(Q36846038)

English

GATA4 is a direct transcriptional activator of cyclin D2 and Cdk4 and is required for cardiomyocyte proliferation in anterior heart field-derived myocardium.

scientific article published on 30 June 2008

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9 January 2020

GATA4 is a direct transcriptional activator of cyclin D2 and Cdk4 and is required for cardiomyocyte proliferation in anterior heart field-derived myocardium (English)

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9 January 2020

6

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9 January 2020

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Anabel Rojas

1

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9 January 2020

Sek Won Kong

2

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9 January 2020

Pooja Agarwal

3

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9 January 2020

Brian Gilliss

4

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9 January 2020

William T Pu

5

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9 January 2020

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30 June 2008

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9 January 2020

Molecular and Cellular Biology

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9 January 2020

28

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9 January 2020

17

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9 January 2020

5420-5431

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9 January 2020

Proteomic analysis of cardiomyocytes differentiation in mouse embryonic carcinoma P19CL6 cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2519727

29 September 2017

Canonical Wnt signaling functions in second heart field to promote right ventricular growth

1 reference

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29 September 2017

Heart field: from mesoderm to heart tube

1 reference

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29 September 2017

Transcriptional pathways in second heart field development

1 reference

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29 September 2017

The KLF family of transcriptional regulators in cardiomyocyte proliferation and differentiation

1 reference

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29 September 2017

Upregulations of Gata4 and oxytocin receptor are important in cardiomyocyte differentiation processes of P19CL6 cells.

1 reference

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29 September 2017

Essential role for cyclin D3 in granulocyte colony-stimulating factor-driven expansion of neutrophil granulocytes

1 reference

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29 September 2017

Development of heart valves requires Gata4 expression in endothelial-derived cells

1 reference

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29 September 2017

A threshold of GATA4 and GATA6 expression is required for cardiovascular development

1 reference

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29 September 2017

TBX5 is required for embryonic cardiac cell cycle progression

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2519727

29 September 2017

Required, tissue-specific roles for Fgf8 in outflow tract formation and remodeling

1 reference

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29 September 2017

p204 is required for the differentiation of P19 murine embryonal carcinoma cells to beating cardiac myocytes: its expression is activated by the cardiac Gata4, Nkx2.5, and Tbx5 proteins

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2519727

29 September 2017

Building the mammalian heart from two sources of myocardial cells

1 reference

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29 September 2017

Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles

1 reference

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29 September 2017

Gata4 expression in lateral mesoderm is downstream of BMP4 and is activated directly by Forkhead and GATA transcription factors through a distal enhancer element

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2519727

29 September 2017

Morphogenesis of the right ventricle requires myocardial expression of Gata4

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2519727

29 September 2017

The roles of GATA-4, -5 and -6 in vertebrate heart development

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2519727

29 September 2017

Cell proliferation and cell cycle control: a mini review

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2519727

29 September 2017

Transcriptional regulation of the murine Connexin40 promoter by cardiac factors Nkx2-5, GATA4 and Tbx5.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2519727

29 September 2017

GATA4 is a dosage-sensitive regulator of cardiac morphogenesis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2519727

29 September 2017

GATA4 is essential for formation of the proepicardium and regulates cardiogenesis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2519727

29 September 2017

GATA transcription factors in the developing and adult heart

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2519727

29 September 2017

Differential expression and function of Tbx5 and Tbx20 in cardiac development

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2519727

29 September 2017

Regulation of cardiac myocyte apoptosis by the GATA-4 transcription factor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2519727

29 September 2017

Isl1 identifies a cardiac progenitor population that proliferates prior to differentiation and contributes a majority of cells to the heart

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2519727

29 September 2017

Developmental anatomy of the heart: a tale of mice and man.

1 reference

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29 September 2017

The generation and utilization of a cancer-oriented representation of the human transcriptome by using expressed sequence tags

1 reference

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29 September 2017

Cdk2 knockout mice are viable

1 reference

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29 September 2017

Cardiac T-box factor Tbx20 directly interacts with Nkx2-5, GATA4, and GATA5 in regulation of gene expression in the developing heart

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2519727

29 September 2017

Cardiac chamber formation: development, genes, and evolution.

1 reference

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29 September 2017

Sizing up the heart: development redux in disease.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2519727

29 September 2017

GATA4 mutations cause human congenital heart defects and reveal an interaction with TBX5

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2519727

29 September 2017

The GATA family (vertebrates and invertebrates).

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2519727

29 September 2017

Microarray analysis of global changes in gene expression during cardiac myocyte differentiation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2519727

29 September 2017

Cardiomyocyte cell cycle regulation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2519727

29 September 2017

The transcription factors GATA4 and dHAND physically interact to synergistically activate cardiac gene expression through a p300-dependent mechanism

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2519727

29 September 2017

Cyclin D-dependent kinases, INK4 inhibitors and cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2519727

29 September 2017

The anterior heart-forming field: voyage to the arterial pole of the heart

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2519727

29 September 2017

Smads, TAK1, and their common target ATF-2 play a critical role in cardiomyocyte differentiation.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2519727

29 September 2017

Proper coronary vascular development and heart morphogenesis depend on interaction of GATA-4 with FOG cofactors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2519727

29 September 2017

Regulation of the retinoblastoma tumor suppressor protein by cyclin/cdks

1 reference

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29 September 2017

A GATA-dependent right ventricular enhancer controls dHAND transcription in the developing heart

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2519727

29 September 2017

The zinc finger-containing transcription factors GATA-4, -5, and -6. Ubiquitously expressed regulators of tissue-specific gene expression.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2519727

29 September 2017

Cardiac tissue enriched factors serum response factor and GATA-4 are mutual coregulators

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2519727

29 September 2017

Chamber formation and morphogenesis in the developing mammalian heart

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2519727

29 September 2017

GATA-dependent recruitment of MEF2 proteins to target promoters

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2519727

29 September 2017

Developmental patterning of the myocardium

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2519727

29 September 2017

GATA-1 blocks IL-6-induced macrophage differentiation and apoptosis through the sustained expression of cyclin D1 and bcl-2 in a murine myeloid cell line M1.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2519727

29 September 2017

Bone morphogenetic proteins induce cardiomyocyte differentiation through the mitogen-activated protein kinase kinase kinase TAK1 and cardiac transcription factors Csx/Nkx-2.5 and GATA-4

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2519727

29 September 2017

Targeted disruption of CDK4 delays cell cycle entry with enhanced p27(Kip1) activity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2519727

29 September 2017

Loss of Cdk4 expression causes insulin-deficient diabetes and Cdk4 activation results in beta-islet cell hyperplasia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2519727

29 September 2017

Role of GATA-1 in proliferation and differentiation of definitive erythroid and megakaryocytic cells in vivo

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2519727

29 September 2017

GATA-6 induces p21(Cip1) expression and G1 cell cycle arrest

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2519727

29 September 2017

The myogenic regulatory gene Mef2 is a direct target for transcriptional activation by Twist during Drosophila myogenesis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2519727

29 September 2017

The cardiac transcription factors Nkx2-5 and GATA-4 are mutual cofactors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2519727

29 September 2017

Requirement of the transcription factor GATA4 for heart tube formation and ventral morphogenesis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2519727

29 September 2017

GATA4 transcription factor is required for ventral morphogenesis and heart tube formation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2519727

29 September 2017

Cyclin D2 is an FSH-responsive gene involved in gonadal cell proliferation and oncogenesis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2519727

29 September 2017

Mouse GATA-4: a retinoic acid-inducible GATA-binding transcription factor expressed in endodermally derived tissues and heart

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2519727

29 September 2017

Identification of G1 kinase activity for cdk6, a novel cyclin D partner

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2519727

29 September 2017

D-type cyclin-dependent kinase activity in mammalian cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2519727

29 September 2017

Transcriptional control by E2F

1 reference

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29 September 2017

Cyclins, Cdks, and cyclin kinase inhibitors.

1 reference

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29 September 2017

D-type cyclins and their cyclin-dependent kinases: G1 phase integrators of the mitogenic response

1 reference

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29 September 2017

The transcription factors GATA4 and GATA6 regulate cardiomyocyte hypertrophy in vitro and in vivo.

1 reference

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27 June 2018

Mice lacking cyclin D1 are small and show defects in eye and mammary gland development.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2519727

27 June 2018

A novel mutation in the GATA4 gene in patients with Tetralogy of Fallot

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5 September 2018

The right ventricle, outflow tract, and ventricular septum comprise a restricted expression domain within the secondary/anterior heart field

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2519727

5 September 2018

Targeted expression of cyclin D2 results in cardiomyocyte DNA synthesis and infarct regression in transgenic mice

1 reference

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5 September 2018

Mouse development and cell proliferation in the absence of D-cyclins.

1 reference

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5 September 2018

Mef2c is a direct transcriptional target of ISL1 and GATA factors in the anterior heart field during mouse embryonic development

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2519727

5 September 2018

mef2c is activated directly by myogenic basic helix-loop-helix proteins during skeletal muscle development in vivo

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2519727

5 September 2018

Spatiotemporal pattern of commitment to slowed proliferation in the embryonic mouse heart indicates progressive differentiation of the cardiac conduction system.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2519727

5 September 2018

Activation of GATA-4 by serotonin in pulmonary artery smooth muscle cells

1 reference

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5 September 2018

Embryonic expression of an Nkx2-5/Cre gene using ROSA26 reporter mice.

1 reference

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5 September 2018

Cerebellar histogenesis is disturbed in mice lacking cyclin D2.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2519727

5 September 2018

Control of early cardiac-specific transcription of Nkx2-5 by a GATA-dependent enhancer.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2519727

5 September 2018

A GATA-dependent nkx-2.5 regulatory element activates early cardiac gene expression in transgenic mice.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2519727

5 September 2018

Control of the G1/S transition

1 reference

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5 September 2018

Transcription factor GATA-2 is required for proliferation/survival of early hematopoietic cells and mast cell formation, but not for erythroid and myeloid terminal differentiation.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2519727

5 September 2018

Cardiac-Specific Deletion of Gata4 Reveals Its Requirement for Hypertrophy, Compensation, and Myocyte Viability

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2519727

4 December 2018

The arterial pole of the mouse heart forms from Fgf10-expressing cells in pharyngeal mesoderm

1 reference

https://pubmed.ncbi.nlm.nih.gov/18591257

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Anthracycline-induced suppression of GATA-4 transcription factor: implication in the regulation of cardiac myocyte apoptosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/18591257

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Combined loss of Cdk2 and Cdk4 results in embryonic lethality and Rb hypophosphorylation

1 reference

https://pubmed.ncbi.nlm.nih.gov/18591257

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Down-regulation of p27Kip1 promotes cell proliferation of rat neonatal cardiomyocytes induced by nuclear expression of cyclin D1 and CDK4. Evidence for impaired Skp2-dependent degradation of p27 in terminal differentiation

1 reference

https://pubmed.ncbi.nlm.nih.gov/18591257

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1128/MCB.00717-08

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18591257%20AND%20SRC:MED&resulttype=core&format=json

9 January 2020

release_nnh3uguaeva6thttswmt57vnwq

1 reference

https://api.fatcat.wiki/v0/release/nnh3uguaeva6thttswmt57vnwq

24 November 2022

based on heuristic

mapped directly with Wikidata item

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18591257%20AND%20SRC:MED&resulttype=core&format=json

9 January 2020

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18591257%20AND%20SRC:MED&resulttype=core&format=json

9 January 2020

ResearchGate publication ID

0 references

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