref.org/works/10.1016/0163-7258(91)90076-X

Protective effect of reduced glutathione against cisplatin-induced renal and systemic toxicity and its influence on the therapeutic activity of the antitumor drug

22 November 2022

317

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22 November 2022

Identifiers

1 reference

release_44kibjwjojgltkgpouqxxx2dfq

17 August 2017

Fatcat ID

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/44kibjwjojgltkgpouqxxx2dfq

mapped directly with Wikidata item

24 November 2022

based on heuristic

1 reference