(Q36430136)

14 August 2017

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title

MHC class II proteins and disease: a structural perspective (English)

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14 August 2017

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14 August 2017

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14 August 2017

Jack L Strominger

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14 August 2017

Christian Siebold

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14 August 2017

language of work or name

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1 April 2006

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Nature Reviews Immunology

14 August 2017

published in

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14 August 2017

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14 August 2017

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14 August 2017

page(s)

271-282

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Three-dimensional structure of the human class II histocompatibility antigen HLA-DR1.

14 August 2017

cites work

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Crystal structure of the human class II MHC protein HLA-DR1 complexed with an influenza virus peptide

21 January 2018

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Examination of possible structural constraints of MHC-binding peptides by assessment of their native structure within their source proteins.

21 January 2018

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Structural basis for the binding of an immunodominant peptide from myelin basic protein in different registers by two HLA-DR2 proteins

21 January 2018

1 reference

Crystal structure of HLA-DR2 (DRA*0101, DRB1*1501) complexed with a peptide from human myelin basic protein

21 January 2018

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Genetic and familial aspects of narcolepsy

21 January 2018

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DQ (rather than DR) gene marks susceptibility to narcolepsy

21 January 2018

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Complex HLA-DR and -DQ interactions confer risk of narcolepsy-cataplexy in three ethnic groups

21 January 2018

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The role of hypocretins (orexins) in sleep regulation and narcolepsy.

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Hypocretin (orexin) deficiency in human narcolepsy.

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A mutation in a case of early onset narcolepsy and a generalized absence of hypocretin peptides in human narcoleptic brains

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Crystal structure of HLA-DQ0602 that protects against type 1 diabetes and confers strong susceptibility to narcolepsy

21 January 2018

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21 January 2018

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Evidence for a primary association of celiac disease to a particular HLA-DQ alpha/beta heterodimer

21 January 2018

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T cells from the small intestinal mucosa of a DR4, DQ7/DR4, DQ8 celiac disease patient preferentially recognize gliadin when presented by DQ8.

21 January 2018

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Gliadin-specific, HLA-DQ(alpha 1*0501,beta 1*0201) restricted T cells isolated from the small intestinal mucosa of celiac disease patients

21 January 2018

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Tissue transglutaminase selectively modifies gliadin peptides that are recognized by gut-derived T cells in celiac disease

21 January 2018

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Structural basis for HLA-DQ2-mediated presentation of gluten epitopes in celiac disease

21 January 2018

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Natural peptides selected by diabetogenic DQ8 and murine I-A(g7) molecules show common sequence specificity

21 January 2018

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Type 1 diabetes: new perspectives on disease pathogenesis and treatment

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HLA-DQ beta gene contributes to susceptibility and resistance to insulin-dependent diabetes mellitus

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Genetic protection from the inflammatory disease type 1 diabetes in humans and animal models

21 January 2018

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Analysis of HLA-DQ genotypes and susceptibility in insulin-dependent diabetes mellitus

21 January 2018

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A correlation between the relative predisposition of MHC class II alleles to type 1 diabetes and the structure of their proteins.

21 January 2018

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Structure of a human insulin peptide-HLA-DQ8 complex and susceptibility to type 1 diabetes

21 January 2018

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Structural basis of peptide binding and presentation by the type I diabetes-associated MHC class II molecule of NOD mice

21 January 2018

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A structural framework for deciphering the link between I-Ag7 and autoimmune diabetes

21 January 2018

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Structures of an MHC class II molecule with covalently bound single peptides

21 January 2018

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Aspartic acid at position 57 of DQ beta chain does not protect against type 1 (insulin-dependent) diabetes mellitus in Japanese subjects

21 January 2018

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Crystal structure of MHC class II I-Ab in complex with a human CLIP peptide: prediction of an I-Ab peptide-binding motif

21 January 2018

1 reference

Refining the rules of gliadin T cell epitope binding to the disease-associated DQ2 molecule in celiac disease: importance of proline spacing and glutamine deamidation

21 January 2018

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The intestinal T cell response to alpha-gliadin in adult celiac disease is focused on a single deamidated glutamine targeted by tissue transglutaminase

21 January 2018

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Association of the B-cell alloantigen DRw4 with rheumatoid arthritis

21 January 2018

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HLA-DR4 subtype frequencies in rheumatoid arthritis indicate that DRB1 is the major susceptibility locus within the HLA class II region

21 January 2018

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The shared epitope hypothesis. An approach to understanding the molecular genetics of susceptibility to rheumatoid arthritis

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Peptide binding specificity of HLA-DR4 molecules: correlation with rheumatoid arthritis association

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Predominantly T-Cell Infiltrate in Rheumatoid Synovial Membranes

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Definition of MHC and T cell receptor contacts in the HLA-DR4restricted immunodominant epitope in type II collagen and characterization of collagen-induced arthritis in HLA-DR4 and human CD4 transgenic mice.

21 January 2018

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An HLA-DR1 transgene confers susceptibility to collagen-induced arthritis elicited with human type II collagen.

21 January 2018

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Specificity of an HLA-DRB1*0401-restricted T cell response to type II collagen.

21 January 2018

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Tracking of proinflammatory collagen-specific T cells in early and late collagen-induced arthritis in humanized mice.

21 January 2018

1 reference

X-Ray Crystal Structure of HLA-DR4 (DRA*0101, DRB1*0401) Complexed with a Peptide from Human Collagen II

21 January 2018

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Cutting edge: the conversion of arginine to citrulline allows for a high-affinity peptide interaction with the rheumatoid arthritis-associated HLA-DRB1*0401 MHC class II molecule

21 January 2018

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21 January 2018

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Identification of a motif for HLA-DR1 binding peptides using M13 display libraries

21 January 2018

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Structural basis for major histocompatibility complex (MHC)-linked susceptibility to autoimmunity: charged residues of a single MHC binding pocket confer selective presentation of self-peptides in pemphigus vulgaris

21 January 2018

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The multiple sclerosis- and narcolepsy-associated HLA class II haplotype includes the DRB5*0101 allele

21 January 2018

1 reference

Mapping multiple sclerosis susceptibility to the HLA-DR locus in African Americans

21 January 2018

1 reference

Selection for T-cell receptor Vβ–Dβ–Jβ gene rearrangements with specificity for a myelin basic protein peptide in brain lesions of multiple sclerosis

21 January 2018

1 reference

Visualization of myelin basic protein (MBP) T cell epitopes in multiple sclerosis lesions using a monoclonal antibody specific for the human histocompatibility leukocyte antigen (HLA)-DR2-MBP 85-99 complex

21 January 2018

1 reference

A functional and structural basis for TCR cross-reactivity in multiple sclerosis

21 January 2018

1 reference

Structural requirements for binding of an immunodominant myelin basic protein peptide to DR2 isotypes and for its recognition by human T cell clones

21 January 2018

1 reference

Unconventional topology of self peptide-major histocompatibility complex binding by a human autoimmune T cell receptor

21 January 2018

1 reference

Structure of a human autoimmune TCR bound to a myelin basic protein self-peptide and a multiple sclerosis-associated MHC class II molecule

21 January 2018

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A pilot trial of Cop 1 in exacerbating-remitting multiple sclerosis

21 January 2018

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Peptide 15-mers of defined sequence that substitute for random amino acid copolymers in amelioration of experimental autoimmune encephalomyelitis

21 January 2018

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Crystal structure of cat muscle pyruvate kinase at a resolution of 2.6 A

21 January 2018

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Expanded T cells from pancreatic lymph nodes of type 1 diabetic subjects recognize an insulin epitope

21 January 2018

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Insulin-dependent diabetes mellitus

21 January 2018

1 reference

A novel NOD-derived murine model of primary Sj�gren's syndrome

31 March 2020

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Genetic analysis of HLA class II alleles and susceptibility to type 1 (insulin-dependent) diabetes mellitus in Japanese subjects

31 March 2020

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31 March 2020

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Treatment of rheumatoid arthritis by selective inhibition of T-cell activation with fusion protein CTLA4Ig

31 March 2020

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Ex vivo characterization of the autoimmune T cell response in the HLA-DR1 mouse model of collagen-induced arthritis reveals long-term activation of type II collagen-specific cells and their presence in arthritic joints

31 March 2020

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31 March 2020

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Immunology of multiple sclerosis

31 March 2020

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A humanized model for multiple sclerosis using HLA-DR2 and a human T-cell receptor

31 March 2020

1 reference

31 March 2020

Identifiers

DOI

10.1038/NRI1805

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Dimensions Publication ID

14 August 2017

1044455988

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