(Q36587803)

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Transcriptomic and proteomic profiling of KEAP1 disrupted and sulforaphane-treated human breast epithelial cells reveals common expression profiles

scientific article published on May 20, 2011

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Europe PubMed Central

PMC publication ID

15 August 2017

Transcriptomic and proteomic profiling of KEAP1 disrupted and sulforaphane-treated human breast epithelial cells reveals common expression profiles (English)

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PMC publication ID

15 August 2017

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Akhilesh Pandey

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Akhilesh Pandey

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A21597922

2 December 2024

Thomas W Kensler

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Thomas W. Kensler

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2 December 2024

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Raghothama Chaerkady

2

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Europe PubMed Central

PMC publication ID

15 August 2017

Kala Visvanathan

5

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15 August 2017

Abena S. Agyeman

1

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2 December 2024

Patrick G. Shaw

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2 December 2024

Nancy E. Davidson

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20 May 2011

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15 August 2017

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3564494

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2 December 2024

https://europepmc.org/articles/PMC3564494

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A21597922

2 December 2024

https://europepmc.org/articles/PMC3564494?pdf=render

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2 December 2024

https://doi.org/10.1007/s10549-011-1536-9

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A21597922

2 December 2024

http://link.springer.com/content/pdf/10.1007/s10549-011-1536-9.pdf

1 reference

10.1007/S10549-011-1536-9

https://api.crossref.org/works/10.1007/S10549-011-1536-9

2 December 2024

http://link.springer.com/article/10.1007/s10549-011-1536-9/fulltext.html

1 reference

10.1007/S10549-011-1536-9

https://api.crossref.org/works/10.1007/S10549-011-1536-9

2 December 2024

http://link.springer.com/content/pdf/10.1007/s10549-011-1536-9

1 reference

10.1007/S10549-011-1536-9

https://api.crossref.org/works/10.1007/S10549-011-1536-9

2 December 2024

Breast Cancer Research and Treatment

1 reference

Europe PubMed Central

PMC publication ID

15 August 2017

132

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Europe PubMed Central

PMC publication ID

15 August 2017

1

1 reference

Europe PubMed Central

PMC publication ID

15 August 2017

175-187

1 reference

Europe PubMed Central

PMC publication ID

15 August 2017

Bioavailability of Sulforaphane from Two Broccoli Sprout Beverages: Results of a Short-term, Cross-over Clinical Trial in Qidong, China

1 reference

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9 September 2017

Aldehyde dehydrogenase 1B1 (ALDH1B1) is a potential biomarker for human colon cancer.

1 reference

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9 September 2017

Cancer statistics, 2010

1 reference

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p62/SQSTM1 is a target gene for transcription factor NRF2 and creates a positive feedback loop by inducing antioxidant response element-driven gene transcription

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3564494

9 September 2017

Sulforaphane- and phenethyl isothiocyanate-induced inhibition of aflatoxin B1-mediated genotoxicity in human hepatocytes: role of GSTM1 genotype and CYP3A4 gene expression

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3564494

9 September 2017

Proteomic analysis of Nrf2 deficient transgenic mice reveals cellular defence and lipid metabolism as primary Nrf2-dependent pathways in the liver.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3564494

9 September 2017

Sulforaphane, a dietary component of broccoli/broccoli sprouts, inhibits breast cancer stem cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3564494

9 September 2017

Systematic review: comparative effectiveness of medications to reduce risk for primary breast cancer

1 reference

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9 September 2017

Characterization of the cancer chemopreventive NRF2-dependent gene battery in human keratinocytes: demonstration that the KEAP1-NRF2 pathway, and not the BACH1-NRF2 pathway, controls cytoprotection against electrophiles as well as redox-cycling comp

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3564494

9 September 2017

Differentiation of a highly tumorigenic basal cell compartment in urothelial carcinoma.

1 reference

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9 September 2017

Genetic versus chemoprotective activation of Nrf2 signaling: overlapping yet distinct gene expression profiles between Keap1 knockout and triterpenoid-treated mice.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3564494

9 September 2017

NRF2 and KEAP1 mutations: permanent activation of an adaptive response in cancer

1 reference

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9 September 2017

Temporal changes in gene expression induced by sulforaphane in human prostate cancer cells

1 reference

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9 September 2017

Evidence for the aldo-keto reductase pathway of polycyclic aromatic trans-dihydrodiol activation in human lung A549 cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3564494

9 September 2017

ALDH1 is a marker of normal and malignant human mammary stem cells and a predictor of poor clinical outcome

1 reference

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9 September 2017

Quantitative proteomics using stable isotope labeling with amino acids in cell culture

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3564494

9 September 2017

Aldo-keto reductase family 1 B10 affects fatty acid synthesis by regulating the stability of acetyl-CoA carboxylase-alpha in breast cancer cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3564494

9 September 2017

Discovery and development of sulforaphane as a cancer chemopreventive phytochemical

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3564494

9 September 2017

Identification of polymorphic antioxidant response elements in the human genome

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3564494

9 September 2017

Molecular basis for chemoprevention by sulforaphane: a comprehensive review.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3564494

9 September 2017

Glutathione peroxidase 2, the major cigarette smoke-inducible isoform of GPX in lungs, is regulated by Nrf2

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3564494

9 September 2017

Comparative functional analysis of human medium-chain dehydrogenases, short-chain dehydrogenases/reductases and aldo-keto reductases with retinoids

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3564494

9 September 2017

Chemoprotection by sulforaphane: keep one eye beyond Keap1.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3564494

9 September 2017

Effects of glucosinolate-rich broccoli sprouts on urinary levels of aflatoxin-DNA adducts and phenanthrene tetraols in a randomized clinical trial in He Zuo township, Qidong, People's Republic of China

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3564494

9 September 2017

Utility of siRNA against Keap1 as a strategy to stimulate a cancer chemopreventive phenotype

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3564494

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3564494

9 September 2017

Modulation of gene expression by cancer chemopreventive dithiolethiones through the Keap1-Nrf2 pathway. Identification of novel gene clusters for cell survival

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3564494

9 September 2017

Identification of Nrf2-regulated genes induced by the chemopreventive agent sulforaphane by oligonucleotide microarray

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3564494

9 September 2017

Analysis of Relative Gene Expression Data Using Real-Time Quantitative PCR and the 2−ΔΔCT Method

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3564494

9 September 2017

Human 3alpha-hydroxysteroid dehydrogenase isoforms (AKR1C1-AKR1C4) of the aldo-keto reductase superfamily: functional plasticity and tissue distribution reveals roles in the inactivation and formation of male and female sex hormones

2 references

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9 September 2017

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21 January 2018

Broccoli sprouts: an exceptionally rich source of inducers of enzymes that protect against chemical carcinogens

1 reference

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9 September 2017

An Nrf2/Small Maf Heterodimer Mediates the Induction of Phase II Detoxifying Enzyme Genes through Antioxidant Response Elements

1 reference

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9 September 2017

Molecular cloning of human type 3 3 alpha-hydroxysteroid dehydrogenase that differs from 20 alpha-hydroxysteroid dehydrogenase by seven amino acids

1 reference

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9 September 2017

Anticarcinogenic activities of sulforaphane and structurally related synthetic norbornyl isothiocyanates

1 reference

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9 September 2017

Isolation and characterization of a spontaneously immortalized human breast epithelial cell line, MCF-10

1 reference

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9 September 2017

Rapid detection of inducers of enzymes that protect against carcinogens

1 reference

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9 September 2017

Regulation of human NAD(P)H:quinone oxidoreductase gene. Role of AP1 binding site contained within human antioxidant response element

1 reference

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9 September 2017

Regulation of aldo–keto reductase AKR1B10 gene expression: Involvement of transcription factor Nrf2

1 reference

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The Expression Patterns of ER, PR, HER2, CK5/6, EGFR, Ki-67 and AR by Immunohistochemical Analysis in Breast Cancer Cell Lines

1 reference

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30 September 2017

Transcriptome analysis of human colon Caco-2 cells exposed to sulforaphane.

1 reference

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30 September 2017

Selective loss of AKR1C1 and AKR1C2 in breast cancer and their potential effect on progesterone signaling

1 reference

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30 September 2017

Oltipraz, 3H-1,2-dithiole-3-thione, and sulforaphane induce overlapping and protective antioxidant responses in murine microglial cells

1 reference

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30 September 2017

Dietary indoles and isothiocyanates that are generated from cruciferous vegetables can both stimulate apoptosis and confer protection against DNA damage in human colon cell lines

1 reference

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30 September 2017

Down-regulation of phosphoglucomutase 3 mediates sulforaphane-induced cell death in LNCaP prostate cancer cells

1 reference

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28 June 2018

In vivo pharmacokinetics and regulation of gene expression profiles by isothiocyanate sulforaphane in the rat.

1 reference

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28 June 2018

Characterization of epithelial phenotypes in mortal and immortal human breast cells

1 reference

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28 June 2018

Serotonin receptors, novel targets of sulforaphane identified by proteomic analysis in Caco-2 cells

1 reference

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20 September 2018

Chemoprevention of familial adenomatous polyposis by natural dietary compounds sulforaphane and dibenzoylmethane alone and in combination in ApcMin/+ mouse.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3564494

20 September 2018

Consuming broccoli does not induce genes associated with xenobiotic metabolism and cell cycle control in human gastric mucosa.

1 reference

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20 September 2018

Preclinical and clinical evaluation of sulforaphane for chemoprevention in the breast.

1 reference

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20 September 2018

Pharmacogenomics of cancer chemopreventive isothiocyanate compound sulforaphane in the intestinal polyps of ApcMin/+ mice.

1 reference

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20 September 2018

Gene expression profiles induced by cancer chemopreventive isothiocyanate sulforaphane in the liver of C57BL/6J mice and C57BL/6J/Nrf2 (-/-) mice

1 reference

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AKR1B10: a new diagnostic marker of non-small cell lung carcinoma in smokers

1 reference

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20 September 2018

Inhibition of aldose reductase enhances HeLa cell sensitivity to chemotherapeutic drugs and involves activation of extracellular signal-regulated kinases

1 reference

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20 September 2018

Quantitative determination of dithiocarbamates in human plasma, serum, erythrocytes and urine: pharmacokinetics of broccoli sprout isothiocyanates in humans

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3564494

20 September 2018

The 4-pregnene and 5alpha-pregnane progesterone metabolites formed in nontumorous and tumorous breast tissue have opposite effects on breast cell proliferation and adhesion

1 reference

https://pubmed.ncbi.nlm.nih.gov/21597922

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Safety, Tolerance, and Metabolism of Broccoli Sprout Glucosinolates and Isothiocyanates: A Clinical Phase I Study

1 reference

https://pubmed.ncbi.nlm.nih.gov/21597922

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Elevation of aldose reductase gene expression in rat primary hepatoma and hepatoma cell lines: implication in detoxification of cytotoxic aldehydes

1 reference

https://pubmed.ncbi.nlm.nih.gov/21597922

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Overexpression of aldose reductase in human cancer tissues

1 reference

https://pubmed.ncbi.nlm.nih.gov/21597922

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Breast Cancer : Basic and Clinical Research

29

4

35

author name string

K Subik

publication date

2010

1 reference

10.1007/S10549-011-1536-9

https://api.crossref.org/works/10.1007/S10549-011-1536-9

2 December 2024

Gene Expression Omnibus: NCBI gene expression and hybridization array data repository

32

1 reference

10.1007/S10549-011-1536-9

https://api.crossref.org/works/10.1007/S10549-011-1536-9

2 December 2024

Medical Science Monitor

55

12

CR525

author name string

M Saraswat

publication date

2006

1 reference

10.1007/S10549-011-1536-9

https://api.crossref.org/works/10.1007/S10549-011-1536-9

2 December 2024

Type 5 17beta-hydroxysteroid dehydrogenase/prostaglandin F synthase (AKR1C3): role in breast cancer and inhibition by non-steroidal anti-inflammatory drug analogs.

59

1 reference

10.1007/S10549-011-1536-9

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2 December 2024

Identifiers

10.1007/S10549-011-1536-9

1 reference

Europe PubMed Central

PMC publication ID

15 August 2017

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

15 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

15 August 2017

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