(Q36429587)

14 August 2017

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title

LRP5/6 in Wnt signaling and tumorigenesis (English)

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14 August 2017

Yonghe Li

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14 August 2017

Guojun Bu

series ordinal

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14 August 2017

language of work or name

English

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publication date

1 October 2005

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14 August 2017

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14 August 2017

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14 August 2017

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14 August 2017

page(s)

673-681

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WNT and beta-catenin signalling: diseases and therapies

14 August 2017

cites work

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LDL receptor relatives at the crossroad of endocytosis and signaling.

21 January 2018

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Wise, a context-dependent activator and inhibitor of Wnt signalling

21 January 2018

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Sclerostin binds to LRP5/6 and antagonizes canonical Wnt signaling

21 January 2018

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21 January 2018

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arrow encodes an LDL-receptor-related protein essential for Wingless signalling

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An LDL-receptor-related protein mediates Wnt signalling in mice

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Low-density lipoprotein receptor-related protein-5 binds to Axin and regulates the canonical Wnt signaling pathway

21 January 2018

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A mechanism for Wnt coreceptor activation

21 January 2018

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Truncated mutants of the putative Wnt receptor LRP6/Arrow can stabilize beta-catenin independently of Frizzled proteins

21 January 2018

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Cbfa1-independent decrease in osteoblast proliferation, osteopenia, and persistent embryonic eye vascularization in mice deficient in Lrp5, a Wnt coreceptor

21 January 2018

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Low-density lipoprotein receptor-related protein 5 (LRP5) is essential for normal cholesterol metabolism and glucose-induced insulin secretion

21 January 2018

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The Wnt co-receptors Lrp5 and Lrp6 are essential for gastrulation in mice

21 January 2018

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SOST is a ligand for LRP5/LRP6 and a Wnt signaling inhibitor

21 January 2018

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Hypomorphic expression of Dkk1 in the doubleridge mouse: dose dependence and compensatory interactions with Lrp6.

21 January 2018

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High bone density due to a mutation in LDL-receptor-related protein 5

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A mutation in the LDL receptor-related protein 5 gene results in the autosomal dominant high-bone-mass trait

21 January 2018

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Six novel missense mutations in the LDL receptor-related protein 5 (LRP5) gene in different conditions with an increased bone density

21 January 2018

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Reduced affinity to and inhibition by DKK1 form a common mechanism by which high bone mass-associated missense mutations in LRP5 affect canonical Wnt signaling

21 January 2018

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The LRP5 high-bone-mass G171V mutation disrupts LRP5 interaction with Mesd.

21 January 2018

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Kremen proteins are Dickkopf receptors that regulate Wnt/beta-catenin signalling

21 January 2018

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The WNT signalling modulator, Wise, is expressed in an interaction-dependent manner during hair-follicle cycling.

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The roles of receptor-associated protein (RAP) as a molecular chaperone for members of the LDL receptor family

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Boca, an endoplasmic reticulum protein required for wingless signaling and trafficking of LDL receptor family members in Drosophila.

21 January 2018

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Mesd encodes an LRP5/6 chaperone essential for specification of mouse embryonic polarity

21 January 2018

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Boca-dependent maturation of beta-propeller/EGF modules in low-density lipoprotein receptor proteins.

21 January 2018

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Wnt proteins in mammary development and cancer

21 January 2018

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Wnt signaling in lung cancer

21 January 2018

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DKK1, a negative regulator of Wnt signaling, is a target of the beta-catenin/TCF pathway

21 January 2018

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FGF-20 and DKK1 are transcriptional targets of beta-catenin and FGF-20 is implicated in cancer and development

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Dickkopf-1, an inhibitor of the Wnt signaling pathway, is induced by p53.

21 January 2018

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Human Dkk-1, a gene encoding a Wnt antagonist, responds to DNA damage and its overexpression sensitizes brain tumor cells to apoptosis following alkylation damage of DNA

21 January 2018

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The role of the Wnt-signaling antagonist DKK1 in the development of osteolytic lesions in multiple myeloma

21 January 2018

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Isolation and biochemical characterization of the human Dkk-1 homologue, a novel inhibitor of mammalian Wnt signaling

21 January 2018

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A functional genomics approach for the identification of putative tumor suppressor genes: Dickkopf-1 as suppressor of HeLa cell transformation

21 January 2018

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Dickkopf 3 inhibits invasion and motility of Saos-2 osteosarcoma cells by modulating the Wnt-beta-catenin pathway

21 January 2018

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An autocrine mechanism for constitutive Wnt pathway activation in human cancer cells

21 January 2018

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Expression of LDL receptor-related protein 5 (LRP5) as a novel marker for disease progression in high-grade osteosarcoma

21 January 2018

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Met proto-oncogene and insulin-like growth factor binding protein 3 overexpression correlates with metastatic ability in well-differentiated pancreatic endocrine neoplasms

21 January 2018

1 reference

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LRP6 expression promotes cancer cell proliferation and tumorigenesis by altering beta-catenin subcellular distribution

21 January 2018

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Expression profile of genes from 12p in testicular germ cell tumors of adolescents and adults associated with i(12p) and amplification at 12p11.2-p12.1.

21 January 2018

1 reference

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21 January 2018

Identifiers

DOI

10.2217/14796694.1.5.673

1 reference

14 August 2017

1 reference