(Q36532741)

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A genome-wide RNAi screen reveals a Trio-regulated Rho GTPase circuitry transducing mitogenic signals initiated by G protein-coupled receptors.

scientific article published on 21 November 2012

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18 February 2020

A genome-wide RNAi screen reveals a Trio-regulated Rho GTPase circuitry transducing mitogenic signals initiated by G protein-coupled receptors (English)

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18 February 2020

G protein-coupled receptor

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18 February 2020

Ramiro Iglesias-Bartolome

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18 February 2020

J. Silvio Gutkind

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18 February 2020

Bruce R Ksander

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Bruce R Ksander

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18 February 2020

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Robert T Dorsam

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18 February 2020

Xiaodong Feng

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18 February 2020

David J Forsthoefel

5

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18 February 2020

Qianming Chen

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18 February 2020

Anne Debant

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18 February 2020

Mark A Seeger

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18 February 2020

Hidemi Teramoto

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18 February 2020

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21 November 2012

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18 February 2020

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18 February 2020

49

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18 February 2020

1

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18 February 2020

94-108

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18 February 2020

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1 reference

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30 September 2017

Genomic screening with RNAi: results and challenges

1 reference

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Frequent somatic mutations of GNAQ in uveal melanoma and blue naevi

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30 September 2017

Trio's Rho-specific GEF domain is the missing Galpha q effector in C. elegans

1 reference

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30 September 2017

Mitogenic signaling pathways induced by G protein-coupled receptors

1 reference

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30 September 2017

Galphaq directly activates p63RhoGEF and Trio via a conserved extension of the Dbl homology-associated pleckstrin homology domain

1 reference

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30 September 2017

The DH and PH domains of Trio coordinately engage Rho GTPases for their efficient activation

1 reference

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30 September 2017

Evolving the lock to fit the key to create a family of G protein-coupled receptors potently activated by an inert ligand

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G-protein-coupled receptors and cancer.

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Cell signalling diversity of the Gqalpha family of heterotrimeric G proteins

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Multiple microalterations detected at high frequency in oral cancer

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30 September 2017

The guanine nucleotide exchange factor p63RhoGEF, a specific link between Gq/11-coupled receptor signaling and RhoA.

1 reference

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Different regulation of the Trio Dbl-Homology domains by their associated PH domains

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Seven-transmembrane receptors

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Leukemia-associated Rho guanine nucleotide exchange factor promotes G alpha q-coupled activation of RhoA.

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Potent activation of RhoA by Galpha q and Gq-coupled receptors.

1 reference

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Human p63RhoGEF, a novel RhoA-specific guanine nucleotide exchange factor, is localized in cardiac sarcomere

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12 December 2020

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10.1016/J.MOLCEL.2012.10.018

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18 February 2020

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18 February 2020

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18 February 2020

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