(Q36579595)

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Pharmacological inhibition of nicotinamide phosphoribosyltransferase (NAMPT), an enzyme essential for NAD+ biosynthesis, in human cancer cells: metabolic basis and potential clinical implications

scientific article published on 13 December 2012

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scholarly article

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Europe PubMed Central

PMC publication ID

15 August 2017

Pharmacological inhibition of nicotinamide phosphoribosyltransferase (NAMPT), an enzyme essential for NAD+ biosynthesis, in human cancer cells: metabolic basis and potential clinical implications (English)

1 reference

Europe PubMed Central

PMC publication ID

15 August 2017

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author name string

Bo Tan

1

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Europe PubMed Central

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15 August 2017

Debra A Young

2

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15 August 2017

Zhao-Hai Lu

3

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15 August 2017

Tao Wang

4

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15 August 2017

Timothy I Meier

5

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15 August 2017

Robert L Shepard

6

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15 August 2017

Kenneth Roth

7

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15 August 2017

Yan Zhai

8

1 reference

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15 August 2017

Karen Huss

9

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15 August 2017

Ming-Shang Kuo

10

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15 August 2017

James Gillig

11

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Europe PubMed Central

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15 August 2017

Saravanan Parthasarathy

12

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Europe PubMed Central

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15 August 2017

Timothy P Burkholder

13

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Europe PubMed Central

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15 August 2017

Michele C Smith

14

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Europe PubMed Central

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15 August 2017

Sandaruwan Geeganage

15

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15 August 2017

Genshi Zhao

16

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15 August 2017

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publication date

13 December 2012

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15 August 2017

Journal of Biological Chemistry

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15 August 2017

288

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Europe PubMed Central

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15 August 2017

5

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Europe PubMed Central

PMC publication ID

15 August 2017

3500-3511

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Europe PubMed Central

PMC publication ID

15 August 2017

A positive/negative ion-switching, targeted mass spectrometry-based metabolomics platform for bodily fluids, cells, and fresh and fixed tissue

1 reference

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Catastrophic NAD+ depletion in activated T lymphocytes through Nampt inhibition reduces demyelination and disability in EAE.

1 reference

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Nicotinamide phosphoribosyltransferase (Nampt): a link between NAD biology, metabolism, and diseases

1 reference

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Nampt: linking NAD biology, metabolism and cancer

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Mitochondrial targeting adaptation of the hominoid-specific glutamate dehydrogenase driven by positive Darwinian selection

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NAD+ and vitamin B3: from metabolism to therapies

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The pharmacokinetics, toxicities, and biologic effects of FK866, a nicotinamide adenine dinucleotide biosynthesis inhibitor

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Nicotinamide adenine dinucleotide metabolism as an attractive target for drug discovery

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Poly(ADP-ribose) polymerase-1-dependent cardiac myocyte cell death during heart failure is mediated by NAD+ depletion and reduced Sir2alpha deacetylase activity

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The NAD biosynthesis pathway mediated by nicotinamide phosphoribosyltransferase regulates Sir2 activity in mammalian cells

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Enzymology of NAD+ homeostasis in man.

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Identifiers

10.1074/JBC.M112.394510

1 reference

Europe PubMed Central

PMC publication ID

15 August 2017

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

15 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

15 August 2017

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