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Exploiting the Epigenome to Control Cancer-Promoting Gene-Expression Programs.
scientific article published on April 2016
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1 reference
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Europe PubMed Central
PMC publication ID
4889129
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27070701%20AND%20SRC:MED&resulttype=core&format=json
retrieved
1 April 2020
title
Exploiting the Epigenome to Control Cancer-Promoting Gene-Expression Programs
(English)
1 reference
stated in
Europe PubMed Central
PMC publication ID
4889129
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27070701%20AND%20SRC:MED&resulttype=core&format=json
retrieved
1 April 2020
author
Gerard L Brien
series ordinal
1
1 reference
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Europe PubMed Central
PMC publication ID
4889129
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27070701%20AND%20SRC:MED&resulttype=core&format=json
retrieved
1 April 2020
author name string
Daria G Valerio
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2
1 reference
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Europe PubMed Central
PMC publication ID
4889129
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27070701%20AND%20SRC:MED&resulttype=core&format=json
retrieved
1 April 2020
Scott A Armstrong
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3
1 reference
stated in
Europe PubMed Central
PMC publication ID
4889129
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27070701%20AND%20SRC:MED&resulttype=core&format=json
retrieved
1 April 2020
publication date
1 April 2016
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Europe PubMed Central
PMC publication ID
4889129
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27070701%20AND%20SRC:MED&resulttype=core&format=json
retrieved
1 April 2020
published in
Cancer Cell
1 reference
stated in
Europe PubMed Central
PMC publication ID
4889129
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27070701%20AND%20SRC:MED&resulttype=core&format=json
retrieved
1 April 2020
volume
29
1 reference
stated in
Europe PubMed Central
PMC publication ID
4889129
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27070701%20AND%20SRC:MED&resulttype=core&format=json
retrieved
1 April 2020
issue
4
1 reference
stated in
Europe PubMed Central
PMC publication ID
4889129
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27070701%20AND%20SRC:MED&resulttype=core&format=json
retrieved
1 April 2020
page(s)
464-476
1 reference
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Europe PubMed Central
PMC publication ID
4889129
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27070701%20AND%20SRC:MED&resulttype=core&format=json
retrieved
1 April 2020
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4889129
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29 September 2017
The pathogenesis of mixed-lineage leukemia
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29 September 2017
Breaking the histone code with quantitative mass spectrometry.
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29 September 2017
Inhibition of BET recruitment to chromatin as an effective treatment for MLL-fusion leukaemia
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29 September 2017
A decade of exploring the cancer epigenome - biological and translational implications
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29 September 2017
BET bromodomain inhibition as a therapeutic strategy to target c-Myc
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29 September 2017
The Y641C mutation of EZH2 alters substrate specificity for histone H3 lysine 27 methylation states
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4889129
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29 September 2017
RNAi screen identifies Brd4 as a therapeutic target in acute myeloid leukaemia
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29 September 2017
Frequent mutation of histone-modifying genes in non-Hodgkin lymphoma
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29 September 2017
MLL-rearranged leukemia is dependent on aberrant H3K79 methylation by DOT1L.
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29 September 2017
Selective killing of mixed lineage leukemia cells by a potent small-molecule DOT1L inhibitor.
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29 September 2017
The diverse functions of Dot1 and H3K79 methylation.
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29 September 2017
Towards cracking the epigenetic code using a combination of high-throughput epigenomics and quantitative mass spectrometry-based proteomics
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29 September 2017
Histone methylation by PRC2 is inhibited by active chromatin marks
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4889129
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29 September 2017
DOT1L, the H3K79 methyltransferase, is required for MLL-AF9-mediated leukemogenesis
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4889129
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29 September 2017
Phosphoproteomic mass spectrometry profiling links Src family kinases to escape from HER2 tyrosine kinase inhibition.
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4889129
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29 September 2017
Role of androgen receptor and associated lysine-demethylase coregulators, LSD1 and JMJD2A, in localized and advanced human bladder cancer.
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PubMed Central
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29 September 2017
Requirement for Dot1l in murine postnatal hematopoiesis and leukemogenesis by MLL translocation.
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4889129
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29 September 2017
Switching addictions between HER2 and FGFR2 in HER2-positive breast tumor cells: FGFR2 as a potential target for salvage after lapatinib failure
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4889129
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29 September 2017
Histone deacetylase (HDAC) inhibitors in recent clinical trials for cancer therapy.
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4889129
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29 September 2017
The Polycomb complex PRC2 and its mark in life
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4889129
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29 September 2017
H3K36 methylation antagonizes PRC2-mediated H3K27 methylation
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4889129
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29 September 2017
AKT inhibition relieves feedback suppression of receptor tyrosine kinase expression and activity
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4889129
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29 September 2017
Somatic mutations at EZH2 Y641 act dominantly through a mechanism of selectively altered PRC2 catalytic activity, to increase H3K27 trimethylation
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4889129
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29 September 2017
Coordinated activities of wild-type plus mutant EZH2 drive tumor-associated hypertrimethylation of lysine 27 on histone H3 (H3K27) in human B-cell lymphomas
1 reference
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4889129
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29 September 2017
Epigenetic antagonism between polycomb and SWI/SNF complexes during oncogenic transformation
1 reference
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4889129
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29 September 2017
The NIH Roadmap Epigenomics Mapping Consortium
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4889129
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29 September 2017
Selective inhibition of BET bromodomains
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4889129
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29 September 2017
Oncogenesis by sequestration of CBP/p300 in transcriptionally inactive hyperacetylated chromatin domains
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4889129
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29 September 2017
Somatic mutations of the histone methyltransferase gene EZH2 in myelodysplastic syndromes
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4889129
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29 September 2017
Inactivating mutations of the histone methyltransferase gene EZH2 in myeloid disorders
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4889129
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29 September 2017
Characterization of an antagonistic switch between histone H3 lysine 27 methylation and acetylation in the transcriptional regulation of Polycomb group target genes
1 reference
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4889129
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29 September 2017
A chromatin-mediated reversible drug-tolerant state in cancer cell subpopulations
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4889129
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29 September 2017
Overexpression of LSD1 contributes to human carcinogenesis through chromatin regulation in various cancers
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4889129
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29 September 2017
Consolidation of the cancer genome into domains of repressive chromatin by long-range epigenetic silencing (LRES) reduces transcriptional plasticity
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4889129
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29 September 2017
Somatic mutations altering EZH2 (Tyr641) in follicular and diffuse large B-cell lymphomas of germinal-center origin
1 reference
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4889129
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29 September 2017
Therapeutic targeting of NOTCH1 signaling in T-cell acute lymphoblastic leukemia
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4889129
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29 September 2017
Transcriptomics: unravelling the biology of transcription factors and chromatin remodelers during development and differentiation.
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4889129
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29 September 2017
Targeting DNA methylation
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4889129
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29 September 2017
A histone H3 lysine 36 trimethyltransferase links Nkx2-5 to Wolf-Hirschhorn syndrome
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4889129
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29 September 2017
Lysine-specific demethylase 1 is strongly expressed in poorly differentiated neuroblastoma: implications for therapy
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4889129
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29 September 2017
Aberrant chromatin at genes encoding stem cell regulators in human mixed-lineage leukemia
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4889129
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29 September 2017
H3K79 methylation profiles define murine and human MLL-AF4 leukemias
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4889129
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29 September 2017
SWI/SNF mediates polycomb eviction and epigenetic reprogramming of the INK4b-ARF-INK4a locus
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4889129
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29 September 2017
The MMSET protein is a histone methyltransferase with characteristics of a transcriptional corepressor
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4889129
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29 September 2017
FDA approval summary: vorinostat for treatment of advanced primary cutaneous T-cell lymphoma
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29 September 2017
MLL translocations, histone modifications and leukaemia stem-cell development
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4889129
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29 September 2017
Chromatin modifications and their function
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4889129
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29 September 2017
Androgen receptor coactivators lysine-specific histone demethylase 1 and four and a half LIM domain protein 2 predict risk of prostate cancer recurrence
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4889129
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29 September 2017
Recruitment of P-TEFb for stimulation of transcriptional elongation by the bromodomain protein Brd4
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4889129
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29 September 2017
The bromodomain protein Brd4 is a positive regulatory component of P-TEFb and stimulates RNA polymerase II-dependent transcription
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4889129
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29 September 2017
LSD1 demethylates repressive histone marks to promote androgen-receptor-dependent transcription
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4889129
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29 September 2017
Loss of acetylation at Lys16 and trimethylation at Lys20 of histone H4 is a common hallmark of human cancer
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4889129
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29 September 2017
Histone demethylation mediated by the nuclear amine oxidase homolog LSD1
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4889129
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29 September 2017
A subset of multiple myeloma harboring the t(4;14)(p16;q32) translocation lacks FGFR3 expression but maintains an IGH/MMSET fusion transcript
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4889129
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29 September 2017
The language of covalent histone modifications
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29 September 2017
The t(4;14) translocation in myeloma dysregulates both FGFR3 and a novel gene, MMSET, resulting in IgH/MMSET hybrid transcripts
1 reference
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4889129
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29 September 2017
Mammalian mediator of transcriptional regulation and its possible role as an end-point of signal transduction pathways
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29 September 2017
Dosage-dependent modifiers of polycomb and antennapedia mutations in Drosophila
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4889129
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29 September 2017
Epigenetic changes may contribute to the formation and spontaneous regression of retinoblastoma
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4889129
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29 September 2017
Identification of a gene, MLL, that spans the breakpoint in 11q23 translocations associated with human leukemias
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PubMed Central
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29 September 2017
Allele-specific hypermethylation of the retinoblastoma tumor-suppressor gene
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4889129
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29 September 2017
The t(4;11) chromosome translocation of human acute leukemias fuses the ALL-1 gene, related to Drosophila trithorax, to the AF-4 gene
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29 September 2017
Involvement of a homolog of Drosophila trithorax by 11q23 chromosomal translocations in acute leukemias
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PubMed Central
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29 September 2017
brahma: a regulator of Drosophila homeotic genes structurally related to the yeast transcriptional activator SNF2/SWI2
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29 September 2017
PRC2 loss amplifies Ras-driven transcription and confers sensitivity to BRD4-based therapies
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27 June 2018
The histone methyltransferase activity of MLL1 is dispensable for hematopoiesis and leukemogenesis
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4889129
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27 June 2018
A trithorax-like gene is interrupted by chromosome 11q23 translocations in acute leukaemias
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4889129
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27 June 2018
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4 September 2018
Building the Connectivity Map of epigenetics: chromatin profiling by quantitative targeted mass spectrometry.
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4 September 2018
Somatic mutations of SUZ12 in malignant peripheral nerve sheath tumors
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4 September 2018
The histone demethylase KDM1A sustains the oncogenic potential of MLL-AF9 leukemia stem cells
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4 September 2018
BRD-NUT oncoproteins: a family of closely related nuclear proteins that block epithelial differentiation and maintain the growth of carcinoma cells.
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4 September 2018
Epigenetic remodeling in colorectal cancer results in coordinate gene suppression across an entire chromosome band.
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4 September 2018
Global histone modification patterns predict risk of prostate cancer recurrence
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4 September 2018
In multiple myeloma, t(4;14)(p16;q32) is an adverse prognostic factor irrespective of FGFR3 expression
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12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Infant leukaemia biology, aetiology and treatment
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12 December 2020
based on heuristic
inferred from PubMed ID database lookup
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12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Identifiers
DOI
10.1016/J.CCELL.2016.03.007
1 reference
stated in
Europe PubMed Central
PMC publication ID
4889129
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27070701%20AND%20SRC:MED&resulttype=core&format=json
retrieved
1 April 2020
PMC publication ID
4889129
1 reference
stated in
Europe PubMed Central
PMC publication ID
4889129
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27070701%20AND%20SRC:MED&resulttype=core&format=json
retrieved
1 April 2020
PubMed publication ID
27070701
1 reference
stated in
Europe PubMed Central
PMC publication ID
4889129
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27070701%20AND%20SRC:MED&resulttype=core&format=json
retrieved
1 April 2020
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